Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury
In this study we show in vitro and in vivo that Park7 has a crucial role in protection from AKI, and upregulated peroxisome activity. These data in combination with published results of Park7's protective role in cardiovascular damage and chronic kidney disease lead us to hypothesize that succinylation of Park7 may ameliorate oxidative damage resulting from AKI and prevent disease progression. This novel mechanism provides a potential therapeutic mechanism that can be targeted.PMID:38695076 | DOI:10.1152/ajprenal.00062.2024 (Source: American Journal of Physiology. Renal Physiology)
Source: American Journal of Physiology. Renal Physiology - May 2, 2024 Category: Physiology Authors: Katherine Pfister Victoria Young Brendon Frankel Anne Silva Barbosa Jordan Burton Joanna Bons Bob Zhang Takuto Chiba Rebecca Uhlean Eric Goetzman Birgit Schilling Sunder Sims-Lucas Source Type: research
Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review
CONCLUSIONS: The literature on bicycling for PwPD has evolved from speed to aerobic studies. The terminology describing types of bicycling was simplified. Of all the outcomes reported, reduction of disease severity achieved the highest frequency of clinical meaningful improvements. Bicycling was comparable with other forms of aerobic training for walking speed and endurance. Opportunities for translation to practice and research are presented.VIDEO ABSTRACT AVAILABLE: for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A462).PMID:38693613 | DOI:10.1097/N...
Source: Physical Therapy - May 2, 2024 Category: Physiotherapy Authors: John L Palmieri Lesley Jones Margaret Schenkman Judith E Deutsch Source Type: research
Structured medication reviews in Parkinson's disease: pharmacists' views, experiences and needs - a qualitative study
CONCLUSION: Although community pharmacist-led SMRs are time-consuming and sometimes logistically challenging, they are of added value in primary care in general, and also in PD, of which treatment occurs mainly in secondary care. It emphasizes the pharmacist's role in PD treatment and might tackle future drug-related issues. Improvements concern multidisciplinary collaboration for optimized SMR execution and results.PMID:38694547 | PMC:PMC11062216 | DOI:10.1177/20420986241237071 (Source: Adv Data)
Source: Adv Data - May 2, 2024 Category: Epidemiology Authors: Nicol G M Oonk Lucille D A Dorresteijn Eline Te Braake Kris L L Movig Job van der Palen Henk-Willem Nijmeijer Mirjam E van Kesteren Christina Bode Source Type: research
PET Ligands for Imaging Mutant Huntingtin Aggregates: A Case Study in Non-For-Profit Scientific Management
Chembiochem. 2024 May 2:e202400152. doi: 10.1002/cbic.202400152. Online ahead of print.ABSTRACTPositron emission tomography imaging of misfolded proteins with high-affinity and selective radioligands has played a vital role in expanding our knowledge of neurodegenerative diseases such as Parkinson's and Alzheimer's disease. The pathogenesis of Huntington's disease, a CAG trinucleotide repeat disorder, is similarly linked to the presence of protein fibrils formed from mutant huntingtin (mHTT) protein. Development of mHTT fibril-specific radioligands has been limited by the lack of structural knowledge around mHTT and a dear...
Source: Chembiochem - May 2, 2024 Category: Biochemistry Authors: Catherine G F Dickmann Selena Milicevic Sephton Roger A Barker Franklin I Aigbirhio Source Type: research
Bicycling for Rehabilitation of Persons With Parkinson Disease: A Scoping Review
CONCLUSIONS: The literature on bicycling for PwPD has evolved from speed to aerobic studies. The terminology describing types of bicycling was simplified. Of all the outcomes reported, reduction of disease severity achieved the highest frequency of clinical meaningful improvements. Bicycling was comparable with other forms of aerobic training for walking speed and endurance. Opportunities for translation to practice and research are presented.VIDEO ABSTRACT AVAILABLE: for more insights from the authors (see the Video, Supplemental Digital Content 1 available at: http://links.lww.com/JNPT/A462).PMID:38693613 | DOI:10.1097/N...
Source: Health Physics - May 2, 2024 Category: Physics Authors: John L Palmieri Lesley Jones Margaret Schenkman Judith E Deutsch Source Type: research
Can boxing relieve symptoms of Parkinson's disease and improve quality of life? A qualitative study of the experiences of participants attending the Danish Parkinson boxing concept
CONCLUSIONS: The experienced impact of participating in PB relates to physical relief of symptoms and improved functioning in everyday life, as well as a mental lift, energy, and joy during and after training sessions. Participants described being motivated to attend PB and to continue their training practice. Thus, PB entails experiences of relief of symptoms and presumably improved quality of life for the participants.PMID:38695285 | DOI:10.1080/09638288.2024.2346238 (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - May 2, 2024 Category: Rehabilitation Authors: Nafisa Mohamed Abdi Yusuf Pernille Bekke Stine Kj ær Wehner Source Type: research
Succinylation of Park 7 Activates a Protective Metabolic Response to Acute Kidney Injury
In this study we show in vitro and in vivo that Park7 has a crucial role in protection from AKI, and upregulated peroxisome activity. These data in combination with published results of Park7's protective role in cardiovascular damage and chronic kidney disease lead us to hypothesize that succinylation of Park7 may ameliorate oxidative damage resulting from AKI and prevent disease progression. This novel mechanism provides a potential therapeutic mechanism that can be targeted.PMID:38695076 | DOI:10.1152/ajprenal.00062.2024 (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - May 2, 2024 Category: Urology & Nephrology Authors: Katherine Pfister Victoria Young Brendon Frankel Anne Silva Barbosa Jordan Burton Joanna Bons Bob Zhang Takuto Chiba Rebecca Uhlean Eric Goetzman Birgit Schilling Sunder Sims-Lucas Source Type: research
The role of age ‐associated alpha‐synuclein aggregation in a conditional transgenic mouse model of Parkinson's disease: Implications for Lewy body formation
In this study, we found that a selective expression of WT (WT-α-syn) or a modified form of α-syn (WT-α-ayn-CL1) which has an increased propensity for aggregation in the dopaminergic neurons could lead to an age-dependent neurodegeneration. We further f ound that accumulation of alpha-syn aggregates in sizes and numbers were age-associated, suggesting a possible mechanism in the formation of Lewy bodies and neurodegeneration in PD. AbstractParkinson's disease (PD) is a common neurodegenerative disorder that is affecting an increasing number of older adults. Although PD is mostly sporadic, genetic mutations have been foun...
Source: Journal of Neurochemistry - May 2, 2024 Category: Neuroscience Authors: Jiahua Li,
Ka Wai Ng,
Chun Chau Sung,
Kenny K. K. Chung Tags: ORIGINAL ARTICLE Source Type: research
The Role of AI and Machine Learning in the Diagnosis of Parkinson ’s Disease and Atypical Parkinsonisms
Parkinson ’s disease is a neurodegenerative movement disorder associated with motor and non-motor symptoms causing severe disability as the disease progresses. The development of biomarkers for Parkinson’s disease to diagnose patients earlier and predict disease progression is imperative. As artificial in telligence and machine learning techniques efficiently process data and can handle multiple data types, we reviewed the literature to determine the extent to which these techniques have been applied to biomarkers for Parkinson’s disease and movement disorders. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 2, 2024 Category: Neurology Authors: Anthaea-Grace Patricia Dennis, Antonio P. Strafella Source Type: research
Cardiac Sympathetic Denervation and Anxiety in Parkinson Disease
Anxiety in Parkinson disease (PD) negatively impacts quality of life. While research predominantly focuses on central nervous system changes, some evidence suggests a connection between peripheral autonomic dysfunctions and PD-related anxiety. The role of the peripheral autonomic nervous system in this context may be overlooked. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 2, 2024 Category: Neurology Authors: G. Carli, P. Kanel, F. Michalakis, S. Roytman, J.L.B. Bohnen, T.P. Wigstrom, P. Scott, R.L. Albin, K.K. Wong, D. Raffel, N.I. Bohnen Source Type: research
Transferrin-conjugated magnetic nanoparticles for the isolation of brain-derived blood exosomal MicroRNAs: A novel approach for Parkinson's disease diagnosis
In this study, we introduce a method using transferrin conjugated magnetic nanoparticles (TMNs) to isolate these exosomes from the plasma of patients with neurological disorders. This TMNs technique is both quick (<35 min) and cost-effective, requiring no high-priced ingredients or elaborate equipment for EV extraction. Our method successfully isolated EVs from 33 human plasma samples, including those from patients with Parkinson's disease (PD), Multiple Sclerosis (MS), and Dementia. Using quantitative polymerase chain reaction (PCR) analysis, we evaluated the potential of 8 exosomal miRNA profiles as biomarker candidat...
Source: Analytica Chimica Acta - May 1, 2024 Category: Chemistry Authors: Yoon Ok Jang Yeonjeong Roh Wangyong Shin Sungyang Jo Bonhan Koo Huifang Liu Myoung Gyu Kim Hyo Joo Lee Zhen Qiao Eun Yeong Lee Minju Lee Joonseok Lee Eun-Jae Lee Yong Shin Source Type: research
The encoding of speech modes in motor speech disorders: whispered versus normal speech in apraxia of speech and hypokinetic dysarthria
This study investigates the encoding of speech modes in individuals with AoS following focal brain damage and in individuals with hypokinetic dysarthria (HD) secondary to Parkinson's disease. Participants with mild-to-moderate MSD and their age-matched controls performed a delayed production task of pseudo-words in two speech modes: normal and whispered speech. While overall accuracy did not differ significantly across speech modes, participants with AoS exhibited longer response latencies for whispered speech, reflecting difficulties in the initiation of utterances requiring an unvoiced production. In contrast, participan...
Source: Clinical Linguistics and Phonetics - May 1, 2024 Category: Speech-Language Pathology Authors: M Bourqui M Lancheros F Assal M Laganaro Source Type: research
Longitudinal prevalence of neurogenic orthostatic hypotension in the idiopathic Parkinson Progression Marker Initiative (PPMI) cohort
CONCLUSIONS: nOH prevalence was greater than non-nOH in the PPMI early PD cohort, with modest prevalence increase over time. Our findings are consistent with prior studies of large cohorts that evaluated nOH, specifically. Those with early PD and nOH were likelier to be older and suffer from greater motor and functional impairment, but OH presence was generally associated with more cognitive impairment.PMID:38692034 | DOI:10.1016/j.autneu.2024.103173 (Source: Autonomic Neuroscience)
Source: Autonomic Neuroscience - May 1, 2024 Category: Neuroscience Authors: Paul Beach J Lucas McKay Source Type: research
Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models
In conclusion, the deficiency of the nuclear hormone receptor nhr-210 in alpha-synuclein expressing strain of C. elegans, results in altered mitochondrial function, coupled with alterations in vital metabolite levels. These findings underline the functional and physiological importance of nhr-210 enrichment in CEPsh glia.PMID:38691171 | DOI:10.1007/s00018-024-05179-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - May 1, 2024 Category: Cytology Authors: Rohil Hameed Anam Naseer Ankit Saxena Mahmood Akbar Pranoy Toppo Arunabh Sarkar Sanjeev K Shukla Aamir Nazir Source Type: research
Transferrin-conjugated magnetic nanoparticles for the isolation of brain-derived blood exosomal MicroRNAs: A novel approach for Parkinson's disease diagnosis
In this study, we introduce a method using transferrin conjugated magnetic nanoparticles (TMNs) to isolate these exosomes from the plasma of patients with neurological disorders. This TMNs technique is both quick (<35 min) and cost-effective, requiring no high-priced ingredients or elaborate equipment for EV extraction. Our method successfully isolated EVs from 33 human plasma samples, including those from patients with Parkinson's disease (PD), Multiple Sclerosis (MS), and Dementia. Using quantitative polymerase chain reaction (PCR) analysis, we evaluated the potential of 8 exosomal miRNA profiles as biomarker candidat...
Source: Analytica Chimica Acta - May 1, 2024 Category: Chemistry Authors: Yoon Ok Jang Yeonjeong Roh Wangyong Shin Sungyang Jo Bonhan Koo Huifang Liu Myoung Gyu Kim Hyo Joo Lee Zhen Qiao Eun Yeong Lee Minju Lee Joonseok Lee Eun-Jae Lee Yong Shin Source Type: research
