Usage of modern technologies like VR therapy, physio therapy along with levodopa in Young-Onset Parkinson's disease patients
Background: Description of the condition: Young-Onset Parkinson's disease (YOPD) usually occurs in the prime age group of the person which usually affects the life of the patient in many ways like social, economical, familial relationship of the person. It is characterized by the progressive degeneration of dopaminergic neurons in the brain. While the symptoms and progression of YOPD are similar to those of later-onset Parkinson's disease, the early age of onset can present unique challenges. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Pavihran, S. Khanduja Source Type: research
Mental health in Parkinson ’s: Uncovering real-world patient experiences in psychological support and care
Background: Prior research has examined the effectiveness of psychological interventions in Parkinson ’s disease (PD), with mixed results. Yet few studies have sought to explore the lived experience of individuals with PD who have accessed professional psychological support. These studies are largely limited to examining specific psychotherapeutic interventions within a research trial context, so whether (and how) psychotherapy may be helpful (or not) in PD in a real world setting is underexplored. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Hunsdon, A.K. Ho Source Type: research
Therapeutic benefit of laughter yoga and deep breathing exercises with oral doses of Withania somnifera root extracts in Parkinson's disease patients.
Background: Laughter has been shown to generally improve mood in physically healthy adults, and specifically in adults with heart disease or cancer, but little research exists regarding the impact of laughter in adults with Parkinson ’s disease (PD). To study new methods of controlling Parkinson’s disease complications by laughter yoga and deep breathing exercise with Withania somnifera root extract (WSE) dose in PD patients in rural Delhi metro population. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Kumar, V. Sharma Source Type: research
Examination of cognitive function in Parkinson's disease patients with chronic kidney disease
Background: Relevance: The development of neurodegenerative diseases in patients with chronic kidney disease is an urgent problem of modern medicine. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Khudayarova, G. Rakhmatullayeva, B. Holmuratova Source Type: research
Suicide Attempt in a Case of Dopamine Agonist Withdrawal Syndrome in Parkinson's Disease
Background: Dopamine agonist withdrawal syndrome (DAWS) results from the reduction or suspension of dopamine agonist medications, it includes mainly psychiatric symptoms, including suicidal behaviors. In patients with Parkinson's disease (PD), the impact of DAWS can be significant in terms of distress and disability; however, we must take this syndrome into account as a threatening condition because suicidal behaviors could develop in the context of DAWS. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Espindola, N. Gonzalez Rojas, G. DaPrat, M. Cesarini, J.L. Etcheverry, E.M. Gatto Source Type: research
Community-based participatory research approach to address health care disparities confronting members of the Black Diaspora with Parkinson ’s disease
Background: Healthcare disparities exist for people with Parkinson ’s disease (PwP) from historically marginalized populations; they are not accurately represented in research, have delayed diagnoses, and inadequate access to care. Community-based participatory research (CBPR) has proven effective to rapidly translate clinical research into local health policy, a nd is well-suited to reduce racial and socioeconomic disparities in healthcare quality and access. This paper describes a framework for using a CBPR approach to understand and address healthcare disparities in our community. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Pacheco, D. Kipnis, D. Delfing, N. Toomer-Mensah, C.E. Macpherson, J. Rieger, A. Parker, R.B. Coley, D. Coley, H. Shah, L. Quinn Source Type: research
Parkinson's disease and its financial impact on the Brazilian public health system
The objective was to compare, over the last 15 years and between regions of Brazil, public resources utilized in PD clinical procedures (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Fortaleza Falc ão, A. Fiorotto de Mattos, G. Henrique Gazonato, P. Tavares Falcão, P. Henrique Tavares de Oliveira, J. Reis Menezes Source Type: research
Age-related incidence of Parkinson's disease patients with Covid-19
Background: Patients with Parkinson's disease can become infected with Covid-19 at any age, depending on the functioning of the immune system. However, Parkinson's disease patients differed in the onset of a higher incidence of Covid-19 infection. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Salimjonov, B. Muminov, Kh.Khalimova, R. Matmurodov Source Type: research
The role of brain-derived neurotrophic factor during Parkinson's disease
Background: Parkinson's disease (PD) is a widespread neurologic disorder. The mechanisms involved in the generation of PD are probably multifactorial and are not fully understood. Brain-derived neurotrophic factor (BDNF) is a neurotrophin implicated in generating and modulating PD. The present study aimed to investigate the role and importance of brain neurotrophic factors in the clinical course of PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: B. Holmuratova, N. Rashidova, K. Khalimova, S. Khudayarova Source Type: research
Cognitive compromise in a cohort of patients from Colombia with DBS for Parkinson's disease treatment
Background: Parkinson's disease has increased its prevalence in Colombia as in the rest of the world, due to several factors, including population aging. This has led to the strengthening for therapies such as DBS, which are known to be effective in symptom control, but with adverse outcomes such as cognitive compromise. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T. L ópez, M. Fonseca, P. Arango, O. Rojas, G. Monsalve, J.C. Diez, J. Lobato, O. Bernal Pacheco Source Type: research
Genetic variability of OBPIIa in Parkinson ’s Disease (PD) patients of Tamil Nadu population, India
Background: Parkinson ’s disease (PD) is a neurodegenerative disorder while olfactory dysfunction is the primary non-motor symptoms observed before the occurrence of motor symptoms. Functional differences in smell within the physiological spectrum have been linked to polymorphisms of particular genes coding for membran e receptors or binding proteins. Studies on polymorphisms in olfactory-binding protein (OBP) has been shown to affect olfaction in PD. The current study explores the olfactory functionality by odour identification test, followed by molecular analysis of OBPIIa polymorphism in three varied PD age gro ups. (...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Venkatesan, S. Priyanka, N. Raj, B. Vellingiri Source Type: research
Computational studies of compounds against alpha-synuclein in Kampavata AKA Parkinson's disease in Ayurveda
Background: Parkinson's disease (PD), the second most common neurodegenerative disorder, it's diagnosis is not yet conceived until half of the dopaminergic neuron degenerates, resulting in longitudinal irreparable damage. Nevertheless, abnormal α-synuclein chronic aggregation and accumulation is the cornerstone to inflammation, oxidative stress, protein dysfunction, apoptosis, mitochondrial dysfunction, and autophagy. Hence, in such a scenario, compounds targeting aggregates can be a way of effectively treating PD and computational-based approaches are cheap and easy for finding hits. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Rajpoot, N. Khatri Source Type: research
Parkinson ’s Disease Psychosis: A systematic review of pharmacological treatment
Background: Parkinson's disease is frequently associated with psychiatric symptomatology, with psychosis emerging as a prevalent manifestation. The effective management of psychosis necessitates a comprehensive, multidisciplinary approach, involving modifications to dopaminergic medications and the introduction of antipsychotics. Given that certain antipsychotics may exacerbate motor symptoms and entail additional side effects, meticulous consideration is paramount in identifying the most suitable therapeutic interventions for optimizing patient well-being. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: G. Costandache Source Type: research
Challenges during prayer (namaz/salah) rituals in Muslim patients with Parkinson ’s disease
Background: It is estimated that there are 40 million Muslims with Parkinson ’s disease (PD). The Islamic prayer ritual, a practice performed five times daily, poses significant challenges for patients with PD (PwPD). This ritual necessitates a series of repetitive physical actions of standing, bowing, prostrating, and sitting. Clinically, it has been observed that these p rayer activities notably impact the quality of life in PwPD. However, to our knowledge, no study has previously investigated this topic. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: B. Çelik, H.K. Sari, G. Ozkaya, R. Yilmaz, M.C. Akbostancı Source Type: research
Wait and see... is it multiple system atrophy type C? A case report
Background: Multiple system atrophy (MSA) is a rare and progressive neurodegenerative disease that can present with several neurological symptoms. MSA is divided in the parkinsonian type (MSA-P) which present mainly with parkinson-like symptoms and cerebellar type (MSA-C) which present with a marked ataxic component. The MSA diagnosis is often confused with other diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Grilo, A.L. Oliveira, T. Jesus, S. Costa Source Type: research
