Olfactory and Gustatory Function is Associated with Global Cognition in Early-stage Parkinson's Disease
Background: Hyposmia is a prevalent non-motor symptom of Parkinson ’s disease (PD). Recent studies have recognized hypogeusia as an additional non-motor symptom in PD. Although there have been reports linking hyposmia to the development of dementia in PD, the association between cognitive function in the early stage of PD and olfactory and gustatory function rema ins largely unexplored. To shed light on this subject, the present study aimed to evaluate the olfactory and gustatory function in early-stage of PD patients without dementia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.E. Kim, H.-i. Ma Source Type: research
Quebec Parkinson Network: The reference for your next research in Parkinson's disease and related disorders
Background: The Quebec Parkinson Network (QPN) is one of the main research networks in Parkinson's Spectrum Disorder. The main objectives are to facilitate collaboration between clinician, patients/participants and researchers,& promote data sharing and open science. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Bogard, C. Degroot, M. Blais, N. Dupr é, E. Fon Source Type: research
An unusual cause of gait disturbance in a patient with Parkinson ’s disease: Beware of mimics and chameleons
Background: The co-occurrence of Parkinson ’s disease (PD) and normal pressure hydrocephalus (NPH) might pose a challenging diagnosis given the unusual combination of both entities and some phenomenological similarities, such as gait impairment. It is crucial not to miss the diagnosis of NPH in a patient with PD since it implies a differen t treatment approach. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Fernandes, A.S. Vedor, C. Soares, M.J. Rosas Source Type: research
Case report of a Parkinson ’s disease patient with early motor fluctuation
We describe a PD patient with early motor fluctuation within 3 years. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Park Source Type: research
Cognition of Parkinson ’s Disease Patients in the On and Off State: A Case Series
Background: Parkinson ’s disease (PD) is a neurodegenerative disorder affecting both motor and non-motor functioning. A common non-motor symptom is cognitive dysfunction. Changes in cognition can be manifested in fluctuations related to off periods. Neuropsychological testing is used to assess one’s cognitive status. However, this is time consuming and cost prohibitive. Creyos is an online cognitive instrument looking at four cognitive areas: memory, reasoning, verbal ability, and concentration. We studied the following measures for memory: spatial short term memory, working memory, and episodic memory; reasoni ng: vis...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Brillman, S. Bhushan Source Type: research
Observational study of Safinamide as an add-on to levodopa monotherapy for Parkinson's disease patients with wearing-off in Japan
This study was an exploratory investigation of the efficacy and safety of safinamide in patients with PD and wearing-off treated with oral levodopa alone. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Nishikawa, T. Hatano, K. Nishioka, S.-I. Ueno, S. Saiki, R. Nakamura, A. Yoritaka, T. Ogawa, Y. Shimo, W. Sako, H. Shimura, Y. Furukawa, T. Kamei, T. Ozawa, T. Ishida, N. Hattori Source Type: research
Establishing exercise habits in patients with Parkinson's disease through an exercise group model
Background: Parkinson's disease(PD) is common neurodegenerative disease. It is clinically characterized by a gradual worsening of motor and non-motor symptoms. Medications can be used to help patients relieve symptoms and maintain quality of life. Studies have found that in addition to drug treatment, exercise can help slow the progression of Parkinson's disease. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. LU, J. Yu Source Type: research
Parkinson ’s Disease Management in a Tertiary Irish Hospital
Background: Currently, there is no existing Irish platform for operationalizing services for People with Parkinson ’s and associated disorders (PwP). The UK-wide Parkinson’s clinical audit was originally developed in 2009, to address the concerns of professionals, patients and their representatives about the quality of care provided to PwP. They completed their eighth audit cycle in 2022. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: C. Gibbons, G. Hughes, S. O'Riordan, B. Dwyer, T. Geraghty Source Type: research
Impact of Falls on Quality of Life among Patients with Parkinson ’s Disease from a Referral Center Ambulatory Care PD Clinic
This study aims to assess the effect of falls on the QoL of PwP based on the Parkinson Disease Questionnaire 8 (PDQ-8) score. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.R.T. Yu, A.D.L. Sarmiento, M. Cua, M.J. Tanglao, R.L. Rosales Source Type: research
If You Don ’t Ask, You Won’t Know: Inclusive Recruitment Strategies for the Parkinson Progression Markers Initiative (PPMI)
Background: Clinical trials under-enroll people with Parkinson ’s disease (PD) who identify as members of minority communities. To address this gap, PPMI launched a task force to ensure recruitment and retention in this international observational study reflects the PD population as a whole. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Mantri, M. Kutler, D. Hakim, A. O'Grady, C. Kelliher, M. Kuhl, S. Fong, R. Dobkin, Parkinson's Progression Markers Initiative Source Type: research
Olfactory subtypes in Parkinson ’s disease, and their longitudinal significance
Background: Patients with Parkinson ’s disease suffer from hyposmia, even before its diagnosis. The olfactory route has been recognized to provide a path for pathobiologic development. Previous studies focused on the dichotomy of olfactory status as hyposmia or not, neglecting subpopulation of PD with normal or delayed impairment of olfaction after the diagnosis. Its longitudinal significance on disease progression was also not investigated. The study investigated the olfactory subtypes and their influence on cognition in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.-W. Yoo, J.-S. Kim Source Type: research
Validation of the Polish Version of the Gastrointestinal Dysfunction Scale for Parkinson's Disease
Background: Gastrointestinal dysfunction is a common non-motor manifestation of Parkinson ’s disease. Digestive tract symptoms are often debilitating for Parkinson's disease patients and may precede motor symptom onset by many years. Up till now, there was no scale available in Polish that thoroughly assessed gastrointestinal symptoms in patients with Parkinson’s disease. The Gastroi ntestinal Dysfunction Scale for Parkinson's Disease (GIDS-PD) is a disease-specific self-report questionnaire, which is used to quantitatively assess three domains (constipation, bowel irritability, upper gastrointestinal symptoms) of gast...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.M. Nowak, A. Antoniak, M. Kopczy ński, W. Zając, K. Sadowski, Ł. Milanowski, D. Koziorowski, M. Figura Source Type: research
Association and Spatiotemporal Progression Patterns of Dopamine Availability and Deep Gray Matter Volume in Parkinson ’s Disease–related Cognitive Impairment
Background: In Parkinson ’s disease (PD), cognitive impairment is common and linked to dopamine depletion and deep gray matter atrophy. We aimed to explore spatiotemporal progression patterns of striatal dopamine availability and regional brain volume based on cognitive status among PD patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.-S. Kim, Y.-S. Oh, C.H. Lyoo, G. Park, H. Kim Source Type: research
Study protocol: Exploration of sternal focused vibrotactile stimulation in people with Parkinson's disease experiencing Freezing of Gait
Background: Freezing of Gait (FoG), a symptom of Parkinson ’s Disease (PD), poses significant challenges. Compensatory strategies like cueing and high-frequency vibrotactile stimulation have proven effective in alleviating FoG severity. Understanding functional mobility, defined as a person's ability to move independently and safely across environments, i s vital for task accomplishment. The potential impact of individualized Focused Sternal Vibrotactile Stimulation (FocuS) on functional mobility and FoG in people with PD (PwPD) over a 2-week period remains unexplored. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Wilhelm, T. Miksch, H. K öttl, J. Janssen, P. Augat Source Type: research
Advanced perspectives for the diagnosis of Parkinson ’s and Alzheimer's disease through machine learning techniques
Background: A new paradigm called Neurodegenerative Elderly Syndrome proposed by Caligiore et al. (2022), conceives Parkinson ’s disease (PD) and Alzheimer’s disease (AD) as different manifestations of a single disease at very early stages. Accordingly, in this study we aim to observe and compare PDs and ADs features importance at baseline, 12-months and 24-months of follow-up, to predict disease conversion and differe ntiate or classify both pathologies. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Malvaso, S. Panarese, M. Catalano, M. Migliore, D. Caligiore Source Type: research
