Electroacupuncture alleviates pain in Parkinson's disease by modulating the microglia-NLRP3 inflammasome-inflammatory factors axis
The objective of this study was to investigate the neuroimmune mechanisms underlying the pain-relieving effects of of electroacupunctur e in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: X.-W. Wang Source Type: research
Persons with Parkinson`s disease show the motor behavioral phenomenon repeated bout rate enhancement during cycling
Background: Parkinson ’s disease is a degenerative condition of the brain that affects a person’s neuromotor control. Cycling is considered to benefit persons with Parkinson’s disease. And rhythmogenesis of pedalling is considered capable of reflecting movement-elicited net neuroexcitation. We investigated whether the motor behavioural phenomenon of repeated bout rate enhancement occurs during submaximal ergometer cycling. Repeated bout rate enhancement is defined as an increase of the freely, or spontaneously, chosen cadence during repeated bouts of pedalling and has previously been reported to occur in recr eationa...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E.A. Hansen, M.J.C. Berner, N.H. Gade, M.H. Bj ørnkjær, A.F. Brekke, V. Grønlund Source Type: research
Changes of vagus nerve cross-sectional area as a disease-specific imaging biomarker in early Parkinson ’s disease patients
This study aimed to compare VN size in patients with Parkinson ’s disease (PD) according to the disease stages and nondegenerative parkinsonian (non-PD) patients using high-resolution ultrasonography (HRUS). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.H. Kang, H.s. Lee, H. Ma, D.-Y. Kwon Source Type: research
Unusual rapid progression of cognitive function in young-onset Parkinson ’s disease: A case report
Background: Young-onset Parkinson's disease (YOPD) is arbitrarily defined as that which produces initial symptoms before the ages of 40, and usually takes a slower progression. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Tsuboi, S. Murakami, S. Fujii, Y. Yamashita, T. Fujioka, Y. Oka, Y. Ueki Source Type: research
Ground Reaction Force Analysis in Parkinson ’s Disease and Freezing of Gait. A secondary analysis of a gait-analysis data set
Background: Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson ’s Disease (PD). Biomechanical analyses for FoG are mainly concerned with spatiotemporal gait analysis and gait alteration in response to dual-tasks. There is limitation in kinetic analyses and especially Ground Reaction Force (GRF) analysis. The aim of the current study is to analyze the GRF in a sample of PD participants, and find the effect of FoG on GRF at off- and on-dopaminergic treatment. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Etoom, O. Elabd Source Type: research
Ups and Downs, Joys and Sorrows: Assessing Patient Priorities in an Interdisciplinary PD Clinic
Background: People with Parkinson disease (PwP) often report difficulty communicating with their clinical team. Narrative medicine strategies, such as the parallel chart (documentation by PwP), can improve communication but can require additional clinician time to review, limiting usability. The 55-word story, a short-form reflective journaling technique, may circumvent this barrier. This pilot study examined the feasibility of integrating a PwP-written 55-word story within a subspecialty interdisciplinary clinic. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Trahair, A. Allen, S. Mantri Source Type: research
The impact of short-term blood pressure variability on dementia in Parkinson ’s disease in relation to the renin-angiotensin system
Background: Cardiovascular dysautonomy and dementia are common non-motor features of Parkinson ’s disease (PD). Apart from orthostatic hypotension, supine hypertension (SH) and abnormal nocturnal blood pressure profile, also short-term blood pressure variability (BPV) may play a role in the pathogenesis of dementia. Role of the renin-angiotensin system (RAS) in this process remains unclear. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Kwasniak-Butowska, J. Slawek, A. Konkel, A. Skrzypkowska, D. Wieczorek, M. Bialecka, E. Szurowska, M. Tomczyk, R. Smolenski Source Type: research
A structural perspective on the interaction between glucocerebrosidase and the positive allosteric modulator BIA 28-6156
Background: BIA 28-6156 is a Phase II clinical candidate for the treatment of patients with Parkinson`s Disease (PD) who have a mutation in the Glucocerobrosidase (GBA1) gene (GBA-PD). Heterozygous GBA1 pathogenic variants are the most common genetic risk factor for PD, accounting for 5-15% of PD patients. Usually, GBA-PD patients present an earlier age of onset, may progress more rapidly, and may experience earlier and more significant cognitive impairment as compared with idiopathic PD patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.M. Dantas, N.M.F.S.A. Cerqueira, V.L. Batalha, L.E. Kiss, T. Karoli, J. Holenz Source Type: research
Caudate dopamine loss, occipital hypoperfusion, and dementia conversion in Parkinson ’s disease: A dual-phase 18F-FP-CIT PET Study
This study aimed to investigate the association between dopamine depletion in the caudate, occipital hypoperfusion, and longitudinal cognitive decline in patients with Parkinson's disease (PD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.J. Chung, S.H. Kim, J.S. Jung, S.R. Lee, C.W. Park, S.H. Jeong, Y. Jeong, Y.J. KIM Source Type: research
Physical exercise as a promising enhancer of global cognition in people with Parkinson ’s disease? A systematic review and meta-analysis
Background: Physical exercise interventions are known to improve quality of life as well as motor and non-motor symptoms in people with Parkinson ’s disease (PD). However, systematic reviews and meta-analyses including cognitive outcomes are rare. Thus, the aim of this study was to perform an updated systematic review and meta-analysis of the effects of physical exercise interventions compared with passive and active control groups (CGs) on global cognition in people with PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A.-K. Folkerts, M. Ernst, R. Gollan, N. Cryns, I. Monsef, N. Skoetz, E. Kalbe Source Type: research
Start Right, Stay Well: Piloting a Screening Tool for Dysphagia and Medication Management for Patients with Parkinson's in the Emergency Department
Background: The Speech and Language Therapy (SLT) Department at Buckinghamshire Healthcare NHS Trust embarked on a pioneering project. The goal: to develop and pilot a new swallow screening tool specifically designed for Parkinson's patients in the Emergency Department (ED). By reducing hospital stays and addressing swallowing difficulties early on, the new tool has the potential to significantly enhance the quality of life for this vulnerable population. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Hornby Source Type: research
Nutritional Problems and Adaptation in Persons with Parkinson ’s Disease - A Qualitative Study
Background: Parkinson ’s disease (PD) is one of the common neurodegenerative disorders. Proper nutrition intake and medications can make better treatment for people with PD. As PD progresses, they may experience various motor and non-motor symptoms which generate unique nutrition problems. Their problems about nutritio n and the way they deal with the problems need more attention. This qualitative study aimed to explore the nutritional problems in people with PD and how they adapted to these problems. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T.-Y. Chen, K.-R. Chen, T.-S. Fan, K.-H.S. Chen, C.-M. Ouyang Source Type: research
Extra-Striatal Cholinergic System Changes in Dopamine Replacement Therapy Responsive versus Non-Responsive Freezing of Gait in Parkinson's Disease: [18F]-FEOBV PET study
Background: Parkinson's disease (PD) is a debilitating condition that can severely impact mobility. As the disease progresses, treatment response to dopaminergic drugs can become less effective, especially for freezing of gait (FoG). Recent research using vesicular acetylcholine transporter (VAChT) PET imaging has implicated degeneration of cholinergic pathways, including in the striatum and limbic archicortex, as key determinants of FoG. However, it is unknown whether changes in the cholinergic system is also implicated in dopaminergic treatment resistance in FoG in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Kanel, M. van Emde Boas, K. Chou, R. Albin, N. Bohnen Source Type: research
Association of Glycated Hemoglobin (HbA1c) levels with Motor Symptoms in Parkinson ’s Disease: A Cross-Sectional Investigation in the Indian Population
Background: Recent research indicates a complex association between glycated hemoglobin (HbA1c) levels and motor symptoms in Parkinson's disease (PD), showing faster decline with both high and low levels. However, there's a lack of research on this link within the Indian PD community. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Choudhary, N. Seervi Source Type: research
Olfactory and Gustatory Function is Associated with Global Cognition in Early-stage Parkinson's Disease
Background: Hyposmia is a prevalent non-motor symptom of Parkinson ’s disease (PD). Recent studies have recognized hypogeusia as an additional non-motor symptom in PD. Although there have been reports linking hyposmia to the development of dementia in PD, the association between cognitive function in the early stage of PD and olfactory and gustatory function rema ins largely unexplored. To shed light on this subject, the present study aimed to evaluate the olfactory and gustatory function in early-stage of PD patients without dementia. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.E. Kim, H.-i. Ma Source Type: research
