The association of olfactory dysfunction with depression in patients with early-onset Parkinson`s disease
This study aimed to evaluate the association between olfactory dysfunction and depression in patients with early-onset Parkinson's disease (EOPD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: T. Dang Thi Huyen, T. Nguyen Vinh, K. Nguyen Vinh, H. Le Thi, U. Ha Ngoc Le, K. Vo Ngoc Chung, T. Tran Ngoc Source Type: research
Exploring Mitochondrial DNA Damage in Neuronal Complex I Deficient Parkinson's Neurons
Background: Mitochondrial dysfunction, particularly Complex I (CI) deficiency, is closely linked with idiopathic Parkinson's Disease (iPD). Its role in dopaminergic neuron degeneration in the substantia nigra pars compacta (SNc) is well-documented, yet its impact beyond this region remains debatable due to conflicting reports. Our groundbreaking research addresses this ambiguity, highlighting that mitochondrial dysfunction is a crucial factor in only a subset of iPD cases. Through immunohistochemical brain tissue analysis, we identified patient clusters: non-mitoPD with normal CI levels and mitoPD with moderate to severe C...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Rubiolo, S. Mostafavi, C. Tzoulis Source Type: research
Parkinson ’s Disease with Hyposmia and Dysautonomia: Does It Represent a Distinct Subtype?
Background: Olfactory dysfunction or dysautonomia is one of PD's earliest prodromal non-motor symptoms. We aimed to investigate whether PD patients with dysautonomia and hyposmia at the de novo stage present different prognoses regarding PD dementia (PDD) conversion, motor complication development, and change in levodopa-equivalent doses (LED). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.H. Yoon, D.H. You, H. Na, S. Kang, K. Baik, M. Park, C.H. Lyoo, Y.H. Sohn, P.H. Lee Source Type: research
Integrity of Dopaminergic Terminals in the Caudate Nucleus Modulates Rest Tremor in Parkinson ’s Disease
Background: Resting tremor (RT) is a symptom of Parkinson's disease (PD) with an uncertain connection to the dopaminergic (DA) system. In contrast to other motor symptoms in PD, severity of tremor does not show a correlation with loss of striatal dopamine, but dopaminergic denervation of specific parts of the basal ganglia has been inconsistently related to tremor-dominant PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Mendon ça, P. Ferreira, F. Oliveira, D. Costa, A. Oliveira-Maia, J. Alves da Silva Source Type: research
Exploring the Role of Genetic Mutations and Clinical Features in the Conversion to α-Synucleinopathies
This study aims to evaluate the influence of genetic mutations and clinical symptoms on the risk of conversion to α-synucleinopathies. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Qin, M. Zhang Source Type: research
Targeting sedentary behavior decreases depressive symptoms and improves sleep in people with Parkinson ’s Disease
Background: Physical Therapy (PT) and regular exercise are an integral part of the management of Parkinson's Disease (PD). Exercise is also known to have a mitigating effect on depressive symptoms. There is increasing evidence that decreasing sedentary behavior is also a valuable tool to manage PD symptoms. We looked at the effect of decreasing sedentary behavior on depressive symptoms in PD by offering an opportunity to replace sedentary behavior with slow paced standing and stepping behavior in the home environment. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. van Emde Boas, C. Pongmala, A. Griggs, G. Carli, N.I. Bohnen Source Type: research
Association between global cognitive function and autonomic dysfunction in patients with de novo Parkinson ’s disease
This study aimed to investigate the relationship between cognitive function and autonomic nervous system in early-stage Parkinson's disease (PD), which has not yet been well established. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: K.-Y. Kwon, J.-H. Park Source Type: research
Interaction between caffeine intake and polymorphisms of PARK16 modifies Parkinson ’s Disease risk
Background: Caffeine intake is associated with a reduced risk of Parkinson ’s disease (PD). However, there is great variability in the degree of neuroprotection conferred by caffeine and A2AR antagonist among individuals, suggesting a possible interaction between caffeine and one’s genetic background. We explore the interaction between caffeine intake and the risk vari ants of one PD susceptibility gene in Asian population, and estimate the PD risk in caffeine-drinkers carrying the variants. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E.K. Tan, Y. Yang, E.Y. Ng, S.E. Saffari Source Type: research
Dopaminergic System Changes in Visuomotor-Cognitive Multitasking Simulating Real-Life Mobility in Parkinson ’s Disease
Background: Mobility involves complex visuomotor-cognitive skills, especially during turns. For people with Parkinson's disease (PwPD), this might be challenging. While striatal dopaminergic losses are critical in PD motor impairments, the brain ’s role in visuomotor-cognitive processing in real-life mobility is less understood. We aim to identify dopaminergic system changes in PwPD during simulated pedestrian crossing conflict scenarios. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Bohnen, G. Carli, A. Biddix, A. Luker, F. Michalakis, L. Ojeda, S. Roytman, R. Albin, P. Scott, P. Kanel Source Type: research
Nomogram for Predicting the Probability of Malnutrition in Parkinson's Disease
Background: The nutritional status of patients with Parkinson's disease is closely related to clinical symptoms. The primary objective of this study was to develop and validate a risk prediction model to identify the risk of malnutrition in patients with Parkinson's disease early. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Q. Huang, X. Zou Source Type: research
Differential symptom cluster responses and predictors of response to repetitive transcranial magnetic stimulation treatment in Parkinson ’s disease: A retrospective study
This study aimed to investigate the related factors for the response to rTMS in PD patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Sun, P. Hu Source Type: research
Genetic literacy of patients with Parkinson ’s disease and their caregivers, and attitudes toward genetic testing: A review
Background: Genetic literacy refers to an individual ’s ability to understand the basics concepts of genetics, apply them to health-related decisions. Genetic literacy influences attitude towards genetic testing and is, in turn, influenced by other factors. Clinicians must be aware of the genetic literacy of their patients and their caregivers befor e advising genetic testing and/or undertaking pre and post-test counseling. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Kamath, V.V. Holla, R. Yadav, N.L. Kamble, P.K. Pal Source Type: research
Differences in Dopamine Transporter Loss Pattern by DaTscan among patients with Parkinson's disease, Dementia with Lewy bodies and Parkinson's disease with dementia
Background: 123-I FP-CIT SPECT (DaTscan) is used to diagnose Parkinson's syndrome, which is determined by ROI count and visual morphology. However, differential diagnosis may be difficult in cases where DaTscan accumulation is significantly reduced compared to clinical symptoms. The aim of this study is to investigate the Differences in Dopamine Transporter Loss Pattern by DaTscan among Parkinson's disease (PD), Dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Senoo, T. Tokashiki, Y. Ohya, A. Nagayama Source Type: research
Clinical characteristics and mortality in Parkinson's disease patients with a history of fractures
Background: Falls and fractures significantly reduce activities of daily living and quality of life in people with Parkinson's disease (PD). Recently, bone health and falls have been highlighted as one of the 'vitals' of PD that should not be overlooked. We aimed to determine the characteristics of PD patients with a history of fracture after disease onset. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Tawara, R. Kurisaki, Y. Komoto, A. Nishioka, K. Hara, C. Nagatoshi, A. Fujimoto, M. Ishizaki, Y. Nishida, Maeda Y., H. Ogata, H. Ueyama Source Type: research
An observational study of Quality of Life in patients with Parkinson ’s Disease pre and post DBS
Background: Motor fluctuations and dyskinesias affect nearly 40% of patients with Parkinson's Disease (PD) after five or more years of levodopa therapy. Deep brain stimulation (DBS) is the most frequently performed surgical procedure in patients with advanced PD with motor fluctuations and dyskinesias. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Jayasree, M. Panigrahi, D.R. Ginjupally Source Type: research
