Feasibility of regional center telehealth visits utilizing a rural research network in people with Parkinson's disease
CONCLUSIONS: Regional center research visits in PwPD in medically underserved areas are feasible and could help improve access to care and research participation in these traditionally underrepresented populations.PMID:38655451 | PMC:PMC11036429 | DOI:10.1017/cts.2024.498 (Source: Rural Remote Health)
Source: Rural Remote Health - April 24, 2024 Category: Rural Health Authors: Tuhin Virmani Lakshmi Pillai Veronica Smith Aliyah Glover Derek Abrams Phillip Farmer Shorabuddin Syed Horace J Spencer Aaron Kemp Kendall Barron Tammaria Murray Brenda Morris Bendi Bowers Angela Ward Terri Imus Linda J Larson-Prior Mitesh Lotia Fred Prio Source Type: research
Combined blood Neurofilament light chain and third ventricle width to differentiate Progressive Supranuclear Palsy from Parkinson's Disease: a machine learning study
In this study, we explored the performance of machine learning models based on MR imaging and blood molecular biomarkers in distinguishing between these two neurodegenerative diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 24, 2024 Category: Neurology Authors: Maria Giovanna Bianco, Costanza Maria Cristiani, Luana Scaramuzzino, Alessia Sarica, Antonio Augimeri, Ilaria Chimento, Jolanda Buonocore, Elvira Immacolata Parrotta, Andrea Quattrone, Gianni Cuda, Aldo Quattrone Source Type: research
Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide & ndash;MXene Composite Electrode
Molecules, Vol. 29, Pages 1936: The Simultaneous Detection of Dopamine and Uric Acid In Vivo Based on a 3D Reduced Graphene Oxide–MXene Composite Electrode
Molecules doi: 10.3390/molecules29091936
Authors:
Lingjun Shang
Ruijiao Li
Haojie Li
Shuaiqun Yu
Xuming Sun
Yi Yu
Qiongqiong Ren
Dopamine (DA) and uric acid (UA) are essential for many physiological processes in the human body. Abnormal levels of DA and UA can lead to multiple diseases, such as Parkinson’s disease and gout. In this work, a three-dimensional reduced graphene oxide–MXene (3D rGO-Ti3C2) composite el...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Lingjun Shang Ruijiao Li Haojie Li Shuaiqun Yu Xuming Sun Yi Yu Qiongqiong Ren Tags: Article Source Type: research
Conservative Versus Operative Treatment of Proximal Humerus Fractures in Older Individuals —an Analysis of Insurance Data
CONCLUSION: The conservative treatment of proximal humerus fracture is associated with a lower overall rate of complications due to surgery or trauma, but also with more MAE and TE and higher overall mortality. These findings underline the need for individualized and risk-adjusted treatment recommendations.PMID:38652842 | DOI:10.3238/arztebl.m2024.0059 (Source: Deutsches Arzteblatt International)
Source: Deutsches Arzteblatt International - April 23, 2024 Category: General Medicine Authors: J Christoph Katthagen Michael J Raschke Karen Fischhuber Janette Iking Ursula Marschall Julia Sussiek Andreas Faldum Josef Stolberg-Stolberg Jeanette K öppe Source Type: research
The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology
In this report, we review the roles that extracellular vesicles can play in biological processes and cellular dysfunction and pathobiology, particularly neurodegenerative diseases. We also examine the potential translational impacts of extracellular vesicles in diagnostics and therapeutic development. ER: endoplasmic reticulum; ROS: reactive oxygen species. AbstractBrain-derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology in health and disease. This review establishes a crucial link between physiological processes leading to EV biogenesis and their impacts on...
Source: Journal of Neurochemistry - April 23, 2024 Category: Neuroscience Authors: Stephanie Tam,
Darcy Wear,
Christopher D. Morrone,
Wai Haung Yu Tags: SYSTEMATIC REVIEW Source Type: research
Gait asymmetry and symptom laterality in Parkinson ’s disease: two of a kind?
ConclusionsWe found a striking mismatch between the side and the degree of asymmetry in different motor domains, i.e., in gait, turning, and distal symptom severity in individuals with PD. We speculate that motor execution in different body parts relies on different neural control mechanisms. Our findings warrant further investigation to understand the complexity of gait asymmetry in PD. (Source: Journal of Neurology)
Source: Journal of Neurology - April 23, 2024 Category: Neurology Source Type: research
Surgicogenomics in GBA1-Related Parkinson Disease: Is the Glass Half Full or Half Empty?
Genetic markers have been instrumental in our pursuit to fully understand Parkinson disease (PD), and “surgicogenomics” offers a promising new approach to further improve our decision-making for deep brain stimulation (DBS). But could this emerging knowledge be a game-changer in our clinical practice? So far, expectations seem to exceed applicability. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - April 23, 2024 Category: Neurology Authors: Philippe A. Salles, Hubert H. Fern ández, Ignacio M. Mata Source Type: research
Sympathetic dysfunction as an early indicator of autonomic involvement in Parkinson ’s disease
ConclusionThe ∆BPVM2 parameter of the VM may help detect autonomic nervous system involvement in early-PD without OH. Our results suggest that sympathetic dysfunction is an early manifestation of autonomic dysfunction in patients with PD. (Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - April 23, 2024 Category: Research Source Type: research
A comprehensive multivariate analysis of the center of pressure during quiet standing in patients with Parkinson's disease
We hypothesized that postural instability observed in individuals with Parkinson's disease (PD) can be classified as distinct subtypes based on comprehensive analyses of various evaluated parameters obtained f... (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - April 23, 2024 Category: Rehabilitation Authors: Shintaro Fujii, Yusaku Takamura, Koki Ikuno, Shu Morioka and Noritaka Kawashima Tags: Research Source Type: research
Underestimated Recurrence Rates after Ablation for Wolff-Parkinson-White Syndrome and Impact on Follow-up Practices
The risk of recurrence after accessory pathway (AP) ablation in patients with Wolff-Parkinson-White (WPW) syndrome ranges between 5-12%.1-3 Given practice variation in duration of follow up after successful AP ablation, data on recurrence risk is largely limited to the first year following catheter ablation2. Cases of late recurrence at our institution prompted us to describe our institutional experience including long-term risk of recurrence of WPW pattern on ECG, accessory pathway characteristics before and after recurrence, and the proportion of recurrence that is symptomatic or asymptomatic to better guide follow-up pr...
Source: Heart Rhythm - April 23, 2024 Category: Cardiology Authors: Brendan J. Burke, Iqbal El Assaad, Wei Liu, Mohamed Kanj, Oussama M. Wazni, Thomas D. Callahan, Bryan Baranowski, Elizabeth V. Saarel, Alison Heilbronner, Peter F. Aziz Source Type: research
Video-based analysis of the blink reflex in Parkinson ’s disease patients
We developed a video-based tool to quantitatively assess the Glabellar Tap Reflex (GTR) in patients with idiopathic Parkinson ’s disease (iPD) as well as healthy age-matched participants. We also video-graphica... (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 23, 2024 Category: Biomedical Engineering Authors: Talisa S. Jansen, G ökhan Güney, Bergita Ganse, Mariana H. G. Monje, Jörg B. Schulz, Manuel Dafotakis, Christoph Hoog Antink and Anne K. Braczynski Tags: Research Source Type: research
ASCL1-mediated direct reprogramming: converting ventral midbrain astrocytes into dopaminergic neurons for Parkinson's disease therapy
In this study, we aimed to develop a new treatment for PD that induces direct reprogramming of dopaminergic neurons (iDAN). Achaete-scute family bHLH transcription factor 1 (ASCL1) is a primary factor that initiates and regulates central nervous system development and induces neurogenesis. In addition, it interacts with BRN2 and MYT1L, which are crucial transcription factors for the direct conversion of fibroblasts into neurons. Overexpression of ASCL1 along with the transcription factors NURR1 and LMX1A can directly reprogram iDANs. Using a retrovirus, GFP-tagged ASCL1 was overexpressed in astrocytes. One week of culture ...
Source: BMB Reports - April 22, 2024 Category: Biochemistry Authors: Sang Hui Yong Sang-Mi Kim Gyeong Woon Kong Seung Hwan Ko Eun-Hye Lee Yohan Oh Sang Hui Yong Source Type: research
Anti-Parkinson potential of hesperetin nanoparticles: < em > in vivo < /em > and < em > in silico < /em > investigations
In this study, hesperetin nanoparticles (HTN) were developed and compared their anti-PD potential with hesperetin (HT) on rotenone induced PD rats. Molecular docking was also performed to evaluate the binding affinity of hesperetin on pathological protein, i.e. D2 dopamine receptors (DR2), using Auto Dock Vina tools. The results showed a higher binding relationship of HTN on dopamine receptors (-7.2 kcal/mol) compared to L-dopa (-6.4 kcal/mol), supporting their potential as drug candidates for PD therapy. HTN was effectively synthesised using the fabrication technique and characterised by zeta potential and SEM analysis. H...
Source: Natural Product Research - April 22, 2024 Category: Biochemistry Authors: Praveen Kumar Pasala DSNBK Prasanth Mithun Rudrapal Ranadheer Reddy Challa Sheikh F Ahmad Bhaskar Vallamkonda Ram Babu R Source Type: research
Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy
Curr Med Chem. 2024 Apr 19. doi: 10.2174/0109298673300496240416114827. Online ahead of print.ABSTRACTThe anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human tissues, have attracted a growing interest in recent years. αLA is a short- -chain sulfur-containing fatty acid occurring in the mitochondria of all kinds of eukaryotic cells. Both the oxidized disulfide of αLA and its reduced form (dihydrolipoic acid, DHLA) exhibit prominent antioxidant function. The amount of αLA inside the human body gradually decreases with age resulting in various health disorders. Its lack can be compensa...
Source: Current Medicinal Chemistry - April 22, 2024 Category: Chemistry Authors: Mariia Shanaida Roman Lysiuk Olha Mykhailenko Nataliia Hudz Abdullateef Abdulsalam Tetiana Gontova Oleksandra Oleshchuk Yana Ivankiv Volodymyr Shanaida Dmytro Lytkin Geir Bj ørklund Source Type: research
Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model
In this study, we explored the role of Carvacrol in suppressing neuroinflammation by regulating NLRP3 inflammasome through Nrf2/HO-1 axis and subsequently, inflammatory cytokines like IL-1β, IL-18 in Rotenone induced PD mice model. Three doses (25 mg/kg, 50 mg/kg, 100 mg/kg p.o.) of Carvacrol were administered to, respectively, three groups (LD, MD, HD), one hour after administration of Rotenone (1.5 mg/kg, i.p.), every day, for 21 days. Treatment with Carvacrol ameliorated the motor impairment caused by Rotenone. It alleviated neurotoxicity and reduced inflammatory cytokines. Further, Carvacrol also alleviated oxidative ...
Source: Brain Research - April 22, 2024 Category: Neurology Authors: Shruti Shah Kamatham Pushpa Tryphena Gurpreet Singh Amrita Kulkarni Poojitha Pinjala Dharmendra Kumar Khatri Source Type: research
