Profile of patients with advanced Parkinson ’s disease treated with Levodopa–entacapone–carbidopa intestinal gel (LECIG)
Background: Levodopa –entacapone–carbidopa intestinal gel infusion (LECIG) is the latest device-aided therapy for advanced Parkinson's disease (APD), approved in Romania in 2021. We aimed to analyze the APD patients' profile initiated on LECIG treatment. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Sz ász, V. Constantin, K. Orbán Kis, S. Bataga, R. Neagoe, M. Ciorba, K. Krisztina, I. Mihály, S. Szatmári Source Type: research
Changes of motor symptoms and regional cerebral blood flow after transcranial direct current stimulation in Parkinson's disease
Background: The possibility to modulate cortical excitability and to promote motor learning has raised interest in Transcranial direct current stimulation (tDCS) as an intervention for PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Hwang Source Type: research
Application of motor rehabilitation programs in the normalization of the psycho-emotional sphere of patients with Parkinson`s disease
Background: To study the effectiveness of the motor rehabilitation programme rehabilitation programme for patients with Parkinson's disease (PD), 48 patients were clinically examined who had undergone a course of motor rehabilitation using the phenomenon of paradoxical kinesia phenomenon and subsequently followed the recommendations in different ways. rehabilitation recommendations. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: I. Voloshyn-Haponov, N. Voloshyna, I. Bogdanova Source Type: research
Characterization of the pattern of daily motor fluctuations in Parkinson ’s disease patients based on home diaries
Background: Parkinson ’s disease (PD) patients are often in their best clinical state when attending medical appointments. It is therefore important for clinicians to be familiar with the typical pattern of motor fluctuations that patients experience and to obtain a good history regarding potential fluctuations even wh en patients are doing well at the time of the evaluation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R.A. Hauser, W. Poewe, J.J. Ferreira, A. Lees, G.S. Liang, M. Fonseca, D. Magalh ães, J. Rocha, P. Soares-da-Silva Source Type: research
Absence of causal relationship between Parkinson ’s disease and subsequent prostate cancer: Evidence from meta-analysis and Mendelian randomization studies
Background: Numerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson ’s Disease (PD). However, the existence of a definitive association remains uncertain. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.-Y. Deng, X.-M. Wang Source Type: research
The potential use of plasma GFAP as a diagnostic and prognostic biomarker of motor subtype in early Parkinson ’s disease
Background: Parkinson ’s disease (PD) is a heterogeneous movement disorder with different motor subtypes including tremor dominant (TD), indeterminate and postural instability, and gait disturbance (PIGD) motor subtypes. Plasma glial fibrillary acidic protein (GFAP) was elevated in PD patients and may be regarded as a biomarker for motor and cognitive progression. Here we explore if there was an association between plasma GFAP and different motor subtypes and whether baseline plasma GFAP level can predict motor subtype conversion. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: N. Che, R. Ou, C. Li, L. Zhang, Q. Wei, S. Wang, Q. Jiang, T. Yang, Y. Xiao, J. Lin, B. Zhao, X. Chen, H. Shang Source Type: research
Nebulized Administration of Roasted Mucuna Powder Using a Hydrogen Water Superheated System in Parkinson's Disease
In this study, we present a new administration method for Mucuna powder and discuss an innovative ideal administration approach. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: R. Neshige Source Type: research
The brain fMRI study of patients with Parkinson's disease and pain induced by contact heat stimulations
Background: To observe the features of functional magnetic resonance imaging (fMRI) of Parkinson's disease with pain( PDP) and Parkinson's disease without pain (nPDP) under contact hot pain stimulation (CHS), and explore the brain network related to pain in PDP. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Qiao-Jun, W. Xiao-Ming Source Type: research
First-year Treatment Intensity and Prognosis in Early Parkinson ’s Disease: A Retrospective, Longitudinal Study in Israel
Background: Given Parkinso ńs disease (PD) heterogeneity, it is challenging to find associations between patients’ characteristics and prognosis. We compared long term disease prognosis among people with Parkinson's Disease (PwPD) by treatment intensity in the first year after PD diagnosis. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Barer, O. S ánchez-Soliño, D. Arkadir, M. Grabarnik-John, G. Chodick, L. Bergmann, C.H. Yan Source Type: research
Association of small right vagus nerve cross-sectional area with abnormal heart rate variability
Background: In Parkinson's disease (PD), autonomic dysfunction occurs throughout the disease course. The vagus nerve is a crucial component of the autonomic nervous system. Cardiac autonomic dysfunction is present in the early stage of PD. The cross-sectional area (CSA) of the vagus nerve, measured by ultrasound, is significantly reduced in PD patients. We aimed to investigate the association between vagus nerve CSA measured by ultrasound and autonomic function in patients with early PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Lee, H.L. Lee, J.-W. Park, S.-B. Koh Source Type: research
The role of neurotrophic factors in development Parkinson's disease dementia
Background: The purpose of our study is to evaluate NGF in the development of cognitive impairment and dementia in patients with PDD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Okhunova, G. Rakhimbaeva Source Type: research
Speech Biomarkers for Dysarthria in Parkinson's Disease — Clinical Validation Across Spanish and Czech Languages
This study investigates reliable speech biomarkers for Parkinson's disease-related dysarthria, ensuring cross-language clinical validity. It assesses performance on sustained phonation (SPA) and rapid syllable repetition (DDK), chosen for practicality and reduced patient-burden. ki:elements SIGMA pipeline extracts clinically relevant speech features, controlling for age and gender influences. Composite scores are evaluated for clinical validity using UPDRS-III, UPDRS-Speech, H&Y scales, and assessed across both languages. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Baykara, F. D örr, J. Rusz, J.R. Orozco-Arroyave, J. Tröger Source Type: research
Risk factors for Parkinson's disease and Parkinson's disease with cognitive impairment in high altitude: A case-control study
Background: To explore the risk factors associated with Parkinson ’s disease (PD) and PD with cognitive impairment (PD-CI) in a high altitude area. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Zhu, Y. Liang Source Type: research
User-Centric Design of a Biochemical Sensor for Parkinson's Disease: A Survey-Based Approach to Understand Community Expectations and Values
The objective is to align the device with scientific and technological standards while prioritizing the practical expectations and values of the end-users. This approach aims to seamlessly integrate advanced technologies into the daily lives of individuals with Parkinson's disease, ultimately improving overall well-being and treatment experience. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: B. Dupre, K. Stromodst, K. House, J. Shupe Source Type: research
STAT3-mediated ferroptosis is involved in α-synuclein pathology
In this study, we aim to explore the exact role of STAT3 in α-synuclein pathology. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Lin, H. Zhang, K. Huang, J. Zhang, E. Tao Source Type: research
