Calcium channel blockers and Parkinson's disease: A systematic review and meta-analysis
This study aimed to conduct a systematic reviewand meta-analysis to assess the relationship between the use of calcium channel blockers (CCB) and the risk and disease progression of PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Lin, D. Pang, C. Li, R. Ou, Y. Yu, Y. Cui, J. Huang, H. Shang Source Type: research
β-Caryophyllene decreases neuroinflammation and exerts neuroprotection of dopaminergic neurons in a model of hemiparkinsonism through inhibition of the NLRP3 inflammasome
Background: Parkinson's disease represents a neurodegenerative condition characterized by the progressive loss of dopaminergic neurons within the Substantia Nigra pars compacta (SNpc), resulting in diminished dopamine levels in the striatum (STR) and chronic neuroinflammation. Recent investigations have proposed the neuroprotective potential of the endocannabinoid system in neurodegenerative disorders. β-caryophyllene (BCP) is recognized for its antioxidant and anti-inflammatory properties, attributed to its activation of the type 2 cannabinoid receptor. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P.A. Brand Rubalcava Source Type: research
TMEM106B knockdown exhibits a neuroprotective effect in Parkinson ’s disease via decreasing inflammation and iron deposition
Background: Increasing evidence indicates that iron accumulation and inflammatory cytokine activation in the brain play an essential role in Parkinson's disease (PD). Emerging evidence indicates that TMEM106B plays an essential role in PD. But whether TMEM106B could act on neuroinflammation and iron metabolism in PD has not yet been investigated. The aim of this study was to investigate the pathological mechanisms of inflammation and iron metabolism of TMEM106B in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Liu, A. Xie Source Type: research
Theta-alpha STN oscillations are associated with motor signs of Parkinson ’s disease
This study aims to investigate the relationship between motor PD symptoms and STN oscillatory activity using the approach of extracting oscillatory peaks with maximum amplitude. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: K. Sayfulina, A. Gamaleya, V. Filyushkina, A. Tomskiy, E. Belova, A. Sedov Source Type: research
Pharmacist consultation in patients with Parkinson ’s Disease in the outpatient clinic
Background: For patients with Parkinson ’s Disease (PD) Punt voor Parkinson at Medisch Centrum Leeuwarden, the Netherlands, implemented pharmacist consultations in January 2022. The main goal was treatment optimization. Specialized pharmacists conducted a medication review and made recommendations to the patient, neurologist and/or gene ral practitioner. The aim of this study was to measure the impact of pharmacist consultation on healthcare utilization, measured by contacts within the hospital. These are preliminary results. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M.M. Akkerman, C.C.M. Stuiijt, A. Warman, B. van Harten Source Type: research
Associated Factors of Depression and Anxiety in Patients with Parkinson ’s Disease
Background: Depression and anxiety are common in patients with Parkinson ’s Disease (PD). We aimed to investigate the associated factors of depression and anxiety in patients with PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Ay, C. Alis, D. Selcuk Demirelli, G. Genc Source Type: research
The Elevated Risk of Dementia in Parkinson's Disease Patients Associated with Metabolic Syndrome
Background: Metabolic syndrome (MetS) is prevalent in the general population, and recent findings have highlighted its role as an independent risk factor for cognitive impairment. The primary objective of this study is to explore the association between MetS and the risk of cognitive impairment within the Parkinson's disease (PD) population. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Kobak Tur, H.B. Kutlu, N. Sever, E. G özke Source Type: research
Parkinson's Disease Social Stigma Perception Scale (PDSP): Development and Pilot Study Of A Measurement Scale
This study aimed to: 1) fill a research gap by developing a scale of stigmatizing attitudes towards PwP (PDSP) and 2) demonstrate its reliability and validity. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A.L. Guerra-Anzaldo, A.J. Hern ández Medrano, W.F. Moguel-Cardín, E.C. Santiago de la Cruz, L.G. Lira Juárez, M.d.l.Á.G. Medrano-Delgado, A.Y. Regalado Mustafá, J.E. Hernández-Rodríguez, D.P. Romero-Terán, A. Domínguez-García, A. Cervantes-Arria Source Type: research
Oscillatory subthalamic cell motor responses are associated with clinical characteristics of Parkinson ’s disease
Background: Basal ganglia neuronal motor responses could be potential biomarkers for deep brain stimulation (DBS) improvements and are being studied extensively. Taking into account previous research we hypothesized changes of subthalamic (STN) activity during voluntary movements in Parkinson ’s disease (PD) patients as follows: the first movement of a series (initiation of a motor program) should lead to alpha activity (7-12 Hz) desynchronisation on a time scale of 2 seconds and each of the rest movements (inside motor program) should desynchronize low-beta activity (12-20 Hz) for a t ime period of 500 ms. (Source: Park...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Nezvinskiy, E. Belova, A. Gamaleya, A. Tomskiy, A. Sedov Source Type: research
Rheumatoid Arthritis and Risk of Parkinson ’s disease in the UK Biobank: A Prospective Study
Background: Multiple evidence has indicated that chronic inflammation induced by rheumatoid arthritis (RA) was associated with the risk of Parkinson ’s disease (PD). However, the results across studies have exhibited inconsistency. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: X. Zheng, S. Wang, Y. Xiao, Q. Jiang, J. Lin, J. Huang, C. Li, H. Shang Source Type: research
Relationship between agricultural vulnerability to organic compound fungicides and herbicides and Parkinson's disease incidence in a rural population in northern India
Background: In the Indian agricultural health study cohort, we evaluated the relationship between prospective exposures to organic fungicides and herbicides and the incidence of Parkinson's disease (PD), generally and by histological subgroup, followed over 4 years in Kanpur district, northern India. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: M. Sharma, D. Khatri Source Type: research
Interaction between caffeine intake and polymorphisms of MCCC1 modifies Parkinson ’s Disease risk
Background: Caffeine intake is associated with a reduced risk of Parkinson ’s disease (PD). However, there is great variability in the degree of neuroprotection conferred by caffeine and A2AR antagonist among individuals, suggesting a possible interaction between caffeine and one’s genetic background. We explore the interaction between caffeine intake and the risk vari ants of one PD susceptibility gene in Asian population, and estimate the PD risk estimates in caffeine-drinkers carrying the variants. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Yang, E.K. Tan, E.Y. Ng, S.E. Saffari Source Type: research
Clinometric Profile of the Korean Version of Cognition Scales for Outcomes in Parkinson ’s Disease
In this study, we aimed to evaluate the validity and reliability of the Korean version of SCOPA-cognition. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Park, H. Hwang Source Type: research
Studying the relationship between different stages of Parkinson's disease and iron metabolism, oxidative stress, and inflammation from Qinghai-Tibetan Plateau Area
Background: To explore the correlation between different stages of Parkinson's disease (PD)and serum iron metabolism, oxidative stress, and inflammation in hypoxic environments. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Yan, A. Zhu Source Type: research
Prodromal and Overt Parkinson ’s Disease Epidemiological Study in Brazil (PROBE-PD study): Preliminary Results
Background: Research on the prevalence of Parkinson's Disease (PD) has predominantly focused on high-income countries, while this data is poorly described in middle- and lower-income countries. The Prodromal and overt Parkinson's Disease Epidemiological Study in Brazil (PROBE-PD) aims to estimate the prevalence of PD and other parkinsonisms (drug-induced, vascular, multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, dementia with Lewy bodies) in Brazil. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L.R.R. Pedrosa, J.S. Duarte, G. Pereira, I. Oliveira, S. Titze-de-Almeida, A. Schuh, C. Reider, G. Valen ça, L.V. Krejcová, B.L. Santos-Lobato Source Type: research
