Genetic Screening in Patients with Parkinson Disease and Deep Brain Stimulation
Background: Deep brain stimulation (DBS) is a well-established therapy for select patients with Parkinson Disease (PD). To increase the odds of favorable outcomes following DBS surgery, a multidisciplinary clinical evaluation is recommended. However, outcomes can still vary. Large-scale studies assessing DBS outcomes of patients with genetic mutations are limited, but current evidence suggests variability in the outcomes of carriers of common mutations in genes such as LRRK2 or GBA. With the increased access to genetic studies, the role of genetic risk factors in predicting the outcomes of DBS surgery is yet to be defined....
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: E. Assaedi, H.M. Chaparro-Solano, D. Floden, I.F. Mata, H.H. Fernandez Source Type: research
TMEM106B aggravates symptoms of Parkinson ’s disease by regulating the autophagy-lysosome pathway
Background: TMEM106B, a gene encoding a lysosome membrane protein, is tightly related to brain aging and neurogenerative diseases, including Parkinson's disease (PD). Recently, TMEM106B mutations have been reported as genetic risk factors for PD. However, whether TMEM106B plays a major role in pathological neurodegeneration in PD has not yet been investigated. In the present study, we aimed to detect the role and mechanism of TMEM106B in PD models. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Xie, Y. Liu Source Type: research
NOX1 triggers ferroptosis and ferritinophagy, contributing to neurodegeneration
Background: Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the midbrain, accompanied by the accumulation of α-synuclein aggregates. The involvement of ferroptosis, a recently identified form of cell death, has been implicated in various neurodegenerative conditions, including PD. Nevertheless, the specific genes responsible for PD-associated ferroptosis and the most effective therapeutic strategies are s till not fully understood. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Wang Source Type: research
TREM2 deficiency aggravates neuroinflammatory response and cognitive impairment via disease-associated microglia in Parkinson ’s disease
This study explored whether TREM2 regulated the phenotype of disease-related microglia (DAM) and plays a protective role in the cognitive impairment in PD, and its mechanism. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: P. Zhang, Y. Zhang Source Type: research
Treg Cells Attenuate Neuroinflammation and Protect Neurons in a Mouse Model of Parkinson's Disease
Background: Regulatory Tcells (Tregs), which secrete transforming growth factor (TGF)- β and interleukin (IL)-10, have essential role in anti-inflammatory and neurotrophic functions. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Huang, Z. Liu, Y.-P. Peng Source Type: research
Dopamine receptor D2 on CD4+ T cells is protective against neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease
Background: Parkinson's disease (PD) is a chronic neurodegenerative disease. Recently, neuroinflammation driven by CD4+ T cells has been involved in PD pathophysiology. Human and murine lymphocytes express all the five subtypes of dopamine receptors (DRs), DRD1 to DRD5. However, roles of DRs particularly DRD2 expressed on CD4+ T cells in PD remain elucidated. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.-H. Qiu, Z. Liu, Y.-P. Peng Source Type: research
Two parallel nigrostriatal subcircuits mediate arousal effect of dopaminergic neurons in substantia nigra pars compacta
This study systematically investigates the role of dopaminergic (DA) neurons in SNc in wakefulness-sleep regulation and delves into the circuit mechanisms, aiming to provide new clues for the pathogenesis of EDS in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Liu, J. Li, Z. Hu, S. Ren, N. Xiong Source Type: research
Fibrinogen exacerbates GCase ubiquitination via ATF5-induced TRIP12 activation in Parkinson's Disease
Background: Blood-brain-barrier disruption occurs in Parkinson's disease (PD), which may be accompanied with the deposition of Fibrinogen (FG) in brain parenchyma. However, the relationship between FG and glucocerebrosidase (GCase) reduction, which may contribute to α-synuclein aggregation in PD, is under investigation. Recently, there is evidence that PD patients without GBA mutation also exhibits GCase reduction in brain, and Thyroid-Hormone-Receptor-Interactor-12 (TRIP12) was found to be a key ubiquitin enzyme of GCase degradation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Zhong, Q. Wang, Z. Huang Source Type: research
Association of Baseline Serum Urate Levels with Longitudinal General Cognition in Non-Demented Parkinson's Disease
This study aimed to assess the relationship between baseline serum urate levels and longitudinal general cognition in non-demented PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.J. Kim Source Type: research
The effect of intraoperative monitoring on final electrode placement in movement disorder patients treated with deep brain stimulation
Background: Intraoperative microelectrode recording (MER) and intraoperative test stimulation (ITS) may provide vital information for optimal electrode placement and clinical outcome in movement disorders patients treated with deep brain stimulation (DBS). The aims of this retrospective study were to determine (i) how often the planned (imaging based) placements of electrodes were changed due to MER and ITS measurements in Parkinson ’s disease (PD), dystonia and essential tremor (ET) patients; (ii) whether the frequency of repositioning changed over time; (iii) whether the patients’ age or disease duration (in PD) infl...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Ibrulj, D. Georgiev, Ž. Samsa, P. Mušič, M. Benedičič, M. Trošt Source Type: research
Characterizing Pain in Parkinson's Disease: Unveiling Types and Underlying Pathophysiology through a Scoping Review
Background: Pain, a pervasive and disabling aspect of Parkinson's disease (PD), necessitates a comprehensive understanding of its types and the intricate mechanisms driving its manifestation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Desai, S. Desai Source Type: research
Sleep Biomarker-Based Characterization of Neurodegenerative Disorder Risk in Parkinsonian Spectrum Disorder Patients
Background: In this pilot study, the diagnostic agreement for sleep biomarker-based neurodegenerative disorder (NDD) risk probabilities was evaluated in patients with isolated REM sleep behavior disorder (iRBD), Parkinson ’s disease (PD) Lewy body disease (LBD), progressive supranuclear palsy (PSP), and controls (CG). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Levendowski, J. Anderson, Y. Cho, C. Walsh, L. Yack, D. Tsuang, J. Lee-Iannotti, B. Boeve, T. Neylan, S. Lewis, E. St. Louis Source Type: research
Effects of Periventricular White Matter Lesions on PD Cognitive Deficits are Mediated by Limbic Cholinergic Deficits in PD
In this study, we want to test the hypothesis that subcortical deep brain vs. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: G. Carli, T. Brown, S. Roytman, A. Biddix, R. Vangel, P. Kanel, R.L. Albin, N.I. Bohnen Source Type: research
The Correlation between Nutritional Status and Quality of Life in Persons with Parkinson ’s disease
This study aimed to investiga te the relationship between nutritional status and QoL in persons with PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: C.-M. Ouyang, T.-Y. Chen, K.-R. Chen, K.-H.S. Chen, T.-S. Fan Source Type: research
Study of the Neuroprotective Potential of gallic acid in the Mouse Model of Parkinson ’s Disease
Background: Parkinson ’s disease (PD), is a neurodegenerative disorder characterised by tremor, rigidity, bradykinesia and impairment of postural balance. Gallic acid, a popular phenolic acid is found in gallnuts, grapes, pomegranates, tea and has wide range of anti-inflammatory, cognitive enhancer,neuroprotective, eff ects thus may be advantageous in the treatment of neurological disease. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S. Rajput, P. Tiwari Source Type: research
