TMEM106B knockdown exhibits a neuroprotective effect in Parkinson ’s disease via decreasing inflammation and iron deposition

Background: Increasing evidence indicates that iron accumulation and inflammatory cytokine activation in the brain play an essential role in Parkinson's disease (PD). Emerging evidence indicates that TMEM106B plays an essential role in PD. But whether TMEM106B could act on neuroinflammation and iron metabolism in PD has not yet been investigated. The aim of this study was to investigate the pathological mechanisms of inflammation and iron metabolism of TMEM106B in PD.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research