Genetic variability of OBPIIa in Parkinson ’s Disease (PD) patients of Tamil Nadu population, India

Background: Parkinson ’s disease (PD) is a neurodegenerative disorder while olfactory dysfunction is the primary non-motor symptoms observed before the occurrence of motor symptoms. Functional differences in smell within the physiological spectrum have been linked to polymorphisms of particular genes coding for membran e receptors or binding proteins. Studies on polymorphisms in olfactory-binding protein (OBP) has been shown to affect olfaction in PD. The current study explores the olfactory functionality by odour identification test, followed by molecular analysis of OBPIIa polymorphism in three varied PD age gro ups.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research