Computational studies of compounds against alpha-synuclein in Kampavata AKA Parkinson's disease in Ayurveda

Background: Parkinson's disease (PD), the second most common neurodegenerative disorder, it's diagnosis is not yet conceived until half of the dopaminergic neuron degenerates, resulting in longitudinal irreparable damage. Nevertheless, abnormal α-synuclein chronic aggregation and accumulation is the cornerstone to inflammation, oxidative stress, protein dysfunction, apoptosis, mitochondrial dysfunction, and autophagy. Hence, in such a scenario, compounds targeting aggregates can be a way of effectively treating PD and computational-based approaches are cheap and easy for finding hits.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research