Experimental studies on computed tomographic peritoneography. Peritoneal and residual renal function tolerance to iodinated contrast media injected into the peritoneal cavity.
This study aimed to determine whether different non-ionic ICM concentrations affect peritoneum and RRF and attempted to evaluate CT peritoneography images to identify the optimal non-ionic ICM concentrations in animals. To this end, 25 male Sprague-Dawley rats were used to establish uraemic models, after which they were injected with a 40-mL mixture of peritoneal dialysate and iohexol at varying concentrations prior to CT peritoneography. Thereafter, two experienced radiologists blinded to the rat groupings evaluated image quality, peritoneal morphology and thickness were assessed using hematoxylin and eosin and Masson sta...
Source: Seminars in Dialysis - March 12, 2020 Category: Urology & Nephrology Authors: Bai J, Dong J, Shu J, Xu Y, Ding W, Chen J Tags: Semin Dial Source Type: research

Effects of Changes in Analytic Variables and Contrast Material on Measurement of Computed Tomography Glomerular Filtration Rates in Healthy Candidates
Conclusion Results from CT-GFR were most accurate when the kidney cortex was selected as the region of interest or when using 60-second time point for whole-kidney assessment, regardless of CM osmolarity. (Source: Journal of Computer Assisted Tomography)
Source: Journal of Computer Assisted Tomography - March 1, 2020 Category: Radiology Tags: Abdominal Imaging Source Type: research

Measuring glomerular filtration rate with iohexol plasma disappearance: blood collection duration is essential for accurate glomerular filtration rate determinations
Recently, Rowe et  al. reported the biological variation of measured glomerular filtration rate (mGFR) and estimated glomerular filtration rate (eGFR) for chronic kidney disease in 20 patients.1 An examination of their iohexol plasma disappearance mGFR protocol shows that the authors administered 5 ml of Omnipaque 2 40 (518 g/l of iohexol; GE Healthcare [Little Chalfont, Buckinghamshire, UK]) and acquired blood specimens at 3 time points with the longest collection time duration of 240 minutes. We acknowledge that there is currently no standardized protocol for an iohexol plasma disappearance procedure for the purpose...
Source: Kidney International - February 19, 2020 Category: Urology & Nephrology Authors: Jesse C. Seegmiller, Natalie Ebert Tags: Letter to the Editor Source Type: research

Enhanced specificity due to method specific limits for relative ion intensities in a high-performance liquid chromatography – tandem mass spectrometry method for iohexol in human serum
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - February 18, 2020 Category: Laboratory Medicine Source Type: research

Impact of CT injector technology and contrast media viscosity on vascular enhancement: Evaluation in a circulation phantom.
Abstract OBJECTIVES: To assess the impact of piston-based vs peristaltic injection system technology and contrast media viscosity on achievable iodine delivery rates (IDRs) and vascular enhancement in a pre-clinical study. METHODS: Four injectors were tested: MEDRAD®Centargo, MEDRAD® Stellant, CT Exprès®, and CT motion™ using five contrast media (iopromide [300 mgI ml-1 and 370 mgI ml-1], iodixanol 320 mgI ml-1, iohexol 350 mgI ml-1, iomeprol 400 mgI ml-1). Three experiments were performed evaluating achievable IDR ...
Source: The British Journal of Radiology - February 4, 2020 Category: Radiology Authors: McDermott M, Kemper C, Barone W, Jost G, Endrikat J Tags: Br J Radiol Source Type: research

A prospective controlled study of metabolic and physiologic effects of kidney donation suggests that donors retain stable kidney function over the first nine years.
While there have been numerous studies of living kidney donors, most have been retrospective without suitable controls and have yielded conflicting results. To clarify this we studied 205 living donor candidates and 203 controls having no medical conditions precluding donation. Before and at six months, one, two, three, six, and nine years after donation we measured iohexol glomerular filtration rate, clinic blood pressure, urine protein excretion and metabolic parameters reported to be affected by kidney function. (Source: Kidney International)
Source: Kidney International - February 3, 2020 Category: Urology & Nephrology Authors: Bertram L. Kasiske, Tracy L. Anderson-Haag, Daniel A. Duprez, Roberto S. Kalil, Paul L. Kimmel, Todd E. Pesavento, Jon J. Snyder, Matthew R. Weir Tags: Clinical Investigation Source Type: research

Distribution of sodium hypochlorite throughout the mesial root canal system of mandibular molars after adjunctive irrigant activation procedures: a micro-computed tomographic study
ConclusionsThe XP-endo Finisher instrument promoted better distribution of irrigant throughout the root canal system, especially in the apical canal segment, when compared to PUI. However, the tested approaches did not differ as to the ability to drive irrigants into the isthmus area.Clinical relevanceThis study highlighted that the XP-endo Finisher instrument presented a better performance to distribute irrigant throughout the root canal system, especially in the apical canal segment compared to positive pressure irrigation and PUI. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - January 27, 2020 Category: Dentistry Source Type: research

Effects of a single-bolus bupivacaine injection into the coccygeal spinal canal of rabbits.
Abstract It has been reported that drugs intended for epidural administration through the lumbosacral junction are accidentally administered into the subarachnoid space frequently in rabbits. Therefore, we evaluated the epidural single-bolus injection technique for the administration of bupivacaine into the coccygeal spinal canal of rabbits. After epidural distribution was confirmed by the injection of iohexol into the coccygeal spinal canal, 0.3 ml/kg 0.5% bupivacaine or 0.3 ml/kg normal saline was injected via the same needle. After the first attempt of iohexol injection, although the contrast was found in the e...
Source: Anal Sci - January 22, 2020 Category: Chemistry Authors: Ong BHE, Hidaka Y, Kaneko Y, Yamamoto S, Mizutani S, Sekiguchi S, Torisu S, Naganobu K Tags: J Vet Med Sci Source Type: research

Intestinal barrier dysfunction in liver cirrhosis assessed by iohexol test.
CONCLUSIONS: Increased IP is found in 23% of cirrhotic patients. Permeability alterations are significantly more pronounced in patients with advanced LC with the presence of ascites and in those with alcoholic etiology. PMID: 31957845 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - January 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

The cotton test redistributes nasal airflow in patients with empty nose syndrome
BackgroundEmpty nose syndrome (ENS) remains a controversial disease primarily associated with inferior turbinate tissue loss. Cotton placement into the inferior meatus often alleviates ENS symptoms within minutes, but the physiologic explanation for this phenomenon is unknown. Computational fluid dynamics (CFD) was employed to evaluate the mechanisms of altered nasal airflow conferred by cotton testing.MethodsSix ENS patients (12 sides) with pre ‐existing sinus computed tomography (CT) imaging were enrolled after marked symptomatic improvement (decrease in score on the Empty Nose Syndrome 6‐Item Questionnaire [ENS6Q] o...
Source: International Forum of Allergy and Rhinology - January 17, 2020 Category: Allergy & Immunology Authors: Jennifer Malik, Andrew Thamboo, Sachi Dholakia, Nicole A. Borchard, Sam McGhee, Chengyu Li, Kai Zhao, Jayakar V. Nayak Tags: ORIGINAL ARTICLE Source Type: research

Assessment of the glomerular filtration rate (GFR) in kidney transplant recipients using Bayesian estimation of the iohexol clearance
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Issue: Ahead of print (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - January 13, 2020 Category: Laboratory Medicine Source Type: research

Assessment of the glomerular filtration rate (GFR) in kidney transplant recipients using Bayesian estimation of the iohexol clearance
Journal Name: Clinical Chemistry and Laboratory Medicine (CCLM) Volume: 58 Issue: 4 Pages: 577-587 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - January 11, 2020 Category: Laboratory Medicine Source Type: research

Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts
ConclusionsAgreement between the iohexol assays and clearance protocols in the 3 investigated cohorts was substantial. Our findings indicate that plasma iohexol clearance measurements can be compared across these studies. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - December 24, 2019 Category: Urology & Nephrology Source Type: research

Measurements of echocardiographic indices and biomarkers of kidney injury in dogs with chronic kidney disease
Publication date: Available online 11 December 2019Source: The Veterinary JournalAuthor(s): M.J. Hezzell, J.D. Foster, M.A. Oyama, J. Buch, G. Farace, J.J. Quinn, M. YerramilliAbstractPathophysiological cardiac and renal interactions are termed cardiovascular-renal disorder (CvRD). Cardiovascular disease/dysfunction secondary to kidney disease (CvRDK), is a leading cause of death in human chronic kidney disease (CKD) patients. The presence and clinical impact of CvRDK in dogs with CKD is unknown. We hypothesized that echocardiographic measurements, and cardiac and renal biomarkers, will be altered in dogs with CKD and asso...
Source: The Veterinary Journal - December 11, 2019 Category: Veterinary Research Source Type: research

Salt-sensitive blood pressure rise in type 1 diabetes patients is accompanied by disturbed skin macrophage influx and lymphatic dilation-a proof-of-concept study.
In conclusion, we show that salt sensitivity in type 1 diabetes patients cannot be explained by the classical concept of extracellular fluid volume expansion. Rather, we open up a potential role for macrophages and the lymphatic system. Future studies on hypertension and diabetes need to scrutinize these phenomena. PMID: 31883728 [PubMed - as supplied by publisher] (Source: Translational Research : the journal of laboratory and clinical medicine)
Source: Translational Research : the journal of laboratory and clinical medicine - December 9, 2019 Category: Laboratory Medicine Authors: Wenstedt EFE, Engberink RHGO, Rorije NMG, van den Born BH, Claessen N, Aten J, Vogt L Tags: Transl Res Source Type: research

Selective bronchography (SB) to confirm bronchopleural fistula (BPF) in patients with persistent air leaks
Bronchopleural fistula(BPF)requires different diagnostic methods to know its location, number and size for a correct treatment. The aim of our study is to compare the computed tomography scan(CT)results with the selective bronchograpy(SB)information in BPF.Retrospective study including SB between 03.2014-2.2019. We analysed patients factors, pathology, CT and SB results and final treatment.SB technique requires instilling 10cc of Yodohexol Omnipaque® through a radiopaque catheter Combicath® during fluoroscopy, under deep sedation with propofol. We have included 27 SB performed under suspicion of BPF in patients wit...
Source: European Respiratory Journal - November 21, 2019 Category: Respiratory Medicine Authors: Jaurrieta Largo, S., De Vega Sanchez, B., Disdier Vicente, C., Belver Blanco, M., Juarros Martinez, S. A., Roig Figueroa, V. Tags: Interventional pulmonology Source Type: research

Preparation of Injectable Egg Albumin Based Composite Implant for Photothermal Therapy of Tumor.
Abstract Polymeric hydrogels featured with three dimensional network structure have found tremendous applications in biomedicine. Herein, we report the synthesis of egg albumin (EA) based multifunctional implant as a carrier that capable of synergistically delivering photothermal transducing agent (poly dopamine, PDA) to tumor. The formation of PDA was achieved by utilizing the basicity of EA, while the formation of hydrogel implant was realized by the in vitro/in vivo near-infrared (NIR) laser induced hyperthermia of PDA. The as-prepared PDA@EA implant exhibits high photothermal conversion efficiency (38.7%). Aft...
Source: Chembiochem - October 15, 2019 Category: Biochemistry Authors: Zhang J, An X, Zheng Y, Chen Y, Wu C, Wang S Tags: Chembiochem Source Type: research

A biodegradable multifunctional porous microsphere composed of carrageenan for promoting imageable trans-arterial chemoembolization.
Abstract Trans-arterial chemoembolization (TACE) has been a mainstream treatment for hepatocellular carcinoma (HCC), accordingly there are more requirements for embolic agents' properties, mainly concentrated on biodegradability and imaging function. A new kind of biodegradable multifunctional porous microspheres (BMPMs) with internal coarse plications are ingeniously designed and manufactured, consisting of carrageenan, inhexol and superparamagnetic iron oxide nanoparticle (SPIO). BMPMs' sound roundness and excellent swelling behavior guarantee them to be smoothly transported into appointed arteries' ends and ach...
Source: International Journal of Biological Macromolecules - October 14, 2019 Category: Biochemistry Authors: Kunliang L, Zhicheng J, Xiaolong H, Dan Y, Yu Z, Haidong Z, Gaojun T, Fei X Tags: Int J Biol Macromol Source Type: research

Estimated Glomerular Filtration Rate Bias in Participants with Severe Obesity Regardless of Deindexation.
Abstract OBJECTIVE: Morbid obesity is associated with a higher independent risk of chronic kidney disease (CKD). Estimated glomerular filtration rate (eGFR) has been evaluated in a limited number of study participants with severe obesity. METHODS: A total of 706 measured GFR (mGFR) results from 598 participants with obesity (BMI ≥ 35 kg/m2 ) were retrospectively collected. The performance of the Modification of Diet in Renal Disease (MDRD) equation, Chronic Kidney Disease-Epidemiology (CKD-EPI) equation, and deindexed eGFR were compared with mGFR from the go...
Source: Obesity - October 3, 2019 Category: Eating Disorders & Weight Management Authors: Guebre-Egziabher F, Brunelle C, Thomas J, Pelletier CC, Normand G, Juillard L, Dubourg L, Lemoine S Tags: Obesity (Silver Spring) Source Type: research

Mass attenuation coefficients, effective atomic numbers and electron densities of some contrast agents for computed tomography
Publication date: Available online 29 September 2019Source: Radiation Physics and ChemistryAuthor(s): Mohammed Sultan Al-Buriahi, Baris T. TongucAbstractIn the clinical computed tomography (CT) examinations, a photon is attenuated as it passes a patient by tissues and contrast agents (CAs). The CAs can increase the visibility of internal structures or fluids within the patient. In this work, we have investigated the photon interaction parameters of some CT contrast agents such as iotrolan, iodixanol, iohexol, ioxilan, ioversol, and iomeprol. The mass attenuation coefficients (μ/ρ) of these contrast agents have been ...
Source: Radiation Physics and Chemistry - September 30, 2019 Category: Physics Source Type: research

Intraoperative cone-beam CT spatial priors for diffuse optical fluorescence tomography.
Abstract A hybrid system for intraoperative cone-beam CT (CBCT) imaging and continuous-wave fluorescence tomography (FT) has been developed using an image-guidance framework. Intraoperative CBCT images with sub-millimeter spatial resolution are acquired with a flat-panel C-Arm. Tetrahedral meshes are generated from CBCT for finite element method implementation of diffuse optical tomography (NIRFAST). Structural data from CBCT is incorporated directly into the optical reconstruction process using Laplacian-type regularization ("soft spatial priors"). Experiments were performed using an in-house optical sy...
Source: Physics in Medicine and Biology - September 30, 2019 Category: Physics Authors: Daly MJ, Chan H, Muhanna N, Akens MK, Wilson BC, Irish JC, Jaffray DA Tags: Phys Med Biol Source Type: research

A novel rat model of contrast-induced nephropathy based on dehydration
ConclusionsA novel CIN rat model based on dehydration and iohexol exposure was established and validated to assist in understanding and preventing CIN. (Source: Journal of Pharmacological Sciences)
Source: Journal of Pharmacological Sciences - September 29, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibition of xanthine oxidoreductase protects against contrast-induced renal tubular injury by activating adenosine monophosphate-activated protein kinase.
Abstract Reactive oxygen species (ROS) play a pivotal role in the development of contrast-induced nephropathy (CIN). The inhibition of xanthine oxidoreductase is known to reduce levels of ROS. We investigated whether febuxostat could attenuate oxidative stress via the activation of adenosine monophosphate-activated protein kinase (AMPK) against CIN. In a mouse model of CIN, renal impairment and tubular injury substantially increased, whereas febuxostat attenuated renal injury. Plasma and kidney xanthine oxidoreductase levels were decreased by febuxostat. Febuxostat administration was accompanied by the upregulatio...
Source: Free Radical Biology and Medicine - September 24, 2019 Category: Biology Authors: Yang KJ, Kim JH, Chang YK, Park CW, Kim SY, Hong YA Tags: Free Radic Biol Med Source Type: research

Nanoagents Based on Poly(ethylene glycol) ‐b‐Poly(l‐thyroxine) Block Copolypeptide for Enhanced Dual‐Modality Imaging and Targeted Tumor Radiotherapy
Polypeptide ‐based nanoagents featuring high iodine content, fascinating physicochemical properties, great simplicity, good safety, and remarkable potency, hold a tremendous potential in both diagnosis and therapy of varying diseases. AbstractFuture healthcare requires development of novel theranostic agents that are capable of not only enhancing diagnosis and monitoring therapeutic responses but also augmenting therapeutic outcomes. Here, a versatile and stable nanoagent is reported based on poly(ethylene glycol) ‐b‐poly(l‐thyroxine) (PEG‐PThy) block copolypeptide for enhanced single photon emission computed tom...
Source: Small - September 20, 2019 Category: Nanotechnology Authors: Xiaolei Gu, Zhehong Zhu, Qianyi Fan, Yaohua Wei, Guanglin Wang, Fenghua Meng, Zhiyuan Zhong, Chao Deng Tags: Full Paper Source Type: research

Microcatheter delivery of neurotherapeutics: compatibility with mesenchymal stem cells.
CONCLUSIONS: BM-hMSC-Delta-24 is compatible with a wide variety of microcatheters and medications commonly used in neuroendovascular therapy. Stem cell viability and viral agent activity do not appear to be affected by catheter configuration or injection velocity. Commercially available microcatheters can be used to deliver stem cell neurotherapeutics via intraarterial routes. PMID: 31491769 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - September 6, 2019 Category: Neurosurgery Authors: Srinivasan VM, Gumin J, Camstra KM, Chen SR, Johnson JN, Shimizu Y, Parker Kerrigan BC, Shpall EJ, Lang FF, Kan P Tags: J Neurosurg Source Type: research

Estimated glomerular filtration rate using a point of care measure of creatinine in patients with iohexol determinate GFR
ConclusionCreatinine measured with the POC has an acceptable performance when used with the CKD-EPI equation to estimate GFR. Its ability to detect GFR
Source: Clinica Chimica Acta - September 2, 2019 Category: Laboratory Medicine Source Type: research

Estimated glomerular filtration rate using a point of care measure of creatinine in patients with iohexol determinate GFR.
CONCLUSION: Creatinine measured with the POC has an acceptable performance when used with the CKD-EPI equation to estimate GFR. Its ability to detect GFR
Source: International Journal of Clinical Chemistry - August 31, 2019 Category: Chemistry Authors: Stojkovic V, Delanaye P, Collard G, Ferrante N, Le Goff C, Lutteri L, Cavalier E Tags: Clin Chim Acta Source Type: research

Abdominal lymphatic drainage after thoracic duct ligation and cisterna chyli ablation in clinically normal cats.
CONCLUSIONS AND CLINICAL RELEVANCE: Abdominal lymphaticovenous anastomoses formed after TDL and CCA in cats. This would support use of these procedures for treatment of cats with idiopathic chylothorax, although additional studies with clinically affected cats are warranted. PMID: 31449451 [PubMed - in process] (Source: American Journal of Veterinary Research)
Source: American Journal of Veterinary Research - August 28, 2019 Category: Veterinary Research Authors: Dickerson VM, Grimes JA, Secrest SA, Wallace ML, Schmiedt CW Tags: Am J Vet Res Source Type: research

A Validation Study on eGFR Equations in Chinese Patients With Diabetic or Non-diabetic CKD
Aims It remains controversial to choose the optimal equation to estimate glomerular filtration rate (GFR) in chronic kidney disease (CKD) patients with diabetes. Materials and Methods 215 diabetic CKD patients and 192 non-diabetic CKD patients were enrolled in this study. Iohexol GFR, serum creatinine (SCr) and Cystatin C(CysC) were measured simultaneously for each patient. SCr- and CysC-based estimated GFR (eGFR) were calculated through eight equations, including three CKD-EPI equations, Revised Lund-Malmö study equation (RLM), CAPA equation and three Full Age Spectrum (FAS) equations. Bias, precision and accurac...
Source: Frontiers in Endocrinology - August 27, 2019 Category: Endocrinology Source Type: research

Dosing Iodinated Contrast Media According to Lean Versus Total Body Weight at Abdominal CT: A Stratified Randomized Controlled Trial
ConclusionTBW- and LBW-based CM dosing yield a similar magnitude and interpatient variability in normalized MHE indices at routine abdominal CT. (Source: Academic Radiology)
Source: Academic Radiology - August 20, 2019 Category: Radiology Source Type: research

PEG-Citrate dendrimer second generation: is this a good carrier for imaging agents In Vitro and In Vivo?
While cancer is the leading cause of human's deaths worldwide, finding an imaging agent which can detect cancer tumours is needed for cancer diagnosis. In the present study, PEG-citrate dendrimer-G2 was used as a nano-carrier of FITC dye and Iohexol to help passive targeting and uptake of both imaging agents in cancer cells/tumour in vitro and in vivo. Dendrimer was synthesisedand the product characterised using LC-MS, FT-IR, DLS, ELS, AFM, and 1HNMR. After FITC loading into dendrimer, MTT was performed to determine the cytotoxicity of formulation on HEK-293 and MCF-7 cells. In vitro imaging using dendrimer-FITC was done v...
Source: IET Nanobiotechnology - August 9, 2019 Category: Nanotechnology Source Type: research

Acute Adverse Reactions to Nonionic Iodinated Contrast Media: A Meta-Analysis
Conclusions The varying pooled incidences of overall and severe AARs to specific types of nonionic ICM do not remain as significant after adjusting confounders. Our results may support nonrestriction of certain types of nonionic ICM in the context of AAR avoidance. (Source: Investigative Radiology)
Source: Investigative Radiology - August 6, 2019 Category: Radiology Tags: Original Articles Source Type: research

AcidoCEST-UTE MRI for the Assessment of Extracellular pH of Joint Tissues at 3 T
Conclusions Measuring extracellular pH in cartilage and meniscus using acidoCEST-UTE MRI is feasible. (Source: Investigative Radiology)
Source: Investigative Radiology - August 6, 2019 Category: Radiology Tags: Original Articles Source Type: research

Technique, protocols and adverse reactions for contrast-enhanced spectral mammography (CESM): a systematic review
AbstractWe reviewed technical parameters, acquisition protocols and adverse reactions (ARs) for contrast-enhanced spectral mammography (CESM). A systematic search in databases, including MEDLINE/EMBASE, was performed to extract publication year, country of origin, study design; patients; mammography unit/vendor, radiation dose, low-/high-energy tube voltage; contrast molecule, concentration and dose; injection modality, ARs  and acquisition delay; order of views; examination time. Of 120 retrieved articles, 84 were included from 22 countries (September 2003–January 2019), totalling 14012 patients. Design was pro...
Source: Insights into Imaging - August 2, 2019 Category: Radiology Source Type: research

Fatal contrast medium-induced adverse response to iohexol in carotid artery angioplasty: A case report
This report describes a 51-year-old man suffering from an ADR to iohexol (Omnipaque 300), which proved fatal. Patient concerns: The patient was admitted to hospital due to intermittent dizziness over 2 years and transient numbness and weakness of the right limbs for 1 week. The patient was investigated using carotid artery angioplasty (CAA), during which the patient suffered a sudden disorder of consciousness and a tonic-clonic seizure leading to status epilepticus. After the CAA, the patient suffered from increasing cerebral edema volume. Diagnoses: Results of digital subtraction angiography and computed tomography ...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Measurement of glomerular filtration rate using a reference method.
Abstract Direct measurement methods of glomerular filtration rate (GFR) are considered as the gold standard to assess kidney function. Following the withdrawal of the Proinuline Serb® specialty by the French National Health Surveillance Agency, iohexol remains the most suitable marker to replace inulin as the marker for GFR in France. The assay is performed by high performance liquid chromatography (HPLC) coupled with ultraviolet (UV) detection or by mass spectrometry. Plasma clearance measurement is the protocol of choice: single-sample protocols dominate, but multiple-sample protocols may be more accurate in...
Source: Annales de Biologie Clinique - August 1, 2019 Category: Biochemistry Authors: Chardon L, Dubourg L, Barin-Le Guellec C, Guinard F, Hannedouche T, Halimi JM, Mariat C Tags: Ann Biol Clin (Paris) Source Type: research

Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-Lima
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 26, 2019 Category: Urology & Nephrology Source Type: research

Estimating glomerular filtration rate in youth with obesity and type 2 diabetes: the iCARE study equation
ConclusionsThe iCARE equation provides a more accurate creatinine-based eGFR in obese youth with and without T2D. Further studies are warranted to evaluate within-subject variability and applicability to lower GFRs and other populations. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - July 26, 2019 Category: Urology & Nephrology Source Type: research

Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy
Kidney in diabetic nephropathy state (DN) is more sensitive to post-contrast acute kidney injury (PC-AKI). Resveratrol (Res) is known to a multi-functional polyphenol compound that has protective functions in acute kidney diseases. Here we aimed to examine whether the resveratrol could potentially ameliorate the PC-AKI following DN, and to explore its underlying mechanism in vivo and in vitro. Twenty-four DN rabbits were randomly divided into four groups: control group (Cont), resveratrol group (Res), iohexol group (PC-AKI), and resveratrol plus iohexol group (Res+PC-AKI). All animals underwent MR examinations 24 hours aft...
Source: Frontiers in Pharmacology - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Glomerular Hyper- and Hypofiltration During Acute Circulatory Failure: Iohexol-Based Gold-Standard Descriptive Study
Conclusions: We demonstrated the feasibility of iohexol clearance measurement in unstable critically ill patients. Normal kidney function is exceptional during the early phase of acute circulatory failure. Glomerular filtration rate estimation by urinary creatinine clearance frequently fails to detect renal impairment. Hyperfiltration is very infrequent. (Source: Critical Care Medicine)
Source: Critical Care Medicine - July 13, 2019 Category: Emergency Medicine Tags: Online Clinical Investigations Source Type: research

Enhanced removal of pharmaceuticals in a biofilter: Effects of manipulating co-degradation by carbon feeding.
This study aimed at investigating the effects of pulsed carbon feeding for promoting the co-degradation of indigenous pharmaceuticals from pre-treated wastewater in a fixed-bed porous biofilm reactor (slow sand filter). The addition of acetate (carbon source) resulted in three different enhancement/limitation effects, which were compound dependent: 1) atenolol and iohexol experienced enhanced co-degradation followed by constant (acetate independent) degradation; 2) metoprolol, iomeprol, diclofenac, propranolol and sulfamethizole co-degradation dependent on aerobic turnover, but inhibited at higher acetate concentrations (6...
Source: Chemosphere - July 5, 2019 Category: Chemistry Authors: Zhang L, Carvalho PN, Bollmann UE, Ei-Taliawy H, Brix H, Bester K Tags: Chemosphere Source Type: research

Next tier in vitro and in vivo nonclinical studies further elucidating the safety and toxicity profile of MB-102, a novel fluorescent tracer agent for measurement of glomerular filtration rate
Publication date: Available online 2 July 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Richard B. Dorshow, Joseph E. BugajAbstractMB-102 was designed for measurement of real-time glomerular filtration rate (GFR). Previously reported in vitro and in vivo nonclinical studies clearly demonstrated negligible toxicity, resulting in FDA clearance for First-in Human, proof of concept clinical studies. The next tier of safety and toxicity studies are reported herein.MB-102 did not demonstrate any phototoxic potential in a BALB/c 3T3 mouse fibroblast study. Co-administration of MB-102 and iohexol resulted in pharmac...
Source: Regulatory Toxicology and Pharmacology - July 3, 2019 Category: Toxicology Source Type: research

Assessment of kidney function in adults
Kidney function is typically assessed by measuring glomerular filtration rate (GFR), and many approaches have been used. Accuracy demands complex techniques involving the use of exogenous filtration markers (e.g. inulin, iohexol, 99mTc-diethylenetriaminepentaacetic acid, 51Cr-ethylenediaminetetraacetic acid). For most clinical purposes, accuracy is sacrificed to practicality, and the blood marker creatinine (whose concentration has an inverse relationship to GFR) is used instead. Serum (or plasma) creatinine has many limitations as a kidney function test, being affected by a variety of non-renal and analytical factors. (Source: Medicine)
Source: Medicine - July 3, 2019 Category: Internal Medicine Authors: Edmund Lamb Tags: Laboratory investigations Source Type: research

Next tier in vitro and in vivo nonclinical studies further elucidating the safety and toxicity profile of MB-102, a novel fluorescent tracer agent for measurement of glomerular filtration rate.
Abstract MB-102 was designed for measurement of real-time glomerular filtration rate (GFR). Previously reported in vitro and in vivo nonclinical studies clearly demonstrated negligible toxicity, resulting in FDA clearance for First-in Human, proof of concept clinical studies. The next tier of safety and toxicity studies are reported herein. MB-102 did not demonstrate any phototoxic potential in a BALB/c 3T3 mouse fibroblast study. Co-administration of MB-102 and iohexol resulted in pharmacokinetic parameters virtually identical to the values observed upon individual administration in beagle dogs. A single dose of ...
Source: Regulatory Toxicology and Pharmacology : RTP - July 2, 2019 Category: Toxicology Authors: Dorshow RB, Bugaj JE Tags: Regul Toxicol Pharmacol Source Type: research

Severe (grade IV) hypersensitivity to iodinated contrast agent in an anesthetized dog.
Abstract An 8-year-old female Labrador dog was anesthetized for contrast-enhanced computed tomography. The dog was sedated with dexmedetomidine and butorphanol and anesthetized with propofol and isoflurane. Upon IV injection of iohexol 350 mg/mL (72 mL), tachycardia, hypotension, and lower airway obstruction developed. Severe hypersensitivity to the contrast agent was suspected. Bronchospasm was treated successfully with epinephrine. Phenylephrine was used for pressure support. While rare, severe hypersensitivity to iodinated contrast agents can occur without evidence of prior exposure. PMID: 31281196 [PubMed...
Source: The Canadian Veterinary Journal - July 1, 2019 Category: Veterinary Research Authors: Basher KL, Porter IR, Martin-Flores M Tags: Can Vet J Source Type: research

Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model
Conclusion: BOLD combined with IVIM is effective to monitor renal pathophysiology associated with CIAKI.Kidney Blood Press Res (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - June 28, 2019 Category: Urology & Nephrology Source Type: research

Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS
This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling systems (VAMS). As an alternative to VAMS a brand new HemaPEN® device for micro-prelevation was also tested.A new high throughput sample preparation protocol adapted for Iohexol quantification from whole blood VAMS samples was developed. The medium term stability study of iohexol in dried whole blood VAMS samples that was conducted showed a good stability of this molecule for up to 12 days.By collecting only 10 μL of blood, iohexol can be analyzed from dr...
Source: Journal of Pharmaceutical Analysis - June 28, 2019 Category: Drugs & Pharmacology Source Type: research

Efficient abatement of an iodinated X-ray contrast media iohexol by Co(II) or Cu(II) activated sulfite autoxidation process.
Abstract Efficient abatement of an iodinated X-ray contrast media iohexol by an emerging sulfite autoxidation advanced oxidation process is demonstrated, which is based on transition metal ion-catalyzed autoxidation of sulfite to form active oxidizing species. The efficacy of the combination of sulfite and transition metal ions (Ag(I), Mn(II), Co(II), Fe(II), Cu(II), Fe(III), or Ce(III)) was tested for iohexol abatement. Co(II) and Cu(II) are proven to show more pronounced catalytic activity than other metals at pH 8.0. According to the quenching studies, sulfate radical (SO4•-) is identified to be the p...
Source: Environmental Science and Pollution Research International - June 25, 2019 Category: Environmental Health Authors: Zhao X, Wu W, Yan Y Tags: Environ Sci Pollut Res Int Source Type: research

Effect of astaxanthin on apoptosis of rat renal tubular epithelial cells induced by iohexol.
In this study, the rat renal tubular epithelial cells (NRK-52E) were treated with iohexol, astaxanthin, astaxanthin plus nicotinamide and nicotinamide. Subsequently, the nuclear morphology was observed by fluorescence staining of DAPI DNA, the apoptosis was detected by flow cytometry, the mitochondrial membrane potential was detected by JC-1 and the SIRT1, P53, Bax, Bcl-2 protein expression level was detected by Western blotting. We found that astaxanthin can reduce nuclear pyknosis and nuclear deep staining, decrease the number of apoptotic cells, up-regulate the expression of proapoptotic proteins P53 and Bax and up-regu...
Source: American Journal of Translational Research - June 22, 2019 Category: Research Tags: Am J Transl Res Source Type: research