Navigating Supply Chain Disruptions of Iodinated Contrast Agent for Neuroimaging and How Business Intelligence Can Help the Decision Process [ADULT BRAIN]
SUMMARY:
A recent coronavirus disease 2019–related shutdown of the main production facility of iohexol in China has led to massive shortages of iodinated contrast material across the globe. This shortage has also jeopardized neuroimaging. In this article, we describe remedies to reduce iodinated contrast material use for stroke imaging, which is its primary use in neuroimaging, that we have implemented in our hospital network. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - July 7, 2022 Category: Radiology Authors: Bammer, R., Amukotuwa, S. A. Tags: ADULT BRAIN Source Type: research
Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation : A Cross-Sectional Study
CONCLUSION: A substantial individual-level discrepancy exists between the mGFR and the eGFR. Laboratories reporting eGFR should consider including the extent of this uncertainty to avoid misinterpretation of eGFR as an mGFR replacement.PRIMARY FUNDING SOURCE: National Institutes of Health.PMID:35785532 | DOI:10.7326/M22-0610 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - July 5, 2022 Category: Internal Medicine Authors: Tariq Shafi Xiaoqian Zhu Seth T Lirette Andrew D Rule Thomas Mosley Kenneth R Butler Michael E Hall Pradeep Vaitla James J Wynn Maria Clarissa Tio Neville R Dossabhoy Eliseo Guallar Javed Butler Source Type: research
Quantifying Individual-Level Inaccuracy in Glomerular Filtration Rate Estimation : A Cross-Sectional Study
CONCLUSION: A substantial individual-level discrepancy exists between the mGFR and the eGFR. Laboratories reporting eGFR should consider including the extent of this uncertainty to avoid misinterpretation of eGFR as an mGFR replacement.PRIMARY FUNDING SOURCE: National Institutes of Health.PMID:35785532 | DOI:10.7326/M22-0610 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - July 5, 2022 Category: Internal Medicine Authors: Tariq Shafi Xiaoqian Zhu Seth T Lirette Andrew D Rule Thomas Mosley Kenneth R Butler Michael E Hall Pradeep Vaitla James J Wynn Maria Clarissa Tio Neville R Dossabhoy Eliseo Guallar Javed Butler Source Type: research
Marked bilateral global persistent CT nephrogram 48 h after percutaneous coronary intervention with contrast-induced nephropathy requiring transient hemodialysis with severe cardiac dysfunction
AbstractAn iodinated contrast medium (CM) is generally excreted into the urinary tract within 3 min after administration. However, some cases present a persistent kidney nephrogram several hours after administration of CM. This phenomenon seems to be associated with the development and acceleration of contrast-induced nephropathy (CIN). A 74-year-old woman with chronic kidney disease and a v ery low ejection fraction (EF) (11%) was admitted to Sapporo Medical University Hospital because of heart failure. Coronary angiography revealed occlusion of the left anterior descending artery (LAD) on day 21 of admission. Percutane...
Source: CEN Case Reports - June 13, 2022 Category: Urology & Nephrology Source Type: research
IJERPH, Vol. 19, Pages 7077: Contrast Media Adverse Drug Reactions in Highly Polluted Environment
This study shows relatively high occurrence of respiratory tract related ADRs in Wrocław. We also prove that it is possible to choose the most optimal contrast agent for patients with specific organ site problems to omit the possible complications. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - June 9, 2022 Category: Environmental Health Authors: Natalia Sauer Wojciech Szlasa Laura Jonderko Krystyna G łowacka Katarzyna Kar łowicz-Bodalska Anna Wiela-Hoje ńska Tags: Article Source Type: research
Continuous Infusion of Iohexol to Monitor Perioperative Glomerular Filtration Rate
Int J Nephrol. 2022 May 24;2022:8267829. doi: 10.1155/2022/8267829. eCollection 2022.ABSTRACTContinuous monitoring of the glomerular filtration rate (GFR) in the perioperative setting could provide valuable information about acute kidney injury risk for both clinical and research purposes. This pilot study aimed to demonstrate that GFR measurement by a continuous 72 hrs iohexol infusion in patients undergoing colorectal cancer surgery is feasible. Four patients undergoing robot-assisted colorectal cancer surgery were recruited from elective surgery listings. GFR was determined preoperatively by the single-sample iohexol cl...
Source: International Journal of Nephrology - June 3, 2022 Category: Urology & Nephrology Authors: Kjellbj ørn Jakobsen Bj ørn O Eriksen Ole M Fuskev åg Stephen J Hodges Lars M Ytreb ø Source Type: research
A Hybrid Model Associating Population Pharmacokinetics with Machine Learning: A Case Study with Iohexol Clearance Estimation
Conclusions In conclusion, this hybrid algorithm represents a significant improvement in comparison to MAP-BE estimation alone. (Source: Clinical Pharmacokinetics)
Source: Clinical Pharmacokinetics - May 31, 2022 Category: Drugs & Pharmacology Source Type: research
Quercetin improves contrast-induced acute kidney injury through the HIF-1 α/lncRNA NEAT1/HMGB1 pathway
CONCLUSIONS: Quercetin diminished cell injury and apoptosis in CI-AKI cell mode via the inhibition of HIF-1α on the lncRNA NEAT1/HMGB1 signalling pathway, offering a potential novel therapeutic target for CI-AKI therapy.PMID:35587223 | DOI:10.1080/13880209.2022.2058558 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 19, 2022 Category: Drugs & Pharmacology Authors: Min Luo Ziyu Liu Zongren Hu Qinghu He Source Type: research
Quercetin improves contrast-induced acute kidney injury through the HIF-1 α/lncRNA NEAT1/HMGB1 pathway
CONCLUSIONS: Quercetin diminished cell injury and apoptosis in CI-AKI cell mode via the inhibition of HIF-1α on the lncRNA NEAT1/HMGB1 signalling pathway, offering a potential novel therapeutic target for CI-AKI therapy.PMID:35587223 | PMC:PMC9122359 | DOI:10.1080/13880209.2022.2058558 (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - May 19, 2022 Category: Drugs & Pharmacology Authors: Min Luo Ziyu Liu Zongren Hu Qinghu He Source Type: research
Short-Term Mitigation Steps During the Iohexol Contrast Shortage: A Single Institution ’s Approach
In the United States, over 40% of CT examinations use iodinated contrast agents (ICAs) for better visualization and assessment of pathophysiological processes [1]. Recent COVID-19 related work slowdowns in Shanghai, China, have affected operations of General Electric (GE) factories and reduced production of Omnipaque (iohexol, GE Healthcare, Milwaukee, Wisconsin) contrast agents, with estimates that the factory will remain at reduced capacity through the end of June 2022, and shortages potentially persisting through the middle to end of the summer [2]. (Source: Journal of the American College of Radiology : JACR)
Source: Journal of the American College of Radiology : JACR - May 17, 2022 Category: Radiology Authors: Gloria Gonzalez, Mahmud Mossa-Basha, Maureen Kohi, Lauren M. Burke Tags: Special Commentary (Opinion) Source Type: research
Effect of different contrast medium injection protocols for analysis of hepatic computed tomography perfusion in healthy dogs
Am J Vet Res. 2022 May 8;83(6):ajvr.21.08.0125. doi: 10.2460/ajvr.21.08.0125.ABSTRACTOBJECTIVE: To evaluate the hepatic CT perfusion (CTP) for determining the appropriate protocol for the dual-input maximum-slope model in dogs.ANIMALS: 5 healthy dogs.PROCEDURES: Each dog underwent CTP with different contrast medium administration protocols. Combinations of three different injected doses of iohexol (450, 600, and 750 mg/kg) and injection durations (5, 10, and 15 seconds) were used. The CT values at the aorta, portal vein, and hepatic parenchyma were measured to create a time-density curve, and CTP parameters were measured s...
Source: American Journal of Veterinary Research - May 7, 2022 Category: Veterinary Research Authors: Takao Amaha Kumiko Ishigaki Chieko Ishikawa Keigo Iizuka Takahiro Nagumo Kei Tamura Kazushi Asano Source Type: research
Effect of different contrast medium injection protocols for analysis of hepatic computed tomography perfusion in healthy dogs
Am J Vet Res. 2022 May 8;83(6):ajvr.21.08.0125. doi: 10.2460/ajvr.21.08.0125.ABSTRACTOBJECTIVE: To evaluate the hepatic CT perfusion (CTP) for determining the appropriate protocol for the dual-input maximum-slope model in dogs.ANIMALS: 5 healthy dogs.PROCEDURES: Each dog underwent CTP with different contrast medium administration protocols. Combinations of three different injected doses of iohexol (450, 600, and 750 mg/kg) and injection durations (5, 10, and 15 seconds) were used. The CT values at the aorta, portal vein, and hepatic parenchyma were measured to create a time-density curve, and CTP parameters were measured s...
Source: American Journal of Veterinary Research - May 7, 2022 Category: Veterinary Research Authors: Takao Amaha Kumiko Ishigaki Chieko Ishikawa Keigo Iizuka Takahiro Nagumo Kei Tamura Kazushi Asano Source Type: research
