Cost-Effectiveness Analysis for the Treatment of Hyperphosphatemia in Predialysis Patients: Calcium-Based versus Noncalcium-Based Phosphate Binders.
Conclusions: Our study finds that sevelamer is potentially cost-effective compared to CaCO3, for the treatment of hyperphosphatemia in predialysis CKD III-V. We propose that sevelamer should be an option in the treatment of Malaysian predialysis patients with hyperphosphatemia, particularly those with high calcium load. PMID: 30327732 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 19, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma.
Authors: Derman BA, Reiser J, Basu S, Paner A Abstract Introduction: Renal insufficiency (RI) in Multiple Myeloma (MM) portends a higher tumor burden and worse prognosis. Reversal of RI in newly diagnosed MM (NDMM) improves patient outcomes, but it is unknown if there is a disparity in renal recovery in NDMM between African Americans (AA) and non-African Americans. Methods: A retrospective chart review was conducted of 690 patients with NDMM at Rush University Medical Center from 2005 to 2016. 118 patients (59 AA and 59 non-AA) with NDMM and an estimated glomerular filtration rate (eGFR)
Source: International Journal of Nephrology - September 27, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study.
We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients. PMID: 30245879 [PubMed] (Source: Internati...
Source: International Journal of Nephrology - September 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk.
Authors: Pasch A, Jahnen-Dechent W, Smith ER Abstract Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients. Phosphate is subject to the blood mineral buffering system which controls the precipitation of calcium and phosphate. Calciprotein particles (CPP), self-assembling complexes of calcium phosphate and serum proteins, are the nanomorphological correlates of this system. CPP1 are spherical, 50-100 nm in diameter, and contain amorphous mineral. CPP2 are oblongated, 100-200nm in the long axis, and they contain a cry...
Source: International Journal of Nephrology - September 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Mortality and Recovery of Renal Function in Acute Kidney Injury Patients Treated with Prolonged Intermittent Hemodialysis Sessions Lasting 10 versus 6 Hours: Results of a Randomized Clinical Trial.
Conclusion: There was no difference in the mortality and recovery of renal function of AKI patients submitted to different durations of PHD and sessions lasting 10 h presented higher filter clotting, hypophosphatemia, and treatment discontinuation. ISRCTN Registry number is ISRCTN33774458. PMID: 30186631 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation.
Authors: Benz K, Hilgers KF, Daniel C, Amann K Abstract Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of ather...
Source: International Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Outcomes in Children with Operated Spina Bifida in Uganda.
Conclusions: Incontinence, ultrasound abnormalities, and hypertension are highly prevalent in a cohort of Ugandan children with spina bifida, including those with low neurological lesions. These findings support the early and universal initiation of CIC with anticholinergic therapy in a low-income setting. PMID: 30174953 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 4, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Pediatric Nephrology and Rheumatology Practice Patterns in Granulomatosis with Polyangiitis: A Midwest Pediatric Nephrology Consortium Study.
Conclusion: This survey has revealed important differences in the way that rheumatologists and nephrologists manage this disease. It highlights the need for well-designed clinical trials in pediatric GPA patients and reveals that both specialties must be represented during consensus-building and clinical trial design efforts. PMID: 30155302 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 31, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Clinical Presentation, Outcomes, and Treatment of Membranous Nephropathy after Transplantation.
Authors: da Silva AQB, de Sandes-Freitas TV, Mansur JB, Medicina-Pestana JO, Mastroianni-Kirsztajn G Abstract There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Clinical and laboratory presentation, histological findings, treatment, and outcomes were detailed. Patients were predominantly ...
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health.
Conclusion: By 2035, about one-quarter of the Singapore residents are expected to have CKD. National policies need to focus on primary disease prevention and early disease detection to avoid delayed treatment of CKD which eventually leads to end-stage renal disease. PMID: 30112209 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Factors Affecting Survival in Geriatric Hemodialysis Patients.
Conclusion: The present study revealed that comorbidities and low performance status at the onset of dialysis had shortened the survival time in the geriatric hemodialysis patient group. PMID: 30112210 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017.
Conclusion: Immune complex glomerulonephritis was the most frequent histological finding, differing from previous reports. To our knowledge this is the first description that classifies biopsy findings according to the probable pathogenic mechanism. PMID: 30050696 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - July 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Microalbuminuria and Retinopathy among Hypertensive Nondiabetic Patients at a Large Public Outpatient Clinic in Southwestern Uganda.
Conclusion: The prevalence of retinopathy and microalbuminuria is high. Clinicians should aim for better control of blood pressure and routinely perform fundoscopy and urine albumin, especially for patients with poorly controlled blood pressure. PMID: 29977618 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - July 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Transforming Growth Factor- β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients.
Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. Int J Nephrol. 2018;2018:8702372 Authors: Hassan MO, Duarte R, Dix-Peek T, Dickens C, Naidoo S, Vachiat A, Grinter S, Manga P, Naicker S Abstract Background: Transforming growth factor-β (TGF-β) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF-β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atheros...
Source: International Journal of Nephrology - July 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System.
Authors: Kuro-O M Abstract The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. It has become increasingly important to investigate mechanisms of aging ...
Source: International Journal of Nephrology - June 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Association of Poor Social Support and Financial Insecurity with Psychological Distress of Chronic Kidney Disease Patients Attending National Nephrology Unit in Sri Lanka.
Conclusions: More than half of the CKD patients were psychologically distressed. Factors such as financial and social support will be worth considering early because of their modifiability. PMID: 29888004 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 12, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations.
Conclusion: The CKD-EPIcr formula appears to be more accurate and correlates better with measured GFR in this cohort of elderly patients. PMID: 29862077 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 5, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Phosphate and Cardiovascular Disease beyond Chronic Kidney Disease and Vascular Calcification.
Authors: Disthabanchong S Abstract Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal disease, widespread vascular calcification occurs as a result of chronic phosphate load. The accumulation of phosphate is likely to occur long before the rise in serum phosphate above the normal range since several observational studies in both general population and early-stage CKD patients have identified the relationship between high-normal serum phosphate and adverse cardiovascular outcomes. Consumption of food high in phosphate increases both fasting and postprandial serum phosphate an...
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Contrast-Induced Nephropathy: Update on the Use of Crystalloids and Pharmacological Measures.
Authors: Patschan D, Buschmann I, Ritter O Abstract Contrast-induced nephropathy (CIN) is a frequent and severe complication in subjects receiving iodinated contrast media for diagnostic or therapeutic purposes. Several preventive strategies were evaluated in the past. Recent clinical studies and meta-analyses delivered some new aspects on preventive measures used in the past and present. We will discuss all pharmacological and nonpharmacological procedures. Finally, we will suggest individualized recommendations for CIN prevention. PMID: 29854458 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.
Authors: Cao L, Sedighi R, Boston A, Premadasa L, Pinder J, Crawford GE, Jegede OE, Harrison SH, Newman RH, Ongeri EM Abstract Diabetes is the leading cause of chronic kidney disease. African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD). Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied. The current study used multiple biomarkers of DKD to evaluate undiagnosed DKD in uninsured and underinsured African American men in Greensboro, North Carolina. Participants consisted of thre...
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease.
Authors: Ougaard MKE, Kvist PH, Jensen HE, Hess C, Rune I, Søndergaard H Abstract Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD p...
Source: International Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

A Web-Based Platform to Collect Data from ESRD Patients Undergoing Dialysis: Methods and Preliminary Results from the Brazilian Dialysis Registry.
Conclusion: The initiative represents an innovative strategy to collect clinical and epidemiologic data of dialysis patients which may be applied to other settings and provides information that can contribute to guiding clinical practice and health care policy. PMID: 29692934 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Restless Legs Syndrome in Dialysis Patients: Does the Dialysis Modality Influence Its Occurrence and Severity?
Conclusions: RLS is frequent in dialysis patients and occurs predominantly in its most severe forms; the dialytic modality seems to have no influence on its occurrence; however, it is more severe in patients on APD. PMID: 29682346 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - April 25, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence of Microalbuminuria in Adult Patients with Sickle Cell Disease in Eastern Saudi Arabia.
Conclusion: Microalbuminuria is a common finding in patients with SCD in eastern Saudi Arabia. Patients with SCD should be screened for MA, and those with positive tests should probably be treated with antiproteinuric agents that may slow the progression to advanced stages of renal failure and decrease the risk of cardiovascular diseases. PMID: 29682347 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - April 25, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Low, rather than High, Body Mass Index Is a Risk Factor for Acute Kidney Injury in Multiethnic Asian Patients: A Retrospective Observational Study.
Authors: Liu AYL, Wang J, Nikam M, Lai BC, Yeoh LY Abstract Background: Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population. Methods: This was a retrospective, single-centre, observational study conducted in Singapore, a multiethnic population. All patients aged ≥21 years and hospitalised from January to December 2013 were recruited. Results: A total of 12,555 patients were eligible for the analysis. A BMI of
Source: International Journal of Nephrology - March 22, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Cancer in ANCA-Associated Glomerulonephritis: A Registry-Based Cohort Study.
Conclusions: Cancer risk did not increase significantly in this cohort with ANCA-associated glomerulonephritis. However, increased risk of nonmelanoma skin cancer, posttransplant cancer, and hematologic cancer indicates an association between immunosuppression and malignancy. PMID: 29403663 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Serial Galactose-Deficient IgA1 Levels in Children with IgA Nephropathy and Healthy Controls.
This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Follow-up measurements were scheduled 6 and/or 12 months later. Analysis of variance and regression models for repeated measures were used to estimate group and time effects. Serum Gd-IgA1 level was higher in initial samples for IgAN patients compared to those of healthy children (P
Source: International Journal of Nephrology - January 16, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Dialysis Provision and Implications of Health Economics on Peritoneal Dialysis Utilization: A Review from a Malaysian Perspective.
Authors: Abdul Manaf MR, Surendra NK, Abdul Gafor AH, Seong Hooi L, Bavanandan S Abstract End-stage renal disease (ESRD) is managed by either lifesaving hemodialysis (HD) and peritoneal dialysis (PD) or a kidney transplant. In Malaysia, the prevalence of dialysis-treated ESRD patients has shown an exponential growth from 504 per million population (pmp) in 2005 to 1155 pmp in 2014. There were 1046 pmp patients on HD and 109 pmp patients on PD in 2014. Kidney transplants are limited due to lack of donors. Malaysia adopts public-private financing model for dialysis. Majority of HD patients were t...
Source: International Journal of Nephrology - December 13, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Complex Monitoring of Biochemical and Radionuclide Parameters in Patients with Metastatic Renal Cell Carcinoma during Immunotherapy.
Conclusions: All mRCC patients after nephrectomy were recommended to undergo biochemical monitoring with inclusion of TGF-β and IL-17A, as well as radionuclide monitoring (CRS) to determine the RF risk at an early stage. PMID: 29201463 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - December 6, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

NT-proBNP, Cardiometabolic Risk Factors, and Nutritional Status in Hemodialysis Patients.
CONCLUSION: In dialysis patients, high NT-proBNP levels must draw attention to cardiac function but also to nutritional status. PMID: 29075534 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 28, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Role of Sodium Bicarbonate in the Management of Some Toxic Ingestions.
Authors: Mirrakhimov AE, Ayach T, Barbaryan A, Talari G, Chadha R, Gray A Abstract Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of ...
Source: International Journal of Nephrology - September 23, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Sleep Parameters in Short Daily versus Conventional Dialysis: An Actigraphic Study.
Authors: Allemand LDES, Nóbrega OT, Lauar JP, Veiga JPR, Camargos EF Abstract Previous studies have observed worse sleep quality in patients undergoing conventional dialysis as compared to daily dialysis. Our aim was to compare the sleep parameters of patients undergoing daily or conventional dialysis using an objective measure (actigraphy). This cross-sectional study was performed in three dialysis centers, including a convenience sample (nonprobability sampling) of 73 patients (36 patients on daily hemodialysis and 37 patients on conventional hemodialysis). The following parameters were evaluated: nocturna...
Source: International Journal of Nephrology - September 17, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Denosumab for Male Hemodialysis Patients with Low Bone Mineral Density: A Case-Control Study.
Authors: Takami H, Washio K, Gotoh H Abstract Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy. However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients. We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD. Seventeen patients were treated with denosumab 60 mg every 6 months, and 20 patients were not treated with denosumab (control group). At seven days, the mean corrected calcium level decreased from 9.2 ± 0.5 mg to 8.5...
Source: International Journal of Nephrology - September 17, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Analysis of T Cell Subsets in Adult Primary/Idiopathic Minimal Change Disease: A Pilot Study.
CONCLUSIONS: In primary/idiopathic minimal change disease, a relative numerical dominance of effector over regulatory T cells can be observed in kidney tissue and peripheral blood. However, larger confirmatory studies are necessary. PMID: 28894608 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 14, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Malignancy in Membranous Nephropathy: Evaluation of Incidence.
We examined the occurrence of malignancy in 201 MN patients in Auckland, New Zealand. We also examined the pathology of renal biopsies from 17 MN patients with malignancies and compared the number of inflammatory cells per glomerulus with matched control patients with MN but no malignancy. RESULTS: 40 malignancies were identified in 37 patients, 28 of which occurred after the MN diagnosis. The standardized incidence ratio (SIR) was 2.1 (95% CI, 1.3-2.85) which was similar between patients ≥ 60 years and those
Source: International Journal of Nephrology - August 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Comparative Performance of Creatinine-Based Estimated Glomerular Filtration Rate Equations in the Malays: A Pilot Study in Tertiary Hospital in Malaysia.
CONCLUSIONS: The 4-MDRD equation seems to perform better in estimating GFR in Malay CKD patients generally and specifically in the subgroup of GFR
Source: International Journal of Nephrology - July 15, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

End-Stage Kidney Failure in Oman: An Analysis of Registry Data with an Emphasis on Congenital and Inherited Renal Diseases.
This study represents a comprehensive population-based epidemiological and etiological report of ESKD patients in Oman commencing RRT. Inherited kidney disease was the leading cause of paediatric ESKD. PMID: 28685101 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - July 9, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Gum Arabic Reduces C-Reactive Protein in Chronic Kidney Disease Patients without Affecting Urea or Indoxyl Sulfate Levels.
CONCLUSIONS: Supplementing the diet of CKD patients with 10-40 g/day of GA significantly reduced CRP level which could have a positive impact on these patients' morbidity and mortality. This trial is registered with Saudi Clinical Trial Registry number 15011402. PMID: 28589039 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 9, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

R229Q Polymorphism of NPHS2 Gene in Group of Iraqi Children with Steroid-Resistant Nephrotic Syndrome.
Conclusion. Polymorphism R229Q of NPHS2 gene is prevalent in Iraqi children with SRNS and SSNS. Further study needs to be done, for other exons and polymorphism of NPHS2 gene in those patients. PMID: 28529802 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 23, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease.
Conclusions. Urinary podocytes expressing uPAR are increased in Fabry patients, especially in untreated patients. The potential contribution of uPAR expression to podocyte detachment merits further studies. PMID: 28523190 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 20, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Febuxostat Attenuates Renal Damage besides Exerting Hypouricemic Effect in Streptozotocin-Induced Diabetic Rats.
Conclusions. Febuxostat significantly attenuated renal damage in STZ-induced diabetic rats in addition to exerting hypouricemic effect. PMID: 28503330 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 17, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Incidence and Risk Factors for Early Acute Kidney Injury in Nonsurgical Patients: A Cohort Study.
Authors: Cely JE, Mendoza EJ, Olivares CR, Sepúlveda OJ, Acosta JS, Barón RA, Diaztagle JJ Abstract Introduction. Detecting acute kidney injury (AKI) in the first days of hospitalization could prevent potentially fatal complications. However, epidemiological data are scarce, especially on nonsurgical patients. Objectives. To determine the incidence and risk factors associated with AKI within five days of hospitalization (EAKI). Methods. Prospective cohort of patients hospitalized in the Internal Medicine Department. Results. A total of 16% of 400 patients developed EAKI. The associated risk factors we...
Source: International Journal of Nephrology - May 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Function and Death in Older Women: Which eGFR Formula Should We Use?
Authors: Canales MT, Blackwell T, Ishani A, Taylor BC, Hart A, Beyth RJ, Ensrud KE Abstract Background. The Berlin Initiative Study (BIS) eGFR equations were developed specifically for aged populations, but their predictive validity compared to standard formulae is unknown in older women. Methods. In a prospective study of 1289 community-dwelling older women (mean age 79.5 years), we compared the performance of the BIS1 SCr-based equation to the CKD-EPIcr and the BIS2 SCr- and Scysc-based equation to the CKD-EPIcr,cysc to predict cardiovascular and all-cause mortality. Results. Prevalence of specific eGFR category ...
Source: International Journal of Nephrology - May 4, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Factors Predicting Renal Function Outcome after Augmentation Cystoplasty.
Authors: Mehmood S, Seyam R, Firdous S, Altaweel WM Abstract We determined the cause of renal deterioration after augmentation cystoplasty (AC). Twenty-nine adult patients with refractory bladder dysfunction and who underwent ileocystoplasty from 2004 to 2015 were studied. Patients with a decline in glomerular filtration rate (GFR) after augmentation were reviewed. The primary outcome was to determine the factors that might lead to deterioration of estimated GFR. Median follow-up was 7.0 ± 2.6 years. Significant bladder capacity, end filling pressure, and bladder compliance were achieved from median 114 &plu...
Source: International Journal of Nephrology - April 4, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Forecasting the Incidence and Prevalence of Patients with End-Stage Renal Disease in Malaysia up to the Year 2040.
Conclusion. The growth of ESRD patients on dialysis in Malaysia can be expected to continue at an alarming rate. Effective steps to address and curb further increase in new patients requiring dialysis are urgently needed, in order to mitigate the expected financial and health catastrophes associated with the projected increase of such patients. PMID: 28348890 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - March 31, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Childhood Nephrotic Syndrome Management and Outcome: A Single Center Retrospective Analysis.
We described the management, patient adherence, and inpatient and outpatient usage of 87 pediatric NS patients diagnosed between 2006 and 2012 in the Atlanta Metropolitan Statistical Area. Multivariable analyses were performed to examine the associations between patient characteristics and disease outcome. We found that 51% of the patients were treated with two or more immunosuppressants. Approximately half of the patients were noted to be nonadherent to medications and urine protein monitoring. The majority (71%) of patients were hospitalized at least once, with a median rate of 0.5 hospitalizations per patient year. Mean...
Source: International Journal of Nephrology - March 24, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Focused Real-Time Ultrasonography for Nephrologists.
Authors: Kaptein MJ, Kaptein EM Abstract We propose that renal consults are enhanced by incorporating a nephrology-focused ultrasound protocol including ultrasound evaluation of cardiac contractility, the presence or absence of pericardial effusion, inferior vena cava size and collapsibility to guide volume management, bladder volume to assess for obstruction or retention, and kidney size and structure to potentially gauge chronicity of renal disease or identify other structural abnormalities. The benefits of immediate and ongoing assessment of cardiac function and intravascular volume status (prerenal), possible u...
Source: International Journal of Nephrology - March 7, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Assessing the Association between Serum Ferritin, Transferrin Saturation, and C-Reactive Protein in Northern Territory Indigenous Australian Patients with High Serum Ferritin on Maintenance Haemodialysis.
Authors: Majoni SW, Lawton PD, Barzi F, Cass A, Hughes JT Abstract Objective. To determine the significance of high serum ferritin observed in Indigenous Australian patients on maintenance haemodialysis in the Northern Territory, we assessed the relationship between ferritin and transferrin saturation (TSAT) as measures of iron status and ferritin and C-reactive protein (CRP) as markers of inflammation. Methods. We performed a retrospective cohort analysis of data from adult patients (≥18 years) on maintenance haemodialysis (>3 months) from 2004 to 2011. Results. There were 1568 patients. The mean age was 53....
Source: International Journal of Nephrology - March 3, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Clinical Utility of Urinary β2-Microglobulin in Detection of Early Nephropathy in African Diabetes Mellitus Patients.
Clinical Utility of Urinary β2-Microglobulin in Detection of Early Nephropathy in African Diabetes Mellitus Patients. Int J Nephrol. 2017;2017:4093171 Authors: Ekrikpo UE, Effa EE, Akpan EE, Obot AS, Kadiri S Abstract Background. Studies have indicated that diabetic tubulopathy may occur earlier than glomerulopathy, therefore providing a potential avenue for earlier diagnosis of diabetic nephropathy. Urinary beta-2-microglobulin (β2m) was investigated in this study as a potential biomarker in the detection of early nephropathy in type 2 diabetics. Methods. One hundred and two diabetic subject...
Source: International Journal of Nephrology - March 3, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Apolipoprotein C-I Levels Are Associated with the Urinary Protein/Urinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study.
Authors: Odaka J, Kanai T, Ito T, Saito T, Aoyagi J, Betsui H, Yamagata T Abstract Humoral factors may cause idiopathic steroid-sensitive nephrotic syndrome (ISSNS). In the present study, we analyzed serum proteins using mass spectrometry (MS) to identify proteins associated with the pathophysiology of pediatric ISSNS. We collected serial serum samples from 33 children during each ISSNS phase; Phase A1 is the acute phase prior to steroid treatment (STx), Phase A2 represents the remission period with STx, and Phase A3 represents the remission period after completion of STx. Children with normal urinalyses (Group B) ...
Source: International Journal of Nephrology - March 3, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research