Prevalence and Management of Hypokalemia in Peritoneal Dialysis Patients in Qatar.
Authors: Hamad A, Hussain ME, Elsanousi S, Ahmed H, Navalta L, Lonappan V, Alali F Abstract Introduction: Hypokalemia is common in patients undergoing peritoneal dialysis (PD). It is associated with increased cardiovascular and all-cause mortality. Treatment usually includes oral potassium supplements, which are poorly tolerated. Our aim was to evaluate the prevalence of hypokalemia in PD patients in Qatar and to improve treatment measures. Methods: All PD patients in Qatar with persistent hypokalemia and on potassium supplement were included. We performed a root cause analysis, and a management pathway was cre...
Source: International Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country.
Authors: Duran CE, Ramírez A, Posada JG, Schweineberg J, Mesa L, Pachajoa H, Estacio M, Manzi E, Aros V, Díaz L, Garcia VH Abstract Introduction: In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans. Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant. We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombi...
Source: International Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Association between High-Sensitivity C-Reactive Protein and Blood Pressure among Children with History of Low Birth Weight Appropriate for Gestational Age, Low Birth Weight Small for Gestational Age, and Normal Birth Weight in Manado, North Sulawesi.
This study aimed to investigate the association between high-sensitivity C-reactive protein (hs-CRP) and blood pressure (BP) in children with a history of LBW appropriate for gestational age (LBW AGA), LBW small for gestational age (LBW SGA), and normal birth weight appropriate for gestational age (NBW AGA). The study cohort comprised children aged 9-12 years who were born in 2007-2010 at Prof. Dr. R. D. Kandou General Hospital Manado and resided in the city of Manado from March to August 2019. The children who met the inclusion criteria were evaluated for BP and hs-CRP level. A total of 120 children who met the inclusion ...
Source: International Journal of Nephrology - January 11, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Etiology of Renal Replacement Therapy in Iran.
Authors: Morovatdar N, Tayebi Nasrabad G, Tsarouhas K, Rezaee R Abstract Introduction: End-stage renal disease (ESRD) is one of the most common life-threatening diseases. In the past two decades, several factors were held responsible as the cause of this condition. The present study aimed to determine the causes of ESRD in the province of Khorasan Razavi, Iran. Materials and Methods: This cross-sectional study was conducted on 2404 ESRD patients who referred to 39 hemodialysis centers in Khorasan Razavi province, Iran, and were registered in the Mashhad University of Medical Sciences (MUMS), between 2000 and De...
Source: International Journal of Nephrology - January 1, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Risk Behaviors in Teens with Chronic Kidney Disease: A Study from the Midwest Pediatric Nephrology Consortium.
Authors: Xiao N, Stolfi A, Malatesta-Muncher R, Bholah R, Kogon A, Eddington A, Chand D, Greenbaum LA, Hanevold C, Tran CL, Chishti A, Davis K, Matloff R, Woroniecki R, Klosterman C, Luckritz K, Omoloja A Abstract Introduction: There is a paucity of information about risk behaviors in adolescents with chronic kidney disease (CKD). We designed this study to assess the prevalence of risk behaviors among teens with CKD in the United States and to investigate any associations between risk behavior and patient or disease characteristics. Methods: After informed consent, adolescents with CKD completed an anonymous, c...
Source: International Journal of Nephrology - January 1, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Serum Sulphate Levels in Hemodialysis Patients.
This study was designed to determine the level of sulphate in hemodialysis patients. Materials and Methods: Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded. Results: Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM, p
Source: International Journal of Nephrology - December 26, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis.
Authors: Sung SA, Kim DH, Oh KH, Han SY, Han KH Abstract Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer. Cathepsin B is a lysosomal cysteine protease that degrades ECM, but its role in the PF remains unclear. Thus, we investigated the role of cathepsin B in PF. Procathepsin B was measured in the 73 PD effluents of 68 patients. Procathepsin B and cathepsin B after exposure of glucose and the effects of cathepsin B on the expression of matrix metalloproteinases (MMPs), tissue inhibitor of meta...
Source: International Journal of Nephrology - December 10, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Authors: Tojo A Abstract As water and solutes are filtered through the slit membrane, it is an a priori concept that a slit membrane is an essential filtration barrier for proteins, including albumin. However, in cases of minimal change nephrotic syndrome, the number of slit membranes is reduced by the foot process effacement and tight junction-like cell adhesion. Furthermore, albumin endocytosis is enhanced in the podocytes under condition of minimal change disease, and albumin is selectively transported by the albumin receptor FcRn. Suppressing the endocytosis of albumin with anti-FcRn antibody decreases the urin...
Source: International Journal of Nephrology - November 30, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Drug-Related Problems and Associated Factors among Patients Admitted with Chronic Kidney Disease at Jimma University Medical Center, Jimma Zone, Jimma, Southwest Ethiopia: A Hospital-Based Prospective Observational Study.
Authors: Garedow AW, Mulisa Bobasa E, Desalegn Wolide A, Kerga Dibaba F, Gashe Fufa F, Idilu Tufa B, Debalke S, Kumela Goro K Abstract Background: There is an alarming rise of chronic kidney disease prevalence globally associated with significant morbidity and mortality necessitating special attention as one of the major growing public health problems. Medication-related problems are common in hospitalized patients including chronic kidney disease and may lead to increase hospital stay and health care cost and augment the risk of morbidity and mortality. Objective: To determine prevalence of medication-related ...
Source: International Journal of Nephrology - November 29, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

High Incidence of Moderately Reduced Renal Function and Lead Bioaccumulation in Agricultural Workers in Assin South District, Ghana: A Community-Based Case-Control Study.
Conclusion: Neglect of the use of PPE may be predisposing the agrochemical workers and community to lead and arsenic bioaccumulation with a consequent reduced haematological and renal function. PMID: 31662908 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 31, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Parathyroid Hormone Measurement in Chronic Kidney Disease: From Basics to Clinical Implications.
Authors: Kritmetapak K, Pongchaiyakul C Abstract Accurate measurement of parathyroid hormone (PTH) is crucial for therapeutic decision-making in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). The second-generation PTH assays, often referred to as "intact PTH" assays, are the current standard and most available assays in clinical practice. However, intact PTH assays measure both full-length biologically active PTH and heterogeneous PTH fragments in the circulation, providing the equivocal value of PTH measurement in patients with CKD-MBD. Due to the variability of PTH assays, pre...
Source: International Journal of Nephrology - October 24, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients.
Conclusion: CKD is often silent until symptomatic uremia during the advanced stages of the disease. The newly identified haplotype will help recognize patients at risk for a rapid progression of CKD to ESRD. Accurate detection and mapping of the genetic variants facilitates improved risk stratification and development of improved and targeted therapeutic management for CKD. PMID: 31534799 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 21, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Comparison of Chronic Hemodialysis Patients under Strict Volume Control with respect to Cardiovascular Disease.
This study is an observational and cross-sectional study including 62 patients with normotensive chronic hemodialysis using no antihypertensive drugs. A series of measurements including ambulatory blood pressure monitoring, left ventricular mass index by echocardiography, common carotid artery intima-media thickness by ultrasound, and body fluids by bioimpedance analysis were conducted for all subjects. Results: The patients were divided into two groups as dippers and nondippers according to their ambulatory blood pressure monitoring results. Average 48 h systolic, diastolic, and mean arterial blood pressure and noctur...
Source: International Journal of Nephrology - July 31, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Variation in Assessing Renal Allograft Rejection: A National Assessment of Nephrology Practice.
Conclusion: Clinical care in the posttransplant setting is highly variable. Biopsies are often ordered in cases where their results do not alter treatment. Additionally, we found that misdiagnosis was common as were opportunities for earlier biopsy and detection of rejection. This evidence suggests that better diagnostic tools may be helpful to determine which transplant patients should be biopsied and which should not. This study suggests that nephrologists and transplant patients need better tests than creatinine and proteinuria and less invasive approaches than routine biopsies to determine when transplant patients shou...
Source: International Journal of Nephrology - June 21, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence and Predictors of Chronic Kidney Disease in a Semiurban Community in Lagos.
Conclusion: The prevalence of CKD in the population is low compared with other studies from other parts of the country, and the predictors included age, hypertension, hyperuricemia, and female gender. This is the first community-based study in Nigeria to identify hyperuricemia as a risk factor for chronic kidney disease in the country. PMID: 31186960 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 14, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Psychosocial Mediators between Socioeconomic Status and Dietary Restrictions among Patients Receiving Hemodialysis in Japan.
This study was a cross-sectional survey of 6,644 outpatients (average age = 66.5 years; 65% males) of hemodialysis facilities across Japan. DRs were assessed by self-reported and objective measures, and SES was assessed based on education and income. Three psychosocial mediators were used: self-efficacy, control expectancy, and social support. Indirect influences of SES through the mediators were evaluated with a multiple mediator model. Although higher education was significantly associated with higher self-reported DRs, higher income was significantly associated with lower self-reported DRs. Significant SES differences i...
Source: International Journal of Nephrology - May 30, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease.
We examined the association of urinary uromodulin concentrations with CKD and with SNP rs1333226 in the UMOD gene. The study included 71 black South Africans with hypertension-attributed CKD with an eGFR ≤ 60ml/min/1.73m2, 52 first-degree relatives, and 58 unrelated controls. Urinary uromodulin concentration was measured using Luminex® multiplex kits. After DNA extraction from blood using the Maxwell® automated platform, genotyping of rs13333226 was performed using real-time PCR using TaqMan® genotyping assays. Urinary uromodulin levels were significantly lower in CKD cases compared to both controls and firs...
Source: International Journal of Nephrology - May 10, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Regulation of (Pro)Renin Receptor in Renin-Positive Smooth Muscle Cells of Kidney Arterioles in Rats with STZ-Induced Diabetes.
Conclusion. The distribution of (pro)renin receptors in afferent arteriolar SMCs is related to renin granulation of SMCs, but independent of angiotensin II plasma or tissue levels in the kidney. PMID: 31049226 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 5, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.
In this study, 27 patients developed acute kidney injury. The three hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group (P
Source: International Journal of Nephrology - April 19, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Retracted: Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.
Authors: International Journal Of Nephrology Abstract [This retracts the article DOI: 10.1155/2018/2903139.]. PMID: 30867964 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - March 16, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients.
Conclusion: The renal dysfunction (defined as decline in eGFR greater than 25%) was found in a quarter of the study population. The long term impact and the clinical implication of it are not clear. Future prospective study is required with large sample size and long duration to ascertain the prevalence of decline greater than 25% in estimated glomerular filtration rate and its progression to chronic kidney disease. PMID: 30863641 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - March 14, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Recovery following Liposomal Amphotericin B-Induced Nephrotoxicity.
Authors: Personett HA, Kayhart BM, Barreto EF, Tosh P, Dierkhising R, Mara K, Leung N Abstract Background: Acute kidney injury (AKI) is a common complication of treatment with liposomal amphotericin B (LAmB). The trajectory of renal recovery after LAmB-associated AKI has not been well described, nor has effect of LAmB dose on recovery of renal function been explored. Objective: Characterize the pattern of renal recovery after incident AKI during LAmB and determine potential influencing factors. Methods: This retrospective cohort study analyzed patients who developed a ≥50% increase in serum creatinine wh...
Source: International Journal of Nephrology - February 28, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.
Conclusion. Insulin and ACEIs based regimens were the most frequently used regimens in the treatment of diabetes mellitus and hypertension comorbidities. Very low income, increased number of prescribed medications, and being a farmer were the predictors of medication nonadherence. PMID: 30805215 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 27, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Functional and Respiratory Capacity of Patients with Chronic Kidney Disease Undergoing Cycle Ergometer Training during Hemodialysis Sessions: A Randomized Clinical Trial.
Conclusion: The systematic training regimen with a cycle ergometer resulted in benefits in the respiratory function and functional capacity in patients with chronic kidney disease undergoing hemodialysis. PMID: 30805216 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 27, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Acid-Base Status Disturbances in Patients on Chronic Hemodialysis at High Altitudes.
Authors: Cely JE, Rocha OG, Vargas MJ, Sanabria RM, Corzo L, D'Achiardi RE, Zúñiga EA Abstract Background: Acid-base disorders have been previously described in patients with chronic hemodialysis, with metabolic acidosis being the most important of them; however, little is known about the potential changes in acid-base status of patients on dialysis living at high altitudes. Methods: Cross-sectional study including 93 patients receiving chronic hemodialysis on alternate days and living in Bogotá, Colombia, at an elevation of 2,640 meters (8,661 feet) over sea level (m.o.s.l.). Measurements ...
Source: International Journal of Nephrology - December 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus.
Authors: Gómez-Sámano MÁ, Almeda-Valdes P, Cuevas-Ramos D, Navarro-Flores MF, Espinosa-Salazar HD, Martínez-Saavedra M, León-Domínguez JA, Enríquez-Estrada VM, López-González AL, Sarmiento-Moreno AL, Rivera-González LA, Juárez-León ÓA, Pérez-González B, Ávila-Palacios Y, Sigala-Pedroza L, Huerta-Ávila E, Vargas-Álvarez MA, Sánchez-Jaimes C, Cárdenas-Vera M, Mehta R, López-Flores A La Torre MA, Manjarrez-Martínez I, Brito-Córdova GX, Zuarth-Vázquez JM, Vega-B...
Source: International Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.
We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse. Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14.9-17.7)] follow-up were retrospectively collected. Results: Overall, 55% of the patients had microscopic polyangiitis (MPA) and 45% had granulomatosis with polyangiitis (GPA). The histopathological classes were focal in 35%, crescentic in 26%, mixed in 20%, and sclerotic glomerulonephritis in 19% of the patients. As induction treatment, a ...
Source: International Journal of Nephrology - November 10, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center.
Authors: Farah RI Abstract Aim: To determine the prevalence and frequency of different pathological patterns of glomerulonephritis (GN) in adolescent (age ≥ 11 years) and adult Jordanian patients. Materials and Methods: A retrospective analysis of all clinical and pathological reports of Jordanian patients who had native renal biopsies at the University of Jordan hospital between January 2007 and March 2018 to assess the prevalence and pathological pattern of GN. The data were analyzed statistically using descriptive statistics, the chi-squared test, and Fisher's exact tests. The level of significance was set at P
Source: International Journal of Nephrology - November 9, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Cost-Effectiveness Analysis for the Treatment of Hyperphosphatemia in Predialysis Patients: Calcium-Based versus Noncalcium-Based Phosphate Binders.
Conclusions: Our study finds that sevelamer is potentially cost-effective compared to CaCO3, for the treatment of hyperphosphatemia in predialysis CKD III-V. We propose that sevelamer should be an option in the treatment of Malaysian predialysis patients with hyperphosphatemia, particularly those with high calcium load. PMID: 30327732 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 19, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Dysfunction and Recovery following Initial Treatment of Newly Diagnosed Multiple Myeloma.
Authors: Derman BA, Reiser J, Basu S, Paner A Abstract Introduction: Renal insufficiency (RI) in Multiple Myeloma (MM) portends a higher tumor burden and worse prognosis. Reversal of RI in newly diagnosed MM (NDMM) improves patient outcomes, but it is unknown if there is a disparity in renal recovery in NDMM between African Americans (AA) and non-African Americans. Methods: A retrospective chart review was conducted of 690 patients with NDMM at Rush University Medical Center from 2005 to 2016. 118 patients (59 AA and 59 non-AA) with NDMM and an estimated glomerular filtration rate (eGFR)
Source: International Journal of Nephrology - September 27, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Urinary Phosphate to Serum Fibroblast Growth Factor 23 Ratio, Deemed the Nephron Index, Is a Useful Clinical Index for Early Stage Chronic Kidney Disease in Patients with Type 2 Diabetes: An Observational Pilot Study.
We examined changes in the nephron index in type 2 diabetes patients with early stage chronic kidney disease (stages 1-3), enrolling 15 patients and retrospectively analysing the follow-up data. After follow-up at 5.4 years, we observed no significant changes in the estimated glomerular filtration rate; the nephron index, however, was significantly reduced between the baseline and the follow-up. We propose that the nephron index may be potentially useful as a biomarker for monitoring the decline of renal function in the early stages of diabetic chronic kidney disease patients. PMID: 30245879 [PubMed] (Source: Internati...
Source: International Journal of Nephrology - September 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Phosphate, Calcification in Blood, and Mineral Stress: The Physiologic Blood Mineral Buffering System and Its Association with Cardiovascular Risk.
Authors: Pasch A, Jahnen-Dechent W, Smith ER Abstract Phosphate is an important cardiovascular risk factor and lowering elevated blood phosphate concentrations is a main therapeutic target in kidney patients. Phosphate is subject to the blood mineral buffering system which controls the precipitation of calcium and phosphate. Calciprotein particles (CPP), self-assembling complexes of calcium phosphate and serum proteins, are the nanomorphological correlates of this system. CPP1 are spherical, 50-100 nm in diameter, and contain amorphous mineral. CPP2 are oblongated, 100-200nm in the long axis, and they contain a cry...
Source: International Journal of Nephrology - September 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Mortality and Recovery of Renal Function in Acute Kidney Injury Patients Treated with Prolonged Intermittent Hemodialysis Sessions Lasting 10 versus 6 Hours: Results of a Randomized Clinical Trial.
Conclusion: There was no difference in the mortality and recovery of renal function of AKI patients submitted to different durations of PHD and sessions lasting 10 h presented higher filter clotting, hypophosphatemia, and treatment discontinuation. ISRCTN Registry number is ISRCTN33774458. PMID: 30186631 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Vascular Calcification in Chronic Kidney Disease: The Role of Inflammation.
Authors: Benz K, Hilgers KF, Daniel C, Amann K Abstract Cardiovascular complications are extremely frequent in patients with chronic kidney disease (CKD) and death from cardiac causes is the most common cause of death in this particular population. Cardiovascular disease is approximately 3 times more frequent in patients with CKD than in other known cardiovascular risk groups and cardiovascular mortality is approximately 10-fold more frequent in patients on dialysis compared to the age- and sex-matched segments of the nonrenal population. Among other structural and functional factors advanced calcification of ather...
Source: International Journal of Nephrology - September 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Outcomes in Children with Operated Spina Bifida in Uganda.
Conclusions: Incontinence, ultrasound abnormalities, and hypertension are highly prevalent in a cohort of Ugandan children with spina bifida, including those with low neurological lesions. These findings support the early and universal initiation of CIC with anticholinergic therapy in a low-income setting. PMID: 30174953 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 4, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Pediatric Nephrology and Rheumatology Practice Patterns in Granulomatosis with Polyangiitis: A Midwest Pediatric Nephrology Consortium Study.
Conclusion: This survey has revealed important differences in the way that rheumatologists and nephrologists manage this disease. It highlights the need for well-designed clinical trials in pediatric GPA patients and reveals that both specialties must be represented during consensus-building and clinical trial design efforts. PMID: 30155302 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 31, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Clinical Presentation, Outcomes, and Treatment of Membranous Nephropathy after Transplantation.
Authors: da Silva AQB, de Sandes-Freitas TV, Mansur JB, Medicina-Pestana JO, Mastroianni-Kirsztajn G Abstract There are scarce data about clinical presentation and outcomes of posttransplant membranous nephropathy (MN), and few reports include a large number of patients. This was a retrospective cohort including adult patients with posttransplant MN transplanted between 1983 and 2015 in a single center (n=41). Only patients with histological diagnosis of MN in kidney grafts were included. Clinical and laboratory presentation, histological findings, treatment, and outcomes were detailed. Patients were predominantly ...
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Projecting the Burden of Chronic Kidney Disease in a Developed Country and Its Implications on Public Health.
Conclusion: By 2035, about one-quarter of the Singapore residents are expected to have CKD. National policies need to focus on primary disease prevention and early disease detection to avoid delayed treatment of CKD which eventually leads to end-stage renal disease. PMID: 30112209 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Factors Affecting Survival in Geriatric Hemodialysis Patients.
Conclusion: The present study revealed that comorbidities and low performance status at the onset of dialysis had shortened the survival time in the geriatric hemodialysis patient group. PMID: 30112210 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 18, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Characterization and Etiopathogenic Approach of Pediatric Renal Biopsy Patients in a Colombian Medical Center from 2007-2017.
Conclusion: Immune complex glomerulonephritis was the most frequent histological finding, differing from previous reports. To our knowledge this is the first description that classifies biopsy findings according to the probable pathogenic mechanism. PMID: 30050696 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - July 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Microalbuminuria and Retinopathy among Hypertensive Nondiabetic Patients at a Large Public Outpatient Clinic in Southwestern Uganda.
Conclusion: The prevalence of retinopathy and microalbuminuria is high. Clinicians should aim for better control of blood pressure and routinely perform fundoscopy and urine albumin, especially for patients with poorly controlled blood pressure. PMID: 29977618 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - July 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Transforming Growth Factor- β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients.
Transforming Growth Factor-β Protects against Inflammation-Related Atherosclerosis in South African CKD Patients. Int J Nephrol. 2018;2018:8702372 Authors: Hassan MO, Duarte R, Dix-Peek T, Dickens C, Naidoo S, Vachiat A, Grinter S, Manga P, Naicker S Abstract Background: Transforming growth factor-β (TGF-β) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF-β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atheros...
Source: International Journal of Nephrology - July 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Molecular Mechanisms Underlying Accelerated Aging by Defects in the FGF23-Klotho System.
Authors: Kuro-O M Abstract The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society. It has become increasingly important to investigate mechanisms of aging ...
Source: International Journal of Nephrology - June 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Association of Poor Social Support and Financial Insecurity with Psychological Distress of Chronic Kidney Disease Patients Attending National Nephrology Unit in Sri Lanka.
Conclusions: More than half of the CKD patients were psychologically distressed. Factors such as financial and social support will be worth considering early because of their modifiability. PMID: 29888004 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 12, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Estimating Renal Function in the Elderly Malaysian Patients Attending Medical Outpatient Clinic: A Comparison between Creatinine Based and Cystatin-C Based Equations.
Conclusion: The CKD-EPIcr formula appears to be more accurate and correlates better with measured GFR in this cohort of elderly patients. PMID: 29862077 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 5, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Phosphate and Cardiovascular Disease beyond Chronic Kidney Disease and Vascular Calcification.
Authors: Disthabanchong S Abstract Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal disease, widespread vascular calcification occurs as a result of chronic phosphate load. The accumulation of phosphate is likely to occur long before the rise in serum phosphate above the normal range since several observational studies in both general population and early-stage CKD patients have identified the relationship between high-normal serum phosphate and adverse cardiovascular outcomes. Consumption of food high in phosphate increases both fasting and postprandial serum phosphate an...
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Contrast-Induced Nephropathy: Update on the Use of Crystalloids and Pharmacological Measures.
Authors: Patschan D, Buschmann I, Ritter O Abstract Contrast-induced nephropathy (CIN) is a frequent and severe complication in subjects receiving iodinated contrast media for diagnostic or therapeutic purposes. Several preventive strategies were evaluated in the past. Recent clinical studies and meta-analyses delivered some new aspects on preventive measures used in the past and present. We will discuss all pharmacological and nonpharmacological procedures. Finally, we will suggest individualized recommendations for CIN prevention. PMID: 29854458 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Undiagnosed Kidney Injury in Uninsured and Underinsured Diabetic African American Men and Putative Role of Meprin Metalloproteases in Diabetic Nephropathy.
Authors: Cao L, Sedighi R, Boston A, Premadasa L, Pinder J, Crawford GE, Jegede OE, Harrison SH, Newman RH, Ongeri EM Abstract Diabetes is the leading cause of chronic kidney disease. African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD). Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied. The current study used multiple biomarkers of DKD to evaluate undiagnosed DKD in uninsured and underinsured African American men in Greensboro, North Carolina. Participants consisted of thre...
Source: International Journal of Nephrology - June 2, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Murine Nephrotoxic Nephritis as a Model of Chronic Kidney Disease.
Authors: Ougaard MKE, Kvist PH, Jensen HE, Hess C, Rune I, Søndergaard H Abstract Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD p...
Source: International Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

A Web-Based Platform to Collect Data from ESRD Patients Undergoing Dialysis: Methods and Preliminary Results from the Brazilian Dialysis Registry.
Conclusion: The initiative represents an innovative strategy to collect clinical and epidemiologic data of dialysis patients which may be applied to other settings and provides information that can contribute to guiding clinical practice and health care policy. PMID: 29692934 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - April 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research