Hemodialysis Adequacy and Its Impact on Long-Term Patient Survival in Demographically, Socially, and Culturally Homogeneous Patients.
Conclusions: Undocumented, uninsured, inadequately hemodialyzed, Afghan patients had a significantly lower one-, two-, and three-year survival as opposed to their Iranian counterparts, probably due to lack of insurance. PMID: 32922996 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 16, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

MicroRNA-451 as an Early Predictor of Chronic Kidney Disease in Diabetic Nephropathy.
Conclusion: MicroRNA-451 is a promising early biomarker for chronic kidney disease in diabetic nephropathy with high sensitivity and specificity. PMID: 32855824 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - August 30, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Tubular Cells from Hibernating Squirrels are Protected against Cisplatin Induced Apoptosis.
Authors: Jain S, Jani A Abstract Hibernating 13-lined ground squirrels are characterized by tolerance of severe hypothermia and hypoperfusion during torpor, followed by periodic warm reperfusion during IBA, conditions which are lethal to nonhibernating mammals. The aim of the present study was to determine whether protection from apoptosis was specific to torpor arousal cycles during hibernation or will also apply to cisplatin treatment on squirrel renal tubular cells (RTECs) that were procured during hibernation. Squirrel and mouse RTECs were treated with cisplatin, a potent inducer of RTEC apoptosis. Squirrel RTE...
Source: International Journal of Nephrology - August 26, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

No Race-Ethnicity Adjustment in CKD-EPI Equations Is Required for Estimating Glomerular Filtration Rate in the Brazilian Population.
Authors: Rocha AD, Garcia S, Santos AB, Eduardo JCC, Mesquita CT, Lugon JR, Strogoff-de-Matos JP Abstract Background: Glomerular filtration rate (GFR) is usually estimated from equations using serum creatinine (sCr), with adjustment for gender, age, and race (black or nonblack). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) is the preferred equation for adults, but it was validated for the United States population. We intended to evaluate if the race-ethnicity adjustment proposed for the sCr-based CKD-EPI equations is appropriate for the Brazilian population. Methods: CKD outpatients had blood...
Source: International Journal of Nephrology - August 2, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Impact of CKD Anaemia on Patients: Incidence, Risk Factors, and Clinical Outcomes-A Systematic Literature Review.
Authors: Palaka E, Grandy S, van Haalen H, McEwan P, Darlington O Abstract Anaemia is a common consequence of chronic kidney disease (CKD); however, the risk factors for its development and its impact on outcomes have not been well synthesised. Therefore, we undertook a systematic review to fully characterise the risk factors associated with the presence of anaemia in patients with CKD and a contemporary synthesis of the risks of adverse outcomes in patients with CKD and anaemia. We searched MEDLINE, EMBASE, and the Cochrane Library from 2002 until 2018 for studies reporting the incidence or prevalence of anaemia a...
Source: International Journal of Nephrology - July 17, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

ACTH Treatment for Management of Nephrotic Syndrome: A Systematic Review and Reappraisal.
Conclusion: ACTH showed benefits in proteinuria reduction across all etiologies of NS. However, more randomized controlled studies with larger population sets and longer follow-ups are imperative to establish causal benefits. New studies into its efficacy in children are also necessary. PMID: 32566293 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 24, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Low-Dose Maintenance Intravenous Iron Therapy Can Prevent Anemia in Children with End-Stage Renal Disease Undergoing Chronic Hemodialysis.
This study evaluated the effect of IV iron maintenance therapy on anemia in children on regular hemodialysis. This retrospective cohort study included 41 pediatric ESRD patients with normal hemoglobin and iron status who underwent regular hemodialysis at the Pediatric Dialysis Unit of Cipto Mangunkusumo Hospital, Indonesia, between January 2015 and April 2019. Among these, 21 received IV iron maintenance therapy with two doses of 2 mg/kg of IV iron sucrose every 2 weeks (the treatment group) and 20 did not (the comparison group). Changes in hemoglobin and transferrin saturation were assessed after 6 weeks of observa...
Source: International Journal of Nephrology - June 24, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

A Simple Tenckhoff Catheter Placement Technique for Continuous Ambulatory Peritoneal Dialysis (CAPD) Using the Bandung Method.
Authors: Jonny, Supriyadi R, Roesli R, Bak Leong G, Hilman LP, Arini FC Abstract Insertion of Tenckhoff catheters for continuous ambulatory peritoneal dialysis by nephrologists remains uncommon in most developing countries, including Indonesia. The aim of this study is to describe our experience on a simple technique of Tenckhoff catheter insertion by a nephrologist called the Bandung method. We conducted a retrospective observational study from May 2012 until December 2018 in 230 patients with end-stage renal disease using the Bandung method, a blind percutaneous insertion approach modified from the Seldinger tech...
Source: International Journal of Nephrology - June 24, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Protective Effects and Mechanisms of Rosuvastatin on Acute Kidney Injury Induced by Contrast Media in Rats.
Authors: Jiang Z, Zhang J, Lu Y Abstract Objective: To explore the protective effect and mechanism of rosuvastatin on acute renal injury induced by a nonionic hypotonic contrast medium in rats. Methods: Forty-eight healthy adult SD rats were randomly divided into three groups: normal control group (NC); contrast medium control group (CM); and rosuvastatin intervention group (RI). The RI group was intragastrically administered with a 10 mg/kg of rosuvastatin 12 h prior to the contrast exposure. All rats in CM and RI groups were inoculated with 10 mL/kg of chemical (IV) while the same volume ...
Source: International Journal of Nephrology - June 10, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence of Hypothyroidism among Dialysis Patients in Palestine: A Cross-Sectional Study.
This study aims to assess the prevalence of thyroid disease (hypo- and hyperthyroidism) among dialysis patients and their associated factors. Methods: This cross-sectional study was conducted in the dialysis unit of An-Najah National University Hospital. 209 dialysis patients (60% were male, 57.6 ± 14.5 years, mean age) meeting our inclusion criteria were tested for thyrotropin (TSH) and free thyroxine (FT4) in addition to routine laboratory tests. Findings. The prevalence of hypothyroidism was assessed as 16.3% (95% CI = 11.29% to 21.3%), overt hypothyroidism was 9.1%, and subclinica...
Source: International Journal of Nephrology - May 28, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Autophagy and mTOR Pathways Mediate the Potential Renoprotective Effects of Vitamin D on Diabetic Nephropathy.
Authors: Khodir SA, Samaka RM, Ameen O Abstract Introduction: Not only is diabetic nephropathy (DN) the most common cause of end-stage renal disease worldwide, but it also increases the risk of mortality up to fourteen times compared to normoalbuminuric diabetic patients. Aim: The aim of the current study was the evaluation of the renoprotective effects of vitamin D in DN and the possible interplay between autophagy and mTOR pathways. Materials and Methods: Fifty male Wistar albino rats were divided (10/group) into control, DN group, insulin-treated DN group, vitamin D-treated DN group, and combined insulin...
Source: International Journal of Nephrology - May 28, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Clinical and Economical Outcomes Associated with Parathyroidectomy: A 5-Year Population-Based Study in a Middle-Income Country with Universal Health Coverage.
Conclusions. There are large regional differences in readmission, ICU admission and mortality rates, and costs of dialysis ESRD patients undergoing PTX belonging to the Colombian contributory regime. The geographic region behaves as an independent predictor of clinical outcomes and costs. PMID: 32411463 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 16, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy.
In this study, we investigated a panel of novel biomarkers in the early diagnosis of CIN and in assessing patient outcomes. Methods: This single-centre, nested, prospective case-controlled study included 30 patients with CIN and 60 matched controls. Serum and urine samples were collected before contrast administration and at 24 hours, 48 hours, and ≥5 days after contrast administration. Concentrations of NGAL, cystatin C, β 2M, IL18, IL10, KIM1, and TNFα were determined using Luminex and ELISA assays. Outcomes were biomarker diagnostic discrimination performance for CIN and mortality after generati...
Source: International Journal of Nephrology - May 16, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Gum Arabic (Acacia Senegal) Augmented Total Antioxidant Capacity and Reduced C-Reactive Protein among Haemodialysis Patients in Phase II Trial.
Authors: Ali NE, Kaddam LA, Alkarib SY, Kaballo BG, Khalid SA, Higawee A, AbdElhabib A, AlaaAldeen A, Phillips AO, Saeed AM Abstract Background: Oxidative processes might increase in patients with end-stage renal disease (ESRD) according to the current literature. Oxidative stress (OS) is a risk factor of atherosclerosis and cardiovascular complications, which are major causes of mortality among ESRD patients. Haemodialysis (HD) is life-saving procedure, nevertheless it is an active chronic inflammatory status that could augment cardiovascular disease and increase mortality. Gum Arabic (GA) has been claimed to act ...
Source: International Journal of Nephrology - April 25, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Spectrum and Clinical Characteristics of Renal Diseases in Ghanaian Adults: A 13-Year Retrospective Study.
Conclusion: This study revealed that patients at the nephrology unit of KATH, Ghana, are mainly adults between ages 46-55. The clinical pattern of renal diseases is dominated by CKD and ESRD. We conclude that hypertension, chronic glomerulonephritis, diabetic nephropathy, and sepsis are the most common causes of renal diseases. The commonest clinical presentations are bilateral leg edema, palpitations, headache, breathlessness, dizziness, and vomiting. Early diagnosis and management of these conditions may prevent or delay the progress to end-stage renal disease. PMID: 32328308 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - April 25, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

N-terminal Pro-B-Type Natriuretic Peptide and Malnutrition in Patients on Hemodialysis.
Authors: Ducros J, Larifla L, Merault H, Galantine V, Bassien-Capsa V, Foucan L Abstract Natriuretic peptides, brain natriuretic peptide (BNP), and N-terminal probrain natriuretic peptide (NT-proBNP) are mainly known as diagnostic markers for heart failure with high diagnostic and prognostic values in the general population. In patients who are undergoing hemodialysis (HD), changes in NT-proBNP can be related to noncardiac problems such as fluid overload, inflammation, or malnutrition and can also be influenced by the dialysis characteristics. The current review aimed to summarize findings from studies on the assoc...
Source: International Journal of Nephrology - March 26, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

PPAR γ and Its Agonists in Chronic Kidney Disease.
PPARγ and Its Agonists in Chronic Kidney Disease. Int J Nephrol. 2020;2020:2917474 Authors: Ma Y, Shi M, Wang Y, Liu J Abstract Chronic kidney disease (CKD) has become a global healthcare issue. CKD can progress to irreversible end-stage renal diseases (ESRD) or renal failure. The major risk factors for CKD include obesity, diabetes, and cardiovascular diseases. Understanding the key process involved in the disease development may lead to novel interventive strategies, which is currently lagging behind. Peroxisome proliferator-activated receptor γ (PPARγ) is one of the ligand-activate...
Source: International Journal of Nephrology - March 13, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Volume in ADPKD Patient Evaluation.
Authors: Galliani M, Vitaliano E, Chicca S, Calvaruso L, Di Lullo L, Iorio F, Tosti ME, Paone A Abstract The clinical manifestations of ADPKD are related to the growth of renal cysts. Renal volume has been recognised as the biomarker that is able to identify those patients at risk of complications (hypertension and haematuria) and at risk of progression to End Stage Renal Disease (ESRD). Recently, several scores have been introduced to predict the evolution of ADPKD. The Mayo Clinic Group developed a classification based on renal volume as measured by CT or MRI and corrected for age and height (Ht-TKV); this allowe...
Source: International Journal of Nephrology - March 13, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Clinical, Paraclinical, and Evolutionary Profiles of Kidney Failure in Gold Miners Hospitalized in a Nephrological Service in a Sub-Saharan African Country.
Conclusion: Chronic kidney failure in gold miners appears to be common and late-managed. A prospective study of kidney disease and its causes at gold mining sites and surrounding areas will assess the extent of the problem in the country and better clarify the prevention of these diseases in our country. PMID: 32110450 [PubMed - as supplied by publisher] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 29, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Serum Sclerostin, Body Composition, and Sarcopenia in Hemodialysis Patients with Diabetes.
Authors: Medeiros MC, Rocha N, Bandeira E, Dantas I, Chaves C, Oliveira M, Bandeira F Abstract Sclerostin (Scl) is an osteoblast-inhibiting glycoprotein that is secreted mainly by osteocytes and is regulated by hormonal changes and skeletal loading. Decreased physical function and high serum Scl concentrations have been reported in chronic renal failure patients but little is known to date about the differences between diabetic and non-diabetic patients on hemodialysis who are susceptible to both sarcopenia and bone fragility. Objective.To determine the prevalence of sarcopenia and its association with serum Scl co...
Source: International Journal of Nephrology - February 27, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Adequacy of Hemodialysis and Its Associated Factors among Patients Undergoing Chronic Hemodialysis in Dar es Salaam, Tanzania.
Authors: Somji SS, Ruggajo P, Moledina S Abstract The worldwide prevalence of maintenance hemodialysis continues to rise. An adequate delivery of hemodialysis dose as measured by Kt/V or urea reduction ratio is a crucial determinant of clinical outcome for chronic hemodialysis patients. The aim of this study was to assess the adequacy of hemodialysis and its associated factors among patients undergoing chronic hemodialysis in Dar es Salaam. This was a cross-sectional study done on patients undergoing chronic hemodialysis in four dialysis centers in Dar es Salaam. Sociodemographic information and treatment character...
Source: International Journal of Nephrology - February 27, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence and Management of Hypokalemia in Peritoneal Dialysis Patients in Qatar.
Authors: Hamad A, Hussain ME, Elsanousi S, Ahmed H, Navalta L, Lonappan V, Alali F Abstract Introduction: Hypokalemia is common in patients undergoing peritoneal dialysis (PD). It is associated with increased cardiovascular and all-cause mortality. Treatment usually includes oral potassium supplements, which are poorly tolerated. Our aim was to evaluate the prevalence of hypokalemia in PD patients in Qatar and to improve treatment measures. Methods: All PD patients in Qatar with persistent hypokalemia and on potassium supplement were included. We performed a root cause analysis, and a management pathway was cre...
Source: International Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence of APOL1 Risk Variants in Afro-Descendant Patients with Chronic Kidney Disease in a Latin American Country.
Authors: Duran CE, Ramírez A, Posada JG, Schweineberg J, Mesa L, Pachajoa H, Estacio M, Manzi E, Aros V, Díaz L, Garcia VH Abstract Introduction: In Colombia, the genetic background of the populations was shaped by different levels of admixture between Natives, European, and Africans. Approximately 35.363 patients have diagnosed chronic kidney disease and according to population studies, 10.4% of these patients are Afro-descendant. We aim to assess the frequency of APOL1 variants G1 and G2 in Afro-descendant patients with ESRD treated at la Fundacion Valle del Lili University Hospital in Cali, Colombi...
Source: International Journal of Nephrology - January 15, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Association between High-Sensitivity C-Reactive Protein and Blood Pressure among Children with History of Low Birth Weight Appropriate for Gestational Age, Low Birth Weight Small for Gestational Age, and Normal Birth Weight in Manado, North Sulawesi.
This study aimed to investigate the association between high-sensitivity C-reactive protein (hs-CRP) and blood pressure (BP) in children with a history of LBW appropriate for gestational age (LBW AGA), LBW small for gestational age (LBW SGA), and normal birth weight appropriate for gestational age (NBW AGA). The study cohort comprised children aged 9-12 years who were born in 2007-2010 at Prof. Dr. R. D. Kandou General Hospital Manado and resided in the city of Manado from March to August 2019. The children who met the inclusion criteria were evaluated for BP and hs-CRP level. A total of 120 children who met the inclusion ...
Source: International Journal of Nephrology - January 11, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Etiology of Renal Replacement Therapy in Iran.
Authors: Morovatdar N, Tayebi Nasrabad G, Tsarouhas K, Rezaee R Abstract Introduction: End-stage renal disease (ESRD) is one of the most common life-threatening diseases. In the past two decades, several factors were held responsible as the cause of this condition. The present study aimed to determine the causes of ESRD in the province of Khorasan Razavi, Iran. Materials and Methods: This cross-sectional study was conducted on 2404 ESRD patients who referred to 39 hemodialysis centers in Khorasan Razavi province, Iran, and were registered in the Mashhad University of Medical Sciences (MUMS), between 2000 and De...
Source: International Journal of Nephrology - January 1, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Risk Behaviors in Teens with Chronic Kidney Disease: A Study from the Midwest Pediatric Nephrology Consortium.
Authors: Xiao N, Stolfi A, Malatesta-Muncher R, Bholah R, Kogon A, Eddington A, Chand D, Greenbaum LA, Hanevold C, Tran CL, Chishti A, Davis K, Matloff R, Woroniecki R, Klosterman C, Luckritz K, Omoloja A Abstract Introduction: There is a paucity of information about risk behaviors in adolescents with chronic kidney disease (CKD). We designed this study to assess the prevalence of risk behaviors among teens with CKD in the United States and to investigate any associations between risk behavior and patient or disease characteristics. Methods: After informed consent, adolescents with CKD completed an anonymous, c...
Source: International Journal of Nephrology - January 1, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Serum Sulphate Levels in Hemodialysis Patients.
This study was designed to determine the level of sulphate in hemodialysis patients. Materials and Methods: Ninety-four prevalent HD patients and 33 patients without renal failure were included in the study. The serum inorganic sulphate levels were measured by turbidimetric technique. Moreover, the serum level of urea, creatinine, albumin, calcium, phosphorus, and parathyroid hormone concentrations was simultaneously recorded. Results: Mean levels of plasma sulphate were significantly higher (0.56 ± 0.17 mM vs 0.31 ± 0.13 mM, p
Source: International Journal of Nephrology - December 26, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis.
Authors: Sung SA, Kim DH, Oh KH, Han SY, Han KH Abstract Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer. Cathepsin B is a lysosomal cysteine protease that degrades ECM, but its role in the PF remains unclear. Thus, we investigated the role of cathepsin B in PF. Procathepsin B was measured in the 73 PD effluents of 68 patients. Procathepsin B and cathepsin B after exposure of glucose and the effects of cathepsin B on the expression of matrix metalloproteinases (MMPs), tissue inhibitor of meta...
Source: International Journal of Nephrology - December 10, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Mechanism Underlying Selective Albuminuria in Minimal Change Nephrotic Syndrome.
Authors: Tojo A Abstract As water and solutes are filtered through the slit membrane, it is an a priori concept that a slit membrane is an essential filtration barrier for proteins, including albumin. However, in cases of minimal change nephrotic syndrome, the number of slit membranes is reduced by the foot process effacement and tight junction-like cell adhesion. Furthermore, albumin endocytosis is enhanced in the podocytes under condition of minimal change disease, and albumin is selectively transported by the albumin receptor FcRn. Suppressing the endocytosis of albumin with anti-FcRn antibody decreases the urin...
Source: International Journal of Nephrology - November 30, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Drug-Related Problems and Associated Factors among Patients Admitted with Chronic Kidney Disease at Jimma University Medical Center, Jimma Zone, Jimma, Southwest Ethiopia: A Hospital-Based Prospective Observational Study.
Authors: Garedow AW, Mulisa Bobasa E, Desalegn Wolide A, Kerga Dibaba F, Gashe Fufa F, Idilu Tufa B, Debalke S, Kumela Goro K Abstract Background: There is an alarming rise of chronic kidney disease prevalence globally associated with significant morbidity and mortality necessitating special attention as one of the major growing public health problems. Medication-related problems are common in hospitalized patients including chronic kidney disease and may lead to increase hospital stay and health care cost and augment the risk of morbidity and mortality. Objective: To determine prevalence of medication-related ...
Source: International Journal of Nephrology - November 29, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

High Incidence of Moderately Reduced Renal Function and Lead Bioaccumulation in Agricultural Workers in Assin South District, Ghana: A Community-Based Case-Control Study.
Conclusion: Neglect of the use of PPE may be predisposing the agrochemical workers and community to lead and arsenic bioaccumulation with a consequent reduced haematological and renal function. PMID: 31662908 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 31, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Parathyroid Hormone Measurement in Chronic Kidney Disease: From Basics to Clinical Implications.
Authors: Kritmetapak K, Pongchaiyakul C Abstract Accurate measurement of parathyroid hormone (PTH) is crucial for therapeutic decision-making in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). The second-generation PTH assays, often referred to as "intact PTH" assays, are the current standard and most available assays in clinical practice. However, intact PTH assays measure both full-length biologically active PTH and heterogeneous PTH fragments in the circulation, providing the equivocal value of PTH measurement in patients with CKD-MBD. Due to the variability of PTH assays, pre...
Source: International Journal of Nephrology - October 24, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Novel Haplotype Indicator for End-Stage Renal Disease Progression among Saudi Patients.
Conclusion: CKD is often silent until symptomatic uremia during the advanced stages of the disease. The newly identified haplotype will help recognize patients at risk for a rapid progression of CKD to ESRD. Accurate detection and mapping of the genetic variants facilitates improved risk stratification and development of improved and targeted therapeutic management for CKD. PMID: 31534799 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - September 21, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Comparison of Chronic Hemodialysis Patients under Strict Volume Control with respect to Cardiovascular Disease.
This study is an observational and cross-sectional study including 62 patients with normotensive chronic hemodialysis using no antihypertensive drugs. A series of measurements including ambulatory blood pressure monitoring, left ventricular mass index by echocardiography, common carotid artery intima-media thickness by ultrasound, and body fluids by bioimpedance analysis were conducted for all subjects. Results: The patients were divided into two groups as dippers and nondippers according to their ambulatory blood pressure monitoring results. Average 48 h systolic, diastolic, and mean arterial blood pressure and noctur...
Source: International Journal of Nephrology - July 31, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Variation in Assessing Renal Allograft Rejection: A National Assessment of Nephrology Practice.
Conclusion: Clinical care in the posttransplant setting is highly variable. Biopsies are often ordered in cases where their results do not alter treatment. Additionally, we found that misdiagnosis was common as were opportunities for earlier biopsy and detection of rejection. This evidence suggests that better diagnostic tools may be helpful to determine which transplant patients should be biopsied and which should not. This study suggests that nephrologists and transplant patients need better tests than creatinine and proteinuria and less invasive approaches than routine biopsies to determine when transplant patients shou...
Source: International Journal of Nephrology - June 21, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prevalence and Predictors of Chronic Kidney Disease in a Semiurban Community in Lagos.
Conclusion: The prevalence of CKD in the population is low compared with other studies from other parts of the country, and the predictors included age, hypertension, hyperuricemia, and female gender. This is the first community-based study in Nigeria to identify hyperuricemia as a risk factor for chronic kidney disease in the country. PMID: 31186960 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - June 14, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Psychosocial Mediators between Socioeconomic Status and Dietary Restrictions among Patients Receiving Hemodialysis in Japan.
This study was a cross-sectional survey of 6,644 outpatients (average age = 66.5 years; 65% males) of hemodialysis facilities across Japan. DRs were assessed by self-reported and objective measures, and SES was assessed based on education and income. Three psychosocial mediators were used: self-efficacy, control expectancy, and social support. Indirect influences of SES through the mediators were evaluated with a multiple mediator model. Although higher education was significantly associated with higher self-reported DRs, higher income was significantly associated with lower self-reported DRs. Significant SES differences i...
Source: International Journal of Nephrology - May 30, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Urinary Uromodulin Levels and UMOD Variants in Black South Africans with Hypertension-Attributed Chronic Kidney Disease.
We examined the association of urinary uromodulin concentrations with CKD and with SNP rs1333226 in the UMOD gene. The study included 71 black South Africans with hypertension-attributed CKD with an eGFR ≤ 60ml/min/1.73m2, 52 first-degree relatives, and 58 unrelated controls. Urinary uromodulin concentration was measured using Luminex® multiplex kits. After DNA extraction from blood using the Maxwell® automated platform, genotyping of rs13333226 was performed using real-time PCR using TaqMan® genotyping assays. Urinary uromodulin levels were significantly lower in CKD cases compared to both controls and firs...
Source: International Journal of Nephrology - May 10, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Regulation of (Pro)Renin Receptor in Renin-Positive Smooth Muscle Cells of Kidney Arterioles in Rats with STZ-Induced Diabetes.
Conclusion. The distribution of (pro)renin receptors in afferent arteriolar SMCs is related to renin granulation of SMCs, but independent of angiotensin II plasma or tissue levels in the kidney. PMID: 31049226 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - May 5, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients.
In this study, 27 patients developed acute kidney injury. The three hour-post-surgery urinary kidney injury molecule 1 was significantly higher in the acute kidney injury group (P
Source: International Journal of Nephrology - April 19, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Retracted: Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.
Authors: International Journal Of Nephrology Abstract [This retracts the article DOI: 10.1155/2018/2903139.]. PMID: 30867964 [PubMed - in process] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - March 16, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Reduced Kidney Function in Tenofovir Disoproxil Fumarate Based Regimen and Associated Factors: A Hospital Based Prospective Observational Study in Ethiopian Patients.
Conclusion: The renal dysfunction (defined as decline in eGFR greater than 25%) was found in a quarter of the study population. The long term impact and the clinical implication of it are not clear. Future prospective study is required with large sample size and long duration to ascertain the prevalence of decline greater than 25% in estimated glomerular filtration rate and its progression to chronic kidney disease. PMID: 30863641 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - March 14, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Renal Recovery following Liposomal Amphotericin B-Induced Nephrotoxicity.
Authors: Personett HA, Kayhart BM, Barreto EF, Tosh P, Dierkhising R, Mara K, Leung N Abstract Background: Acute kidney injury (AKI) is a common complication of treatment with liposomal amphotericin B (LAmB). The trajectory of renal recovery after LAmB-associated AKI has not been well described, nor has effect of LAmB dose on recovery of renal function been explored. Objective: Characterize the pattern of renal recovery after incident AKI during LAmB and determine potential influencing factors. Methods: This retrospective cohort study analyzed patients who developed a ≥50% increase in serum creatinine wh...
Source: International Journal of Nephrology - February 28, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.
Conclusion. Insulin and ACEIs based regimens were the most frequently used regimens in the treatment of diabetes mellitus and hypertension comorbidities. Very low income, increased number of prescribed medications, and being a farmer were the predictors of medication nonadherence. PMID: 30805215 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 27, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Functional and Respiratory Capacity of Patients with Chronic Kidney Disease Undergoing Cycle Ergometer Training during Hemodialysis Sessions: A Randomized Clinical Trial.
Conclusion: The systematic training regimen with a cycle ergometer resulted in benefits in the respiratory function and functional capacity in patients with chronic kidney disease undergoing hemodialysis. PMID: 30805216 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - February 27, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Acid-Base Status Disturbances in Patients on Chronic Hemodialysis at High Altitudes.
Authors: Cely JE, Rocha OG, Vargas MJ, Sanabria RM, Corzo L, D'Achiardi RE, Zúñiga EA Abstract Background: Acid-base disorders have been previously described in patients with chronic hemodialysis, with metabolic acidosis being the most important of them; however, little is known about the potential changes in acid-base status of patients on dialysis living at high altitudes. Methods: Cross-sectional study including 93 patients receiving chronic hemodialysis on alternate days and living in Bogotá, Colombia, at an elevation of 2,640 meters (8,661 feet) over sea level (m.o.s.l.). Measurements ...
Source: International Journal of Nephrology - December 26, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

A Higher Fructose Intake Is Associated with Greater Albuminuria in Subjects with Type 2 Diabetes Mellitus.
Authors: Gómez-Sámano MÁ, Almeda-Valdes P, Cuevas-Ramos D, Navarro-Flores MF, Espinosa-Salazar HD, Martínez-Saavedra M, León-Domínguez JA, Enríquez-Estrada VM, López-González AL, Sarmiento-Moreno AL, Rivera-González LA, Juárez-León ÓA, Pérez-González B, Ávila-Palacios Y, Sigala-Pedroza L, Huerta-Ávila E, Vargas-Álvarez MA, Sánchez-Jaimes C, Cárdenas-Vera M, Mehta R, López-Flores A La Torre MA, Manjarrez-Martínez I, Brito-Córdova GX, Zuarth-Vázquez JM, Vega-B...
Source: International Journal of Nephrology - November 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.
We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse. Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14.9-17.7)] follow-up were retrospectively collected. Results: Overall, 55% of the patients had microscopic polyangiitis (MPA) and 45% had granulomatosis with polyangiitis (GPA). The histopathological classes were focal in 35%, crescentic in 26%, mixed in 20%, and sclerotic glomerulonephritis in 19% of the patients. As induction treatment, a ...
Source: International Journal of Nephrology - November 10, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Glomerulonephritis Pattern at a Jordanian Tertiary Care Center.
Authors: Farah RI Abstract Aim: To determine the prevalence and frequency of different pathological patterns of glomerulonephritis (GN) in adolescent (age ≥ 11 years) and adult Jordanian patients. Materials and Methods: A retrospective analysis of all clinical and pathological reports of Jordanian patients who had native renal biopsies at the University of Jordan hospital between January 2007 and March 2018 to assess the prevalence and pathological pattern of GN. The data were analyzed statistically using descriptive statistics, the chi-squared test, and Fisher's exact tests. The level of significance was set at P
Source: International Journal of Nephrology - November 9, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research

Cost-Effectiveness Analysis for the Treatment of Hyperphosphatemia in Predialysis Patients: Calcium-Based versus Noncalcium-Based Phosphate Binders.
Conclusions: Our study finds that sevelamer is potentially cost-effective compared to CaCO3, for the treatment of hyperphosphatemia in predialysis CKD III-V. We propose that sevelamer should be an option in the treatment of Malaysian predialysis patients with hyperphosphatemia, particularly those with high calcium load. PMID: 30327732 [PubMed] (Source: International Journal of Nephrology)
Source: International Journal of Nephrology - October 19, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Source Type: research