Sesamin ameliorates nonalcoholic hepatic steatosis by inhibiting CD36-mediated hepatocyte lipid accumulation in vitro and in vivo
In this study, we observed the anti-hepatic steatosis effects of Ses in palmitate/oleate (PA/OA)-incubated primary mouse hepatocytes, AML12 hepatocytes, and HepG2 cells, as well as in high-fat, high-cholesterol diet-induced NASH mice. RNA sequencing analysis revealed that cluster of differentiation 36 (CD36), a free fatty acid (FA) transport protein, was involved in the Ses-mediated inhibition of hepatic fat accumulation. Moreover, the overexpression of CD36 significantly increased hepatic steatosis in both Ses-treated PA/OA-incubated HepG2 cells and NASH mice. Furthermore, Ses treatment suppressed insulin-induced de novo ...
Source: Biochemical Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Ya-Ping Bai Teng Zhang Zheng-Yan Hu Yan Zhang De-Guo Wang Meng-Yun Zhou Ying Zhang Fang Zhang Xiang Kong Source Type: research
Occurrence of coliforms and biofilm-forming bacteria in raw, treated, and distributed water from two waterwork systems in Osun State, Southwestern Nigeria
This study assessed the bacteriological quality of raw, treated, and distributed water from Ede-Erinle and Opa reservoirs in Osun State, Nigeria. This was to determine the potability of water from these waterwork stations. Eighteen sampling points were established across the two reservoir networks for this study. Samples were collected bi-monthly for two annual cycles. Serial dilution and pour plate methods were employed for the enumeration of bacterial load. Total heterotrophic bacteria count (THBC) and total coliform bacteria count (TCBC) were enumerated on nutrient and MacConkey agar at 37 °C, respectively. Bacterial i...
Source: Journal of Water and Health - April 28, 2024 Category: Environmental Health Authors: Abayomi Tolulope Oyewale Babatunde Wumi Odetoyin Anthonia Olufunke Oluduro Israel Funso Adeniyi Source Type: research
Fennel seeds extract prevents fructose-induced cardiac dysfunction in a rat model of metabolic syndrome via targeting abdominal obesity, hyperuricemia and NF- κβ inflammatory pathway
CONCLUSION: Findings could suggest FSE as a complementary supplement for preventing MetS and associated cardiac outcomes. However, well controlled clinical studies are still needed.PMID:38678740 | DOI:10.1016/j.tice.2024.102385 (Source: Tissue and Cell)
Source: Tissue and Cell - April 28, 2024 Category: Cytology Authors: Azza Mohamad El-Wakf Mamdouh Rashad El-Sawi Hadeer Mahmoud El-Nigomy Eman Mohamad El-Nashar Norah Saeed Al-Zahrani Nasser G Alqahtani Rashid A Aldahhan Zienab Helmy Eldken Source Type: research
A review on the nexus of autophagy genes from the perspective of polycystic ovary syndrome
Biol Cell. 2024 Apr 28:e202300069. doi: 10.1111/boc.202300069. Online ahead of print.ABSTRACTPolycystic ovary syndrome or PCOS is an endocrine disorder in women of reproductive age. It is a diversified multi factorial disorder and diagnosis is very complicated because of its overlapping symptoms some of which are irregular menstrual cycle, acne in face, excess level of androgen (AE), insulin resistance, obesity, cardiovascular disease, mood disorder and type 2 diabetes (T2DM). PCOS may be caused by hormonal imbalance, genetic and epigenetic vulnerability, hypothalamic and ovarian troubles. PCOS is essentially hyperandrogen...
Source: Biology of the Cell - April 28, 2024 Category: Cytology Authors: Arifa Khatun Taslima Nasrin Md Samim Hassan Mehboob Hoque Muddasarul Hoda Safdar Ali Source Type: research
Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):107-112. doi: 10.14715/cmb/2024.70.4.17.ABSTRACTParkinson's disease (PD) is defined as a progressive neurodegenerative disease in middle-aged and elderly people. The therapeutic effect of ω-3 PUFAs in several neurodegenerative diseases has been well recognized. Nevertheless, whether nutrition supplementing ω-3 PUFAs exerts a neuroprotective role in PD remains elusive. Bioinformatics revealed 2D chemical structural formula of three components. Mice received indicated treatment with saline, MPTP or ω-3 PUFAs according to grouping. Behavioral function of mice was measured t...
Source: Mol Biol Cell - April 28, 2024 Category: Molecular Biology Authors: Yezi Xia Yinwei Zhang Ying Li Xiaojing Li Yaling Wu Qi Yao Source Type: research
Advancements in Nano-Enhanced microalgae bioprocessing
Bioresour Technol. 2024 Apr 26:130749. doi: 10.1016/j.biortech.2024.130749. Online ahead of print.ABSTRACTMicroalgae are promising sources of valuable compounds: carotenoids, polyunsaturated fatty acids, lipids, etc. To overcome the feasibility challenge due to low yield and attain commercial potential, researchers merge technologies to enhance algal bioprocess. In this context, nanomaterials are attractive for enhancing microalgal bioprocessing, from cultivation to downstream extraction. Nanomaterials enhance biomass and product yields (mainly lipid and carotenoids) through improved nutrient uptake and stress tolerance du...
Source: Bioresource Technology - April 28, 2024 Category: Biotechnology Authors: Yamini Sumathi Cheng-Di Dong Reeta Rani Singhania Chiu-Wen Chen Baskar Gurunathan Anil Kumar Patel Source Type: research
Oscillatory shear stress promotes endothelial senescence and atherosclerosis via STING activation
Biochem Biophys Res Commun. 2024 Apr 23;715:149979. doi: 10.1016/j.bbrc.2024.149979. Online ahead of print.ABSTRACTEndothelial dysfunction is an initiating factor in atherosclerosis. Endothelial cells (ECs) are constantly subject to blood flow shear stress, and atherosclerotic plaques tend to occur in aortic bends or bifurcations impaired by low oscillatory shear stress (OSS). However, the mechanism that how OSS affects the initiation and progression of atherosclerosis remains to be explored. Here, we first reported that OSS can promote endothelial dysfunction and atherogenesis in vivo and in vitro by activating STING path...
Source: Biochemical and Biophysical Research communications - April 28, 2024 Category: Biochemistry Authors: Mengdie Dong Minghong Chen Yunjia Zhang Xian He Jiao Min Yongkang Tan Huiyuan Wei Xinyu Li Xiang Chen Longbin Zheng Quanwen Yin Xuesong Li Hongshan Chen Hong Jiang Source Type: research
Prenatal diethylhexylphthalate exposure disturbs adult Leydig cell function via epigenetic downregulation of METTL4 expression in male rats
In conclusion, prenatal DEHP exposure reduces testosterone by downregulating CYP11A1 and HSD3B2 via m6A epigenetic regulation and induction of autophagy protection in adult Leydig cells as a response to DEHP exposure.PMID:38678792 | DOI:10.1016/j.ecoenv.2024.116391 (Source: Ecotoxicology and Environmental Safety)
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Qiqi Zhu Shanshan Zhu Qiyao Li Chunnan Hu Chengshuang Pan Huitao Li Yang Zhu Xiaoheng Li Yunbing Tang Ren-Shan Ge Source Type: research
A systematic review on garbage enzymes and their applications in environmental processes
Ecotoxicol Environ Saf. 2024 Apr 27;277:116369. doi: 10.1016/j.ecoenv.2024.116369. Online ahead of print.ABSTRACTUnderstanding the new insight on conversion of organic waste into value-added products can improve the environmental activities driven by microorganisms and return the nutrients to environment and earth. Here, we comprehensively review the available knowledge on application of garbage enzyme (GE) for different environmental activities including waste activated sludge, composting process, landfill leachate treatment, soil remediation and wastewater treatment with special focus on their efficiency. To identify pee...
Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Hasan Pasalari Arash Moosavi Majid Kermani Roya Sharifi Mahdi Farzadkia Source Type: research
Distribution of Urinary Trace Element Exposure and Dietary Sources in Women Over 50 in an Agricultural Region- A community-based KoGES cohort study
CONCLUSIONS: Our study underscores the significant gap in understanding urinary concentrations of trace elements in women aged over 50. With higher concentrations of certain elements compared to previous studies and significant correlations between age, smoking, and specific food sources, it is imperative to address this gap through targeted dietary source-specific risk management.PMID:38679278 | DOI:10.1016/j.envres.2024.118973 (Source: Environmental Research)
Source: Environmental Research - April 28, 2024 Category: Environmental Health Authors: Nam H Cho Sohyeon Choi Min Joo Kim Young Joo Park Aram Lee Min Kyong Moon Gowoon Lee Inae Lee Kyungho Choi Joon-Hyop Lee Jeongim Park Source Type: research
Alleviative effects of sulfated polysaccharide from Ishige Okamurae against DSS-induced ulcerative colitis via inhibiting inflammation and modulating gut microbiota
Int J Biol Macromol. 2024 Apr 26:131915. doi: 10.1016/j.ijbiomac.2024.131915. Online ahead of print.ABSTRACTA water-soluble polysaccharide from the brown alga Ishige Okamurae, designated IOP-0, was obtained by preparative anion-exchange and size-exclusion chromatography. Chemical and spectroscopic investigations revealed that IOP-0 was a sulfated fucoidan with a backbone primarily composed of 3-linked and 4-linked-L-fucose with sulfate groups at C-2/C-4 of the 3-linked-L-fucose. The protective effect of IOP-0 on ulcerative colitis was evaluated in this work. The results showed that IOP-0 could significantly alleviate the s...
Source: International Journal of Biological Macromolecules - April 28, 2024 Category: Biochemistry Authors: Ling Qin Hui Xu Junhan Cao Kai Wang Liping Zhang Mengke Yao Huan Lin Changfeng Qu Jinlai Miao Source Type: research
I'll Have What She's Having (But Not What They're Having): The Moderating Role of Group Membership in the Effect of Social Norms on Food Choice in an Online Environment
Appetite. 2024 Apr 26:107374. doi: 10.1016/j.appet.2024.107374. Online ahead of print.ABSTRACTThe modern food-rich environment has contributed to the rise of unhealthy diets linked to noncommunicable diseases. Previous in-person research has found that the effect of social norms on food intake is greater when set by a perceived in-group member relative to an out-group member. Given recent increased social media use, we investigated whether this effect of group membership extends to food choices and to normative information presented remotely online. Participants (N = 179 female university students, 18-32 years) viewed a Fa...
Source: Appetite - April 28, 2024 Category: Nutrition Authors: Juliana Marie Gleaves Eva Kemps Ivanka Prichard Marika Tiggemann Source Type: research
Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells
Cell Mol Biol (Noisy-le-grand). 2024 Apr 28;70(4):107-112. doi: 10.14715/cmb/2024.70.4.17.ABSTRACTParkinson's disease (PD) is defined as a progressive neurodegenerative disease in middle-aged and elderly people. The therapeutic effect of ω-3 PUFAs in several neurodegenerative diseases has been well recognized. Nevertheless, whether nutrition supplementing ω-3 PUFAs exerts a neuroprotective role in PD remains elusive. Bioinformatics revealed 2D chemical structural formula of three components. Mice received indicated treatment with saline, MPTP or ω-3 PUFAs according to grouping. Behavioral function of mice was measured t...
Source: Cellular and Molecular Biology - April 28, 2024 Category: Molecular Biology Authors: Yezi Xia Yinwei Zhang Ying Li Xiaojing Li Yaling Wu Qi Yao Source Type: research
Development and validation of a photograph-based instrument to assess nutrition literacy: the NUTLY project
Appetite. 2024 Apr 26:107377. doi: 10.1016/j.appet.2024.107377. Online ahead of print.ABSTRACTMost instruments measuring nutrition literacy evaluate theoretical knowledge, not necessarily reflecting skills relevant to food choices. We aimed to develop and validate a photograph-based instrument to assess nutrition literacy (NUTLY) among adults in Portugal. NUTLY assesses the ability to distinguish foods with different nutritional profiles; from each of several combinations of three photographs (two foods with similar contents and one with higher content) participants are asked to identify the food with the highest energy/so...
Source: Appetite - April 28, 2024 Category: Nutrition Authors: Sofia Sousa Gabriela Albuquerque Milton Severo Ana Rute Costa Pedro Moreira Nuno Lunet Patr ícia Padrão Source Type: research
More than the worksite cafeteria: the workplace food environment of small and medium-sized enterprises in the Netherlands
CONCLUSIONS: In SMEs, an overall comprehensive picture of the food environment points to its limited active encouragement of healthy food choices, particularly so in small SMEs without a worksite cafeteria. Company characteristics strongly influence SME food environments and should be considered when developing interventions improving SME worksite food environments.PMID:38679460 | DOI:10.1017/S1368980024000946 (Source: Public Health Nutrition)
Source: Public Health Nutrition - April 28, 2024 Category: International Medicine & Public Health Authors: Lisanne Geboers Emely de Vet Fr édérique C Rongen Maartje P Poelman Source Type: research
