Prenatal diethylhexylphthalate exposure disturbs adult Leydig cell function via epigenetic downregulation of METTL4 expression in male rats

In conclusion, prenatal DEHP exposure reduces testosterone by downregulating CYP11A1 and HSD3B2 via m6A epigenetic regulation and induction of autophagy protection in adult Leydig cells as a response to DEHP exposure.PMID:38678792 | DOI:10.1016/j.ecoenv.2024.116391

Source: Ecotoxicology and Environmental Safety - April 28, 2024 Category: Environmental Health Authors: Qiqi Zhu Shanshan Zhu Qiyao Li Chunnan Hu Chengshuang Pan Huitao Li Yang Zhu Xiaoheng Li Yunbing Tang Ren-Shan Ge Source Type: research