Calorie Restriction and Fasting Benefit the Aging Heart
In conclusion, fasting-induced autophagy is beneficial for ensuring cardiac function, preventing disease, and improving longevity. However, additional studies in vivo in animal models of cardiac aging are needed to determine the specific molecular mechanisms involved in normalizing autophagy by fasting. In addition, large-scale studies on humans are needed. Importantly, further in vitro research should be directed toward human cardiac tissues to better understand the molecular mechanisms of fasting-induced autophagy and its beneficial effects on longevity pathways and prevention of cardiovascular disease.
Link: ht...
Source: Fight Aging! - April 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing Approaches to Improving Aged Stem Cell Function
A variety of approaches show some promise in improving the function of stem cells in aged tissues. Stem cell populations support their tissue by providing a supply of daughter somatic cells to replace losses. This supply diminishes over time as stem cells reduce their activity for reasons that descend from the known root causes of aging, but which are not fully understood in detail. To the degree that reduced stem cell function is a response to the aged environment rather than a consequence of damage inherent to these cells, then it is useful to find ways to force stem cells to be more active. Whether this is the case may ...
Source: Fight Aging! - April 24, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ozempic And Other Weight Loss Drugs Will Only Work With Digital Health
Weight loss injections are now widely used as miracle drugs for effortless skinniness. But without digital health, they just won’t work in the long run. The U.S. Food and Drug Administration, the FDA, approved Wegovy, a semaglutide injection for chronic weight management in adults with obesity or overweight with at least one weight-related condition for use in addition to a reduced calorie diet and increased physical activity in 2021.
Semaglutide was originally used for the treatment of type 2 diabetes, and was found to have a major lucky side effect: being very effective in assisting weight loss. Semaglutide inject...
Source: The Medical Futurist - April 23, 2024 Category: Information Technology Authors: Andrea Koncz Tags: Digital Health Research weight management weight loss Ozempic Wagevy Source Type: blogs
6 Foods That Protect Against Memory Loss
The foods all contain an anti-inflammatory that combats age-related changes in the brain. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 22, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Memory Nutrition Source Type: blogs
Hippocratic AI Raises $53 Million Series A at a $500 Million Valuation
Company Releases First Product: Generative AI-Powered Staffing Marketplace for Healthcare and will use Funds to Accelerate Further Product Development and Conduct Phase Three Safety Testing for its LLM
Hippocratic AI, the company building the first safety-focused Large Language Model (LLM) for healthcare, today announced the close of a $53 million Series A funding round at a $500 million valuation, bringing total funding to $120 million. Today, the company also released its first product for phase three safety testing: a staffing marketplace for healthcare where health systems, payors, and others can “hire” generative ...
Source: EMR and HIPAA - April 22, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT a16z Andreessen Horowitz Bio Health Capsule Cincinnati Children’s ELNA Evernow Fraser Health General Catalyst Guidehealth HarmonyCares Health IT Funding Health IT Fundings Health IT Investmen Source Type: blogs
Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases.
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A Population Study Correlates Air Pollution with Faster Cognitive Aging
https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/
A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Bis(monoacylglycero)phosphates Accumulate in Aged Tissues
Lipid metabolism is changed and disrupted with advancing age, as is the case for all complex mechanisms in the body. There are a great many different lipids present in the body; even the list of classes of lipid is a long one. Finding specific changes that relate to aging can be interesting, but the challenge lie in better understanding how those changes come about, and whether they causes significant harm to tissues. Many age-related changes in molecular biochemistry are far downstream of the important causes of aging and do not cause much further disruption in and of themselves.
In recent years, laboratory resea...
Source: Fight Aging! - April 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Endothelial Cellular Senescence Contributes to Loss of Capillary Density
The consensus of the research community on senescent cells in old tissues is that (a) their presence causes harm, and (b) treatments based on the selective removal of such cells will be beneficial, reversing many aspects of aging and age-related disease. These cells secrete a pro-inflammatory mix of signal molecules that is disruptive to tissue structure and function when maintained over time. Cells become senescent constantly throughout life, only to be destroyed by programmed cell death or by the immune system. With advancing age, newly created senescent cells are cleared ever more slowly, however, and thus the burden of...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Vitamin Deficiency Linked to Moodiness, Lack Of Motivation And Tiredness
The vitamin may have a direct effect on the brain and has also been linked to Parkinson's disease and dementia. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 18, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Mental Health Nutrition Source Type: blogs
GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance
Lizzie is a 13-year-old with a great sense of humor. She tells it like it is, especially to her Mom, Jackie, who admits to being a bit of an Almond Mom (the parent who is stuck in a weight-focused diet culture). Jackie leads a very healthy lifestyle and has never had to deal with being
Read more…
GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 17, 2024 Category: General Medicine Authors: Karla Lester, MD Tags: Meds Obesity Pediatrics Source Type: blogs
Science Snippet: Breaking Down Biodegradability
Have you ever noticed plastic utensils or paper plates labeled as “biodegradable” and wondered what that meant? Materials are biodegradable when microorganisms such as bacteria can break them down into their building blocks.
Biodegradable Plastics
Plastic is everywhere: Milk jugs, grocery bags, and takeout containers are just a few examples. There are many types of plastic, but they’re all made up of long chains of repeating subunits called polymers. These polymers are designed to be durable and resistant to factors like heat, sunlight, and water, which makes them useful in a variety of situations.
Toget...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - April 17, 2024 Category: Research Authors: Chrissa Chverchko Tags: Chemistry, Biochemistry and Pharmacology STEM Education Bacteria Science Snippet Source Type: blogs
Bacterial Peptides Improve Mitochondrial Function in Intestinal Tissues
This study reveals a potential treatment for human mitochondrial diseases.
Link: https://doi.org/10.1016/j.celrep.2024.114067 (Source: Fight Aging!)
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Higher Taurine Intake in the Diet Correlates with Some Measures of Strength in Middle Age
Taurine is a amino acid mainly found in fish and meat in the diet. It is not an essential amino acid, and can be synthesized in humans. Circulating taurine levels in the bloodstream decline with age by about 50% by middle age for reasons that have yet to be determined. Studies in aged mice and non-human primates have shown modestly improved function and slowed aging following taurine supplementation. Past human studies of taurine supplementation have produced entirely unimpressive outcomes, but given that they predated present aging clocks it may be that the researchers were evaluating the wrong metrics. Taurine may act on...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Inducing Low Body Temperature via Torpor Slows Aging in Mice
Past evidence has suggested that the lowered body temperature characteristic of calorie restriction is important to the slowed aging that results in short-lived mammals. One might compare that to the strong evidence for upregulated autophagy to be the driving factor in slowed aging produced by the practice of calorie restriction. Researchers here conduct a similar study, inducing a reduction in metabolic rate, dietary intake, and body temperature in mice via activation of a specific brain region. As in past research, the resulting slowed aging was shown to be driven by that lowered body temperature rather than any of the o...
Source: Fight Aging! - April 16, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Breakfast That Quadruples Weight Loss In The Long-Term
People following this diet lost four times as much weight as those just following a standard low-carb diet all day long. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 15, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
