Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
TLR2 Important in the Dysfunction of Hair Follicles
Dysfunction in hair follicles and loss of the capacity for hair growth is a perhaps surprisingly complex aspect of aging and disease. For all the the basic mechanisms of hair growth are well-investigated, the hair follicle is a complex structure, and hair growth involves the collaboration of many cell types, activities, and signaling that shifts over time as the follicle progresses through the stages of growth. It has proven to be hard to pin down any one specific mechanism as vital, and it may turn out to be the case that no one specific mechanism is the key to preventing loss of hair with advancing age and other circumst...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Common Vitamin That Doubles Weight Loss
Study participants lost weight without dieting or making other lifestyle changes. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 12, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Polypharmacy and prescribing cascades [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join us for a discussion on medication awareness and prescribing cascades with Paula Rochon, a geriatrician. As we embark on a new year, many focus on diet and exercise resolutions, but overlooking medication management can have profound implications for health. With
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Polypharmacy and prescribing cascades [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 11, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Geriatrics Medications Source Type: blogs
Intermittent Methionione Restriction may be an Improvement on Continuous Methionine Restriction
Regulatory systems that detect low levels of the essential amino acid methionine are one of the more important triggers for the metabolic response to fasting and calorie restriction. Methionine is not manufactured in mammalian cells, can only be obtained from the diet, but is nonetheless essential for protein synthesis. Thus reducing only methionine levels in the diet can capture a sizable fraction of the benefits of calorie restriction.
While it is possible for a self-experimenter armed with time, a suitable database of methionine content by food type, and considerable willpower to practice significant levels of me...
Source: Fight Aging! - April 10, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Can Digital Technologies Help Overcome Diabetes? An Assessment of the Recent PHTI Review
Payers are always wary about funding new treatments for illnesses and conditions: When millions of dollars are at stake, payers want demonstrated improvements in outcomes. So do doctors and patients, before they go through the trouble of adopting a course of treatment. So there was much consternation recently when the Peterson Health Technology Institute (PHTI) released a report saying that digital interventions weren’t helping people with diabetes much and weren’t worth their added costs.
PHTI has a comprehensive and detailed assessment framework that it applies to health care technologies to determine whether...
Source: EMR and HIPAA - April 8, 2024 Category: Information Technology Authors: Andy Oram Tags: Clinical Health IT Company Healthcare IT Telemedicine and Remote Monitoring A1c ANdy Molnar Behavior Change Behavior Health CGM Continuous Glucose Monitoring Dario Health diabetes Diabetes Monitoring Digital Health Digital Ther Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
This Simple Technique Can Double Weight Loss Results
This weight loss is achieved without making changes to exercise or diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 6, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
How to control high blood pressure without medications
Just because you have been told that your blood pressure is above normal need not mean that you are tied up to medications lifelong. Changes in lifestyle can definitely bring down your blood pressure even without medications. In those already taking medications, the dose of medications can be brought down by important lifestyle changes. Some lucky ones may be able to stop medications as well. But you have to continue monitoring your blood pressure regularly so that any recurrence can be picked up.
One of the important ways in which to reduce elevated blood pressure is by reducing extra weight. Roughly the blood pressure mi...
Source: Cardiophile MD - April 6, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
An Urgent Call to Raise Awareness of Heart Disease in Women
By KELLY CARROLL
There is a dire need to raise awareness about heart disease in women. It is the number one killer of American women, and key data points reveal a lack of cognizance among doctors and women.
An assessment of primary care physicians published in 2019 revealed that only 22% felt extremely well prepared to evaluate cardiovascular disease risks in female patients. A 2019 survey of American women showed that just 44% recognized heart disease as the number one cause of death in women. Ten years earlier, in 2009, the same survey found that 65% of American women recognized heart disease as the leading cause o...
Source: The Health Care Blog - April 5, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice heart disease Kelly Carroll Life Essential 8 prevention Womens health Source Type: blogs
Healthy Together Acquires Kinsa Health to Build AI Illness Forecasting & Expand into New Markets
Healthy Together, a leading health technology company specializing in Software as a Service (SaaS) solutions for State-level Health & Human Services programs, is excited to announce the successful acquisition of Kinsa Health, a powerful and robust AI platform that provides predictive insights for pharmaceutical companies, retailers, illness product companies, public health agencies, hospital systems, and communities.
The acquisition advances Healthy Together’s mission to improve collective health and make government and enterprises more efficient. By integrating Kinsa’s AI illness forecasting engine into He...
Source: EMR and HIPAA - April 5, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Health IT Acquisitions Healthcare M&A Healthy Together Inder Singh Jared Allgood Kinsa Health Source Type: blogs
Transient Pockets of Hypoxia in the Mammalian Brain
Evidence suggests that the mammalian brain is operating at the very edge of its capacity, supplied with just enough oxygen and nutrients to barely get by. That exercise produces measurable short-term gains in cognitive function, while blood flow is increased, is one point in favor of this view. Another is provided here, in which researchers note that it is entirely normal to observe transient areas of hypoxia in the brain at rest, and that the occurrence of these regions is diminished by the increased blood flow of exercise. It is an open question as to what to do with this finding: we can imagine future technologies that ...
Source: Fight Aging! - April 5, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A View of Type 2 Diabetes as Accelerated Aging
The mortality characteristics resulting from type 2 diabetes look very much like an accelerated form of normal aging, as noted in today's open access paper reporting on a large epidemiological study. This mortality characteristic is so much like aging that at times in the past researchers have used animal models of type 2 diabetes as stand-ins for aging, in order to conduct studies more rapidly. Type 2 diabetes is a metabolic disease, a condition that usually arises from excess fat tissue, and is characterized by chronic inflammation, excessive blood sugar, high levels of circulating advanced glycation end-products, and ot...
Source: Fight Aging! - April 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Interview with Stefany Shaheen: Revolutionizing diabetes care through cell therapies
I had the extraordinary opportunity to chat with Stefany Shaheen, the Chief Strategy Officer of Advanced Regenerative Manufacturing Institute (ARMI) and BioFab USA, about the transformative potential of cell therapies for individuals living with diabetes. Stefany shared her remarkable journey, insights on cell therapies’ current status, approval challenges, and how the diabetes community can contribute to advancing research in this field.
A few months before this discussion with Stefany, I had the opportunity to hear Dean Kamen speak at the recent ...
Source: Scott's Diabetes Blog - April 1, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
