Why People Prefer Ultra-Processed Foods — Surprisingly, It ’ s Not The Taste
The study challenges the assumption that ultra-processed foods are 'hyperpalatable' -- they are not. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 26, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Nutrition Source Type: blogs

Towards Adjustment of the Gut Microbiome to Slow Aging
This paper makes the reasonable argument that means of modestly slowing aging will emerge from ways to reverse age-related changes in the varied microbial populations making up the gut microbiome. The gut microbiome changes with age, in ways that provoke chronic inflammation while also diminishing the supply of metabolites necessary for tissue function. Given the evidence generated from human and animal studies over the past decade, it is reasonable to think that the gut microbiome has as much influence on the course of long-term health as lifestyle choices relating to diet and exercise. Aging is a complex natural...
Source: Fight Aging! - December 25, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, December 25th 2023
This study generates a comprehensive single-cell transcriptomic atlas of human atherosclerosis including 118,578 high-quality cells from atherosclerotic coronary and carotid arteries. By performing systematic benchmarking of integration methods, we mitigated data overcorrection while separating major cell lineages. Notably, we define cell subtypes that have not been previously identified from individual human atherosclerosis scRNA-seq studies. Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome...
Source: Fight Aging! - December 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Red Wine Headaches Explained: This Flavonoid Could Be To Blame
The flavonoid interferes with the metabolism of alcohol. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 23, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Alcohol Nutrition Source Type: blogs

Weekly Roundup – December 23, 2023
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week. New HIPAA Security Rule – and Enforcement – Is Coming in 2024. Mike Semel said updates to the HIPAA Security Rule should be in place by the end of next year, as ONC plans to release a draft rule in the spring. Along the same lines, we can expect HHS to ask for additional enforcement authority for OCR so the agency can clear its backlog of HIP...
Source: EMR and HIPAA - December 23, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs

Induction of Autophagy Slows High Fat Diet Induced Atherosclerosis in Mice
Atherosclerosis is the name given to the growth of fatty lesions in blood vessel walls, narrowing and weakening blood vessels, and eventually rupturing to cause a heart attack or stroke. This is the primary cause of human mortality. Many approaches have been demonstrated to slow the progression of atherosclerosis in the most commonly used mouse models, in which atherosclerosis is rapidly induced by a combination of high fat diet and the disabling of genes, such as APOE and LDLR, that are important to maintain normal blood cholesterol levels and cholesterol transport. Very few approaches have been shown to produce a reducti...
Source: Fight Aging! - December 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Season Health Announces Strategic Asset Acquisition from Wellory to Expand Clinical Network of Registered Dietitians and Insurance Coverage
Season Health, the leading integrated food-as-medicine platform, today announced the closing of a strategic acquisition of clinical assets from Wellory, one of the largest networks of registered dietitians in the country providing medical nutrition therapy to patients nationwide. This accelerates Season’s growth by significantly expanding its provider network and its ability to offer comprehensive, personalized nutrition care to more patients, including those looking for in-network benefits. Since its founding in 2019 by Emily Hochman and Jeni Fahy, Wellory has focused on unlocking access to quality nutrition care se...
Source: EMR and HIPAA - December 21, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT 8VC Andreessen Horowitz Emily Hochman Health IT Acquisitions Healthcare M&A Jeni Fahy Josh Hix LRVHealth Season Season Health Wellory Source Type: blogs

Inflammaging in the Inner Ear, a Path to Hearing Loss
Inflammaging is a blanket term for the inappropriate inflammatory reaction of the immune system to the accumulation of molecular damage and other changes that take place with age. Constant, low-grade, unresolved inflammatory activation of the immune system is a feature of aging. It alters cell behavior for the worse and is disruptive to tissue structure and function. A number of different mechanisms contribute to forming and maintaining the state of inflammaging, such as pro-inflammatory signaling produced by ever-larger numbers of senescent cells, and innate immune recognition of mislocalized mitochondrial DNA that result...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

How to Measure Healthspan in Mice
Somewhere in the list of topics that are not given a great deal of thought outside the research community, there is the issue of how exactly one goes about measuring healthspan in mice, the length of life spent in good health. There is no standardization to speak of, and what is called healthspan in one study is typically assessed with a completely different set of measures from what is called healthspan in another study. Thus there are groups attempting to promote specific well-defined approaches to assessment of healthspan in animal models, in the hope that others adopt them in order to make data on the effects of interv...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

2 Antioxidant Vitamins Reduce Vascular Dementia Risk By 88%
Cognitive performance is improved by taking these antioxidant vitamins regularly over the years. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 19, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs

5 Things We Learnt About Investments In Digital Health: Our E-book
At The Medical Futurist (TMF), and especially at The Medical Futurist Institute, we don’t usually deal with investment-related news and announcements. We receive many press releases coming from incubators and venture capital firms each week, but we never share them on our channels. Even though we focus on technologies and trends rather than companies of interest to investors, this doesn’t mean that we don’t keep a close eye on all these developments.  We are in close contact with many digital health startup founders, analyze the technologies they work on and objectively share news relevant to investors. A...
Source: The Medical Futurist - December 19, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Artificial Intelligence in Medicine Biotechnology Health Sensors & Trackers MySugr theranos invest portable diagnostics Gary rule Kardia CliniCloud tmfi alivecor MagicLeap covid19 digital health investors pandemic ecg R Source Type: blogs

Reviewing the Contributions of Circadian Rhythm Dysfunction and Dysbiosis to Blood-Brain Barrier Leakage
The blood-brain barrier is a layer of specialized cells wrapping blood vessels that pass through the brain. Only certain molecules and cells are admitted. The metabolism of the brain is thus isolated from that of the rest of the body. In particular, the immune system of the brain is quite different from that of the rest of the body. Unfortunately, this isolation is a vulnerability when, like all biological systems, the blood-brain barrier begins to break down and leak. The leakage of inappropriate molecules and cells into the brain provokes inflammation and dysfunction, and this is likely a contributing factor in the devel...
Source: Fight Aging! - December 18, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team. « Back to Top Aged Transplant Organs Cause Harm to Younger Recipients https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/ Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Ozempic: miracle drug or a band-aid for obesity?
An excerpt from Dr. T’s Drop the Fat Diet: 12 Steps to Leaner You Forever. Semaglutide, a medication often marketed as Ozempic, Wegovy, or Rybelsus, has gained immense popularity in recent years. This is especially true in an age where diabetes and obesity are on the rise. The medication is being seen as a panacea Read more… Ozempic: miracle drug or a band-aid for obesity? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 16, 2023 Category: General Medicine Authors: Tags: Meds Obesity Source Type: blogs