More Visceral Fat, Greater Cognitive Decline in Later Life
Modern studies of the effects of excess body weight on long term health use measures, such as waist circumference or weight-adjusted waist index, that are more sensitive to visceral fat than subcutaneous fat. Excess visceral fat in the abdomen is actively harmful, in large part via causing an increased level of chronic inflammation via a variety of distinct mechanisms. Chronic inflammation accelerates the onset and drives the progression of neurodegenerative conditions, and thus might be expected to correlate with cognitive decline.
Some studies suggest that excessive obesity can lead to cognitive decline and deme...
Source: Fight Aging! - February 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
PEG TubeDemented and contractedCachectic stage before skeletonAnother stroke last weekChoking on her own salivaStaring off to the right Imaginary windows or mirrorsAnybody ’s guessIt won ’t help her, I tried to sayBut not with any convictionThe family insisted:A feeding tube for nutritionMom needs it to get better The bite block framed Her swollen dry tongueHer eyes watered.Then glazed over I began to feedThe lighted black scopeDown her throat .When it occurred to meTo wonder if anyone had asked If she was even hungry2/20/24 (Source: Buckeye Surgeon)
Source: Buckeye Surgeon - February 20, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Beyond Ozempic: Why one size doesn ’t fit all in weight loss
I grew up in Birmingham, Alabama, which is generally associated with a diet of all fried food. Prior to medical school, I thought many adults around me would eventually succumb to a diagnosis of hypertension and diabetes since they didn’t appear to think either was a big deal. However, my medical education quickly revealed that
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Beyond Ozempic: Why one size doesn’t fit all in weight loss originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 19, 2024 Category: General Medicine Authors: Janese S. Laster, MD Tags: Conditions Obesity Source Type: blogs
Age-Related Changes in mTORC1-Related Nutrient Sensing Degrade Intestinal Stem Cell Function
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
Link: https://doi.org/10.1126/sciadv.adi2671 (Source: Fight Aging!)
Source: Fight Aging! - February 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 19th 2024
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 18, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Vitamin B12 Deficiency: A Troubling Facial Sign
As many as one-in-eight people could be low in vitamin B12. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 17, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Gut Microbiome Changes Correlate with Low Grip Strength in Older People
This study aimed to explore the metabolic mechanisms and potential biomarkers associated with declining HGS among older adults. We recruited 15 age- and environment-matched inpatients (age, 77-90 years) with low or normal HGS. Liquid chromatography-mass spectrometry (LC-MS) and 16S ribosomal DNA (rDNA) gene sequencing were performed to analyze the metabolome of serum and stool samples and the gut microbiome composition of stool samples. Spearman's correlation analysis was used to identify the potential serum and fecal metabolites associated with HGS.
We assessed the levels of serum and fecal metabolites belonging to...
Source: Fight Aging! - February 15, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Abdominal Fat Correlates with Cognitive Decline
This study investigated the association between abdominal adiposity at baseline and change in cognitive function in community-dwelling older adults using longitudinal data collected separately for men and women over 10 years. Cognitive function was evaluated biennially using the Mini-Mental State Examination (MMSE) over 10 years. Waist circumference (WC) was measured at the naval level, and subcutaneous fat area (SFA) and visceral fat area (VFA) were assessed using baseline computed tomography scans.
This study included 873 older adults. In men, the groups with the highest levels of WC, SFA, and VFA exhibited a grea...
Source: Fight Aging! - February 15, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cool Images: Radiant in Red
Happy Valentine’s Day! In place of red roses, we hope you’ll accept a bouquet of beautiful scientific images featuring rich, red hues. Be sure to click all the way through to see the festive protein flowing through your blood!
For more scientific photos, illustrations, and videos in all the colors of the rainbow, visit our image and video gallery.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 14, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Molecular Structures Cellular Imaging Cool Images Proteins Source Type: blogs
Best books on brain health and cognitive fitness according to ChatSpot and ChatGPT
Out of curiosity we queried a couple popular AI chatbots, ChatSpot and ChatGPT free versions, about the best books in a couple of key topics we discuss a lot in this blog. Here are the fascinating results, and some brief commentary at the end. (Links open corresponding Amazon book pages.)
Best books on brain health, per ChatSpot:
There are several great books on brain health that provide valuable insights and practical tips. Here are some highly recommended ones:
1. “The Brain That Changes Itself” by Norman Doidge: This book explores the concept of neuroplasticity and how the brain can rewire itself to overcome various...
Source: SharpBrains - February 14, 2024 Category: Neuroscience Authors: SharpBrains Tags: Books Education & Lifelong Learning brain-books Brain-Fitness brain-health-books ChatGPT ChatSpot cognitive-fitness cognitive-health-books neuroplasticity Source Type: blogs
The power of nutrition in cancer prevention
In its annual cancer statistics report released this week, the American Cancer Society (ACS) predicted over 2 million new cancer cases and over 600,000 cancer deaths in the United States in 2024. The ACS cites decreased smoking rates, earlier detection, and improved treatments as the primary reasons for decreased death rates from cancer in recent decades. Missing
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The power of nutrition in cancer prevention originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 13, 2024 Category: General Medicine Authors: Dr. Roxanne Becker Tags: Conditions Nutrition Source Type: blogs
Slash Your COVID Risk By 40% With This Simple Dietary Change (M)
Learn how your food choices could drastically reduce your chances of COVID infection. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - February 13, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: COVID19 subscribers-only Source Type: blogs
Now is a good time to reassess your medications with your clinician
Now that we are embarking on a new year, many of us take on annual resolutions with a focus on diet and exercise. Overlooked is another important way to improve our health: increasing awareness of our medications. Nearly 4 in 10 adults over the age of 65 living in the United States are prescribed five
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Now is a good time to reassess your medications with your clinician originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 12, 2024 Category: General Medicine Authors: Paula Rochon, MD, Jerry Gurwitz, MD, and Lisa McCarthy, PharmD Tags: Meds Geriatrics Source Type: blogs
Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people.
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Greater Individual Wealth Correlates with Longer Life Expectancy
https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/
Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
