Mechanisms for the Benefits to Long Term Vascular Health Provided by Exercise
The vascular system responds favorably to exercise at any age. A large portion of the benefits of exercise derive from improvements to vascular function throughout the body, and physical fitness can be maintained further into old age than most people believe to be the case. The flip side of this point is that a sizable fraction of the declines of later life are a matter of disuse, people living a more sedentary life than is optimal for the health and function of muscles, heart, and brain. These the most energy-hungry tissues and those that see the worst outcomes from a decline in vascular function and consequently reduced ...
Source: Fight Aging! - January 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 29th 2024
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 28, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Tour of Geroscience, Largely Focused on Unambitious Goals in the Treatment of Aging
Geroscience is a philosophy of development, suggesting that aging can be slowed and we should work towards means to do so. In practice, geroscience is, more or less, the the name given to that part of the research and development community that aims to produce means to alter metabolism to modestly slow aging. It is best represented by the development of supplements and repurposing of very well studied drugs, near all of which produce smaller benefits to long-term heath than regular moderate exercise, and none of which can match the benefits provided by the practice of calorie restriction. It is entirely unambitious. This l...
Source: Fight Aging! - January 26, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Interview with Andrew Steele on the Need for Advocacy for Aging Research
Those of us who have been involved in advocacy for aging research and the development of therapies to treat aging as a medical condition for long enough will remember the early 2000s, a time in which a million dollars of new funding for a specific project or specific non-profit was an amazing, novel, rare event. Given that $3 billion, a sizable fraction of all investment into all forms of medical biotech in 2022, was invested into one entity focused on one approach to the treatment of aging, Altos Labs, we might forgive advocates who think that the job is done, that the argument has been made and heard, that it is time to ...
Source: Fight Aging! - January 25, 2024 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
7 Things To Expect From AI In Healthcare This Year
The past year was all about artificial intelligence, with a particular focus on its integration into healthcare in our universe. At The Medical Futurist, we have extensively explored how AI is reshaping the healthcare landscape, outlining what to expect and how to prepare for these transformative changes.
As we move into 2024, it’s time to continue our forward-looking journey. This year promises to be a blend of consolidation and revolution. Some trends we’ve previously identified are beginning to solidify and integrate into the fabric of healthcare systems, while others are just starting to unfold.
In th...
Source: The Medical Futurist - January 25, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF AI AI in medicine artificial intelligence artificial intelligence in healthcare Source Type: blogs
What Do Fats Do in the Body?
It’s common knowledge that too much cholesterol and other fats can lead to disease and that a healthy diet involves watching how much fatty food we eat. However, our bodies need a certain amount of fat to function—and we can’t make it from scratch.
Hepatocytes, like the one shown here, are the most abundant type of cell in the human liver. One important role they play is producing bile, a liquid that aids in digesting fats. Credit: Donna Beer Stolz, University of Pittsburgh.
Triglycerides, cholesterol, and other essential fatty acids—the fats our bodies can’t make on their own—store energy, ins...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 24, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Common questions Source Type: blogs
10 Dietary Ways To Stop Cognitive Decline And Memory Loss
The latest research on dietary adjustments that could help to reduce memory loss and lower dementia risk and brain age. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 23, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Correlations Between Chronic Inflammation and Poverty and Raised Risk of Mortality
Researchers here report on an epidemiological analysis of the effects of relative poverty and chronic inflammation on health and life span. It is well known that socioeconomic status correlates with mortality and life expectancy. There is a great deal of debate over which of the numerous mechanisms potentially involved in this correlation contribute the largest share of the effect size. Separately, chronic inflammation is disruptive to tissue structure and function, increases with age, and is known to increase risk and accelerate progression of all of the common age-related fatal conditions. As one might expect, the povert...
Source: Fight Aging! - January 23, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 22nd 2024
In this study, we found that DMC reduced the SASP level in senescent cells. Furthermore, senescent cells enter irreversible cell cycle arrest, which involves the activation of p53/p21 and Rb/p16. In this study we found that the expression levels of p21 and p16 were decreased after DMC treatment. The downregulation of p21 may be attributed to the decrease of p53. In this study, we found that the mRNA level of p53 was reduced after DMC treatment.
Ferroptosis is an iron-dependent cell death process, which is accompanied by iron accumulation. Our previous study reported an important role of FECH, an enzyme inserts ferro...
Source: Fight Aging! - January 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How Your Eating Routine Could Reduce Heart Attack Risk By One-Third
Diet is not the only thing that can improve cardiovascular health, adopting this meal timing is also important. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 20, 2024 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Heart Disease Source Type: blogs
How To Approach Exercise in 2024
This article was reviewed by psychologist Fouad Monzer)
The post How To Approach Exercise in 2024 appeared first on Pick the Brain | Motivation and Self Improvement. (Source: PickTheBrain | Motivation and Self Improvement)
Source: PickTheBrain | Motivation and Self Improvement - January 19, 2024 Category: Consumer Health News Authors: Rayen Monzer Tags: featured health and fitness productivity tips exercise Source Type: blogs
OXR1 and Retromer Function in Aging
Researchers here employ a combination of genetic manipulation and calorie restriction in order to find mechanisms that might be important in aging. This leads them to retromer function, where the retromer is a complex system involved in recycling receptor proteins found in the cell membrane. Reduced retromer function leads to changes in cell behavior and survival that contribute to aging and disease. The gene OXR1 is necessary for retromer function, but its expression declines with age, suggesting it as a target for therapies to slow this aspect of age-related cellular dysfunction.
Dietary restriction (DR) delays ...
Source: Fight Aging! - January 19, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pretty Darned Near Absolutely Perfect Bagels
One of the challenges with making bread is that I want to bake more bread than my husband and I can eat. At best, it takes us a week to get through a loaf, slicing, freezing, thawing and toasting our slices one by one. When the sliced bread in the freezer piles up, I make breadcrumbs. Even with that, we still struggle to finish up what’s in the freezer before I want to bake bread again.
My reason for not eating as much bread as I make is that I’m always on a diet. This is not the issue for Mr TBTAM, who can eat as much bread as he wants and still weighs the same as he did the day I married him. But the brea...
Source: The Blog That Ate Manhattan - January 18, 2024 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Bread Breakfast Absolute Bagels Everything recipe Source Type: blogs
Ppp1r17 Upregulation in the Hypothalamus Slows the Aging of Metabolism in Mice
Researchers here describe a specific issue in the aging of metabolism connected to the activity of Ppp1r17 in the hypothalamus in the brain. This affects the sympathetic nervous system, leading to reduced innervation of fat tissue, which in turn negatively affects many tissues via altered availability of circulating nutrients, signal molecules, and the like. The researchers note a few points at which they can intervene to stop this decline, either Ppp1r17 in the brain, or the circulating molecule eNAMPT released by fat cells. The effect size on life span in mice is modest, and there is the remaining question of why this de...
Source: Fight Aging! - January 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chicken farming undergoes a radical shift: the rise of cell-cultivated meat
Following in his father’s footsteps, my son is a third-year medical student and by the time he completes his training, cell-cultivated chicken meat may be replacing meat from slaughtered birds. My home state of Alabama is one of the top chicken-producing states, but in the future, poultry production may take place in stainless steel tanks,
Read more…
Chicken farming undergoes a radical shift: the rise of cell-cultivated meat originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - January 16, 2024 Category: General Medicine Authors: R. Jason Newsom, MD, MPH Tags: Conditions Nutrition Source Type: blogs
