Considering the Non-Genomic Hallmarks of Aging
The Hallmarks of Aging were first published some years ago now, long enough to be expanded upon and much debated. The hallmarks are a list of characteristic changes in cell and tissue biochemistry noted to take place with advancing age, some of which are likely causes of age-related degeneration, some of which are likely downstream consequences, and all of which interact with one another. As often happens in such matters, the original hallmarks of aging drew from, and then eclipsed in terms of attention, the much earlier Strategies for Engineered Negligible Senescence (SENS) list of forms of cell and tissue damage that are...
Source: Fight Aging! - November 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
One Daily Serving Of This Food Slows Brain Aging By 11 Years
Eat up! They preserve your memory and thinking skills. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 13, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
How confident are clinicians to deliver pain self-management?
Over the past few weeks I’ve been talking about pain self management from many perspectives. It’s an important topic because most people living with pain will be self managing most of the time. Being able to confidently self manage leads to less disability, distress and lives that look like life, not some endless healthcare regime.
A paper by Penlington et al., (2023) explored confidence beliefs of clinicians working in the UK in primary or community settings prior to a training programme that was then delivered to them. The sample included in the survey is therefore a subset of those who might be expected t...
Source: HealthSkills Weblog - November 12, 2023 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Coping Skills Coping strategies Pain conditions Research Science in practice Health healthcare pain management Therapeutic approaches Source Type: blogs
AI and special needs adults: The AI Guardian is in sight
Over the past decade I ' ve written on social media about the concept of an AI Guardian, but I realize I ' ve never put it into a blog post [4]. With the release of the LLM AIs [1] including ChatGP4,ChatGPT plugins, and recentlyGPT Agents (GPTs) the AI Guardian is much closer than I ' d expected. So it ' s time to write something.First, of course, I decided to ask ChatGPT. I ' ve never seen the concept of an AI Guardian online, but evidently I ' ve been looking in the wrong places. As of its April 2023 incarnationChatGPT4 has quite a bit to say:You: What do you know about the concept of an " AI Guardian " for sp...
Source: Be the Best You can Be - November 11, 2023 Category: Disability Tags: autism cognition cognitive impairment computer finance nsAI smartphone smartphone4all sport support technology Source Type: blogs
Rosuvastatin or Atorvastatin , Which is good and safe ?
Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry.
Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically establishe...
Source: Dr.S.Venkatesan MD - November 10, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs
Will the AMA Support A Move Toward Single Payer Health Care?
By MIKE MAGEE
The Politico headline in 2019 declared dramatically, “The Most Powerful Activist in America is Dying.” This week, 4 1/2 years later, their prophecy came true, as activist Ady Barkan succumbed at age 39 to ALS leaving behind his vibrant wife, English professor, Rachael King, and two small children, Carl,7, and Willow,3.
His journey, as one of the nation’s leading activists for a single-payer health care system began, not coincidentally, began with his diagnosis of A.L.S. in 2016, 4 months after the birth of his first child. His speech at the Democratic National Convention fully exposed his conditio...
Source: The Health Care Blog - November 8, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Ady Barkan AMA Mike Magee Single payer Source Type: blogs
3D Printing In Medicine And Healthcare – The Ultimate List
3D printing has demonstrated huge potential for the future of medicine in the previous years, and its development is unstoppable. See the impressive list of 3D-printed healthcare materials and medical equipment below!
How does 3D printing in medicine work?
3D printing in medicine is part of the innovative process called additive manufacturing, which means producing three-dimensional solid objects from a digital file. How the technology works, we explained in our article on bioprinting here.
As technology evolves, researchers work on various solutions. For example, engineers from the University of Buffalo have ...
Source: The Medical Futurist - November 7, 2023 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Biotechnology Future of Medicine Healthcare Design Medical Education Personalized Medicine 3d printed biomaterial tissue engineering Video bioprinting GC1 Innovation Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
...
Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Worrying Mental Sign Of Vitamin D Deficiency
Vitamin D may be linked to critical neurotransmitters and inflammatory markers. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 3, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Depression Nutrition Source Type: blogs
Evidence for Menopause in Wild Chimpanzees
Few mammalian species exhibit menopause. It is thought that humans evolved into this state of post-reproductive old age in part because older individuals can help to enhance the reproductive fitness of their direct offspring. This view is known as the "grandmother hypothesis". The same behavior is observed in orcas, one of the few other mammals to exhibit menopause. Researchers here provide evidence for chimpanzees to undergo menopause, which is a strike against the grandmother hypothesis, as chimpanzee elders do not assist their offspring in this way.
A team of researchers studying the Ngogo community of wild chi...
Source: Fight Aging! - November 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Vitamin B12 Deficiency: The Facial Sign That May Be A Symptom
Around one-in-four people may have a vitamin B12 deficiency. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - November 1, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Lung Chip Mimics Radiation Injury
Researchers at the Wyss Institute at Harvard University have developed a microfluidic chip that can recreate some of the features of radiation-induced lung injury. The lungs are very sensitive to radiation, and this can limit the application of radiotherapy to treat cancer. Accurately modeling radiation-induced lung injury could assist in developing new methods to prevent and treat the phenomenon, but it has been difficult to study this before the advent of advanced organ-on-a-chip models. The lung chip presented here contains human lung alveolar epithelial cells interfacing with lung capillary cells. The goal is to recrea...
Source: Medgadget - November 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Radiation Oncology harvard wyssinstitute Source Type: blogs
Why Do Cells Die?
You might know that tiny individual units called cells make up your body. But did you know some of your cells die every day as a part of their normal life cycle? These deaths are balanced by other cells splitting into two identical cells, a process called mitosis.
A confocal microscope films two cells: The cell on the left undergoes a type of cell death called apoptosis, and the one on the right undergoes mitosis. Credit: Dr. Dylan Burnette, Vanderbilt University School of Medicine.
Regulated Cell Death
For the most part, cells die in a controlled way in response to specific signals that tell them to. The cell ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - November 1, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Cellular Processes Common questions Source Type: blogs
Reviewing the Role of Insulin in Aging
The relationship between insulin metabolism and aging is one of the most studied areas of the field, with decades of researchers putting in time to deepen the understanding of the web of interactions surrounding insulin. Yet this has failed to lead to any practical outcome when it comes to slowing or reversing aging. Researchers now have an incrementally better idea as to why obesity, metabolic syndrome, and type 2 diabetes shorten life and worsen health, but that was well understood to be the case well prior to the advent of modern biotechnology.
Experimental studies in animal models of aging such as nematodes, f...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
