Rosuvastatin or Atorvastatin , Which is good and safe ?

Statins belong to a group of drugs, stolen and reengineered from the blueprint of natural Chinese red yeast rice (Monocoline K) in the late 1980s. The rest is the remarkable history in the pharma industry. Statins directly interrupt the cholesterol synthesis by blocking HMG-CoA within the hepatocytes. It significantly lowers the LDL, fights human vascular atherosclerosis. It makes the plaque either regress, prevent progress, make it harder and in the process make them less vulnerable . There are innumerable studies that document the evidence. Statin has become a must-prescribe drug in any one with clinically established CAD or even in concealed CAD. Guidelines are available to prescribe statins various intensity, depending on the risk profile. Which statin ? There has been a long list of statins. Many of them have retired from the ring .Currently, the fight is between Atorvastatin, a Rosuvastatin. Like Pepsi vs. Coke. Note the graphic ,A meteoric rise of one drug since 2005 . (Can you guess the reason ?) ATRORVA or ROSUVA Which one should I choose ? There is very little “one to one” comparison study between Rosuvastatin and Atorvastatin .The gap in the pros and cons are narrow. Following points are observed, without much dispute. 1.Rosuvaststin is more powerful. 2.Plaque stabilisation effect is not different((Satrun, study NEJM 2011 based on IVUS) 3.New onset diabetic risk is more likely with Rosuvastatin 4.Worsening of catarac...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: Uncategorized acc aha atorvastatin vs rosuvastatin avert study bmj esc jamanetwork lancet lipid association lodestar study lodestar trial bmj nejm saturn trial simvastatin statins which statin superior Source Type: blogs