Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Breaking free from sugar addiction: Why cold turkey doesn ’ t work
We know how dangerous sugar can be to our health. Excess sugar intake has been linked to cardiovascular disease, diabetes, and even our immune system health. But giving it up is easier said than done. One question that people often have is, “Do I have to completely give up sugar, like, all of it? Cold
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Breaking free from sugar addiction: Why cold turkey doesn’t work originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 2, 2024 Category: General Medicine Authors: Nicole Avena Tags: Conditions Nutrition Source Type: blogs
This Is The Effect Of Sugar On Your Brain ’ s Memory Centres (M)
The sweet enemy of memory lurking in your diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - March 2, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia subscribers-only Source Type: blogs
Answer to Case 739
Answer toParasite Case of the Week 739:Loa loamicrofilariaeThanks to everyone who wrote in with comments. We received a lot of different responses including some of the sheathed and unsheathed microfilariae. Therefore, this is a great time to review my approach to identifying microfilariae in blood specimens. You can also readthis articleI wrote with Blaine Mathison and Marc Couturier that provides a diagnostic algorithm for microfilariae in blood. In this algorithm, we recommend first measuring the length of the microfilariae. If they are small (<200 micrometers long), then it is likely to be one of theMansonella...
Source: Creepy Dreadful Wonderful Parasites - March 2, 2024 Category: Parasitology Source Type: blogs
Mitochondrial Uncoupler BAM15 Modestly Extends Life in Flies
In conclusion, BAM15-mediated restriction of bioenergetic efficiency prolongs life span and health span in Drosophila fed a ND or HFD. Improvements in life span and health span in ND were supported by synergistic enhancement of muscular redox capacity.
Link: https://doi.org/10.1111/acel.14107 (Source: Fight Aging!)
Source: Fight Aging! - February 29, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What Does Virtual First Mean In Healthcare?
In recent years, the term “virtual first” has been gaining traction in the healthcare space. Health insurance companies have been adopting such approaches and there’s even the IMPACT consortium from the Digital Medicine Society that was formed to support virtual first initiatives.
However, the novelty of the concept and similarities with terms such as “telehealth” or “virtual visits” indicate the need for a proper introduction. This is what we aim to do with this article that gets us acquainted with the concept, compares it with other similar approaches and considers some of its challenges.
What i...
Source: The Medical Futurist - February 29, 2024 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF virtual-first healthcare virtual first hybrid care Source Type: blogs
The Gut Microbiome and Alzheimer's Disease
The balance of microbial populations making up the gut microbiome changes with age, both a loss of microbes generating beneficial metabolites and an increase in the number of inflammatory microbes. Separately from this harmful process, a number of studies have shown that that aged gut microbiome is distinctly different in patients with Alzheimer's disease, suggesting that there may be a meaningful contribution to disease onset and progression arising from the gut. The precise mechanisms involved have yet to be identified. While inflammation has an important role in Alzheimer's disease, the contribution of an Alzheimer's-li...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Repeated Cycles of a Fasting-Mimicking Diet Reduce Measures of Biological Age
We report on the secondary outcome measures of the FMD-trial (NCT02158897) which are biomarkers associated with aging or age-related diseases, and metabolic syndrome, including visceral and hepatic fat, lymphoid/myeloid ratios, and blood markers, which were not investigated in the original report.
We show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging), and increased lymphoid to myeloid ratio, an indicator of immune system age. Based on the Klemera-Doubal measure of biological a...
Source: Fight Aging! - February 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why Flight Emergency Medical Kits Need A Digital Health Upgrade
A few weeks ago a doctor used an Apple Watch to aid an elderly woman who suffered a medical emergency on a flight. NHS doctor Rashid Riaz, from Hereford, borrowed the device from a flight attendant to check the patient’s oxygen levels.
“The Apple Watch helped me find out the patient had low oxygen saturation,” the medic explained. Later, he also called on all airlines to consider having emergency physician kits as standard, which would ideally include tools to take basic measurements, diabetic and blood pressure meters, and an oxygen saturation monitor.
We all know that aircraft have some medical su...
Source: The Medical Futurist - February 27, 2024 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Health Sensors & Trackers portable diagnostics emergency medicine Healthcare technology flight medicine wearables Source Type: blogs
Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way that can be compensated for by adding more leucine to the diet. Whether this actually works is a matter for debate; the evidence is mixed. The question is never whether the mechanism exists, the question is whether it has a large enough effect size to matter.
Given this impetus for a greater intake of dietary leucine in later life, it is interesting to see the re...
Source: Fight Aging! - February 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 26th 2024
In conclusion, mTORC1 signaling contributes to the ISC fate decision, enabling regional control of intestinal cell differentiation in response to nutrition.
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Reviewing the Development of Senotherapeutics to Treat Aging
https://www.fightaging.org/archives/2024/02/reviewing-the-development-of-senotherapeutics-to-treat-aging/
Senescent cells accumulate with age and contribute meaningfully to chronic inflammation and degenerative aging. Destroying these cells produces rapid and sizable reversal of age-related diseases in mice, demonstrating that the presence of senescence cells ...
Source: Fight Aging! - February 25, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Going beyond the usual advice for eating healthy [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join Francisco M. Torres, an interventional physiatrist. As the author of Dr. T’s Drop the Fat Diet: 12 Steps to Leaner You Forever, Dr. Torres shares invaluable findings from recent clinical studies, revealing which diets truly enhance longevity. Discover the secrets
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Going beyond the usual advice for eating healthy [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 25, 2024 Category: General Medicine Authors: The Podcast by KevinMD Tags: Podcast Obesity Source Type: blogs
Digital Health, Menopause, And The $150 Billion Ignorance
The idea of this story came from personal experience. During the past year, I have spent countless hours and a bucketload of money trying to figure out what the heck is wrong with my health. I was feeling worse and worse, having various symptoms, totally inexplicable with my impeccable test results. During this journey, not a single doctor asked or suggested that my symptoms may come from entering perimenopause – the stage of life of women preceding menopause.
I am 47 years old, and as I have learned since then, extremely average in starting to have perimenopause symptoms at the age of 47. Also very average ...
Source: The Medical Futurist - February 22, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF Lifestyle medicine female health menopause tech Source Type: blogs
A Popular Science View of Recent Thinking on DNA Damage as a Cause of Aging
There are presently two views of the way in which stochastic DNA damage can contribute to aging. Most DNA damage occurs in inactive genes in cells that will not replicate many more times, and thus cannot possibly produce systemic consequences throughout large regions of the body. The first argument for a way in which random DNA damage can produce a broader effect is via somatic mosaicism, in which mutational damage occurs in stem cells, allowing those mutations to spread throughout tissue over time. It is unclear as to how to measure the contribution of this process to age-related loss of function, however, and its contrib...
Source: Fight Aging! - February 21, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Test results!
Hi everyone! Oh dear, I’ve been gone for quite some time, haven’t I? Life really does get in the way of plans sometimes.
In this period, in addition to being super busy with a million other things, I’ve been focusing on getting my arthritic knee in shape. There’s no going back to the knee I had in my 20s, of course, but I can try at least to stop it from getting worse, mainly with physiotherapy. Okay, but enough about my knee….that’s not the reason I’ve written this post…
Today I have some good news that I’d like to share with you…
Here’s the news: I just...
Source: Margaret's Corner - February 21, 2024 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll boswellia curcumin osteoarthritis Source Type: blogs
