The Intermittent Fasting Diet That Most People Can Stick To
The hours of fasting suitable for most people who want to lose weight but keep their energy and mood high. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 5, 2023 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Weight Loss Source Type: blogs
Muscle TFEB Overexpression Slows Cognitive Aging in Mice
Muscle tissue is metabolically active, and affects the operation of other organs. At this time, a good map of the important signals that pass between muscle and other tissues has yet to be created. Maintenance of muscle mass and function in later life clearly produces a more systemic benefit than simply postponing weakness and frailty, but the details of the biochemistry are not well understood. Thus researchers can perform muscle-specific interventions in animal models, such as the one noted here, show a slowing of cognitive aging to result from that intervention, but not have a good grasp of how exactly how the altered m...
Source: Fight Aging! - December 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
The Common Signs Of Vitamin D Deficiency
Vitamin D deficiency is more common in winter. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - December 4, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Effects of Diet on Life Expectancy
It is somewhat interesting to see a careful analysis of diet and life expectancy, using the sizable UK Biobank population, that does not contain any of the words "calorie", "weight", or "obesity". The effects of calorie intake on health over the long-term are sizable, even if we focus only on mechanisms associated with the gain of weight. Visceral fat is metabolically active, generates an increased burden of senescent cells, and contributes to the chronic inflammation of aging via a range of different mechanisms.
Thus one would assume that buried underneath this set of data on what it is that people eat is a more re...
Source: Fight Aging! - December 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Why is the National Academies Appointing Alcohol-Industry Funded Researchers to Serve on Panel to Review the Health Effects of Alcohol?
In conclusion, there is no doubt that Dr. Mukamal should be removed from the National Academies panel in order to preserve the integrity of both the panel and of the National Academies itself.Although Dr. Rimm was not involved in the solicitation of funding, he didserve as a principal investigator of the MACH trial. Thus, he has been funded by the alcohol industry and this conflict of interest should disqualify him from participating in, much less chairing the panel. Dr. Rimmshould be removed from the National Academies panel in order to
preserve the integrity of both the panel and of the National Academies
itself.T...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - November 30, 2023 Category: Addiction Source Type: blogs
What Do We Need To Have AI-Equipped Nanobots In Medicine
Disease, noun [archaic]: A historical term used to describe various physical and mental ailments that affected organisms, primarily humans, in an era before the advent of comprehensive nanomedical and genetic interventions. In the technologically primitive past, diseases were common causes of discomfort, dysfunction, and mortality, often requiring medical treatment and care. Modern advances and nanobots in medicine have rendered this term obsolete, as conditions previously classified as diseases are now either preventable or entirely curable at the molecular level.
Are we on the brink of a brave new world where disease...
Source: The Medical Futurist - November 30, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Nanotechnology nanobots nanobots in medicine AI Source Type: blogs
Assessing Markers of Cellular Senescence in the CALERIE Study of Calorie Restriction
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice. (Source: Fight Aging!)
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Using Explainable AI in the Production of Biological Age Measures
Standard approaches to generating aging clocks from biological data produce algorithmic combinations of factors that are opaque. It is entirely unclear as to how they relate to underlying mechanisms of damage and dysfunction that produce degenerative aging, and thus hard to use them as a tool to assess ways to modify those mechanisms. Explainable artificial intelligence is a term of art used to describe approaches to machine learning that produce more insight into how the final product actually works, what factors went into its construction, how it relates to underlying processes. Given that the primary challenge in the fi...
Source: Fight Aging! - November 28, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
SEMCAP Health Continues Strategic Investment in SafeRide Health and Secures Memorial Hermann Health System Co-Investment
Recent Series C Financing of Leading Non-Emergency Medical Transportation Platform Fuels Rapid National Expansion
SEMCAP Health announces its continued support of portfolio company, SafeRide Health, with participation in the company’s recently announced Series C funding. This follows SEMCAP Health’s November 2021 initial investment in SafeRide Health, the leading network optimization platform for Non-Emergency Medical Transportation (NEMT). SafeRide Health’s ability to improve member experience and reduce costs for Medicaid and Medicare Advantage beneficiaries also attracted a strategic investment from Memorial Herm...
Source: EMR and HIPAA - November 27, 2023 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Feby Abraham Health IT Funding Health IT Fundings Health IT Investment Memorial Hermann Memorial Hermann Health System Ralph Muller Robbins Schrader SafeRide Health SEMCAP SEMCAP Health Vic Kats Source Type: blogs
How Patient Activation Made It Possible to Thrive with Kidney Disease
By DAVE WHITE
It had been 10 years since I’d seen a doctor when I arrived at the Emergency Room at George Washington University Hospital in October 2009. I was able to climb the first flight of stairs, but after I froze on the second, they brought me in on a wheelchair.
That was the first time I heard the dreaded words, “Your kidneys aren’t working.” I was put on dialysis immediately, and my life transformed into a series of tests and procedures. But even after three weeks at the hospital, it didn’t sink in that there was no cure.
I checked most risk factors for kidney disease: I ate the wrong foods, smo...
Source: The Health Care Blog - November 27, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Policy chronic kidney disease Dave White Patient Activation Measure Patient Activism patient advocacy Source Type: blogs
Learning from Laron Syndrome
The longest lived mice are still those engineered to lack functional growth hormone or growth hormone receptor. That record was established more than 20 years ago, and remains in place even as an energetic research and development community focused on treating aging as a medical condition has come into being. In part this is the case because research has largely focused on approaches known to produce lesser effects on aging in mice, such as the discovery of small molecules that mimic portions of the calorie restriction response. In part it is because the pace of development in the life sciences is ever slower than we would...
Source: Fight Aging! - November 23, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
An Aging Clock Derived from Images of the Lens of the Eye
In this study, we used informative lens photographs to generate LensAge as an innovative indicator to reveal aging status of lens based on deep learning (DL) models. Under ideal physiological conditions (both genetic and environmental), biological age should be synchronized with chronological age. While in reality, there are almost always differences between biological age and chronological age, which is considered to result from individually different aging processes. Therefore, we measured the difference between LensAge and chronological age as the LensAge index to assess an individual's aging rate relative to peers, and...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Assessing Pentadecanoic Acid In Vitro
The work on pentadecanoic acid noted here is interesting, but should be taken with a grain of salt given that it is performed in vitro. In general, one should expect any given set of mechanisms in the cell to be associated with many different means of manipulation. It is interesting to see a fatty acid capable of touching on the same mechanisms as rapamycin, but remember that the ability to influence the same mechanistic targets does not necessarily translate to the same ability to produce a modest slowing of aging in animal studies. So the usual advice stands here, to wait for the animal studies before getting too excited...
Source: Fight Aging! - November 22, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
