mTORC1 Inhibition in Neurons Only Extends Life in Nematode Worms
General inhibition of mTOR slows aging, a calorie restriction mimetic effect, but comes with a range of side-effects, given that mTOR is a regulator of growth and development. mTOR forms two different protein complexes, mTORC1 and mTORC2. In recent years, work to produce drugs based on mTOR inhibition has focused on selectively inhibiting mTORC1 in order to reduce side-effects. Researchers here report further reduction in side-effects in short-lived nematode worms by restricting mTORC1 inhibition to neurons only.
mTORC1 (mechanistic target of rapamycin complex 1) is a metabolic sensor that promotes growth when nut...
Source: Fight Aging! - October 6, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
What is the physician ’ s role in the food is medicine movement?
In the early 1990s, complementary and alternative medicine (CAM) began its rise with the development of the National Institutes of Health’s CAM center. However, scientists and clinicians struggled with the decision of whether or not to allow individuals access to information on these CAM approaches. I was part of that discourse as I was invited
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What is the physician’s role in the food is medicine movement? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - October 4, 2023 Category: General Medicine Authors: Deb Kennedy, PhD Tags: Conditions Nutrition Source Type: blogs
3 Common Diets Compared: One Doubles Weight Loss
People in the study lost an average of nine pounds using the diet. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - October 3, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
An Estrogen-Related Receptor Agonist Exercise Mimetic Performs Well in Mice
Researchers here demonstrate in mice an effective approach to mimicking some of the adaptive responses to exercise, and sustaining those responses over time. Exercise mimetics have undergone a sedate pace of development in comparison to the larger body of work on calorie restriction mimetics, intended to mimick some of the sweeping changes to metabolism that occur at low nutrient levels, and the field isn't yet as well established. Still, some interesting lines of work have emerged, such as the program noted here.
The new drug, known as SLU-PP-332, doesn't affect appetite or food intake. Nor does it cause mice to ...
Source: Fight Aging! - October 3, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Malnutrition Can Impact Wound Healing
Malnutrition can have a significant impact on wound healing. Proper wound healing is a complex process that involves various cellular and biochemical reactions. When the body is malnourished, it lacks the essential nutrients necessary for these processes, which can lead to delayed or impaired wound healing. Here are some key relationships between malnutrition and wound healing:
1. Protein Deficiency: Protein is crucial for tissue repair and the production of collagen, which is essential for wound healing. Malnourishment, especially a lack of adequate protein intake, can lead to a delay in wound closure and reduced tensile ...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - October 2, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Improving Medical Care Jeff Levine MD J Source Type: blogs
A Outsider's Popular Science View of the Longevity Industry and Academia
A brace of popular science articles on aging research were recently published at the Economist. Like many of these views from a distance written by journalists on the outside, peering into the field, one must assume that its existence is largely the result of the sizable investments made over the last two years into the development of therapies based on partial reprogramming. The Altos Labs funding in particular represented a meaningful fraction of all investment into biotech made that year. That tends to attract attention. From there, an investigator would notice an additional broad focus on cellular senescence, many comp...
Source: Fight Aging! - October 2, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Continued Study of Urolithin A to Improve Mitochondrial Function
Urolithin A is one of a number of compounds available as supplements that can improve mitochondrial function in older individuals. Like others, urolithin A may function by improving the mitochondrial quality control process of mitophagy, responsible for removing damaged and worn mitochondria. Mitophagy becomes less efficient with age, and this is one of the contributing factors to age-related loss of mitochondrial function and its harmful impact on tissues. Like other supplement based approaches to improving mitochondrial function, it is likely that regular exercise delivers larger gains than those demonstrated for supplem...
Source: Fight Aging! - October 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Refillable Device for Drug Delivery Past the Blood-Brain Barrier: Interview with Mike Maglin, CEO at CraniUS
CraniUS, a medtech company based in Baltimore, has developed the NeuroPASS drug delivery system. The technology is designed to deliver drugs to the brain, and it can bypass the blood-brain barrier. This layer of specialized endothelium significantly restricts which drug molecules can enter the brain, normally greatly limiting treatment options for patients with brain-based disease.
The NeuroPASS device is implanted into the skull, where it sits under the scalp. The device inserts catheters into the brain tissue which allow for controlled infusions of drug when required. The implant can be easily refilled from outside, a...
Source: Medgadget - September 29, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Medicine Neurology Neurosurgery Oncology Source Type: blogs
WHO Report: Tackling Hypertension Could Avert 76M Deaths Globally
Conclusion
Hypertension, often referred to as the “silent killer,” isn’t just a mere health term; it’s a pressing global challenge with vast implications.
As the World Health Organization’s report underscores, controlling high blood pressure is more than a matter of personal health. It’s about potentially averting millions of deaths worldwide by 2050.
It’s heartening to see countries like Canada and South Korea lead the charge with effective treatment programs, offering hope and a pathway for others to follow.
Yet, the contrasting statistics on sodium intake and the p...
Source: The EMT Spot - September 26, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: News Source Type: blogs
A Certain Type of Media Outlet that Chooses to Generate Confusion About Longevity Science
There is a certain type of media entity and journalist that really only cares about name dropping the wealthy and the famous, and has absolutely no interest in accuracy, education, understanding, factual conveyance of information, all of those pleasant things that make the world turn. Thus there will continue to be articles about ongoing intitiatives relating to aging, such as the one I'll reluctantly point out today, that are abysmal. This sort of article is abysmal because it actively, willfully conflates a whole set of very different activities with very different merits under one heading, while appealing to lowest comm...
Source: Fight Aging! - September 25, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Wound Bed Preparation is a Crucial Strategy to Heal Chronic Wounds
There are dozens of wound care products available, and the practitioner is often overwhelmed and confused by the variety of choices. The best way to choose the correct product is understanding the concept of wound bed preparation – a crucial aspect of wound care that creates a systematic approach to an optimal strategy for wound healing. It encompasses various actions to facilitate the healing process by addressing the condition of the wound bed. Wound bed preparation helps reduce the risk of infection, promotes tissue regeneration, and accelerates the healing process. The following 9 steps are key considerations i...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - September 24, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care Risk Management aging skin bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Healthcare Quality Improvin Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Preventing Burnout: Self-Care Practices for Client Wellbeing
Understanding and addressing burnout has become imperative for maintaining mental health in today's fast-paced world. This guide empowers individuals with tools and strategies to prevent burnout and cultivate a balanced life. Delve into the science of burnout, discover the pivotal role of self-care, and equip yourself with practical techniques to achieve optimal Well-being.
The Science of Burnout
Unveiling the psychology behind burnout entails exploring its familiar signs and symptoms and comprehending the profound toll it can take on mental, physical, and emotional well-being. Recognizing these indicators is the fir...
Source: PickTheBrain | Motivation and Self Improvement - September 22, 2023 Category: Consumer Health News Authors: Erin Falconer Tags: career featured psychology self-improvement burnout self care Source Type: blogs
A Proven Sign Of Vitamin B12 Deficiency
Around one-quarter of people may have a vitamin B12 deficiency. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - September 21, 2023 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
