Abdominal Fat Correlates with Cognitive Decline

This study investigated the association between abdominal adiposity at baseline and change in cognitive function in community-dwelling older adults using longitudinal data collected separately for men and women over 10 years. Cognitive function was evaluated biennially using the Mini-Mental State Examination (MMSE) over 10 years. Waist circumference (WC) was measured at the naval level, and subcutaneous fat area (SFA) and visceral fat area (VFA) were assessed using baseline computed tomography scans. This study included 873 older adults. In men, the groups with the highest levels of WC, SFA, and VFA exhibited a greater decline in MMSE score than the groups with the lowest levels, with standardized coefficient β: WC, -0.12; SFA, -0.13; VFA, -0.11. In women, the group with the highest level of WC and SFA showed a greater decline in MMSE score than the group with the lowest level, with β: WC, -0.12; SFA, -0.18), but VFA was not associated with cognitive decline. Link: https://doi.org/10.1016/j.jnha.2024.100175
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