Existing Geroprotective Drugs May Not Interact Well with Exercise

The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individually modestly slow aging is often instead a modest reduction in healthspan or life span. This is one of the many reasons as to why I favor the development of therapies to repair the underlying cell and tissue damage of aging, treatments that can be applied once for lasting benefit, and which produce actual rejuvenation, a reversing of the progression of aging. These therapies would not need to be continuously applied, and instead be used very intermittently. We should expect such a repair therapy that targets one form of damage to have little interaction with other repair-based therapies that targeting other forms of damage. Every such therapy should hence provide an incremental benefit. Demonstrating that to be the case is in fact the present focus of the LEV Foundation. Exercise, or rather the maintenance of physical fitness, is an interventio...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs