Collaborative Modeling to Compare Different Breast Cancer Screening Strategies: A Decision Analysis for the US Preventive Services Task Force
CONCLUSIONS: This modeling analysis suggests that biennial mammography screening starting at age 40 years reduces breast cancer mortality and increases life-years gained per mammogram. More intensive screening for women with greater risk of breast cancer diagnosis or death can maintain similar benefit-to-harm trade-offs and reduce mortality disparities.PMID:38687505 | DOI:10.1001/jama.2023.24766 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Amy Trentham-Dietz Christina Hunter Chapman Jinani Jayasekera Kathryn P Lowry Brandy M Heckman-Stoddard John M Hampton Jennifer L Caswell-Jin Ronald E Gangnon Ying Lu Hui Huang Sarah Stein Liyang Sun Eugenio J Gil Quessep Yuanliang Yang Yifan Lu Juhee Son Source Type: research
Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome
This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]-10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-P...
Source: Oncology Research - April 30, 2024 Category: Cancer & Oncology Authors: Jingjing Chen Dan Wang Zequn Wang Mengyuan Han Houqing Yin Wenting Zhou Ribai Yan Yan Pan Source Type: research
Association of the bitter taste genes TAS2R38 and CA6 and breast cancer risk; a case-control study of Polish women in Poland and Polish immigrants in USA
In conclusion for the joint population and the joint effect for the two bitter sensing genes, we observed an increase in BC risk for the bitterness non-tasters, association which is in the opposite direction to our original hypothesis.PMID:38687739 | DOI:10.1371/journal.pone.0300061 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Dorota Łukasiewicz-Śmietańska Dariusz Godlewski El żbieta Nowakowska Andrzej Szpak El żbieta Chabros Grzegorz Juszczyk Jadwiga Charzewska Dorothy Rybaczyk-Pathak Source Type: research
The association between dietary fiber intake and gastric cancer: a pooled analysis of 11 case-control studies
CONCLUSION: Our analysis supports the hypothesis that dietary fiber intake may exert a protective effect on GC.PMID:38687390 | DOI:10.1007/s00394-024-03388-w (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Giulia Collatuzzo Jacqueline Cortez Lainez Claudio Pelucchi Eva Negri Rossella Bonzi Domenico Palli Monica Ferraroni Zuo-Feng Zhang Guo-Pei Yu Nuno Lunet Samantha Morais Lizbeth L ópez-Carrillo David Zaridze Dmitry Maximovitch Marcela Guevara Vanessa San Source Type: research
Determinants of early-onset colorectal cancer: a multicenter case-control study in Iran
CONCLUSION: Early-onset CRC was related to the intake of vegetables, vitamin D and red meat in Iran. Early-onset rectum cancer was associated with regular opium use. Family history was associated with early CRC and early rectum cancer, particularly below the age of 35.PMID:38687254 | DOI:10.1097/CEJ.0000000000000888 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Giulia Collatuzzo Monireh Sadat Seyyedsalehi Hamideh Rashidian Maryam Hadji Roya Safari-Faramani Abbas Rezaianzadeh Reza Malekzadeh Kazem Zendehdel Paolo Boffetta Source Type: research
HEBE project: Healthy aging versus inflamm-aging: The role of physical exercise in modulating the biomarkers of age-associated and environmentally determined chronic diseases, study protocol
PLoS One. 2024 Apr 30;19(4):e0300011. doi: 10.1371/journal.pone.0300011. eCollection 2024.ABSTRACTInflamm-aging refers to the chronic low-grade inflammation that occurs with aging and cellular senescence, and it is linked to various diseases. Understanding the markers involved in inflammation and aging, as well as their interaction with environmental factors and bodily control mechanisms, can provide crucial tools for assessing the resilience (i.e. the ability to adapt and improve) of the human body, particularly in the presence of chronic degenerative conditions or vulnerable life stages, that place the individual and the...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Francesca Bianchi Elia Mario Biganzoli Valentina Bollati Mario Clerici Daniela Lucini Chiara Mand ò Federica Rota HEBE Consortium Source Type: research
Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome
This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]-10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-P...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jingjing Chen Dan Wang Zequn Wang Mengyuan Han Houqing Yin Wenting Zhou Ribai Yan Yan Pan Source Type: research
Antiglycating Effects of Spirulina platensis Aqueous Extract on Glucose-Induced Glycation of Bovine Serum Albumin
This study investigates the interaction between glucose and Bovine Serum Albumin (BSA), along with the protective effects of Spirulina platensis PCC 7345 aqueous extract. Phycobiliproteins (phycocyanin, phycoerythrin, and allophycocyanin) in the extract were quantified using spectrophotometry. The extract's anti-glycation potential was assessed by analyzing its effects on albumin glycation, fluorescent advanced glycation end products (AGEs), thiol group oxidation, and β-amyloid structure generation. Additionally, its antidiabetic potential was evaluated by measuring α-amylase and α-glucosidase enzyme inhibition. Results...
Source: Chemistry and Biodiversity - April 30, 2024 Category: Biochemistry Authors: Additiya Paramanya Abeeb Oyesiji Abiodun Mohammad Shamsul Ola Ahmad Ali Source Type: research
Vitamin A - a scoping review for Nordic nutrition Recommendations 2023
In conclusion, there were limited new outcomes-based data for vitamin A and health outcomes.PMID:38686175 | PMC:PMC11057411 | DOI:10.29219/fnr.v67.10229 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 30, 2024 Category: Nutrition Authors: Thomas Olsen Ulf H Lerner Source Type: research
Vitamin A - a scoping review for Nordic nutrition Recommendations 2023
In conclusion, there were limited new outcomes-based data for vitamin A and health outcomes.PMID:38686175 | PMC:PMC11057411 | DOI:10.29219/fnr.v67.10229 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 30, 2024 Category: Nutrition Authors: Thomas Olsen Ulf H Lerner Source Type: research
The underrated role of psychosocial determinants of dietary choices
Int J Food Sci Nutr. 2024 Apr 30:1-2. doi: 10.1080/09637486.2024.2345691. Online ahead of print.NO ABSTRACTPMID:38686674 | DOI:10.1080/09637486.2024.2345691 (Source: International Journal of Food Sciences and Nutrition)
Source: International Journal of Food Sciences and Nutrition - April 30, 2024 Category: Nutrition Authors: Giuseppe Grosso Source Type: research
Screening of the effective sites of Cichorium glandulosum against hyperuricemia combined with hyperlipidemia and its network pharmacology analysis
This study aims to explore the pharmacological effects and mechanisms of Cichorium glandulosum on this comorbidity through a combination of animal experiments, network pharmacology, and molecular docking techniques. A rat model of hyperuricaemia combined with hyperlipidaemia was established through a high-fat and high-purine diet, and the effective parts of the aqueous extract of Cichorium glandulosum to reduce uric acid and lipid levels were screened and the components of the parts were analysed by LC-MS/MS. The active components, core targets, and key pathways were analysed using network pharmacology and validated by mol...
Source: Computational Biology and Chemistry - April 30, 2024 Category: Bioinformatics Authors: Zhiguo Yang Bo Lyu Bin Ma Yuefeng Gao Dongmei Qin Source Type: research
Combined effect of freshwater salinization and harmful algae on the benthic invertebrate Chironomus pallidivittatus
This study simultaneously examined the joint toxicity of salinity and different cyanobacterial diets on the behavior, development, select biomarkers, and partial life cycle of Chironomus pallidivittatus (Diptera). High concentrations of salts (e.g., 1 g/L Ca2+ and Mg2+) and toxic Microcystis had synergistic toxicity, inhibiting development, burrowing ability and causing high mortality of C. pallidivittatus, especially for the Mg2+ treatment, which caused around 90% death. Low Ca2+ concentration (e.g., 0.01 g/L) promoted larval burrowing ability and inhibited toxin accumulation, which increased the tolerance of Chironomus t...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Shenghe Cai Yan Zhang Min Pan Zhizhong Zhang Bin Lu Cuicui Tian Chunbo Wang Tao Fang Xingqiang Wu Source Type: research
Combined effect of freshwater salinization and harmful algae on the benthic invertebrate Chironomus pallidivittatus
This study simultaneously examined the joint toxicity of salinity and different cyanobacterial diets on the behavior, development, select biomarkers, and partial life cycle of Chironomus pallidivittatus (Diptera). High concentrations of salts (e.g., 1 g/L Ca2+ and Mg2+) and toxic Microcystis had synergistic toxicity, inhibiting development, burrowing ability and causing high mortality of C. pallidivittatus, especially for the Mg2+ treatment, which caused around 90% death. Low Ca2+ concentration (e.g., 0.01 g/L) promoted larval burrowing ability and inhibited toxin accumulation, which increased the tolerance of Chironomus t...
Source: Chemosphere - April 30, 2024 Category: Chemistry Authors: Shenghe Cai Yan Zhang Min Pan Zhizhong Zhang Bin Lu Cuicui Tian Chunbo Wang Tao Fang Xingqiang Wu Source Type: research
On the structural and mechanical properties of mixed coconut and olive oil oleogels and bigels
Int J Biol Macromol. 2024 Apr 27:131942. doi: 10.1016/j.ijbiomac.2024.131942. Online ahead of print.ABSTRACTThe interaction of monoglycerides and phytosterols in olive- and coconut oil on the structuring of oleogels was analyzed. Specifically, bigels with gelatin hydrogel in different ratios (40: 60 and 60:40 w/w) were formed. The physicochemical and microstructural attributes of these systems were assessed. The olive oil to coconut oil ratio (0-100 w/w) and the added oleogelators affected the crystal structure and the mechanical properties of the oleogels. Polarized light microscopy revealed that the addition of coconut o...
Source: International Journal of Biological Macromolecules - April 30, 2024 Category: Biochemistry Authors: K Zampouni N Sideris E Tsavdaris E Katsanidis Source Type: research
