Randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo - results of the HI-Light Vitiligo trial.
CONCLUSION: Combination treatment with home-based hand-held NB-UVB plus TCS is likely to be superior to TCS alone for treatment of localised vitiligo. Combination treatment was relatively safe and well tolerated but was only successful in around a quarter of participants.
PMID: 33006767 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2020 Category: Dermatology Authors: Thomas KS, Batchelor JM, Akram P, Chalmers JR, Haines RH, Meakin GD, Duley L, Ravenscroft JC, Rogers A, Sach TH, Santer M, Tan W, White J, Whitton ME, Williams HC, Cheung ST, Hamad H, Wright A, Ingram JR, Levell NJ, Goulding JMR, Makrygeorgou A, Bewley A, Tags: Br J Dermatol Source Type: research
Olopatadine/mometasone combination nasal spray in allergic rhinitis: a profile of its use
AbstractOlopatadine/mometasone furoate combination nasal spray (Ryaltris®; referred to hereafter as olopatadine/mometasone), a convenient fixed-dose combination (FDC) of the antihistamine olopatadine and the corticosteroid mometasone furoate, is approved in Australia for the treatment of symptoms associated with allergic rhinitis (AR) and rhinoconjunctivitis in patients 12 years of age and older. Olopatadine/mometasone is an effective treatment for seasonal and perennial AR, providing statistically significant and clinically meaningful relief of nasal symptoms relative to monocomponents and/or placebo in clinical trials...
Source: Drugs and Therapy Perspectives - September 26, 2020 Category: Drugs & Pharmacology Source Type: research
Montelukast combined with intranasal mometasone furoate versus intranasal mometasone furoate; a comparative study in treatment of adenoid hypertrophy
Publication date: November–December 2020Source: American Journal of Otolaryngology, Volume 41, Issue 6Author(s): Aboubakr Elshafey Ras, Mona Hosny Hamed, Abdelrahman Ahmed Abdelalim (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - September 18, 2020 Category: Endocrinology Source Type: research
Study on the Slow-release Mometasone Furoate Injection of PLGA for the Treatment of Knee Arthritis.
CONCLUSION: This study shows that the microspheres prepared in this study have sufficient ability of stable drug release at least 35 days, with good efficacy and high safety. In addition, mometasone furoate can be used as a potential candidate drug for 35 day long-term injection.
PMID: 32940181 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 16, 2020 Category: Drugs & Pharmacology Authors: Liang Y, Zhang J, Zhao X, Wang M, Ding S, Wang Y, Chen Y, Liu J Tags: Curr Drug Deliv Source Type: research
AERD Associated Nasal Polyposis: Efficacy of Postoperative Antileukotriene Therapy in Comparison with Aspirin Desensitization. A Retrospective Study
Conclusion: Postoperative treatment with leukotriene-receptor-antagonists and aspirin desensitization both significantly reduce nasal polyp recurrence. MT has a positive effect on subjective sinonasal outcomes and patients ’ quality of life over time.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - August 10, 2020 Category: Allergy & Immunology Source Type: research
Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis
ConclusionsAR patients, especially those with severe nasal obstruction, could have ETD. The local conditions of the pharyngeal orifices of the eustachian tubes are closely related to the symptoms of ETD. After treatment with nasal glucocorticoids and oral antihistamines, eustachian tube function can significantly improve as nasal symptoms subside.Trial registration Chinese Clinical Trial Registery (ChiCTR2000029071) Registered 12 January 2020 —Retrospectively registered,http://www.chictr.org.cn/edit.aspx?pid=48328&htm=4 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 14, 2020 Category: Allergy & Immunology Source Type: research
Mometasone Furoate Loaded Aspasomal Gel for Topical Treatment of Psoriasis: Formulation, Optimization, In-Vitro and In-Vivo Performance.
Authors: Shinde G, Desai P, Shelke S, Patel R, Bangale G, Kulkarni D
Abstract
Present investigation was aimed to develop Aspasomal gel of Mometasone Furoate for the treatment Psoriasis and deliver drug at controlled rate and decrease dosing frequency. The vesicles were fabricated using film hydration method and optimized using 32 factorial Design and were evaluated for percent drug loading, vesicle size, Zeta potential, Polydispersity index and morphological studies. Gel was prepared using carbopol by loading optimized drug loaded asposomes and was evaluated for drug content, pH, viscosity and spreadabilit...
Source: Journal of Dermatological Treatment - July 2, 2020 Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Management of chronic rhinosinusitis with steroid nasal irrigations: a viable non ‐surgical alternative in the COVID‐19 Era
ConclusionsAfter a trial of NSI, 64.4% of patients with CRS no longer met candidacy for ESS and had a significant improvement in SNOT ‐22 scores. This supports the use of nasal steroid irrigations in the medical management of CRS with and without surgical intervention and with and without nasal polyposis.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - June 21, 2020 Category: Allergy & Immunology Authors: Auddie M. Sweis,
Tran B. Locke,
Jennifer E. Douglas,
Theodore C. Lin,
Brian M. Sweis,
Alyssa M. Civantos,
David W. Kennedy Tags: LETTER TO THE EDITOR Source Type: research
Randomized clinical trial to evaluate mometasone lavage vs spray for patients with chronic rhinosinusitis without nasal polyps who have not undergone sinus surgery
ConclusionBoth MFNS and mometasone nasal irrigations are beneficial in symptom management of CRS. Our study suggests that patients who perform mometasone lavage do better in a clinically meaningful way, but our results are not definitive and further studies are warranted. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - May 28, 2020 Category: Allergy & Immunology Authors: Pawina Jiramongkolchai,
Andrew Peterson,
Dorina Kallogjeri,
Jake J. Lee,
Sara Kukuljan,
Adam Liebendorfer,
John S. Schneider,
Cristine N. Klatt ‐Cromwell,
Andrew J. Drescher,
Jay F. Piccirillo Tags: ORIGINAL ARTICLE Source Type: research
Effectiveness of a combined 308-nm excimer lamp and topical mid-potent steroid treatment for facial vitiligo: a preliminary, randomized double-blinded controlled study
This study aimed to assess the effectiveness of a combined 308-nm excimer lamp and topical steroid therapy compared with the lamp alone for treating facial vitiligo. Symmetrical, nonsegmental facial vitiligo subjects were recruited. All facial lesions were irradiated with a 308-nm excimer lamp twice weekly for a total of 24 sessions. The lesions on each side of the face were randomly allocated to have topical mometasone furoate cream or the cream base alone applied once daily for 12 weeks. Clinical improvement was evaluated by a blinded dermatologist and the participants. A total of sixteen sides of the face were assesse...
Source: Lasers in Medical Science - May 26, 2020 Category: Laser Surgery Source Type: research
Fixed-dose combination of indacaterol/glycopyrronium/mometasone furoate once-daily versus salmeterol/fluticasone twice-daily plus tiotropium once-daily in patients with uncontrolled asthma: A randomised, Phase IIIb, non-inferiority study (ARGON)
The efficacy and safety of once-daily (o.d.) fixed-dose combination of indacaterol (IND), glycopyrronium (GLY) and mometasone furoate (MF) via Breezhaler ® versus concurrent administration of salmeterol/fluticasone (SAL/FLU) twice-daily (b.i.d.) via Accuhaler®+Tiotropium (TIO) o.d. via Respimat® was evaluated in patients with uncontrolled asthma. (Source: Respiratory Medicine)
Source: Respiratory Medicine - May 25, 2020 Category: Respiratory Medicine Authors: Christian Gessner, Oliver Kornmann, Jorge Maspero, Richard van Zyl-Smit, Matthias Kr üll, Anna Salina, Pritam Gupta, Sebastien Bostel, Sebastian Fucile, Lorena Garcia Conde, Pascal Pfister Source Type: research
A randomized, double-blind study to compare the efficacy and safety of two doses of mometasone furoate delivered via Breezhaler® or Twisthaler® in patients with asthma
Publication date: Available online 7 May 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Roland Buhl, Ana-Maria Tanase, Motoi Hosoe, Weihua Cao, Ivan Demin, Christian Bartels, Jürgen Jauernig, Dominik Ziegler, Francesco Patalano, Bettina Hederer, Frank Kanniess, Hanns-Christian Tillmann (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 7, 2020 Category: Respiratory Medicine Source Type: research
Comparison Between Effectiveness of Topical Mometasone Furoate Nasal Spray Versus Topical Fluticasone Furoate Nasal Spray in the Treatment of Chronic Rhinosinusitis: A One Year Hospital Based Study
AbstractTo compare the effectiveness between topical mometasone furoate nasal spray versus topical fluticasone furoate nasal spray in the treatment of chronic rhinosinusitis. Randomized control trial was conducted involving 70 patients. One group received topical mometasone furoate nasal spray and the other group received fluticasone furoate nasal spray for 3 weeks. All patients were prescribed oral ciprofloxacin for 3 weeks and were subjectively evaluated using the Lund and Mackay staging system and objectively using nasal endoscopy by the Lund and Kennedy scoring system. There was no inter group significance but all p...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - May 5, 2020 Category: ENT & OMF Source Type: research
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Compound Glycyrrhizin Capsules Combined with a Topical Corticosteroid in Adults with Chronic Eczema.
Conclusion: For adults with chronic eczema, OCG capsules combined with TCS is an effective and well-tolerated treatment, suggesting that OCG may be a useful nonsteroidal agent with an additional effect for the treatment of chronic eczema by TCS.
PMID: 32308712 [PubMed] (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - April 22, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Ciliary beat frequency of in vitro human nasal epithelium measured with the simple high-speed microscopy is applicable for safety studies of nasal drug formulations.
In conclusion, characterization of the ciliary activity of nasal MucilAir™ in vitro model and its response to relevant agents with herein developed efficient and reproducible set up for CBF analysis show great potential of this model for airway ciliotoxicity studies.
PMID: 32311434 [PubMed - as supplied by publisher] (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - April 16, 2020 Category: Toxicology Authors: Tratnjek L, Kreft M, Kristan K, Kreft ME Tags: Toxicol In Vitro Source Type: research
