Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats
CONCLUSION: MF maintains anti-inflammatory activity when administered by systemic routes and exerts less impact on metabolism when administered orally in male and female rats, effects that are GR-dependent and reversible. Category: Metabolic Disorders and Endocrinology.PMID:36893817 | DOI:10.1016/j.bcp.2023.115486 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - March 9, 2023 Category: Drugs & Pharmacology Authors: Priscila L Zimath Milena S Almeida Maciel A Bruxel Alex Rafacho Source Type: research
Efficacy of once-daily, single-inhaler, fixed-dose combination of mometasone/indacaterol/glycopyrronium in patients with asthma with or without persistent airflow limitation: Post hoc analysis from the IRIDIUM study
A novel, once-daily, fixed-dose combination of mometasone furoate/indacaterol acetate/glycopyrronium bromide (MF/IND/GLY) delivered via Breezhaler ® is the first inhaled corticosteroid/long-acting ꞵ2-agonist/long-acting muscarinic antagonist (ICS/LABA/LAMA) therapy approved for the maintenance treatment of asthma in adults inadequately controlled on ICS/LABA combination. In patients with asthma and persistent airflow limitation (PAL), maxim al treatment, especially with combination is suggested. This post hoc analysis of data from the IRIDIUM study assessed the efficacy of MF/IND/GLY in asthma patients with and without ...
Source: Respiratory Medicine - March 8, 2023 Category: Respiratory Medicine Authors: Richard N. Van Zyl-Smit, Huib AM. Kerstjens, Jorge F. Maspero, Konstantinos Kostikas, Motoi Hosoe, Ana- Maria Tanase, Peter D'Andrea, Karen Mezzi, Dominic Brittain, David Lawrence, Kenneth R. Chapman Tags: Original Research Source Type: research
Effect of an Intranasal Corticosteroid in Young Children With Chronic Rhinosinusitis
This randomized clinical trial presents data about the clinical efficacy and changes in nasopharyngeal microbiome in children aged 4 to 8 years after treatment with intranasal mometasone furoate for chronic rhinosinusitis. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - February 27, 2023 Category: Pediatrics Source Type: research
Methotrexate for recurrent chronic rhinosinusitis with nasal polyps: A randomized, controlled, phase 2 clinical trial
ConclusionLow-dose MTX was a safe and effective maintenance therapy for patients with recurrent postoperative CRSwNPs. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - January 19, 2023 Category: Allergy & Immunology Authors: Asli Cakir Cetin,
Yesim Tuncok,
Pembe Keskinoglu,
Mualla Aylin Arici,
Fatos Onen,
Mustafa Cenk Ecevit Tags: ORIGINAL ARTICLE Source Type: research
Effectiveness of Intranasal Mometasone Furoate vs Saline for Sleep-Disordered Breathing in Children
This randomized clinical trial investigates the effectiveness of intranasal mometasone furoate compared with intranasal saline for the treatment of obstructive sleep-disordered breathing in children. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - January 17, 2023 Category: Pediatrics Source Type: research
Patient Satisfaction and Sensory Attributes of Nasal Spray Treatments of Olopatadine Hydrochloride/Mometasone Furoate Monohydrate and Azelastine Hydrochloride/Fluticasone Propionate for Allergic Rhinitis in Australia – An Observational Real-World Clinical Study
(Source: Patient Preference and Adherence)
Source: Patient Preference and Adherence - January 14, 2023 Category: International Medicine & Public Health Tags: Patient Preference and Adherence Source Type: research
Methotrexate for recurrent chronic rhinosinusitis with nasal polyps: A randomized controlled phase II clinical trial
ConclusionLow-dose MTX was a safe and effective maintenance therapy for patients with recurrent postoperative CRSwNP.This article is protected by copyright. All rights reserved (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - December 28, 2022 Category: Allergy & Immunology Authors: Asli CAKIR CETIN,
Yesim TUNCOK,
Pembe KESKINOGLU,
Mualla Aylin ARICI,
Fatos ONEN,
Mustafa Cenk ECEVIT Tags: ORIGINAL ARTICLE Source Type: research
Dose delivery characteristics and lung deposition of indacaterol/glycopyrronium/mometasone furoate (IND/GLY/MF) and IND/MF via Breezhaler(R) device: An Alberta Idealised Throat (AIT) evaluation
Conclusion: Both IND/GLY/MF and IND/MF FDC products demonstrated similar lung deposition and highly consistent doses over the wide range of investigated flow rates, despite differences in the composition of the formulations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Jauernig, J., Fiebich, K., Singh, D., Jaumont, X., Mezzi, K., Jaumont, X. Tags: 05.01 - Airway pharmacology and treatment Source Type: research
Effect of momethasone furoate combined with loratadine and montelukast sodium on inflammatory factors and pulmonary function in children with allergic rhinitis
CONCLUSION: Both mometasone furoate combined with either loratadine or montelukast sodium had good effects in AR, while the first option had a faster inhibitory effect on inflammatory factors and a better protection of lung function in children.PMID:36398245 | PMC:PMC9641454 (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - November 18, 2022 Category: Research Authors: Weili Dai Ni Zhen Xiaoyan Qin Jingpeng Cao Source Type: research
