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Efficacy of Mometasone Furoate Cream Sodium Alginate Skin Repair Mask in Atopic Dermatitis Treatment
CONCLUSION: Mometasone furoate cream sodium Alginate Skin Repair Mask has an ideal clinical effect in the treatment of atopic dermatitis. Compared with single mometasone furoate cream, the combination of sodium Alginate Skin Repair Mask can further improve the patient's condition, improve the quality of life of the patient, and reduce the risk of adverse reactions and disease recurrence. The higher total effective rate in the combined group indicates that the addition of Alginate Skin Repair Mask to the treatment regimen resulted in improved outcomes for patients with atopic dermatitis (AD). This translates to better contr...
Source: Alternative Therapies in Health and Medicine - March 2, 2024 Category: Complementary Medicine Authors: Haili Ma Ying Zhao Xiujuan Xia Source Type: research

Efficacy and safety of the combination nasal spray olopatadine hydrochloride-mometasone furoate in the treatment of allergic rhinitis
ConclusionIn summary, AH and INCS will remain the main groups of active ingredients in the treatment of allergic rhinitis in the future. In combination preparations such as the new combination nasal spray olopatadine hydrochloride-mometasone furoate, they are highly effective and safe, thus opening up new perspectives, especially for patients with moderate and severe allergic rhinitis from the age of 12 years. (Source: Allergo Journal International)
Source: Allergo Journal International - January 22, 2024 Category: Allergy & Immunology Source Type: research

Topical sodium valproate-loaded nanospanlastics versus conventional topical steroid therapy in alopecia areata: a randomized controlled study
ConclusionBoth topical SV and steroids are of comparable modest efficacy. Thus, further evaluation of SV is due in combination with intralesional steroids and other anti-inflammatory treatment modalities, together with developing individualized approaches based on baseline beta-catenin level.ClinicalTrials.gov IdentifierNCT05017454,https://clinicaltrials.gov/ct2/show/NCT05017454. (Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - January 3, 2024 Category: Dermatology Source Type: research

Topical and oral steroids for otitis media with effusion (OME) in children
CONCLUSIONS: Overall, oral steroids may have little effect in the treatment of OME, with little improvement in the number of children with normal hearing and no effect on quality of life. There may be a reduction in the proportion of children with persistent disease after 12 months. However, this benefit may be small and must be weighed against the potential for adverse effects associated with oral steroid use. The evidence for nasal steroids was all low- or very low-certainty. It is therefore less clear if nasal steroids have any impact on hearing, quality of life or persistence of OME. Evidence on adverse effects was ver...
Source: Cochrane Database of Systematic Reviews - December 13, 2023 Category: General Medicine Authors: Caroline A Mulvaney Kevin Galbraith Katie E Webster Mridul Rana Rachel Connolly Ben Tudor-Green Tal Marom Mat Daniel Roderick P Venekamp Anne Gm Schilder Samuel MacKeith Source Type: research

Molecules, Vol. 28, Pages 7859: Multi-Gram Scale Synthesis and Characterization of Mometasone Furoate EP Impurity C
This study also includes the systematic investigation of the final acylation step, as well as the characterization of the difuroate enol ether intermediate and its conversion to the target impurity C. (Source: Molecules)
Source: Molecules - November 30, 2023 Category: Chemistry Authors: Riccardo Ronchetti Luigi Alfonso Pannone Bruno Cerra Emidio Camaioni Gianfranco Lopopolo Emanuele Attolino Antimo Gioiello Tags: Article Source Type: research

122 Psoriasis modeling with an advanced immunocompetent in vitro system
An advanced disease in vitro model to recapitulate psoriasis feature has been developed by using an human multi-compartment reconstructed full-thickness skin (3C System) co-cultured in the dermal compartment with THP-1 cells. The psoriatic phenotype was induced by exposure to a mixture of Th-1 cytokines (IL-17, IL-22 and TNF α) in the culture media during 48h. Two anti-psoriatic reference products have been evaluated: Product A containing mometasone furoate and Product B containing calcipotriol and betamethasone compared to negative (NC) and positive (PC) controls). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - November 1, 2023 Category: Dermatology Authors: M. Meloni, F. Rescigno, M. Le Roux, C. Baudoin, C. Pellevoisin Source Type: research

Steroid-Eluting Implants: An Adjunctive Therapy After Double-Stage Laryngotracheal Reconstruction
CONCLUSIONS: Steroid-eluting implants appear to be a safe and effective adjunctive therapy in the routine surveillance of pediatric patients with a tracheostomy who have undergone dsLTR. They may help combat granulation formation and restenosis seen in some dsLTR patients.PMID:37776286 | DOI:10.1177/00034894231202067 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - September 30, 2023 Category: ENT & OMF Authors: Emily Drury Brian Anderson Michael Haupert Prasad John Thottam Source Type: research

Vitamin D supplementation improves the therapeutic effect of mometasone on allergic rhinitis
This study aimed to investigate the efficacy and safety of vitamin D supplementation in the treatment of allergic rhinitis (AR) using mometasone. A total of 140 patients with moderate and severe AR treated at our hospital between January 2017 and August 2020 were recruited as subjects for this study. The patients were randomly divided into control and experimental groups, with 70 patients in each group. Mometasone nasal spray was used in both groups, and vitamin D was administered to the experimental group for four weeks. The total nasal symptom scores (TNSS) and rhinoconjunctivitis quality of life questionnaire (RQLQ) wer...
Source: Acta Biochim Pol - September 16, 2023 Category: Biochemistry Authors: Minfei Guo Source Type: research