Letter to the editor: indacaterol/glycopyrronium/mometasone furoate compared with salmeterol/fluticasone propionate in patients with asthma: a randomized controlled cross-over study
Indacaterol (IND; 150 μg), glycopyrronium (GLY; 50 μg) and mometasone furoate (MF; 160 μg [high-dose ICS] and 80 μg [medium-dose ICS]) have been formulated as a once-daily (o.d.) fixed-dose combination treatme... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2020 Category: Respiratory Medicine Authors: Henrik Watz, Jens M. Hohlfeld, Dave Singh, Jutta Beier, Zuzana Diamant, Jinming Liu, Shucheng Hua, Khalid Abd-Elaziz, Pascale Pinot, Ieuan Jones and Hanns-Christian Tillmann Tags: Letter to the Editor Source Type: research
Mometasone furoate for children with asthma: A meta-analysis
Mometasone furoate shows some potential in treating paediatric asthma. We conduct a systematic review and meta-analysis to explore the efficacy and safety of mometasone furoate for paediatric asthma. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 23, 2020 Category: Emergency Medicine Authors: Jing Lei, Songdong Ma Source Type: research
WITHDRAWN: Mometasone furoate for children with asthma: A meta-analysis
This paper was withdrawn due to concerns over repetitive publication. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - February 23, 2020 Category: Emergency Medicine Authors: Jing Lei, Songdong Ma Source Type: research
The use of quantitative analysis and Hansen solubility parameter predictions for the selection of excipients for lipid nanocarriers to be loaded with water soluble and insoluble compounds
Publication date: Available online 31 January 2020Source: Saudi Pharmaceutical JournalAuthor(s): Pedzisai A. Makoni, Janeeta Ranchhod, Kasongo Wa. Kasongo, Sandile M. Khamanga, Roderick B. WalkerAbstractThe aim of these studies was to determine the miscibility of different API with lipid excipients to predict drug loading and encapsulation properties for the production of solid lipid nanoparticles and nanostructured lipid carriers. Five API exhibiting different physicochemical characteristics, viz., clarithromycin, efavirenz, minocycline hydrochloride, mometasone furoate, and didanosine were used and six solid lipids as we...
Source: Saudi Pharmaceutical Journal - February 1, 2020 Category: Drugs & Pharmacology Source Type: research
Serious Asthma Outcomes and Asthma Exacerbations with Maintenance on Inhaled Corticosteroid (Mometasone Furoate)/Long-Acting Beta Agonist (Formoterol) Combination Compared to Step Down to Mometasone Monotherapy
ConclusionsIn this post-hoc analysis of a large dataset, maintenance on ICS/LABA with MF/F is not associated with an increased risk of SAOs and also significantly reduces the risk of AEX compared with step-down from ICS/LABA to MF. ClinicalTrials.gov number, NCT01471340. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 23, 2020 Category: Allergy & Immunology Source Type: research
Omalizumab versus intranasal steroids in the post-operative management of patients with allergic fungal rhinosinusitis
This study aimed at evaluating the effect of omalizumab on the clinical course of patients undergoing surgery for AFRS.Materials and methodsThis is a two-arm prospective, randomized, single blind clinical trial among patients with AFRS. Twenty patients were included and randomly divided into two groups: Group A; 10 patients received a single subcutaneous injection of omalizumab (Xolair ‘ Novartis) (150 mg) 2 weeks postoperatively. Group B: 10 patients received local steroids nasal sprays (budesonide or mometasone furoate, 100 μg twice daily for 6 months, starting 2 weeks postoperatively. All patients underwent histo...
Source: European Archives of Oto-Rhino-Laryngology - December 31, 2019 Category: ENT & OMF Source Type: research
Comparing the Effects of Proactive Treatment with Tacrolimus Ointment and Mometasone Furoate on the Epidermal Barrier Structure and Ceramide Levels of Patients with Atopic Dermatitis.
Conclusion: The results show that proactive treatment with TAC is superior in restoring the skin barrier.
PMID: 31865821 [PubMed - as supplied by publisher] (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - December 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Impact of physicochemical properties of nasal spray products on drug deposition and transport in the pediatric nasal cavity model
Publication date: Available online 3 December 2019Source: International Journal of PharmaceuticsAuthor(s): Tomasz R. Sosnowski, Piotr Rapiejko, Jarosław Sova, Katarzyna DobrowolskaAbstractThe study is focused on the analysis of physicochemical properties of selected nasal sprays of mometasone furoate, and the influence of these properties on aerosol quality and penetration in the pediatric nose. After the determination of drugs surface tension and viscosity, spray geometry and size distribution of aerosol droplets, the topical delivery of each drug to different parts of the pediatric model of the nose with the flexible ve...
Source: International Journal of Pharmaceutics - December 4, 2019 Category: Drugs & Pharmacology Source Type: research
Randomized, self-controlled, prospective assessment of the efficacy of mometasone furoate local application in reducing acute radiation dermatitis in patients with head and neck squamous cell carcinomas
Background:
Acute radiation dermatitis (ARD) is a common adverse effect in patients undergoing radiotherapy. Mometasone furoate cream (MMF) was reported to significantly reduce ARD, especially in breast cancer. Clinically, ARD is more critical and more difficult to prevent in patients with head and neck squamous cell carcinoma (HNSCC) than in those with breast cancer, because a higher dose of radiotherapy is required in HNSCC cases. The aim of this study was to evaluate the effect of MMF local application on radiation dermatitis in patients with HNSCC.
Methods:
HNSCC patients scheduled for bilateral radical radiothera...
Source: Medicine - December 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research
Dupilumab (DPL) Improves Upper and Lower Airway Outcomes in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) with Nonsteroidal Anti-inflammatory Drug-Exacerbated Respiratory Disease (NSAID-ERD): Pooled Results From SINUS-24, SINUS-52 Phase 3 Trials
Conclusion: DPL improved upper and lower airway outcomes and reduced type 2 biomarkers in CRSwNP pts with NSAID-ERD in the pooled SINUS-24/52 population and was well tolerated. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Laidlaw, T. M., Mullol, J., Canonica, G. W., Bachert, C., Han, J. K., Zhang, M., Lu, X., Patel, N., Graham, N. M., Staudinger, H., Mannent, L. P., Amin, N. Tags: Allergy and immunology Source Type: research
Lung function normalization with indacaterol/glycopyrronium/mometasone furoate in patients with asthma
Conclusion: Patients with asthma are more likely to achieve normal or near-normal lung function and to remain rescue medication free with IND/GLY/MF compared with high-dose S/F or placebo. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chapman, K. R., Watz, H., Beier, J., Singh, D., Hohlfeld, J. M., Diamant, Z., Scholz, V., Sarkar, A., Jones, I., Li, R., Pinot, P., Tillmann, H.-C. Tags: Airway pharmacology and treatment Source Type: research
Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate following once daily inhalation as a fixed-dose combination in healthy subjects
Conclusion: There was no clinically relevant pharmacokinetic interaction between IND, GLY and MF when administered as IND/GLY/MF. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Tillmann, H.-C., Ethell, B., Abdallah, N., Machineni, S., Drollmann, A., Last, S., Hahn, M., Radhakrishnan, R., Ignatenko, S., Vaidya, S. Tags: Airway pharmacology and treatment Source Type: research
Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate as a fixed-dose combination in Japanese and Caucasian healthy subjects
Conclusion: Pharmacokinetics of IND, GLY and MF (high and medium dose) when delivered as fixed-dose combination were comparable between Japanese and Caucasian subjects. IND/GLY/MF was safe and well tolerated in both ethnic groups. These results confirm that no dose adjustment for IND/GLY/MF is required in Asian population. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Tillmann, H.-C., Inoue, S., Vaidya, S., Sakita, Y., Machineni, S., Kobayashi, K., Furihata, K. Tags: Airway pharmacology and treatment Source Type: research
Indacaterol/glycopyrronium/mometasone furoate combination consistently shows lung function benefits in patients with asthma
Conclusion: IND/GLY/MF o.d. consistently demonstrates clinically and statistically significant improvements in lung function compared with high-dose S/F b.i.d. and placebo in patients with mild, moderate and severe asthma in two separate Phase II studies. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: Chapman, K. R., Watz, H., Beier, J., Singh, D., Hohlfeld, J. M., Diamant, Z., Scholz, V., Sarkar, A., Jones, I., Li, R., Pinot, P., Tillmann, H.-C. Tags: Airway pharmacology and treatment Source Type: research
Efficacy and safety of once-daily low-dose indacaterol/mometasone via Breezhaler in symptomatic adult and adolescent patients with inadequately controlled asthma: Phase III randomised QUARTZ study findings
Conclusion: In symptomatic asthma pts, IND/MF significantly improved lung function and asthma control versus MF. This supports IND/MF as efficacious maintenance therapy for asthma (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 20, 2019 Category: Respiratory Medicine Authors: DAndrea, P., Kornmann, O., Mucsi, J., Kato, M., Bandelli, L., Sen, B. Tags: Airway pharmacology and treatment Source Type: research
