Complications Associated with PROPEL Mometasone Furoate Bioabsorbable Drug-eluting Sinus Stents From 2012 to 2020
CONCLUSIONS: PROPEL sinus stents have been shown to be effective in preventing sinus outflow obstruction after functional endoscopic sinus surgery. Both adverse events to patients and device malfunctions are reported infrequently. A more comprehensive understanding of rare postmarket complications seen with PROPEL sinus stents may further aid informed decision-making regarding their usage.PMID:34342518 | DOI:10.1177/19458924211035641 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 3, 2021 Category: ENT & OMF Authors: Viraj N Shah Luke J Pasick Daniel A Benito Michael K Ghiam Christine D'Aguillo Source Type: research
Complications Associated with PROPEL Mometasone Furoate Bioabsorbable Drug-eluting Sinus Stents From 2012 to 2020
CONCLUSIONS: PROPEL sinus stents have been shown to be effective in preventing sinus outflow obstruction after functional endoscopic sinus surgery. Both adverse events to patients and device malfunctions are reported infrequently. A more comprehensive understanding of rare postmarket complications seen with PROPEL sinus stents may further aid informed decision-making regarding their usage.PMID:34342518 | DOI:10.1177/19458924211035641 (Source: American Journal of Rhinology and Allergy)
Source: American Journal of Rhinology and Allergy - August 3, 2021 Category: ENT & OMF Authors: Viraj N Shah Luke J Pasick Daniel A Benito Michael K Ghiam Christine D'Aguillo Source Type: research
Cost-Utility Analysis of Fixed-Dose Combination of Indacaterol Acetate Glycopyrronium Bromide and Mometasone Furoate as a Maintenance Treatment in Adult Patients with Asthma Not Adequately Controlled with a Maintenance Combination of a Long-Acting Beta-Agonist and a High Dose of an Inhaled Corticosteroid Who Experienced One or More Asthma Exacerbations in the Previous Year
ConclusionThe results indicate that IND/GLY/MF is cost effective against the considered comparators in a cohort representative of adult patients with asthma in Italy. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - July 31, 2021 Category: Drugs & Pharmacology Source Type: research
Hypothalamic ‐pituitary‐adrenal axis suppression and intranasal corticosteroid use: A systematic review and meta‐analysis
ConclusionOverall, the use of INCS carries a low risk for AI. Although modest, this risk may differ depending on the length of duration and type of INCS used. Informing patients of these risks is of importance for the treatment of chronic sinonasal conditions. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - July 14, 2021 Category: Allergy & Immunology Authors: Gianluca Sampieri,
Amirpouyan Namavarian,
John J. W. Lee,
Amr F. Hamour,
John M. Lee Tags: ORIGINAL ARTICLE Source Type: research
Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler ® Device in Patients with Asthma
ConclusionTwo-compartment popPK models adequately described the pharmacokinetics of IND, GLY and MF. The effect of covariates was not clinically relevant. The pharmacokinetic profiles of MF were comparable for combination products at corresponding medium- or high-dose inhaled corticosteroids. On a population level, the pharmacokinetics of IND and GLY were comparable between patients with asthma and COPD. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - July 1, 2021 Category: Drugs & Pharmacology Source Type: research
The buck stops with us
In this volume of The Journal, Bickel et al compare 2 time epochs bracketing a change made by a public insurance payer that eliminated coverage of beclomethasone diproprionate, or BDP, by metered-dose inhaler (MDI) in favor of mometasone furoate (MF), available as MDI or dry powder inhaler (DPI). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - June 23, 2021 Category: Pediatrics Authors: Denise M. Goodman Tags: The Editors' Perspectives Source Type: research
Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial
Int Immunopharmacol. 2021 Jun 12;98:107871. doi: 10.1016/j.intimp.2021.107871. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the usage of mometasone furoate nasal spray in the recovery of patients with severe microsmia or anosmia induced by COVID-19. This was a prospective clinical trial on non-hospitalized adult patients with COVID-19 (>18 years) who had severe microsmia or anosmia within two weeks. The subjects were randomly assigned to the mometasone furoate group (100 mcg twice daily) or sodium chloride group (0.9%); both groups also received olfactory training for 4 weeks. The primary outcome ...
Source: International Immunopharmacology - June 20, 2021 Category: Allergy & Immunology Authors: Hossein Kasiri Nima Rouhani Ebrahim Salehifar Monireh Ghazaeian Sahar Fallah Source Type: research
Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial
Int Immunopharmacol. 2021 Jun 12;98:107871. doi: 10.1016/j.intimp.2021.107871. Online ahead of print.ABSTRACTThe aim of this study was to evaluate the usage of mometasone furoate nasal spray in the recovery of patients with severe microsmia or anosmia induced by COVID-19. This was a prospective clinical trial on non-hospitalized adult patients with COVID-19 (>18 years) who had severe microsmia or anosmia within two weeks. The subjects were randomly assigned to the mometasone furoate group (100 mcg twice daily) or sodium chloride group (0.9%); both groups also received olfactory training for 4 weeks. The primary outcome ...
Source: International Immunopharmacology - June 20, 2021 Category: Allergy & Immunology Authors: Hossein Kasiri Nima Rouhani Ebrahim Salehifar Monireh Ghazaeian Sahar Fallah Source Type: research
Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis
CONCLUSION: Isotonic seawater spray containing chamomile liquid extract is seen as a good alternative treatment option for allergic rhinitis patients.PMID:34142567 | DOI:10.1177/00034894211025411 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - June 18, 2021 Category: ENT & OMF Authors: Yavuz Atar Semih Karaketir Imran Aydogdu H üseyin Sari Hasan Sami Bircan Yavuz Uyar Enis Ekincioglu Seyma G örcin Karaketir Enes Atac G üler Berkiten Source Type: research
Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis
CONCLUSION: Isotonic seawater spray containing chamomile liquid extract is seen as a good alternative treatment option for allergic rhinitis patients.PMID:34142567 | DOI:10.1177/00034894211025411 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - June 18, 2021 Category: ENT & OMF Authors: Yavuz Atar Semih Karaketir Imran Aydogdu H üseyin Sari Hasan Sami Bircan Yavuz Uyar Enis Ekincioglu Seyma G örcin Karaketir Enes Atac G üler Berkiten Source Type: research
Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis
CONCLUSION: Isotonic seawater spray containing chamomile liquid extract is seen as a good alternative treatment option for allergic rhinitis patients.PMID:34142567 | DOI:10.1177/00034894211025411 (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - June 18, 2021 Category: ENT & OMF Authors: Yavuz Atar Semih Karaketir Imran Aydogdu H üseyin Sari Hasan Sami Bircan Yavuz Uyar Enis Ekincioglu Seyma G örcin Karaketir Enes Atac G üler Berkiten Source Type: research
Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler ® Device in Patients with Asthma
ConclusionTwo-compartment popPK models adequately described the pharmacokinetics of IND, GLY and MF. The effect of covariates was not clinically relevant. The pharmacokinetic profiles of MF were comparable for combination products at corresponding medium- or high-dose inhaled corticosteroids. On a population level, the pharmacokinetics of IND and GLY were comparable between patients with asthma and COPD. (Source: European Journal of Drug Metabolism and Pharmacokinetics)
Source: European Journal of Drug Metabolism and Pharmacokinetics - May 22, 2021 Category: Drugs & Pharmacology Source Type: research
A Systematic Approach in the Development of the Morphologically-Directed Raman Spectroscopy Methodology for Characterizing Nasal Suspension Drug Products
This study investigated the utility of the morphologically-directed Raman spectroscopy (MDRS) method to investigate the particle size distribution (PSD) of nasal suspensions. Dissolution was also investigated as an orthogonal technique. Nasal suspension formulations containing different PSD of mometasone furoate monohydrate (MFM) were manufactured. The PSD of the MFM batches was characterized before formulation manufacture using laser diffraction and automated imaging. Upon formulation manufacture, the droplet size, single actuation content, spray pattern, plume geometry, the API dissolution rate, and the API PSD by MDRS w...
Source: The AAPS Journal - May 18, 2021 Category: Drugs & Pharmacology Source Type: research
Comparison of Cytokines in Skin Biopsies and Tape Strips from Adults with Atopic Dermatitis
In this study, we examined the gene expression of cytokines in skin biopsies and cytokines in stratum corneum tape strips collected from adults with AD. We collected punch biopsies and tape strips from healthy controls (n = 6) and subjects with AD (n = 12) at baseline and after 2 weeks of topical treatment with mometasone furoate 0.1% cream. We found that IFN- γ, IL-13, and IL-10 mRNA (biopsies) and IL-1β protein expression levels (tape strips) were significantly increased in lesional AD skin compared to healthy control skin. Treatment with topical corticosteroid led to a significant decrease in mRNA levels for IL-13 and...
Source: Dermatology - May 10, 2021 Category: Dermatology Source Type: research
Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial
This study is registered with ClinicalTrials.gov, NCT03085797.FINDINGS: From May 25, 2017, to Dec 12, 2018, 854 patients were screened for eligibility. 414 patients were randomly assigned with 407 included in the ITT population; 206 received mepolizumab and 201 received placebo. Total endoscopic nasal polyp score significantly improved at week 52 from baseline with mepolizumab versus placebo (adjusted difference in medians -0·73, 95% CI -1·11 to -0·34; p<0·0001) and nasal obstruction VAS score during weeks 49-52 also significantly improved (-3·14, -4·09 to -2·18; p<0·0001). Adverse events considered related t...
Source: Respiratory Care - April 19, 2021 Category: Respiratory Medicine Authors: Joseph K Han Claus Bachert Wytske Fokkens Martin Desrosiers Martin Wagenmann Stella E Lee Steven G Smith Neil Martin Bhabita Mayer Steven W Yancey Ana R Sousa Robert Chan Claire Hopkins SYNAPSE study investigators Source Type: research
