The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis
Conclusions: Our results suggest only a minor role forFLG mutation status on the overall microbiome, which is rather caused by differences in the present genera than by microbe richness and evenness.Dermatology (Source: Dermatology)
Source: Dermatology - January 18, 2022 Category: Dermatology Source Type: research

Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation
Conclusion: Syndromic HS can be considered as a polygenic autoinflammatory condition; currently WES is a diagnostic tool allowing more accurate genotype-phenotype correlation.Dermatology (Source: Dermatology)
Source: Dermatology - January 14, 2022 Category: Dermatology Source Type: research

Performance of Ultrasound for Identifying Morphological Characteristics and Thickness of Cutaneous Basal Cell Carcinoma: A Systematic Review
Advances in ultrasound technology and non-surgical treatments of basal cell carcinomas (BCCs) have raised the need to study the performance of high-frequency ultrasound (HFUS) in BCCs. We aimed to assess the performance of HFUS in the evaluation of BCCs to formulate recommendations for its uses and conducted a systematic review of the literature to do so. A search of Central, Medline, Embase, CINHAL, and Web of Science was performed using key/MESH terms “ultrasonography” and “basal cell carcinoma” (January 2005–December 2020). We included primary studies reporting biopsy-confirmed BCCs for whi...
Source: Dermatology - January 13, 2022 Category: Dermatology Source Type: research

Erratum
Dermatology (Source: Dermatology)
Source: Dermatology - January 12, 2022 Category: Dermatology Source Type: research

Defining the Validity of Skin Self-Examination as a Screening Test for the Detection of Suspicious Pigmented Lesions: A Meta-Analysis of Diagnostic Test Accuracy
Conclusions: SSE can detect suspicious pigmented lesions with reasonable sensitivity and relatively high specificity, with the AUC suggesting acceptable discriminatory ability.Dermatology (Source: Dermatology)
Source: Dermatology - January 3, 2022 Category: Dermatology Source Type: research

Reliability Assessment and Validation of the Skin Hyperpigmentation Index Compared to the Physician Global Assessment Score
Conclusion: There is evidence that the SHI is a reliable instrument for measuring skin hyperpigmentation, and can be used by nonexperienced clinicians.Dermatology (Source: Dermatology)
Source: Dermatology - December 30, 2021 Category: Dermatology Source Type: research

Tattoos Dermatological Complications: Analysis of 53 Cases from Northern Poland
Conclusions: This is the first report presenting multiple cases of tattoo complications from Eastern Europe. The results of the study are consistent with other researches, showing a similar distribution of tattoo complications and that across the different pigments used, the red ink is most frequently responsible for tattoo reactions. We emphasize the usefulness of dermoscopic examination in the diagnosis of tattoo-related infections and draw the reader ’s attention to the rare, yet hazardous complications connected with peri-tattooing anaphylaxis.Dermatology (Source: Dermatology)
Source: Dermatology - December 30, 2021 Category: Dermatology Source Type: research

A Commentary on the “Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption”
Acneiform eruption is a devastating cutaneous side effect of cetuximab, a monoclonal antibody used to treat a variety of cancers. Despite its effectiveness, many patients avoid or discontinue it after experiencing its dermatological side effects as it negatively impacts their quality of life (QoL). This displays the immense need for multidisciplinary collaboration to prevent and treat cetuximab-induced acneiform eruption (CIAE). Prevention methods include, but are not limited to, education, skin care routines, and prophylactic drugs. The following measures reduce the likelihood of developing CIAE and decrease its severity,...
Source: Dermatology - December 29, 2021 Category: Dermatology Source Type: research

Efficacy Assessment of the High-Frequency High-Intensity Focused Ultrasound as a New Treatment for Actinic Keratosis
Conclusions: 20-MHz HIFU could be an effective and safe alternative treatment for AK.Dermatology (Source: Dermatology)
Source: Dermatology - December 21, 2021 Category: Dermatology Source Type: research

The Personal Impact of Daily Wound Care for Hidradenitis Suppurativa
Conclusion: HS wound management imposes a substantial personal burden on patients. There is a clear unmet need for HS-specific wound dressings and wound care provisions, and a greater awareness of the condition and its impact is needed among clinicians.Dermatology (Source: Dermatology)
Source: Dermatology - December 20, 2021 Category: Dermatology Source Type: research

Dermoscopic Nevus Patterns Associated with Melanoma Patients
Conclusion: Melanoma patients tend to present a higher number of common reticular nevi on the back and lower limbs, as well as atypical nevi with a complex pattern, especially reticular, reticular-homogeneous, and reticular-globular on the back.Dermatology (Source: Dermatology)
Source: Dermatology - December 10, 2021 Category: Dermatology Source Type: research

A Multicentre Randomised Controlled Study Evaluating the Effect of a Standardised Education Programme on Quality of Life, Disease Severity, and Disease Knowledge in Patients with Moderate-To-Severe Psoriasis: The EDUPSO Study
Conclusions: The standardised education programme did not improve HRQoL and disease severity in psoriasis, but led to a significant improvement in patient knowledge about the disease and increased patient satisfaction.Dermatology (Source: Dermatology)
Source: Dermatology - December 9, 2021 Category: Dermatology Source Type: research

Trichoscopic Signs in Dermatomyositis, Systemic Lupus Erythematosus, and Systemic Sclerosis: A Comparative Study of 150 Patients
Conclusions: Trichoscopy is a valuable tool possessing diagnostic and prognostic values for CTDs. Specific trichoscopic features allow adequate distinction between DM, SLE, and SSc and may help identify active disease.Dermatology (Source: Dermatology)
Source: Dermatology - December 8, 2021 Category: Dermatology Source Type: research

Comparing the Accuracy of ABCD-10 and SCORTEN in Predicting the In-Hospital Mortality of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multi-Institutional Study from Central China
Conclusion: ABCD-10 showed acceptable overall performance, but revealed mortality underestimation and was inferior to the performance of SCORTEN. In consistence with SCORTEN, ABCD-10 was a better model when using values collected at day 3 of hospitalization relative to day 1.Dermatology (Source: Dermatology)
Source: Dermatology - December 7, 2021 Category: Dermatology Source Type: research

From the Cochrane Library: Statins and Fibrates for Preventing Melanoma
Dermatology (Source: Dermatology)
Source: Dermatology - December 6, 2021 Category: Dermatology Source Type: research

Effectiveness of Emollients in the Prevention of Atopic Dermatitis in Infants: A Meta-Analysis
Conclusions: We found that the difference in incidence rate of AD between the experimental and control groups was not statistically significant. However, due to different methods of using emollients, different follow-up times and different sample sizes included in this meta-analysis, a definitive conclusion could not be reached in this study. In the future, it is still necessary to carry out randomized controlled, multicenter, large-sample trials with an excellent study design and high methodological quality on early application of emollients in high-risk infants to prevent AD.Dermatology (Source: Dermatology)
Source: Dermatology - December 6, 2021 Category: Dermatology Source Type: research

Evaluation of Psoriasis Area and Severity Index Thresholds as Proxies for Systemic Inflammation on an Individual Patient Level
Conclusion: Specific PASI thresholds were not well suited to predict elevated biomarkers of systemic inflammation and cardiovascular risk on an individual patient level. Therefore, PASI, and possibly other purely cutaneous measures, may not be ideal as stand-alone parameters to define disease severity and eligibility for systemic treatment. Our results are relevant for the ongoing discussion on the definition of psoriasis severity and eligibility for systemic treatment. Further research addressing the added value of a set of biomarkers of systemic inflammation in the assessment of psoriasis severity would be desirable.Derm...
Source: Dermatology - December 1, 2021 Category: Dermatology Source Type: research

Burn Hemangioma: A New Variant of Hemangioma
Conclusion: Burn hemangioma should be considered a new variant of hemangioma rather than a type of pyogenic granuloma that follows second-degree burns. They have many similarities with infantile hemangioma, both clinically and histopathologically.Dermatology (Source: Dermatology)
Source: Dermatology - November 30, 2021 Category: Dermatology Source Type: research

Brodalumab Is Associated with High Rates of Complete Clearance and Quality of Life Improvement: A Subgroup Analysis of Patients with Psoriasis and Concomitant Psoriatic Arthritis
Conclusions: Treatment with brodalumab rapidly results in high levels of complete and sustained skin clearance and greater cumulative treatment benefit in patients with moderate-to-severe psoriasis versus ustekinumab, regardless of concomitant PsA status.Dermatology (Source: Dermatology)
Source: Dermatology - November 25, 2021 Category: Dermatology Source Type: research

Excision Margin and Survival in Patients with High-Risk, Primary Cutaneous Melanoma: A Retrospective Study Based on Surveillance Epidemiology and End Result (SEER) Database
Conclusions: Wider excision margin greater than 2 cm did not provide any additional therapeutic benefits compared to narrow excision margin between 1 and 2 cm. A 2-cm margin is adequate and safe for high-risk primary melanoma of the skin thicker than 2 mm.Dermatology (Source: Dermatology)
Source: Dermatology - November 24, 2021 Category: Dermatology Source Type: research

Effective and Safe Treatment of Psoriatic Disease with the Anti-IL-23p19 Biologic Tildrakizumab: Results of a Real-World Prospective Cohort Study in Nonselected Patients
Conclusions: Patients treated in routine practice with tildrakizumab differed substantially from the phase 3 studies. Despite systemic pre-treatment and increased comorbidity, tildrakizumab showed comparable efficacy and safety in the KTC. Prospective cohort studies are a suitable tool to generate RWE before registry data become available.Dermatology (Source: Dermatology)
Source: Dermatology - November 12, 2021 Category: Dermatology Source Type: research

Erratum
Dermatology (Source: Dermatology)
Source: Dermatology - November 11, 2021 Category: Dermatology Source Type: research

Predicting Severe Renal and Gastrointestinal Involvement in Childhood Immunoglobulin A Vasculitis with Routine Laboratory Parameters
Conclusion: Our data suggest C3 to be an exclusive predictor for severe renal involvement and D-dimer level to be positively associated with the severity of GI involvement. Prediction models consisting of the above parameters were built for obtaining prognostic information in the early phase of IgAV.Dermatology (Source: Dermatology)
Source: Dermatology - November 8, 2021 Category: Dermatology Source Type: research

Contents Vol. 237, 2021
Dermatology 2021;237:I –X (Source: Dermatology)
Source: Dermatology - November 2, 2021 Category: Dermatology Source Type: research

Acknowlegment to Referees for Dermatology 2021
Dermatology 2021;237:1050 –1052 (Source: Dermatology)
Source: Dermatology - November 2, 2021 Category: Dermatology Source Type: research

Pyoderma Gangrenosum and Interleukin Inhibitors: A Semi-Systematic Review
Background: Pyoderma gangrenosum (PG) is a rare ulcerating skin disease associated with multiple comorbidities and increased mortality. In recent decades, newer biologics such as interleukin inhibitors have been used to treat PG; however, the literature is scarce, consisting predominantly of case reports and caseseries. The aim of our review was to evaluate the effectiveness and safety of interleukin inhibitors for the treatment of PG in adults.Summary: A literature search was conducted using search terms related to PG and interleukin inhibitors in databases such as PubMed, Embase, Scopus, Web of Science, and Cochrane Libr...
Source: Dermatology - October 28, 2021 Category: Dermatology Source Type: research

Therapeutic Impact and Management of Persistent Head and Neck Atopic Dermatitis in Dupilumab-Treated Patients
Conclusion: AD localization in exposed areas at the baseline and AD persistency at the head/neck may have a negative impact on certain treatment response parameters to dupilumab therapy.Dermatology (Source: Dermatology)
Source: Dermatology - October 28, 2021 Category: Dermatology Source Type: research

Drug Adherence and Persistence of Patients with Moderate to Severe Psoriasis Treated with Biologic Medications in a US Commercially Insured Population
Conclusions: In this large healthcare claims database analysis of psoriasis patients treated with seven different biologic medications, adherence was numerically higher among those treated with UST or GUS. UST and GUS were also associated with numerically greater persistence.Dermatology (Source: Dermatology)
Source: Dermatology - October 28, 2021 Category: Dermatology Source Type: research

Should Targeted Therapy Be Continued in BRAF-Mutant Melanoma Patients after Complete Remission?
Conclusions: This real-life study provided long-term data in patients who discontinued targeted therapy after CR. Most patients experienced a relapse in the first year after targeted therapy discontinuation, of whom 50% were in the first 3 months. After targeted therapy resumption, 53% of relapsing patients achieved an objective response. Patients should be followed during the first year after treatment discontinuation. In addition, patients with less than 3 metastatic sites, a baseline LDH level with normal ranges, men, and patients responding rapidly to treatment would be more likely to maintain a CR after treatment disc...
Source: Dermatology - October 27, 2021 Category: Dermatology Source Type: research

A Closer Look at Bleach Baths: Evidence, Tub Size, and Instructions
Dilute sodium hypochlorite (bleach) baths have been used in routine care for many dermatologic conditions, namely atopic dermatitis. The benefits of bleach baths in reducing bacterial carriage have been well documented; however, the instructions often require subjective interpretation of bathtub size and may result in varying concentrations of bleach. Herein, we review the evidence for use of bleach baths and provide a method for ensuring that proper bleach concentrations are achieved.Dermatology (Source: Dermatology)
Source: Dermatology - October 25, 2021 Category: Dermatology Source Type: research

Efficacy of Photodynamic Therapy for the Treatment of Bowen ’s Disease: A Meta-Analysis of Randomized Controlled Trials
Conclusions: This meta-analysis shows that photodynamic therapy can be used in the treatment of Bowen ’s disease with better efficacy, less recurrence, and better cosmetic outcomes than cryotherapy and 5-FU. Some methods, including ablative fractional CO2 laser, can be applied in combination with photodynamic therapy to improve efficacy. However, which laser-assisted photodynamic therapy scheme has the most advantages in the treatment of Bowen ’s disease warrants further exploration.Dermatology (Source: Dermatology)
Source: Dermatology - October 15, 2021 Category: Dermatology Source Type: research

Prevalence and Clinical Characteristics of Hidradenitis Suppurativa Phenotypes in a Large Dutch Cohort
Dermatology (Source: Dermatology)
Source: Dermatology - October 14, 2021 Category: Dermatology Source Type: research

< b > < i > Staphylococcus aureus < /i > < /b > and Antibiotics in Cutaneous T-Cell Lymphoma
Dermatology (Source: Dermatology)
Source: Dermatology - October 7, 2021 Category: Dermatology Source Type: research

The Incidence of Cutaneous Malignant Melanoma in Eastern Newfoundland and Labrador, Canada, from 2007 to 2015
Conclusion: The incidence of cutaneous malignant melanoma in Eastern Newfoundland and Labrador is increasing at a faster rate than in any other region in Canada. Health care providers should work to be aware of the clinical trends and risk factors associated with this disease to facilitate early detection and prevent morbidity.Dermatology (Source: Dermatology)
Source: Dermatology - October 5, 2021 Category: Dermatology Source Type: research

Dermatology Life Quality Index among Different Cultures: A Neglected Bias Needs to Be Addressed
Dermatology (Source: Dermatology)
Source: Dermatology - September 24, 2021 Category: Dermatology Source Type: research

Cutaneous Leiomyoma: A Clinical Study of 152 Patients
Conclusion: In patients with multiple piloleiomyomas HLRCC must be ruled out as it is confirmed in a high proportion of cases. The probability of fumarate hydratase mutation is greater in multiple piloleiomyomas involving both the trunk and upper extremities in the same patient.Dermatology (Source: Dermatology)
Source: Dermatology - September 23, 2021 Category: Dermatology Source Type: research

Skin Eruptions in Acute Hemorrhagic Edema of Young Children: Systematic Review of the Literature
This study carefully characterizes type, distribution, and evolution of skin eruption in acute hemorrhagic edema. The data help physicians to rapidly and noninvasively make the clinical diagnosis of this vasculitis.Dermatology (Source: Dermatology)
Source: Dermatology - September 22, 2021 Category: Dermatology Source Type: research

< b > < i > TERT < /i > < /b > Promoter Mutational Status in the Management of Cutaneous Melanoma: Comparison with Sentinel Lymph Node Biopsy
Conclusions: The predictive value ofTERTp mutations may be similar to that of SLN biopsy and its integration in the management algorithm of melanoma patients should be considered.Dermatology (Source: Dermatology)
Source: Dermatology - September 21, 2021 Category: Dermatology Source Type: research

International Dermatology Outcome Measures (IDEOM): Report from the 2020 Annual Meeting
In this report, we summarize the work presented by each IDEOM workgroup (psoriasis, psoriatic arthritis, hidradenitis suppurativa, acne, pyoderma gangrenosum, and actinic keratosis) at the 2020 IDEOM Virtual Annual Meeting.Dermatology (Source: Dermatology)
Source: Dermatology - September 17, 2021 Category: Dermatology Source Type: research

Occult Blood in Feces Is Associated with Increased Risk of Psoriasis
Conclusion: The risk of psoriasis was significantly increased in patients with positive FIT results compared to the FIT-negative population.Dermatology (Source: Dermatology)
Source: Dermatology - September 16, 2021 Category: Dermatology Source Type: research

Coronary Inflammation Assessed by Perivascular Fat Attenuation Index in Patients with Psoriasis: A Propensity Score-Matched Study
Conclusion: Patients with psoriasis have a higher atherosclerotic burden as quantified by CT-LeSc and less coronary inflammation as detected by perivascular FAI around the most proximal of the three major epicardial vessels. The usefulness of perivascular FAI for evaluating coronary inflammation in patients with chronic low-grade inflammatory disease such as psoriasis should be verified.Dermatology (Source: Dermatology)
Source: Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Smoking and Periodontitis Can Play a Synergistic Role in the Development of Psoriasis: A Nationwide Cohort Study
Conclusion: Our study highlights periodontitis as a potential independent risk factor for psoriasis, increasing awareness of the synergistic role of smoking and periodontitis in the pathogenesis of psoriasis.Dermatology (Source: Dermatology)
Source: Dermatology - September 15, 2021 Category: Dermatology Source Type: research

Primary Localized Cutaneous Amyloidosis: A Retrospective Study of an Uncommon Skin Disease in the Largest Tertiary Care Center in Switzerland
Conclusion: Our data show that PCLA is a rare disease in central Europe but can also be expected in a predominantly Caucasian population. The best treatment response was achieved with a combination of UVA1 phototherapy and high-potency topical corticosteroids.Dermatology (Source: Dermatology)
Source: Dermatology - September 15, 2021 Category: Dermatology Source Type: research

LAight ® Therapy Significantly Enhances Treatment Efficacy of 16 Weeks of Topical Clindamycin Solution in Hurley I and II Hidradenitis Suppurativa: Results from Period A of RELIEVE, a Multicenter Randomized, Controlled Trial
Conclusion: The results of the primary endpoint analysis of period A of the RELIEVE study show that the combined therapy with LAight ® and topical clindamycin 1% solution, resulted in a significantly higher decrease in disease severity and an improvement of quality of life in comparison to topical clindamycin 1% solution monotherapy. Treatment was well tolerated, and side effects were all mild and transitory. These data speak fo r the implementation of the combined treatment as a first-line therapy in Hurley stage I and II HS. LAight® therapy as long-term monotherapy (results from period B), will be analyzed in a c...
Source: Dermatology - September 14, 2021 Category: Dermatology Source Type: research

Pruritus, Pain, and Depression Associated with the Most Common Skin Diseases: Data from the French Study “Objectifs Peau”
Conclusion: Pruritus, pain, or other sensory symptoms were found to be common not only in classic pruritic skin diseases but also in acne, rosacea, or warts. The association of pruritus and pain dramatically increased psychological suffering. These symptoms must be systematically searched for in patients, especially since new therapeutic possibilities are emerging for the symptomatic treatment of pruritus.Dermatology (Source: Dermatology)
Source: Dermatology - September 7, 2021 Category: Dermatology Source Type: research

Proton Pump Inhibitors Are Associated with Increased Risk of Psoriasis: A Nationwide Nested Case-Control Study
Conclusions: PPI use might be associated with an increased risk of developing psoriasis or as an epiphenomenon. Further prospective studies are needed to elucidate the association and underlying mechanisms.Dermatology (Source: Dermatology)
Source: Dermatology - September 2, 2021 Category: Dermatology Source Type: research

Clinical Outcomes of Advanced-Stage Cutaneous Lymphoma under Low-Dose Gemcitabine Treatment: Real-Life Data from the German Cutaneous Lymphoma Network
Conclusions: This retrospective analysis supports the use of low-dose gemcitabine therapy in CTCL, demonstrating with 62% OR and PFS of 12 months an almost identical response rate and survival as compared to the standard dose therapy reported in previous studies but with a significantly improved safety profile and tolerability.Dermatology (Source: Dermatology)
Source: Dermatology - September 2, 2021 Category: Dermatology Source Type: research

Hidradenitis Suppurativa in a Large Cohort of Italian Patients: Evaluation of the Burden of Disease
Conclusion: This study offers insight into the disease burden of HS in an Italian population. Our results underline the impact of QoL evaluation, also with the use of the HIDRAdisk, in clinical routine as a support to validated severity clinical and instrumental indexes for a “360-degree” assessment of HS patient’s burden of disease.Dermatology (Source: Dermatology)
Source: Dermatology - September 2, 2021 Category: Dermatology Source Type: research

From the Cochrane Library: Emollients and Moisturizers for Eczema
Dermatology (Source: Dermatology)
Source: Dermatology - September 2, 2021 Category: Dermatology Source Type: research

Melanotan II User Experience: A Qualitative Study of Online Discussion Forums
Conclusion: Motivations for MT II use included the pursuit of a tanned appearance, often in anticipation of sun holidays and fitness/body building competitions. Clinicians should be aware not only of the potential risks in relation to pigmented skin lesions, but also remain cognisant of the other medical hazards associated with the use of this substance, namely transmission of infectious diseases, use of potentially contaminated products, polypharmacy, and sunbed exposure.Dermatology (Source: Dermatology)
Source: Dermatology - August 31, 2021 Category: Dermatology Source Type: research