Autophagy in Skin Diseases
Autophagy, or self-eating, is an evolutionarily conserved process in which cytosol and organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for the degradation and recycling of cytoplasmic components in eukaryotes. It is well recognized that autophagy plays an important role in maintaining cellular homeostasis under physiological and pathophysiological con ­ditions and the upregulation of autophagy may serve as an adaptive process to provide nutrients and energy when under stresses. Recently, studies have illustrated that autophagy is intricately related to skin d...
Source: Dermatology - July 3, 2019 Category: Dermatology Source Type: research

Trends in Melanoma Mortality in the Population Groups of South Africa
The incidence of cutaneous melanoma (CM) is increasing in countries around the world. However, little is known about melanoma trends in African countries by population group. We studied CM mortality in South Africa from 1997 to 2014 to partly address this knowledge gap. Unit record mortality data for all South Africans who died from CM (n = 8,537) were obtained from Statistics South Africa. Join-point regression models were used to assess whether there was a statistically significant change in the direction and/or magnitude of the annual trends in CM mortality. A significant increasing trend of 11% per year was observed in...
Source: Dermatology - July 3, 2019 Category: Dermatology Source Type: research

The Impact of Focality and Centricity on Vulvar Intraepithelial Neoplasia on Disease Progression in HIV+ Patients: A 10-Year Retrospective Study
Conclusion: Both focality and centricity have effects on interval to recurrence and final patient outcome, with multifocal disease having a poorer prognosis. Centricity and focality should be recorded at the time of diagnosis and act as a warning for disease recurrence. HIV+ VIN patients with multifocal disease and/or known immunosuppression (low CD4+ lymphocyte counts) should be regarded as “high-risk” patients and treated accordingly.Dermatology (Source: Dermatology)
Source: Dermatology - June 28, 2019 Category: Dermatology Source Type: research

Analysis of the Risk Factors for Postherpetic Neuralgia
Conclusion: Pain during the acute stage of herpes zoster, age greater than 70 years, and serious type of skin lesion are risk factors for postherpetic neuralgia (p #x3c; 0.05, OR #x3e;1).Dermatology (Source: Dermatology)
Source: Dermatology - June 28, 2019 Category: Dermatology Source Type: research

HPV Infection Downregulates the Expression of Autophagy-Related Genes in Condylomata Acuminata
Conclusions: These findings showed that HPV infection downregulated the expression of ATGs in CA. Additionally, there were no differences in the expression of ATGs between the different HPV genotype infection groups. This study provided new insights into the autophagic response to HPV infection.Dermatology (Source: Dermatology)
Source: Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Adherence to Over-the-Counter Antimicrobial Washes in Hidradenitis Suppurativa Patients
Dermatology (Source: Dermatology)
Source: Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Socioeconomic Costs and Health Inequalities from Psoriasis: A Cohort Study
Conclusion: In Denmark, psoriasis has a significant impact on health care costs, income and employment, and is associated with a range of comorbidities.Dermatology (Source: Dermatology)
Source: Dermatology - June 25, 2019 Category: Dermatology Source Type: research

Adult Atopic Dermatitis in Hospitalized Patients: Comparison between Those with Childhood-Onset and Late-Onset Disease
Conclusions: Elderly patients with LOAD constitute the majority of adults hospitalized with AD. As in ambulatory AD patients, there are significant differences in medical background, clinical picture, laboratory characteristics, and response to treatment between hospitalized LOAD and COAD patients. There is a need to determine diagnostic criteria and treatment guidelines for these patients.Dermatology (Source: Dermatology)
Source: Dermatology - June 21, 2019 Category: Dermatology Source Type: research

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance
Atopic dermatitis (AD) is a complex disease that is thought to be triggered by environmental factors in genetically susceptible individuals. Twin studies have estimated the heritability of AD to be approximately 75%, with the null (loss-of-function) mutations of the gene encoding filaggrin(FLG) (chromosome 1q21.3) as the strongest known genetic risk factor. The discovery of the filaggrin gene was important in the emerging model for AD pathogenesis, combining skin barrier function with adaptive and innate immunity. Assisted by the recent development of large-scale high-throughput genomics, more than 30 genetic loci have bee...
Source: Dermatology - June 14, 2019 Category: Dermatology Source Type: research

Hereditary Angio-Oedema for Dermatologists
Among angio-oedema patients, hereditary angio-oedema (HAE) should not be overlooked. Besides skin swellings, these patients might have very painful abdominal attacks and potentially life-threatening angio-oedema of the upper airway. They will not respond to traditional anti-allergic therapy with antihistamines, corticosteroids, and adrenaline, and instead need specific drugs targeting the kallikrein-kinin pathway. Classically, patients with HAE have a quantitative or qualitative deficiency of the C1 inhibitor (C1INH) due to different mutations inSERPING1, although a new subtype with normal C1INH has been recognised more re...
Source: Dermatology - June 5, 2019 Category: Dermatology Source Type: research

Association of Psoriasis with Psychiatric Hospitalization in United States Children and Adults
Conclusions: Children and adults with psoriasis had increased hospitalization for multiple MH disorders, which were associated with a considerable financial burden.Dermatology (Source: Dermatology)
Source: Dermatology - June 4, 2019 Category: Dermatology Source Type: research

Exploration of the Product of the 5-Point Investigator ’s Global Assessment and Body Surface Area (IGA × BSA) as a Practical Minimal Disease Activity Goal in Patients with Moderate-to-Severe Psoriasis
Conclusion: IGA × BSA could be a valid measure highly associated with achievement of MDA.Dermatology (Source: Dermatology)
Source: Dermatology - May 29, 2019 Category: Dermatology Source Type: research

The Recurrence of Onychocryptosis when Treated with Phenolization: Does Phenol Application Time Play a Role? A Follow-Up Study on 622 Procedures
Conclusion: In this observational study, 4 min with no interruptions seems to be the appropriate application time of phenol when using CMP for the treatment of onychocryptosis. A randomized controlled trial should be carried out to confirm our results.Dermatology (Source: Dermatology)
Source: Dermatology - May 29, 2019 Category: Dermatology Source Type: research

Intralesional Triamcinolone for Fistulous Tracts in Hidradenitis Suppurativa: An Uncontrolled Prospective Trial with Clinical and Ultrasonographic Follow-Up
Conclusions: Our study suggests that ILT is beneficial for small fistulous tracts in HS.Dermatology (Source: Dermatology)
Source: Dermatology - May 29, 2019 Category: Dermatology Source Type: research

Attenuation of Severe Generalized Junctional Epidermolysis Bullosa by Systemic Treatment with Gentamicin
Severe generalized junctional epidermolysis bullosa (JEB), a lethal genodermatosis, is mainly caused by premature termination codons (PTCs) in one of the three genes encoding the anchoring protein laminin-332. Only symptomatic treatment has been established; overcoming PTCs by aminoglycosides may represent an interesting alternative. This retrospective study aimed at assessing for the first time the clinical effects of systemic gentamicin application in infants with severe generalized JEB. Five patients, homozygous or compound-heterozygous for PTCs in the geneLAMB3, were treated with gentamicin which was administered intra...
Source: Dermatology - May 27, 2019 Category: Dermatology Source Type: research

The Broad-Spectrum Impact of Hidradenitis Suppurativa on Quality of Life: A Comparison with Psoriasis
Conclusions: When compared to many different skin conditions, and in particular to psoriasis, HS was the most impairing condition, even at low levels of clinical severity.Dermatology (Source: Dermatology)
Source: Dermatology - May 23, 2019 Category: Dermatology Source Type: research

A Retrospective Cohort Study on Patients with Lentigo Maligna Melanoma
Conclusion: Male gender, age over 70 at diagnosis, and a Breslow thickness greater than 0.75 mm were associated with a statistically significant decrease in overall disease-free survival in the current study. The results of the study confirm the favorable outcome of LMM. However, diagnosed patients should undertake regular follow-ups. The intensity of follow-up in these patients can be individualized based on the probability of recurrence/metastasis and overall survival. Furthermore, the study showed that SLNB might not be a necessary staging procedure in patients with LMM.Dermatology (Source: Dermatology)
Source: Dermatology - May 22, 2019 Category: Dermatology Source Type: research

< b > < i > Staphylococcus epidermidis < /i > < /b > : A Potential New Player in the Physiopathology of Acne?
Background:Cutibacterium acnes has been identified as one of the main triggers of acne. However, increasing knowledge of the human skin microbiome raises questions about the role of other skin commensals, such asStaphylococcus epidermidis, in the physiopathology of this skin disease.Summary: This review provides an overview of current knowledge of the potential role ofS. epidermidis in the physiopathology of acne. Recent research indicates that acne might be the result of an unbalanced equilibrium betweenC. acnes andS. epidermidis,according to dedicated interactions. Current treatments act onC. acnesonly. Other treatment o...
Source: Dermatology - May 22, 2019 Category: Dermatology Source Type: research

Disease-Free Survival for Patients with Thin Melanomas according to the American Joint Committee on Cancer 8th Edition
Conclusions: The AJCC 8th edition seems to be a better tool for staging thin melanomas.Dermatology (Source: Dermatology)
Source: Dermatology - May 22, 2019 Category: Dermatology Source Type: research

Dupilumab and Alopecia: Causative or Therapeutic?
Dermatology (Source: Dermatology)
Source: Dermatology - April 18, 2019 Category: Dermatology Source Type: research

A Comparative Study of Google Search Trends for Melanoma, Breast Cancer and Prostate Cancer in Finland
Dermatology (Source: Dermatology)
Source: Dermatology - April 18, 2019 Category: Dermatology Source Type: research

< b > < i > Staphylococcus aureus < /i > < /b > and Host Immunity in Recurrent Furunculosis
Staphylococcus aureus is one of the severest and most persistent bacterial pathogens. The most frequentS. aureus infections include impetigo, folliculitis, furuncles, furunculosis, abscesses, hidradenitis suppurativa, and mastitis.S. aureus produces a great variety of cellular and extracellular factors responsible for its invasiveness and ability to cause pathological lesions. Their expression depends on the growth phase, environmental factors, and location of the infection. Susceptibility to staphylococcal infections is rooted in multiple mechanisms of host immune responses and reactions to bacterial colonization. Immunol...
Source: Dermatology - April 18, 2019 Category: Dermatology Source Type: research

Comorbidity of Vitamin A and Vitamin D Deficiency Exacerbates the Severity of Atopic Dermatitis in Children
Conclusions: VA and VD co-deficiency may exacerbate AD symptoms in children, but the specific mechanism underlying this relationship requires further study. These findings may indicate the need for studies evaluating the use of VD and VA as potential treatments for AD patients.Dermatology (Source: Dermatology)
Source: Dermatology - April 15, 2019 Category: Dermatology Source Type: research

Radiotherapy in Periocular Cutaneous Malignancies: A Retrospective Study
Conclusion: RT, which provides a good therapeutic response with minimal adverse events, is a therapy option for periocular cutaneous malignancies.Dermatology (Source: Dermatology)
Source: Dermatology - April 3, 2019 Category: Dermatology Source Type: research

Emergency Consultations in Dermatology in a Secondary Referral Hospital in Southern Switzerland: A Prospective Cross-Sectional Analysis
Conclusions: Our study indicates that the dermatological diagnoses in the emergency visits significantly differ from those of the routinely scheduled appointments. In a significant portion of patients, the use of an emergency consultation was not justified. This study provides support to the idea that a specific training is required to manage dermatological emergencies and that efforts should be made to reduce unjustified emergency visit use.Dermatology (Source: Dermatology)
Source: Dermatology - March 31, 2019 Category: Dermatology Source Type: research

Switching from Secukinumab to Ustekinumab in Psoriasis Patients: Results from a Multicenter Experience
Conclusion: Ustekinumab was safe and effective in treating patients unresponsive to secukinumab.Dermatology (Source: Dermatology)
Source: Dermatology - March 31, 2019 Category: Dermatology Source Type: research

IL-33/ST2 Axis Regulates Vasculogenic Mimicry via ERK1/2-MMP-2/9 Pathway in Melanoma
Conclusion: IL-33 can directly act on melanoma cells and promote its development.Dermatology (Source: Dermatology)
Source: Dermatology - March 31, 2019 Category: Dermatology Source Type: research

The Evolution of Quality of Life Assessment and Use in Dermatology
The creation of the Dermatology Life Quality Index (DLQI) questionnaire facilitated many studies on the impact of skin diseases on patients ’ quality of life (QoL). Many national and international guidelines recommend QoL assessment in dermatology, and some of them contain detailed recommendations on treatment goals and changes of treatment approaches based on DLQI score banding and minimal clinically important difference. The methodo logy of QoL in strument development and validation is constantly becoming more rigorous. Initiatives on selection of core outcome sets for skin diseases are focused on clinical trials b...
Source: Dermatology - March 31, 2019 Category: Dermatology Source Type: research

Long Hair throughout the Ages
Dermatology (Source: Dermatology)
Source: Dermatology - March 20, 2019 Category: Dermatology Source Type: research

Augmented Intelligence in Dermatology: Fantasy or Future?
Dermatology (Source: Dermatology)
Source: Dermatology - March 20, 2019 Category: Dermatology Source Type: research

Augmentation of Understanding in Clinical Practise and Big Data Analytics
Dermatology (Source: Dermatology)
Source: Dermatology - March 15, 2019 Category: Dermatology Source Type: research

Insights into Worldwide Interest in Tattoos Using Google Trends
Dermatology (Source: Dermatology)
Source: Dermatology - March 7, 2019 Category: Dermatology Source Type: research

Idiopathic Papular Dermatitis in the Spectrum of Chronic Papular Eruptions (Subacute Prurigo): Reappraisal and Diagnostic Algorithm
Conclusions: Chronic papular eruptions encompass a wide range of skin diseases. In more than half of the cases, the etiopathogenesis remains unclear. On the basis of our results, we propose a diagnostic algorithm for idiopathic papular dermatitis.Dermatology (Source: Dermatology)
Source: Dermatology - March 7, 2019 Category: Dermatology Source Type: research

Characterization of the Blood Microbiota in Korean Females with Rosacea
Dermatology (Source: Dermatology)
Source: Dermatology - March 7, 2019 Category: Dermatology Source Type: research

Immunoregulatory Effects of Neuropeptides on Endothelial Cells: Relevance to Dermatological Disorders
Many skin diseases, including psoriasis and atopic dermatitis, have a neurogenic component. In this regard, bidirectional interactions between components of the nervous system and multiple target cells in the skin and elsewhere have been receiving increasing attention. Neuropeptides released by sensory nerves that innervate the skin can directly modulate functions of keratinocytes, Langerhans cells, dermal dendritic cells, mast cells, dermal microvascular endothelial cells and infiltrating immune cells. As a result, neuropeptides and neuropeptide receptors participate in a complex, interdependent network of mediators that ...
Source: Dermatology - February 26, 2019 Category: Dermatology Source Type: research

Use of Complementary and Alternative Therapies in Outpatients with Atopic Dermatitis from a Dermatological University Department
Conclusion: CAM use is frequent in both children and adult AD patients. CAM users are characterized by long disease duration, a significant disease burden and by having a longer education. The high prevalence of CAM may indicate that patients ’ expectations regarding treatment of AD are not redeemed in the conventional health care system.Dermatology (Source: Dermatology)
Source: Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Pembrolizumab for Unresectable or Metastatic Melanoma in Patients Older than 85 Years of Age
Conclusion: These results indicate that pembrolizumab treatment in patients older than 85 years may induce responses but is associated with a high risk of toxicity and impaired autonomy.Dermatology (Source: Dermatology)
Source: Dermatology - February 6, 2019 Category: Dermatology Source Type: research

A Retrospective Review of Dupilumab for Hand Dermatitis
Dermatology (Source: Dermatology)
Source: Dermatology - February 6, 2019 Category: Dermatology Source Type: research

Idiopathic Generalized Exfoliative Dermatitis and Association with Antihypertensive Drugs and Statins: A Retrospective Case-Control Study
Conclusions: There was insufficient evidence to suggest a significant relationship between the chronic use of antihypertensive drugs or statins and idiopathic GED in this study, despite previous evidence reporting this might be so. Further case-control studies with larger sample sizes are needed to evaluate this association.Dermatology (Source: Dermatology)
Source: Dermatology - February 4, 2019 Category: Dermatology Source Type: research

Spanish Validation of the GEPARD Questionnaire for the Detection of Psoriatic Arthritis in Argentinian Patients with Psoriasis
Conclusions: The GEPARDa version has proven to be a diagnostic tool with excellent performance so that it can be considered a valid tool for the detection of PsA in Argentinian patients.Dermatology (Source: Dermatology)
Source: Dermatology - January 17, 2019 Category: Dermatology Source Type: research

Long-Wave Medical Infrared Thermography: A Clinical Biomarker of Inflammation in Hidradenitis Suppurativa/Acne Inversa
Conclusion: MIT is a promising tool for the detection of inflammation severity in HS lesions and can be used as a clinical biomarker in evaluation studies of medical and surgical HS treatment.Dermatology (Source: Dermatology)
Source: Dermatology - January 16, 2019 Category: Dermatology Source Type: research

Influence of the Topographic Vascular Distribution of the Face on Dermal Filler Accidents
Conclusions: The highest index of vascular lesions and especially visual alterations occurred for fillings of the upper third of the face. To prevent and avoid this type of lesion, it is advisable to avoid, as much as possible, treatments with filling materials in the upper third of the face, mainly including the glabellar and nasal region (III) and supraorbital region (VIII).Dermatology (Source: Dermatology)
Source: Dermatology - January 16, 2019 Category: Dermatology Source Type: research

The Effectiveness of Topical Cerium Nitrate-Silver Sulfadiazine Application on Overall Outcome in Patients with Calciphylaxis
Conclusions: Cerium nitrate may lead to vascular decalcification and chelation of reactive oxygen species, and prevent infection. Cerium nitrate-silver sulfadiazine was associated with better outcomes and should be tested in a prospective comparative trial in CPX patients.Dermatology (Source: Dermatology)
Source: Dermatology - January 3, 2019 Category: Dermatology Source Type: research

Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study
Conclusion: Both ruxolitinib and tofacitinib could be considered effective and well-tolerated treatments for extensive AA.Dermatology (Source: Dermatology)
Source: Dermatology - December 19, 2018 Category: Dermatology Source Type: research

Psoriasis: Keratinocytes or Immune Cells – Which Is the Trigger?
Background: Psoriasis is a common, chronic inflammatory skin disorder, which can significantly impact quality of life. Despite major breakthroughs in our understanding of the pathogenesis of psoriasis, the chronological order of the underlying mechanisms leading to the development of psoriatic plaques remains to be completely understood.Summary: Although psoriasis is classically perceived as a T-cell disease, it is now well recognized that T lymphocytes do not function in exclusivity. This theory is supported by evidence from transgenic murine models that develop marked psoriasiform disease. In addition, immune cells and c...
Source: Dermatology - December 19, 2018 Category: Dermatology Source Type: research

Confocal Microscopy and Lentigo Maligna: An in vivo Pilot Study for the Assessment of Response to Imiquimod Therapy
Conclusion: In patients not suitable for surgical intervention imiquimod treatment is an appropriate treatment alternative. Thereby, in vivo RCM was demonstrated to be an excellent examining device, which not only allows diagnosis of LM, but also therapy and follow-up examinations. An important benefit of RCM, in contrast to conventional histopathology, is the simple handling with in vivo examination of epidermal skin without any pain for the patient.Dermatology (Source: Dermatology)
Source: Dermatology - December 14, 2018 Category: Dermatology Source Type: research

A Review of Scabies: An Infestation More than Skin Deep
Human scabies, a common infestation, has a worldwide distribution with a variable impact and presentation depending on the clinical situation. In developed, high-income settings, health institution and residential home outbreaks challenge health and social care services. In resource-poor settings, it is the downstream sequelae of staphylococcal and streptococcal bacteraemia, induced by scratching, which have a significant impact on the long-term health of communities. Over the past decade scabies has been recognised as a “neglected tropical disease” (NTD) by the World Health Organisation, has an accepted practi...
Source: Dermatology - December 14, 2018 Category: Dermatology Source Type: research

Dermatonutrigenomics: Past, Present, and Future
Dermatology (Source: Dermatology)
Source: Dermatology - November 29, 2018 Category: Dermatology Source Type: research

Facial and Extrafacial Lesions in an Ethnically Diverse Series of 91 Patients with Frontal Fibrosing Alopecia Followed at a Single Center
Conclusions: There is a significant association among Hispanic/Latino ethnicity, facial papules, and premenopausal status, which may portend a susceptibility to severer disease and prompt early and aggressive treatment in this group.Dermatology (Source: Dermatology)
Source: Dermatology - November 22, 2018 Category: Dermatology Source Type: research

Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study
Conclusions: Our findings show that an improvement was reached in only about a third of all cases. High response rates with only mild side effects (in 16 out of 35 patients) were observed.Dermatology (Source: Dermatology)
Source: Dermatology - November 21, 2018 Category: Dermatology Source Type: research