Tablet allergen immunotherapy (TAIT) requires tight management
(Source: Allergo Journal International)
Source: Allergo Journal International - January 11, 2021 Category: Allergy & Immunology Source Type: research

A gender-specific approach to occupational allergic contact dermatitis
ConclusionGender-distribution in OACD reflects differences in occupations with respect to men and women as evidenced by working sectors and haptens involved in the pathogenesis. (Source: Allergo Journal International)
Source: Allergo Journal International - December 17, 2020 Category: Allergy & Immunology Source Type: research

House dust mite immunotherapy in Germany: real-world adherence to a  subcutaneous allergoid and a sublingual tablet
The objective of this study was to evaluate real-world adherence to house dust mite (HDM) AIT with a subcutaneous (SCIT) allergoid preparation and a subl ingual (SLIT) tablet.Patients and methodsIn this retrospective cohort analysis of a  German longitudinal prescription database, patients receiving either a HDM-SCIT allergoid (n = 5677) or a HDM-SLIT tablet (n = 4720) were compared over a 3-year observation period. Study endpoints included adherence and days on therapy (DoT). Univariate statistical tests were used to assess the significance of the differences between SCIT vs...
Source: Allergo Journal International - December 17, 2020 Category: Allergy & Immunology Source Type: research

Rapid protocol for irinotecan desensitization: a  case report and literature review
(Source: Allergo Journal International)
Source: Allergo Journal International - December 10, 2020 Category: Allergy & Immunology Source Type: research

Healthcare provision for insect venom allergy patients during the COVID-19 pandemic
AbstractThe population prevalence of insect venom allergy ranges between 3 –5%, and it can lead to potentially life-threatening allergic reactions. Patients who have experienced a systemic allergic reaction following an insect sting should be referred to an allergy specialist for diagnosis and treatment. Due to the widespread reduction in outpatient and inpatient care c apacities in recent months as a result of the COVID-19 pandemic, the various allergy specialized centers in Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy will continue to re...
Source: Allergo Journal International - December 8, 2020 Category: Allergy & Immunology Source Type: research

How will climate change alter the dynamics of airborne pollen and pollen load of allergenic plants?
ConclusionThe assumption that climate warming in Linz over 26  years should have increased pollen concentrations of allergenic plants was not confirmed. On the contrary, trend analyses showed that the pollen load has decreased. Hence, the increase in sensitization to pollen allergens and of the prevalence of pollen allergies ask for other explanations. (Source: Allergo Journal International)
Source: Allergo Journal International - December 8, 2020 Category: Allergy & Immunology Source Type: research

Health care situation in patients with allergic respiratory diseases with special focus on specific immunotherapy
ConclusionAnalysis of the care situation with regard to the specific immunotherapy in cases of allergic respiratory diseases (VerSITA) provides a  solid basis for future research and for informing decision-makers in order to develop measures to optimize care. (Source: Allergo Journal International)
Source: Allergo Journal International - November 20, 2020 Category: Allergy & Immunology Source Type: research

Airlines provide too little information for allergy sufferers!
DiscussionThe information offered by many airlines for passengers with allergies is insufficient. To offer greater guidance, updated information has been formulated in German and English, and its use is recommended. (Source: Allergo Journal International)
Source: Allergo Journal International - November 20, 2020 Category: Allergy & Immunology Source Type: research

Marker allergens in Hymenoptera venom al lergy — Characteristics and potential use in precision medicine
AbstractBackgroundA  comprehensive diagnostic work-up is essential to ensure adequate patient management for the potentially life-threatening condition of Hymenoptera venom allergy (HVA). This includes an unambiguous identification of the allergy-relevant venom as prerequisite for successful venom-specific immunothera py (VIT). If the clinical history does not allow the identification of the culprit insect, diagnosis is often hampered by positive test results to various venoms. Modern component-resolved diagnostics (CRD) applying marker allergens of Hymenoptera venoms has created new opportunities which facilitat e th...
Source: Allergo Journal International - November 17, 2020 Category: Allergy & Immunology Source Type: research

Clinical performance of house-dust-mite-specific subcutaneous immunotherapy in a  postmarket noninterventional setting
(Source: Allergo Journal International)
Source: Allergo Journal International - October 20, 2020 Category: Allergy & Immunology Source Type: research

Anti-inflammatory substances from onions could be an option for treatment of COVID-19 —a hypothesis
(Source: Allergo Journal International)
Source: Allergo Journal International - October 20, 2020 Category: Allergy & Immunology Source Type: research

Abstracts, 12th Symposium of the Working Group on Insect Venom Allergy, German Society of Allergy and Clinical Immunology (DGAKI), Frankfurt, Germany, November 20/21, 2020
(Source: Allergo Journal International)
Source: Allergo Journal International - October 5, 2020 Category: Allergy & Immunology Source Type: research

Use of allergy tests to identify dietary and environmental triggers of eosinophilic esophagitis: protocol for a  systematic review
SummaryPurposeEosinophilic esophagitis (EoE) is a  chronic immune-mediated esophageal disease. Most EoE patients have atopic comorbidities and they test positive when allergy tests are performed. Our aim is to critically assess the relation of allergens detected by allergy tests with clinically confirmed triggers of EoE.MethodsA  systemic review and meta-analysis will be conducted, which will involve searching electronic databases using predetermined search terms, in order to identify relevant studies. Studies will be independently screened against predefined eligibility criteria and subgroup analysis will be use...
Source: Allergo Journal International - September 30, 2020 Category: Allergy & Immunology Source Type: research

Incidence rate of severe adverse drug reactions to nonionic contrast media at the National Hospital Organization Osaka National Hospital
DiscussionAlthough the rate of severe adverse drug reactions in this study appears to be higher than expected, the sample size of 42,501 patients is insufficient to conclusively determine the incidence and mortality rates of adverse drug reactions, as these rates are extremely low. Further studies are required to estimate the countrywide prevalence of adverse drug reactions in response to contrast media. (Source: Allergo Journal International)
Source: Allergo Journal International - September 9, 2020 Category: Allergy & Immunology Source Type: research

Is the concept of “peanut-free schools” useful in the routine management of peanut-allergic children at risk of anaphylaxis?
ConclusionIn order to address the fears and concerns of patients, parents, and school staff, it is mandatory to develop various coping strategies. These should enable and ensure the safety and participation of food-allergic pupils in classes and other school activities. Therefore, it is important to implement adequate measures for allergen avoidance and emergency treatment for students with confirmed food allergies. (Source: Allergo Journal International)
Source: Allergo Journal International - August 31, 2020 Category: Allergy & Immunology Source Type: research

Abstracts of the 15th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 30, 2020 Category: Allergy & Immunology Source Type: research

Suspected penicillin allergy: risk assessment using an algorithm as an antibiotic stewardship project
ConclusionTriage of patients with suspected BLA is urgently required. While allergy testing, including provocation testing, represents the most reliable solution, this is not feasible in all patients due to the high prevalence of BLA allergies. The risk stratification algorithm developed for the authors ’ hospital represents a tool suitable to making a contribution to rational antibiotic therapy. (Source: Allergo Journal International)
Source: Allergo Journal International - August 26, 2020 Category: Allergy & Immunology Source Type: research

Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
ConclusionThe free combination therapies of mast cell stabilizers, decongestants, AHs and nasal GCs, frequently used in the routine care of patients with AR, cannot be recommended because they are not evidence-based. Due to the fact that over-the-counter antiallergic drugs are not reimbursable in Germany, there is no medical supervision of the therapy. In addition, there are doubts about appropriate treatment, especially of patients with persistent rhinitis with severe symptoms, as these patients often use several preparations at the same time to alleviate their symptoms. (Source: Allergo Journal International)
Source: Allergo Journal International - July 19, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs: results of an Austrian cohort study
ConclusionOPT with alternative NSAIDs are useful in patients with NSAID hypersensitivity as tolerability varies between the individual substances. (Source: Allergo Journal International)
Source: Allergo Journal International - July 13, 2020 Category: Allergy & Immunology Source Type: research

Identification of a  53 kDa protein, as a new high molecular weight allergen from Fraxinus excelsior (Ash) pollen
In this study, a high molecular weight allergen from ash pollen was identified.MethodsIn all, 20 individuals allergic to ash participated in the study. Characterization and immunoreactivity of ash pollen proteins was performed using sodium dodecyl sulfate polyacrylamide electrophoresis (SDS-PAGE), two-dimensional (2D) gel electrophoresis and immunoblotting.ResultsImmunoglobulin E (IgE)-binding proteins with apparent molecular mass ranging from 9  to 110 kDa were detected in ash pollen extract. Serum IgE of 7 (35%) patients reacted with a 53-kDa protein band. Analysis of 2D immunoblots showed several I...
Source: Allergo Journal International - June 29, 2020 Category: Allergy & Immunology Source Type: research

Anaphylaxis to lidocaine and cross-reactivity to articaine and prilocaine with tolerance to bupivacaine
(Source: Allergo Journal International)
Source: Allergo Journal International - June 23, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to biologics (part  II): classifications and current diagnostic and treatment approaches
ConclusionHSRs to BS are gradually increasing with the widening of their clinical use and indications. It is very important to prevent HSRs and to know the degree of severity as well as the emergency treatment algorithm. This review summarizes the diagnostic tests that should be applied: (a)  immediately during/after a reaction, and (b) subsequently, and in the case that a switch of BS is not possible, desensitization is an option. (Source: Allergo Journal International)
Source: Allergo Journal International - June 18, 2020 Category: Allergy & Immunology Source Type: research

A  prediction of dust mite populations in different categories of housing quality in Auckland, New Zealand
ConclusionsOccupant behaviour is suggested as an influencing factor with a  call for policy makers to consider real-time feedback loops to dwelling occupants, in conjunction with structural interventions, to improve the health of the interior environment. (Source: Allergo Journal International)
Source: Allergo Journal International - June 17, 2020 Category: Allergy & Immunology Source Type: research

Omalizumab in three children with severe vernal keratoconjunctivitis
ConclusionAlthough the clinical benefit of omalizumab in asthma and chronic spontaneous urticaria (CSU) has been established in several clinical trials, there are very little data about its effect on severe VKC. In addition to few previously reported cases we can report the rapid effectiveness of omalizumab in VKC clinically and in terms of quality of life. Randomized trials are needed to include omalizumab in third-line treatment of VKC for prevention of visual impairment and further sequelae such as corneal damage. (Source: Allergo Journal International)
Source: Allergo Journal International - May 25, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to biologics (part  I): allergy as an important differential diagnosis in complex immune-derived adverse events
ConclusionThere is an urgent need for a  simpler symptom- or system-based classification and scoring system to create an awareness for HSRs to BSs. A better understanding of the pathophysiology of HSRs and increased clinical experience in the treatment of side effects will provide timely control of unexpected reactions. As a result, im munotherapy with BSs will become safer in the future. (Source: Allergo Journal International)
Source: Allergo Journal International - May 11, 2020 Category: Allergy & Immunology Source Type: research

Dietary implications in acetylsalicylic acid intolerance
ConclusionDietary therapy in ASA-intolerant patients is not recommended. (Source: Allergo Journal International)
Source: Allergo Journal International - May 10, 2020 Category: Allergy & Immunology Source Type: research

Development of a  practice guideline for dietary counselling of children with IgE-mediated food allergy
ConclusionThis guideline provides a  comprehensive guide to dietary counselling for food allergy by dietitians in Switzerland. It will inform best practice and improve patient-centred care and encourage a consistent approach, but it will need to be reviewed and updated as more robust evidence is produced. (Source: Allergo Journal International)
Source: Allergo Journal International - April 6, 2020 Category: Allergy & Immunology Source Type: research

Current challenges in molecular diagnostics of insect venom allergy
AbstractBackgroundAdvanced component-resolved diagnostics (CRD) in Hymenoptera venom allergy (HVA) has improved the precise description of individual sensitization profiles. However, diagnostic gaps, peptide-based cross-reactivity, early identification of severe reactors and diagnosis of patients with a  clear history of sting reactions but negative specific IgE and skin tests, remain challenging.MethodsSystematic literature search in PubMed and critical analysis of recently published studies on insect venom allergy diagnostics.Results and discussionCRD has increased the sensitivity of IgE testing and improved the dis...
Source: Allergo Journal International - March 8, 2020 Category: Allergy & Immunology Source Type: research

Natural history of systemic reactions and risk factors in children and adults with Hymenoptera venom allergy
ConclusionsThere is limited evidence with regard to the natural history of HVA both in adults and in children. Several risk factors may influence the natural history of HVA, namely patient-related, allergen-related and reaction-related. Other factors are inherent to the use of venom immunotherapy (VIT). (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research

Venom immunotherapy in patients with mastocytosis
ConclusionsPatients with primary MCAS and IgE-mediated HVA are candidates to receive VIT. Their management does not differ much from general population with the exception of VIT duration. (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research

Venom immunotherapy in Europe and the United States
AbstractBackgroundHymenoptera stings are accountable for significant morbidity and deterioration in health-related quality of life due to the allergic reactions they cause, the most severe of which can culminate in fatal anaphylaxis. The availability of high quality venom extracts for use in the diagnosis and treatment of insect venom allergy has improved the prognosis and the health-related quality of life of venom-allergic patients. All over the world subcutaneous venom immunotherapy is currently the most effective form of allergen-based immunotherapy with an early, sustained and long-term efficacy. Even though the type ...
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research

Mastocytosis as a  risk factor for insect venom allergy
ConclusionsMastocytosis represents a risk factor for severe reaction in patients with HVA. An early diagnosis of CMD in these patients is very important since they are at high risk of severe osteoporosis and early therapy can be immediately started. Moreover, proper advice and prescription of adrenaline can be assessed. Finally, in order to stop venom immunotherapy or whether to continue it lifelong, diagnosis of CMD has to be carried out. (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research

Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
AbstractPhysicians think of mast cells and IgE primarily in the context of allergic disorders, including fatal anaphylaxis. This ‘bad side’ of mast cells and IgE is so well accepted that it can be difficult to think of them in other contexts, particularly those in which they may have beneficial functions. However, there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions par tially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites. Accordingl...
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research

Anaphylactic reaction at a  pizzeria in a 13-year-old female patient
(Source: Allergo Journal International)
Source: Allergo Journal International - February 19, 2020 Category: Allergy & Immunology Source Type: research

Allergy to tree-of-heaven pollen in Germany: detection by positive nasal provocation
(Source: Allergo Journal International)
Source: Allergo Journal International - February 19, 2020 Category: Allergy & Immunology Source Type: research

Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-00110-9Affiliation and disclaimer have been misrepresented and are hereby corrected:Vera  Mahler:Affiliation: Med. Faculty, Friedrich-Alexander-University (FAU) Erlangen-N ürnberg, Germany.Disclaimer: The views expressed in this … (Source: Allergo Journal International)
Source: Allergo Journal International - February 11, 2020 Category: Allergy & Immunology Source Type: research

Abstracts of the 32nd Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 14, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Consumer protection and risk assessment: sensitising substances in consumer products
Correction to:Allergo J Int 2019 28:167 –182https://doi.org/10.1007/s40629-019-0093-3The article “Consumer protection and risk assessment: sensitising substances in consumer products”, written by Hermann-Josef Thierse and Andreas Luch, was originally published Online First without Open Access. … (Source: Allergo Journal International)
Source: Allergo Journal International - November 14, 2019 Category: Allergy & Immunology Source Type: research

Severe skin reactions: clinical picture, epidemiology, etiology, pathogenesis, and treatment
ConclusionThe rarity and unpredictability of the reactions make a  randomized double-blind therapeutic trial extremely difficult. Using meta-analyses, it is possible to trace a trend in the use of systemic treatment options. Supportive care remains the most important treatment strategy for all clinical entities. (Source: Allergo Journal International)
Source: Allergo Journal International - November 10, 2019 Category: Allergy & Immunology Source Type: research

ARIA guideline 2019: treatment of allergic rhinitis in the German health system
DiscussionA  comprehensive ICP guideline can reflect real-life care better than traditional guideline models. (Source: Allergo Journal International)
Source: Allergo Journal International - October 21, 2019 Category: Allergy & Immunology Source Type: research

Drug-induced anaphylaxis —elicitors, mechanisms and diagnosis
AbstractDrugs are one of the major causes of anaphylaxis. For example 2346  cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs;n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly as so...
Source: Allergo Journal International - October 16, 2019 Category: Allergy & Immunology Source Type: research

Characterization of a  cohort of storage mite sensitized subjects
ConclusionsSM are a  common sensitization in the study population and should be included in standard skin prick test arrays. Cross sensitization to house dust mites is limited and nasal symptoms are most frequent. Nasal provocation testing is necessary to secure clinical diagnosis of allergy and further research is ne eded to evaluate the clinical relevance of the high sensitization rates found for intradermal testing. (Source: Allergo Journal International)
Source: Allergo Journal International - October 9, 2019 Category: Allergy & Immunology Source Type: research

Ash pollen allergy and aerobiology
ConclusionSymptoms in individuals sensitized to ash pollen vary according to the pollen count and may be masked by pollen from other trees that flower at the same time of year. Sensitization to ash/Ole  e 1 can be higher than to birch/Bet v 1. The determination of IgE to common ash (Fraxinus excelsior) is more sensitive than to American ash (Fraxinus americana). Ash dieback due to Chalara appears to increase pollen emission. Allergies to ash pollen can be significantly underestimated due to a  failure to (correctly) identify them; they can also be masked by other pollen families (birch). Harmful or...
Source: Allergo Journal International - September 29, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-0100-8In the “Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics” Figs. 5 and 6 (allergy passports) are in German. Here you will find the allergy passports in … (Source: Allergo Journal International)
Source: Allergo Journal International - September 18, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 14th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 28, 2019 Category: Allergy & Immunology Source Type: research

IgE-mediated hypersensitivity to chlorhexidine among first-year dental students
ConclusionsAlthough most participants reported no known exposure to CHX, 8.6% showed CHX sensitisation suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reactions in the future. (Source: Allergo Journal International)
Source: Allergo Journal International - August 11, 2019 Category: Allergy & Immunology Source Type: research

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
AbstractThis guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a  consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories cle arly exceeds the number of confirmed cases. The large number of suspected BLA allerg...
Source: Allergo Journal International - July 21, 2019 Category: Allergy & Immunology Source Type: research

What we learned from TAO – 10 years of German therapy allergen ordinance
ConclusionsIn Germany, TAO ensures that all previously untested named patient products for the treatment of frequent allergies are subjected to an assessment of their risk/benefit ratio according to the current state of science. (Source: Allergo Journal International)
Source: Allergo Journal International - July 14, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Air pollutants and primary allergy prevention
Correction to:Allergo J Int 2018https://doi.org/10.1007/s40629-018-0078-7An error was identified in the review on “Air pollutants and primary allergy prevention”. The given PM2.5 increment of 2  µg/m3 was wrong and should be replaced with an increment of 5  µg/m3.This was the case on:Page  9, legend … (Source: Allergo Journal International)
Source: Allergo Journal International - June 26, 2019 Category: Allergy & Immunology Source Type: research

Atopic eczema score of emotional consequences —a questionnaire to assess emotional consequences of atopic eczema
ConclusionAESEC is a  questionnaire for assessing the emotional consequences of living with AE. It may prove useful in evaluating the burden of disease, beyond skin symptoms and time-specific quality of life. (Source: Allergo Journal International)
Source: Allergo Journal International - June 2, 2019 Category: Allergy & Immunology Source Type: research