One Health: areas in the living environment of people and animals and their effects on allergy and asthma
ConclusionBiodiverse green spaces, especially forests and meadows, may offer some protection against asthma and allergies. Contact with soil and ground also seems important for the diverse skin microbiome, especially in childhood, and thus presumably beneficial for the immune system. Therefore, people and man ’s best friend, the dog, should spend sufficient time in green, biodiverse environments, despite—or perhaps because—of rapid urbanization. People should also actively create such biodiverse surroundings in their closer living environment. On a broader level, in the spirit of the One Health co ncept, those respo...
Source: Allergo Journal International - May 17, 2022 Category: Allergy & Immunology Source Type: research

Improved IgG antibody diagnostics of hypersensitivity pneumonitis and pulmonary mycoses by means of newly evaluated serum antibody ranges and frequencies using IgG ImmunoCAP ™
ConclusionThis study is the first to evaluate the ranges not only of avian andAspergillus fumigatus antigens, as has been done up to now, but also of antibodies against 24  other environmental antigens. Quantification of IgG antibodies regarding their specific ranges can help to improve the serodiagnostics of immune-mediated lung diseases. In the lower ranges IgG antibodies are mainly physiological, while higher ranges correlate with the mentioned diseases as HP and ABPA/allergic bronchopulmonary mycoses (ABPM). The determined frequencies of the eight HP antibodies can be helpful in establishing HP screening tests. (Sourc...
Source: Allergo Journal International - May 17, 2022 Category: Allergy & Immunology Source Type: research

“Adrenaline junkie”: a case report of repeated use of epinephrine
(Source: Allergo Journal International)
Source: Allergo Journal International - May 12, 2022 Category: Allergy & Immunology Source Type: research

Epithelial barrier hypothesis and the development of allergic and autoimmune diseases
AbstractThe “epithelial barrier hypothesis” proposes that genetic predisposition to epithelial barrier damage, exposure to various epithelial barrier–damaging agents and chronic periepithelial inflammation are responsible for the development of allergic and autoimmune diseases. Particularly, the introduct ion of more than 200,000 new chemicals to our daily lives since the 1960s has played a major role in the pandemic increase of these diseases. The epithelial barrier constitutes the first line of physical, chemical, and immunological defence against external factors. A leaky epithelial barrier init iates the transl...
Source: Allergo Journal International - May 4, 2022 Category: Allergy & Immunology Source Type: research

White paper peanut allergy
AbstractThe current management of a  primary IgE-mediated peanut allergy consists of the two basic pillars “exposure prophylaxis” with avoidance of the allergen and “emergency therapy” with short-term treatment of an acute allergic reaction after accidental ingestion. Accidental reactions are common despite attempted avoidanc e. The severity of an allergic or even anaphylactic reaction after accidental ingestion is difficult to assess prior to reaction. In addition, reaction thresholds may vary depending on the accompanying augmentation factor. Therefore, every peanut allergic patient should receive individual die...
Source: Allergo Journal International - April 26, 2022 Category: Allergy & Immunology Source Type: research

Allergologic pitfalls in animal-assisted interventions
(Source: Allergo Journal International)
Source: Allergo Journal International - April 14, 2022 Category: Allergy & Immunology Source Type: research

Rhinitis allergica in storage mite allergy
ConclusionThe position paper gives recommendations for the diagnosis and therapy of allergic rhinitis in case of storage mite allergy. AIT is recommended in symptomatic allergy and proven storage mite allergy. Reliable detection by provocation testing is advised in this persistent allergy. The therapy should be carried out independently of the treatment of a  possible house dust mite allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - March 28, 2022 Category: Allergy & Immunology Source Type: research

Anaphylaxis to food additives
AbstractA  variety of additives found in foodstuffs have been associated with triggering of a number of clinical pictures. Hypersensitivity reactions of allergic and non-allergic etiology have been widely described, but are reported to be rare overall. This review presents a selection of food additives for which anaphylactic reactions have been described. These include colorants (e.g., tartrazine, carmine, patent blue), preservatives (e.g., sulfites, sodium benzoate), and thickeners/gelling agents (e.g., carboxymethylcellulose, guar, gum arabic). Possible diagnostic procedures (skin test, specific IgE , cellular antigen ...
Source: Allergo Journal International - March 11, 2022 Category: Allergy & Immunology Source Type: research

It ’s all in the mix: allergy to fenugreek in a boy with known sumac nut sensitization
(Source: Allergo Journal International)
Source: Allergo Journal International - March 7, 2022 Category: Allergy & Immunology Source Type: research

Chronic spontaneous urticaria following ChAdOx1-S COVID-19 vaccination
(Source: Allergo Journal International)
Source: Allergo Journal International - March 7, 2022 Category: Allergy & Immunology Source Type: research

Part  I: Insect stings and bites—Beyond the realm of bee and wasp allergies
SummaryBackgroundInsects are a  very diverse group of animals and valuable members of any ecosystem. Allergies to bees and wasps (order: Hymenoptera) are well known in Europe. Allergies, toxicities, and the spread of diseases by other insects are also possible but quite frequently are not diagnosed.SourcesA  MEDLINE search on allergy caused by stinging and biting insects apart from bees and wasps was conducted. All relevant articles were evaluated, and a selection of relevant publications and cases from our outpatient units are used to illustrate our arguments.Content and implicationsAllergies to insects following bites...
Source: Allergo Journal International - February 17, 2022 Category: Allergy & Immunology Source Type: research

Part  II: Insect allergies—Inhalation and ingestion
SummaryBackgroundAllergies to insect stings and bites are common and were partly discussed in part  I of this article series. Other mechanisms leading to allergen contact, sensitization, and potential allergy to insects or insects’ compounds can be hard to suspect and diagnose due to their sometimes-hidden character in food or dust.AimsWe aim to provide an overview of allergic reactions to insects elicited by mechanisms other than sting or bite reactions.SourcesA  PubMed search on allergy and insects apart from bees and wasps was conducted, articles were selected and included, and a series of relevant publications and...
Source: Allergo Journal International - February 11, 2022 Category: Allergy & Immunology Source Type: research

Frequency of positive allergy tests in children, adults and seniors
ConclusionInhalant allergies play a  relevant role until old age. Food allergies are mainly a disease of infancy, and contact allergies predominantly affect adult women. (Source: Allergo Journal International)
Source: Allergo Journal International - February 2, 2022 Category: Allergy & Immunology Source Type: research

Long-term benefits of targeted micronutrition with the holoBLG lozenge in house dust mite allergic patients
ConclusionsSustained long-term reduction of TNSS (primary endpoint) and sustained long-term improvement of secondary endpoints (temporal evolution of all symptom scores and well-being) were demonstrated 7 –8 months after cessation of holoBLG supplementation, indicative of a long-lasting nature of immune resilience induced by holoBLG.Trial registrationThe study was registered at clinicaltrials.gov (NCT04872868). (Source: Allergo Journal International)
Source: Allergo Journal International - January 13, 2022 Category: Allergy & Immunology Source Type: research

White paper peanut allergy —part 2: Diagnosis of peanut allergy with special emphasis on molecular component diagnostics
ConclusionThe most important diagnostic measures in determining the diagnosis of peanut allergy are clinical history and detection of sensitizations, also via component-based diagnostics. However, in case of unclear results, the gold standard —an oral food challenge—should always be used. (Source: Allergo Journal International)
Source: Allergo Journal International - December 6, 2021 Category: Allergy & Immunology Source Type: research