Crowd-sourced symptom data in pollen allergy: testing a  novel study approach for assessing the efficacy of food supplements
ConclusionThe study design relied on the evaluation of crowd-source symptom data alone by comparing the participants with a  baseline. The participant adherence turned out lower than expected; however a trend for reduced symptoms was found and is also supported by the quality-of-life questionnaire. (Source: Allergo Journal International)
Source: Allergo Journal International - January 29, 2024 Category: Allergy & Immunology Source Type: research

Efficacy and safety of the combination nasal spray olopatadine hydrochloride-mometasone furoate in the treatment of allergic rhinitis
ConclusionIn summary, AH and INCS will remain the main groups of active ingredients in the treatment of allergic rhinitis in the future. In combination preparations such as the new combination nasal spray olopatadine hydrochloride-mometasone furoate, they are highly effective and safe, thus opening up new perspectives, especially for patients with moderate and severe allergic rhinitis from the age of 12  years. (Source: Allergo Journal International)
Source: Allergo Journal International - January 22, 2024 Category: Allergy & Immunology Source Type: research

Diagnostic gap due to missing patch test allergens —status quo and possible scenarios for mitigation
SummaryAccording to European Directive 2001/83/EC, test and therapeutic allergens are medicinal products in all Member States of the European Union. This applies equally to prick test and to patch test (PT) allergens (haptens). All test allergens commercially marketed in Germany are finished medicinal products requiring marketing authorization (MA). Currently, 211  PT substances are authorized in Germany, and an additional 59 are in an ongoing MA process and are marketable under a transitional provision until a decision on MA is made. The regulatory guidance (CMDh/399/2019) of the Co-ordination Group for Mutual Recogni...
Source: Allergo Journal International - January 12, 2024 Category: Allergy & Immunology Source Type: research

Tattoo allergy —diagnosis on a circuitous route?
DiscussionDiagnosis of tattoo allergy is challenging. The IVDK Tattoo Study  2.0 enables the identification of metals and pigments in skin samples, the preparation of individual patch test preparations with pigments, and the investigation of specific T lymphocytes in blood samples. In addition, assessment of the clinical relevance can be improved by exposure data and resu lts of laboratory diagnostics. (Source: Allergo Journal International)
Source: Allergo Journal International - December 21, 2023 Category: Allergy & Immunology Source Type: research

Evaluation of systemic inflammation markers in patients with rhinitis
ConclusionWe found that systemic circulation of inflammatory cells was significantly increased in rhinitis with/without allergy compared to the control group. This study showed that not only AR, but also NAR triggers a  systemic increase of inflammation which supports the link between rhinitis and comorbid conditions such as asthma. Therefore, effective treatment may be suggested for local inflammation and its systemic manifestations. (Source: Allergo Journal International)
Source: Allergo Journal International - December 18, 2023 Category: Allergy & Immunology Source Type: research

Predictive value of the systemic immune inflammation index and systemic inflammatory response index on omalizumab drug survival in chronic spontaneous urticaria
ConclusionThis study suggests the potential utility of SIRI as a  superior predictive indicator for omalizumab’s drug survival in CSU patients compared to SII. Concomitant autoimmune disease or baseline IgE levels did not significantly affect the drug’s effectiveness. (Source: Allergo Journal International)
Source: Allergo Journal International - December 12, 2023 Category: Allergy & Immunology Source Type: research

Successful desensitization to asfotase alfa in hypophosphatasia: a  case report and IgE-mediated mechanism confirmation
(Source: Allergo Journal International)
Source: Allergo Journal International - December 8, 2023 Category: Allergy & Immunology Source Type: research

Contact allergy to medical devices
ConclusionWith continued development of medical devices, new contact allergens are introduced. The declaration of their ingredients is necessary for rapid diagnosis and future prevention. (Source: Allergo Journal International)
Source: Allergo Journal International - November 9, 2023 Category: Allergy & Immunology Source Type: research

Orchestration of inflammation in contact allergy by innate immune and cellular stress responses
ConclusionSkin inflammation in ACD is orchestrated by the interplay of the innate immune system and cellular stress responses. (Source: Allergo Journal International)
Source: Allergo Journal International - November 9, 2023 Category: Allergy & Immunology Source Type: research

Hives but no urticaria —what could it be?
This article summarizes common differential diagnoses of urticaria. (Source: Allergo Journal International)
Source: Allergo Journal International - November 2, 2023 Category: Allergy & Immunology Source Type: research

Non-occupational epoxy resin allergy
DiscussionNon-occupational epoxy resin allergy may be acquired not only from do-it-yourself activities in the narrow sense, which should be considered when taking the medical history. The association between epoxy resin and fragrance allergy does not go beyond the general level of associations between contact allergies with each other. (Source: Allergo Journal International)
Source: Allergo Journal International - October 30, 2023 Category: Allergy & Immunology Source Type: research

Chronic spontaneous urticaria —status quo and future
AbstractChronic spontaneous urticaria (CsU) is a  chronic inflammatory dermatosis whose etiology is not yet fully understood. In affected patients, it is often associated with a high limitation of health-related quality of life, which necessitates effective therapeutic management. Different immune cell populations such as mast cells, eosinophili c and basophilic granulocytes, and T cells are involved in the pathogenesis of CsU, whereby mast cells playing a key role. In addition, type I autoallergic reactions with auto IgE antibodies or type IIb autoimmune reactions with auto IgG antibodies have been identified in a ...
Source: Allergo Journal International - October 11, 2023 Category: Allergy & Immunology Source Type: research

Cyclophilins and gibberellin-regulated proteins in IgE-mediated allergic diseases
SummaryThe prevalence of immunoglobulin E (IgE)-mediated allergic diseases is currently experiencing an epidemic trend characterized by an increase in both the number of affected individuals and the proportion of patients with multiple sensitizations. The majority of these multiple sensitizations are attributed to IgE reactions to genuine allergenic proteins from unrelated species. However, there is a  growing trend of patients becoming sensitized to highly cross-reactive molecules, such as profilins, polcalcins, lipocalins, serum albumins, tropomyosins, and non-specific lipid transfer proteins (nsLTPs). In addition, alle...
Source: Allergo Journal International - October 4, 2023 Category: Allergy & Immunology Source Type: research

Urticaria in childhood —what’s new?
AbstractUrticaria can manifest at any age, including infants and young children. Urticaria is one of the most prevalent skin diseases in childhood. As in adults, a  distinction is made between acute and chronic urticaria, with chronic urticaria further classified into chronic spontaneous urticaria and inducible urticaria. According to the current German S3 guideline for classification, diagnosis, and treatment of urticaria, existing literature suggests that the prevalence, disease characteristics, causes, and also the response to treatment are very similar in children and adults. The clinical hallmark of urticaria is the...
Source: Allergo Journal International - September 22, 2023 Category: Allergy & Immunology Source Type: research

Abstracts of the 18th German Allergy Congress, Bonn, September 14 –16, 2023
(Source: Allergo Journal International)
Source: Allergo Journal International - August 30, 2023 Category: Allergy & Immunology Source Type: research