White paper on peanut allergy  – part 1: Epidemiology, burden of disease, health economic aspects
AbstractPeanuts are Leguminosae, commonly known as the legume or pea family, and peanut allergy is among the most common food allergies and the most common cause of fatal food reactions and anaphylaxis.The prevalence of peanut allergy increased 3.5-fold over the past two decades reaching 1.4 –2% in Europe and the United States. The reasons for this increase in prevalence are likely multifaceted. Sensitization via the skin appears to be associated with the development of peanut allergy and atopic eczema in infancy is associated with a high risk of developing peanut allergy.Until recently, the only possible manage...
Source: Allergo Journal International - September 28, 2021 Category: Allergy & Immunology Source Type: research

Messages for patients and relatives from the 2021 update of the guideline on acute therapy and management of anaphylaxis
(Source: Allergo Journal International)
Source: Allergo Journal International - September 27, 2021 Category: Allergy & Immunology Source Type: research

Correction to: Health care situation in patients with allergic respiratory diseases with special focus on specific immunotherapy
(Source: Allergo Journal International)
Source: Allergo Journal International - September 22, 2021 Category: Allergy & Immunology Source Type: research

Risk factors in bee and Vespula venom allergy: state of the art
SummaryBackgroundCorrect recognition of risk factors enables individualized management and treatment of venom allergic patients.MethodsSystematic research and review of current literature regarding the risk of (1)  severe sting-induced anaphylaxis, (2) anaphylactic adverse event during venom immunotherapy (VIT), and (3) treatment failure.Results and discussion(1)  Mastocytosis is the most important risk factor for severe sting-induced anaphylaxis. Hereditary α‑tryptasemia was recently identified as a genetic predictor of severe reactions. Older age is clearly associated with an increased ri...
Source: Allergo Journal International - September 15, 2021 Category: Allergy & Immunology Source Type: research

Abstracts of the 16th German Allergy Congress Dresden, September 30 –October 2, 2021
(Source: Allergo Journal International)
Source: Allergo Journal International - September 3, 2021 Category: Allergy & Immunology Source Type: research

Nasal cytology identifies allergic rhinitis phenotypes for managing allergen immunotherapy in clinical practice
AbstractBackgroundsAllergic rhinitis (AR) and non-allergic rhinitis with eosinophils (NARES) share type  2 inflammation characterized by nasal eosinophilic infiltrate. Allergen immunotherapy (AIT) is the unique specific treatment for AR, but some patients do not respond. AIT failure may depend on possible comorbidity, mainly concerning NARES.MethodsIn all, 33  patients (15 men, mean age 44 years) with AR due to house dust mites allergy were enrolled and treated with sublingual AIT using a monomeric allergoid (LAIS). AIT lasted 3 years. Symptom perception was assessed by visual analog scale (VA...
Source: Allergo Journal International - September 1, 2021 Category: Allergy & Immunology Source Type: research

Type  I allergic reactions to roe deer (Capreolus capreolus), red deer (Cervus elaphus), and chamois (Rupicapra rupicapra) in a single hunter
(Source: Allergo Journal International)
Source: Allergo Journal International - August 24, 2021 Category: Allergy & Immunology Source Type: research

Real world effectiveness and cost consequences of grass pollen SCIT compared with SLIT and symptomatic treatment
ConclusionAIT represents a  cost-effective treatment option for patients with allergic rhinitis compared with symptomatic treatment. SCIT appeared to be dominant and cost-effective, due in particular to higher patient adherence and lower drug costs. (Source: Allergo Journal International)
Source: Allergo Journal International - August 6, 2021 Category: Allergy & Immunology Source Type: research

Anaphylatic reaction after chamomile tea consumption
(Source: Allergo Journal International)
Source: Allergo Journal International - July 21, 2021 Category: Allergy & Immunology Source Type: research

Twenty years after index reaction: Recall phenomenon with anaphylactic reaction upon intradermal test with low molecular weight heparins
(Source: Allergo Journal International)
Source: Allergo Journal International - July 19, 2021 Category: Allergy & Immunology Source Type: research

Correction to: Targeted micronutrition for allergic patients —possible applications of a food for special medical purposes
(Source: Allergo Journal International)
Source: Allergo Journal International - July 19, 2021 Category: Allergy & Immunology Source Type: research

Face masks suitable for preventing COVID-19 and pollen allergy. A  study in the exposure chamber
ConclusionWearing a  mask during pollen season can be recommended as an effective nondrug option for people with a pollen allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - July 14, 2021 Category: Allergy & Immunology Source Type: research

Answers to burning questions for clinical allergologists related to the new COVID-19 vaccines
ConclusionThe data available so far do not show a  significantly increased risk of immediate-type allergic reactions in atopic persons. In almost all cases, atopic patients can be vaccinated without problems. Standardized follow-up tests after suspected allergic reactions or CARPA-mediated reactions are currently limited. (Source: Allergo Journal International)
Source: Allergo Journal International - July 14, 2021 Category: Allergy & Immunology Source Type: research

Nutrition therapy in peanut allergy
ConclusionThis requires close cooperation between pediatricians or allergists, allergy-experienced nutritionists or dieticians and ideally psychologists. Furthermore, the membership of a  patient organization and the participation of affected persons and their environment in training measures (e.g. anaphylaxis training) is useful. (Source: Allergo Journal International)
Source: Allergo Journal International - June 21, 2021 Category: Allergy & Immunology Source Type: research

Immunologically relevant aspects of the new COVID-19 vaccines —an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper
ConclusionDespite the need for a  patient-specific risk–benefit assessment, the consensus among experts is that patients with immunological diseases in particular benefit from the induced immune protection after COVID-19 vaccination and do not have an increased risk of side effects. (Source: Allergo Journal International)
Source: Allergo Journal International - June 18, 2021 Category: Allergy & Immunology Source Type: research

Use of telemedicine by practising allergists before and during the SARS-CoV-2 pandemic
ConclusionThe use of telemedical services, especially video consultations, increased significantly during the SARS-CoV ‑2 pandemic in Germany. The majority of respondents perceive the implementation as positive and can imagine continuing to use telemedical methods after the end of the pandemic. (Source: Allergo Journal International)
Source: Allergo Journal International - June 11, 2021 Category: Allergy & Immunology Source Type: research

Targeted micronutrition for allergic patients —possible applications of a food for special medical purposes
SummaryA  novel and recently launched food for special medical purposes was discussed by a multidisciplinary expert panel as an option for allergic patients. The newly developed lozenge contains the whey protein beta-lactoglobulin (BLG) as well as the micronutrients iron, zinc and vitamin A. BLG loaded w ith ligands (holo-BLG) is discussed as one factor of the allergy-protective farm effect in numerous scientific studies. Further studies reveal that holo-BLG shuttles its ligands specifically to immune cells, where it balances the specific nutrient demand and can thus lead to immune resilience. Based on ...
Source: Allergo Journal International - May 19, 2021 Category: Allergy & Immunology Source Type: research

The farm effect revisited: from β-lactoglobulin with zinc in cowshed dust to its application
ConclusionIt seems obvious that in addition to microbes and their products, holo-BLG also plays an important role in the protective farm effect. Therefore, in a  newly developed lozenge for dietary management of allergies, based on the farm effect, zinc attached to holo-BLG is one of the key ingredients. (Source: Allergo Journal International)
Source: Allergo Journal International - May 6, 2021 Category: Allergy & Immunology Source Type: research

Anaphylaxis: subjective symptom reports of patients with a  special focus on “near-death” experiences
SummaryAlmost all anaphylactic reactions are associated with subjective symptoms, which are also referred to “prodromi”, and are often not taken seriously. In 100 patients categorized with different severity grades, subjective symptoms were investigated in a personal interview with free/open questions regarding subjective feelings and symptoms (duration 5–90 min). After the interview, the patient s were asked to complete a questionnaire about the exact occurrence of the reaction. Special focus was given to near-death experiences in severe reactions. Patients described feelings of “e...
Source: Allergo Journal International - April 21, 2021 Category: Allergy & Immunology Source Type: research

Compensating functional iron deficiency in patients with allergies with targeted micronutrition
SummaryIron deficiency is associated with atopy. Iron deficiency during pregnancy increases the risk of atopic diseases in children, while both allergic children and adults are more likely to have iron deficiency anemia. Immunologically, iron deficiency leads to activation of antigen-presenting cells, promotion of Th2 cells and enables antibody class switch in B  cells. In addition, iron deficiency primes mast cells for degranulation, while an increase in their iron content inhibits their degranulation. Many allergens, especially those with lipocalin and lipocalin-like protein structures, are able to bind iron and eit...
Source: Allergo Journal International - April 20, 2021 Category: Allergy & Immunology Source Type: research

Practical handling of allergic reactions to COVID-19 vaccines
ConclusionAllergy testing is not necessary for the vast majority of allergic patients prior to COVID-19 vaccination with currently licensed vaccines. In case of allergic/anaphylactic reactions after vaccination, allergy workup is recommended, as it is for a  small potential risk population prior to the first vaccination. Evaluation and approval of diagnostic tests should be done for this purpose. (Source: Allergo Journal International)
Source: Allergo Journal International - April 19, 2021 Category: Allergy & Immunology Source Type: research

Environmental factors: a  “missing link” in COVID-19
(Source: Allergo Journal International)
Source: Allergo Journal International - April 9, 2021 Category: Allergy & Immunology Source Type: research

Real-life safety study of an accelerated cluster immunotherapy with a  house dust mite native extract in patients with allergic rhinitis or rhinoconjunctivitis
(Source: Allergo Journal International)
Source: Allergo Journal International - March 15, 2021 Category: Allergy & Immunology Source Type: research

Expert consensus on practical aspects in the treatment of chronic urticaria
DiscussionThese supporting treatment recommendations serve as an addendum to the current CU guideline and provide support in dealing with CU patients in everyday practice. The aim is to ensure that patients suffering from CU achieve complete freedom of symptoms with the help of an optimal therapy. (Source: Allergo Journal International)
Source: Allergo Journal International - February 24, 2021 Category: Allergy & Immunology Source Type: research

Current developments in the treatment of peanut allergy
AbstractPeanut allergy is a  potentially life-threatening disease because it leads to severe allergic reactions, especially in children but also in adults. So far, allergen avoidance is the most effective therapy for treating peanut allergy. In this article, current developments of peanut allergy specific immunotherapy are cr itically discussed based on the existing literature. These include sublingual, epicutaneous and oral peanut immunotherapy. Nonspecific treatment approaches with new-targeted antibodies such as anti-IgE (omalizumab) or anti-IL-4/IL-13 receptor antibodies (dupilumab) can also be used to treat peanu...
Source: Allergo Journal International - February 24, 2021 Category: Allergy & Immunology Source Type: research

Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA
SummaryTwo employees of the National Health Service (NHS) in England developed severe allergic reactions following administration of BNT162b2 vaccine against COVID-19 (coronavirus disease 2019). The British SmPC for the BNT162b2 vaccine already includes reference to a  contraindication for use in individuals who have had an allergic reaction to the vaccine or any of its components. As a precautionary measure, the Medicines and Healthcare products Regulatory Agency (MHRA) has issued interim guidance to the NHS not to vaccinate in principle in “patients with se vere allergies”. Allergic reactions to vac...
Source: Allergo Journal International - February 24, 2021 Category: Allergy & Immunology Source Type: research

Telemedicine in allergology: practical aspects
AbstractSince spring 2020, the wide-ranging contact restriction measures in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have also led to a  reduction in physician–patient contacts in the ambulatory care setting. Telemedicine applications will increasingly provide a way to efficiently deliver patient care under infection control measures. In allergology, telemedical as well as digital applications can also significantly facilitate e veryday clinical practice. However, the technical and legal hurdles associated with the implementation of digital strategies must be ...
Source: Allergo Journal International - February 22, 2021 Category: Allergy & Immunology Source Type: research

Targeted micronutrition via holo-BLG based on the farm effect in house dust mite allergic rhinoconjunctivitis patients – first evaluation in a standardized allergen exposure chamber
AbstractPurposeEvaluation of a lozenge for targeted micronutrition (holo-BLG), a  new invention based on the farm effect, in house dust mite (HDM) allergic rhinoconjunctivitis (ARC) patients in a standardized allergen exposure chamber (AEC).MethodsEligible HDM allergic patients were exposed to HDM raw material in an AEC for 120  min before (V1) and after (V3) 3 months of holo-BLG supplementation. Nasal, conjunctival, bronchial and other symptoms were rated by the patients every 10 min and, wellbeing, peak nasal inspiratory flow (PNIF), and lung function parameters every 30 min. Primary endpoint was the...
Source: Allergo Journal International - February 22, 2021 Category: Allergy & Immunology Source Type: research

Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update
(Source: Allergo Journal International)
Source: Allergo Journal International - January 28, 2021 Category: Allergy & Immunology Source Type: research

Allergenic pollen: is it also an indoor problem?
(Source: Allergo Journal International)
Source: Allergo Journal International - January 28, 2021 Category: Allergy & Immunology Source Type: research

Tablet allergen immunotherapy (TAIT) requires tight management
(Source: Allergo Journal International)
Source: Allergo Journal International - January 11, 2021 Category: Allergy & Immunology Source Type: research

A gender-specific approach to occupational allergic contact dermatitis
ConclusionGender-distribution in OACD reflects differences in occupations with respect to men and women as evidenced by working sectors and haptens involved in the pathogenesis. (Source: Allergo Journal International)
Source: Allergo Journal International - December 17, 2020 Category: Allergy & Immunology Source Type: research

House dust mite immunotherapy in Germany: real-world adherence to a  subcutaneous allergoid and a sublingual tablet
The objective of this study was to evaluate real-world adherence to house dust mite (HDM) AIT with a subcutaneous (SCIT) allergoid preparation and a subl ingual (SLIT) tablet.Patients and methodsIn this retrospective cohort analysis of a  German longitudinal prescription database, patients receiving either a HDM-SCIT allergoid (n = 5677) or a HDM-SLIT tablet (n = 4720) were compared over a 3-year observation period. Study endpoints included adherence and days on therapy (DoT). Univariate statistical tests were used to assess the significance of the differences between SCIT vs...
Source: Allergo Journal International - December 17, 2020 Category: Allergy & Immunology Source Type: research

Rapid protocol for irinotecan desensitization: a  case report and literature review
(Source: Allergo Journal International)
Source: Allergo Journal International - December 10, 2020 Category: Allergy & Immunology Source Type: research

Healthcare provision for insect venom allergy patients during the COVID-19 pandemic
AbstractThe population prevalence of insect venom allergy ranges between 3 –5%, and it can lead to potentially life-threatening allergic reactions. Patients who have experienced a systemic allergic reaction following an insect sting should be referred to an allergy specialist for diagnosis and treatment. Due to the widespread reduction in outpatient and inpatient care c apacities in recent months as a result of the COVID-19 pandemic, the various allergy specialized centers in Germany, Austria, and Switzerland have taken different measures to ensure that patients with insect venom allergy will continue to re...
Source: Allergo Journal International - December 8, 2020 Category: Allergy & Immunology Source Type: research

How will climate change alter the dynamics of airborne pollen and pollen load of allergenic plants?
ConclusionThe assumption that climate warming in Linz over 26  years should have increased pollen concentrations of allergenic plants was not confirmed. On the contrary, trend analyses showed that the pollen load has decreased. Hence, the increase in sensitization to pollen allergens and of the prevalence of pollen allergies ask for other explanations. (Source: Allergo Journal International)
Source: Allergo Journal International - December 8, 2020 Category: Allergy & Immunology Source Type: research

Health care situation in patients with allergic respiratory diseases with special focus on specific immunotherapy
ConclusionAnalysis of the care situation with regard to the specific immunotherapy in cases of allergic respiratory diseases (VerSITA) provides a  solid basis for future research and for informing decision-makers in order to develop measures to optimize care. (Source: Allergo Journal International)
Source: Allergo Journal International - November 20, 2020 Category: Allergy & Immunology Source Type: research

Airlines provide too little information for allergy sufferers!
DiscussionThe information offered by many airlines for passengers with allergies is insufficient. To offer greater guidance, updated information has been formulated in German and English, and its use is recommended. (Source: Allergo Journal International)
Source: Allergo Journal International - November 20, 2020 Category: Allergy & Immunology Source Type: research

Marker allergens in Hymenoptera venom al lergy — Characteristics and potential use in precision medicine
AbstractBackgroundA  comprehensive diagnostic work-up is essential to ensure adequate patient management for the potentially life-threatening condition of Hymenoptera venom allergy (HVA). This includes an unambiguous identification of the allergy-relevant venom as prerequisite for successful venom-specific immunothera py (VIT). If the clinical history does not allow the identification of the culprit insect, diagnosis is often hampered by positive test results to various venoms. Modern component-resolved diagnostics (CRD) applying marker allergens of Hymenoptera venoms has created new opportunities which facilitat e th...
Source: Allergo Journal International - November 17, 2020 Category: Allergy & Immunology Source Type: research

Clinical performance of house-dust-mite-specific subcutaneous immunotherapy in a  postmarket noninterventional setting
(Source: Allergo Journal International)
Source: Allergo Journal International - October 20, 2020 Category: Allergy & Immunology Source Type: research

Anti-inflammatory substances from onions could be an option for treatment of COVID-19 —a hypothesis
(Source: Allergo Journal International)
Source: Allergo Journal International - October 20, 2020 Category: Allergy & Immunology Source Type: research

Abstracts, 12th Symposium of the Working Group on Insect Venom Allergy, German Society of Allergy and Clinical Immunology (DGAKI), Frankfurt, Germany, November 20/21, 2020
(Source: Allergo Journal International)
Source: Allergo Journal International - October 5, 2020 Category: Allergy & Immunology Source Type: research

Use of allergy tests to identify dietary and environmental triggers of eosinophilic esophagitis: protocol for a  systematic review
SummaryPurposeEosinophilic esophagitis (EoE) is a  chronic immune-mediated esophageal disease. Most EoE patients have atopic comorbidities and they test positive when allergy tests are performed. Our aim is to critically assess the relation of allergens detected by allergy tests with clinically confirmed triggers of EoE.MethodsA  systemic review and meta-analysis will be conducted, which will involve searching electronic databases using predetermined search terms, in order to identify relevant studies. Studies will be independently screened against predefined eligibility criteria and subgroup analysis will be use...
Source: Allergo Journal International - September 30, 2020 Category: Allergy & Immunology Source Type: research

Incidence rate of severe adverse drug reactions to nonionic contrast media at the National Hospital Organization Osaka National Hospital
DiscussionAlthough the rate of severe adverse drug reactions in this study appears to be higher than expected, the sample size of 42,501 patients is insufficient to conclusively determine the incidence and mortality rates of adverse drug reactions, as these rates are extremely low. Further studies are required to estimate the countrywide prevalence of adverse drug reactions in response to contrast media. (Source: Allergo Journal International)
Source: Allergo Journal International - September 9, 2020 Category: Allergy & Immunology Source Type: research

Is the concept of “peanut-free schools” useful in the routine management of peanut-allergic children at risk of anaphylaxis?
ConclusionIn order to address the fears and concerns of patients, parents, and school staff, it is mandatory to develop various coping strategies. These should enable and ensure the safety and participation of food-allergic pupils in classes and other school activities. Therefore, it is important to implement adequate measures for allergen avoidance and emergency treatment for students with confirmed food allergies. (Source: Allergo Journal International)
Source: Allergo Journal International - August 31, 2020 Category: Allergy & Immunology Source Type: research

Abstracts of the 15th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 30, 2020 Category: Allergy & Immunology Source Type: research

Suspected penicillin allergy: risk assessment using an algorithm as an antibiotic stewardship project
ConclusionTriage of patients with suspected BLA is urgently required. While allergy testing, including provocation testing, represents the most reliable solution, this is not feasible in all patients due to the high prevalence of BLA allergies. The risk stratification algorithm developed for the authors ’ hospital represents a tool suitable to making a contribution to rational antibiotic therapy. (Source: Allergo Journal International)
Source: Allergo Journal International - August 26, 2020 Category: Allergy & Immunology Source Type: research

Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
ConclusionThe free combination therapies of mast cell stabilizers, decongestants, AHs and nasal GCs, frequently used in the routine care of patients with AR, cannot be recommended because they are not evidence-based. Due to the fact that over-the-counter antiallergic drugs are not reimbursable in Germany, there is no medical supervision of the therapy. In addition, there are doubts about appropriate treatment, especially of patients with persistent rhinitis with severe symptoms, as these patients often use several preparations at the same time to alleviate their symptoms. (Source: Allergo Journal International)
Source: Allergo Journal International - July 19, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs: results of an Austrian cohort study
ConclusionOPT with alternative NSAIDs are useful in patients with NSAID hypersensitivity as tolerability varies between the individual substances. (Source: Allergo Journal International)
Source: Allergo Journal International - July 13, 2020 Category: Allergy & Immunology Source Type: research

Identification of a  53 kDa protein, as a new high molecular weight allergen from Fraxinus excelsior (Ash) pollen
In this study, a high molecular weight allergen from ash pollen was identified.MethodsIn all, 20 individuals allergic to ash participated in the study. Characterization and immunoreactivity of ash pollen proteins was performed using sodium dodecyl sulfate polyacrylamide electrophoresis (SDS-PAGE), two-dimensional (2D) gel electrophoresis and immunoblotting.ResultsImmunoglobulin E (IgE)-binding proteins with apparent molecular mass ranging from 9  to 110 kDa were detected in ash pollen extract. Serum IgE of 7 (35%) patients reacted with a 53-kDa protein band. Analysis of 2D immunoblots showed several I...
Source: Allergo Journal International - June 29, 2020 Category: Allergy & Immunology Source Type: research