Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
AbstractThis guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a  consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories cle arly exceeds the number of confirmed cases. The large number of suspected BLA allerg...
Source: Allergo Journal International - July 22, 2019 Category: Allergy & Immunology Source Type: research

What we learned from TAO – 10 years of German therapy allergen ordinance
ConclusionsIn Germany, TAO ensures that all previously untested named patient products for the treatment of frequent allergies are subjected to an assessment of their risk/benefit ratio according to the current state of science. (Source: Allergo Journal International)
Source: Allergo Journal International - July 15, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Air pollutants and primary allergy prevention
Correction to:Allergo J Int 2018https://doi.org/10.1007/s40629-018-0078-7An error was identified in the review on “Air pollutants and primary allergy prevention”. The given PM2.5 increment of 2  µg/m3 was wrong and should be replaced with an increment of 5  µg/m3.This was the case on:Page  9, legend … (Source: Allergo Journal International)
Source: Allergo Journal International - June 27, 2019 Category: Allergy & Immunology Source Type: research

Atopic eczema score of emotional consequences —a questionnaire to assess emotional consequences of atopic eczema
ConclusionAESEC is a  questionnaire for assessing the emotional consequences of living with AE. It may prove useful in evaluating the burden of disease, beyond skin symptoms and time-specific quality of life. (Source: Allergo Journal International)
Source: Allergo Journal International - June 3, 2019 Category: Allergy & Immunology Source Type: research

Update of reference values for IgG antibodies against typical antigens of hypersensitivity pneumonitis
AbstractBackgroundSpecific (s)IgG antibodies against environmental and occupational antigens, especially from bacteria, moulds, yeasts, birds and chemicals play an important role for hypersensitivity pneumonitis (HP). An increased serum level of sIgG is one criterion in the diagnostic procedure of HP and crucial for the detection of the triggering antigen for successful avoidance of further exposure. In contrast to specific IgE, sIgG concentrations in healthy individuals vary greatly depending on the antigen, which makes it difficult to differentiate from patients with HP. The aim of this study is to update or establish sI...
Source: Allergo Journal International - May 27, 2019 Category: Allergy & Immunology Source Type: research

Development of subcutaneous allergen immunotherapy (part  2): preventive aspects and innovations
ConclusionSCIT preparations are among the most innovative treatment options in the immunotherapy of allergic diseases. Due to the numerous immunological approaches, they will make treatment safer and more effective in the future with reduced effort. (Source: Allergo Journal International)
Source: Allergo Journal International - May 13, 2019 Category: Allergy & Immunology Source Type: research

German pollen calendar 4.0: update of the regional pollen calendars 4.0 with measurement data for the period 2011 –2016
(Source: Allergo Journal International)
Source: Allergo Journal International - May 2, 2019 Category: Allergy & Immunology Source Type: research

Effectiveness of a  portable air filtration device in reducing allergen exposure during household chores
DiscussionTypical household chores can result in high levels of exposure to indoor dust and allergens. The use of an AP however can reduce the inhalable dust concentrations, but the effect on allergen exposure was in most cases not large enough to achieve statistical significance. (Source: Allergo Journal International)
Source: Allergo Journal International - April 29, 2019 Category: Allergy & Immunology Source Type: research

Case series of anaphylactic reactions after rabies vaccinations with gelatin sensitization
AbstractSide effects due to allergic reactions to vaccine antigen or to additives such as chicken protein or gelatin have been known for some time. Recent findings regarding reactions mediated via the carbohydrate epitope galactose-alpha-1,3-galactose (alpha-gal), a  constituent of animal gelatin, broaden the spectrum of gelatin-related allergies. This case series presents four patients who developed anaphylactic reactions following rabies vaccination using the vaccine Rabipur®. After appropriate allergy testing by skin prick testing and the determination of specific IgE to allergens in the vaccine, triggering by ...
Source: Allergo Journal International - April 18, 2019 Category: Allergy & Immunology Source Type: research

Evolution of subcutaneous allergen immunotherapy (part  1): from first developments to mechanism-driven therapy concepts
ConclusionWhen adequately administered by physicians with allergological expertise, SCIT preparations are safe, well-tolerated, and clinically effective. (Source: Allergo Journal International)
Source: Allergo Journal International - April 15, 2019 Category: Allergy & Immunology Source Type: research

Consumer protection and risk assessment: sensitising substances in consumer products
ConclusionsToday, skin sensitising substances can be legally regulated and labelled and, depending on the exposure, their content in consumer products can be reduced or eliminated. Furthermore, the risk assessment of potentially sensitising substances makes consumer products safer. Further improvements in research approaches are required in the area of health and consumer protection with regard to allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - April 2, 2019 Category: Allergy & Immunology Source Type: research

Wheat-dependent exercise-induced anaphylaxis with Tri-a-14-sensitization as part of a  lipid transfer protein syndrome
(Source: Allergo Journal International)
Source: Allergo Journal International - February 14, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 31st Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 29, 2019 Category: Allergy & Immunology Source Type: research

Guideline: Hereditary angioedema due to C1 inhibitor deficiency
(Source: Allergo Journal International)
Source: Allergo Journal International - January 17, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 31th Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 15, 2019 Category: Allergy & Immunology Source Type: research

Prevalence of Hymenoptera venom allergy and sensitization in the population-representative German KORA cohort
ConclusionsSelf-reported Hymenoptera sting reactions and venom sensitization are frequent in the general German population. In many cases, sensitization and clinically relevant allergy are not observed in the same individual, indicating that comprehensive diagnostic approaches are a  prerequisite for the identification of patients at risk for severe reactions. (Source: Allergo Journal International)
Source: Allergo Journal International - January 9, 2019 Category: Allergy & Immunology Source Type: research

Comparison of extended intervals and dose reduction of omalizumab for asthma control
This study evaluated asthma control after either dosage interval extension or dose reduction in patients with asthma controlled by omalizumab.MethodsThirty-seven patients were assigned to receive either extended treatment interval (n = 26) or a reduction in omalizumab dosage (n = 11). The primary outcome was time until loss of asthma control.ResultsNineteen patients (73%) of the extended interval group maintained good asthma control for at least 7 –39 months. Of the remaining 7 patients, the median time to loss of asthma control was 8 months (range 5–35 months). In con...
Source: Allergo Journal International - December 14, 2018 Category: Allergy & Immunology Source Type: research

Occupational asthma due to tampico fiber bystander exposure in a  brush production company—case report and literature review
ConclusionTampico fibers are robust fibers obtained from the leaves of the MexicanAgave lechugilla. The literature describes several cases of skin reactions in the form of irritant contact dermatitis due to occupational exposure to agave leaves or contact with agave sap. In the present case, the asthma symptoms of a  female worker in a brush factory were attributed to inhalant bystander exposure to tampico fibers in the workplace. The unequivocal evidence of sensitization to tampico fibers met the medical requirements for the recognition of an occupational disease (BK 4301). (Source: Allergo Journal International)
Source: Allergo Journal International - December 3, 2018 Category: Allergy & Immunology Source Type: research

Alpha-tocopherol acetate nasal spray in the treatment of pollen-induced allergic rhinitis
This study compared the effectiveness and tolerability of alpha-tocopherol acetate nasal spray (ATANS) to those of beclomethasone nasal spray (BNS) and loratadine (LT) for the treatment of pollen-induced allergic rhinitis.MethodsThis active-controlled, patient-preference, observational trial lasted 7  days. Tested variables were nasal symptoms, endoscopic examination, additional medications, general effectiveness, safety, and tolerability.ResultsOf 116 patients, 63  patients decided to use ATANS, 32 BNS and 21 LT. During the treatment, the mean daily rhinitis symptom score decreased significantly in all...
Source: Allergo Journal International - November 28, 2018 Category: Allergy & Immunology Source Type: research

Safety of a  high-dose house dust mite allergoid in pediatric patients
(Source: Allergo Journal International)
Source: Allergo Journal International - November 6, 2018 Category: Allergy & Immunology Source Type: research

Allergen immunotherapy for oral allergy syndrome: what is the evidence for efficacy?
ConclusionReliable recommendations on the use of AIT with pollen allergens in pollen-related food allergy are not possible as yet. AIT with birch pollen allergens appears to have a  positive effect on concomitant food allergy in some patients with birch pollen allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - October 25, 2018 Category: Allergy & Immunology Source Type: research

Omalizumab as a  last resort therapy for intractable, severe chronic allergic rhinosinusitis
(Source: Allergo Journal International)
Source: Allergo Journal International - October 24, 2018 Category: Allergy & Immunology Source Type: research

Reminder system for adrenaline autoinjectors does not work
(Source: Allergo Journal International)
Source: Allergo Journal International - October 19, 2018 Category: Allergy & Immunology Source Type: research

Correction to: Fragrances as allergens
Correction to:Allergo  J Int 2018https://doi.org/10.1007/s40629-018-0075-xThe conflicts of interest of the authors Axel Schnuch and Peter Griem had been omitted.The correct information is given … (Source: Allergo Journal International)
Source: Allergo Journal International - October 19, 2018 Category: Allergy & Immunology Source Type: research

Air pollutants and primary allergy prevention
ConclusionIf the evidence for the causal role of air pollutants in the onset of allergies is inconclusive, one must assume that it is probably not possible to achieve primary prevention of allergies by improving air quality. However, there is sufficient evidence to show that air pollutants can trigger exacerbations of allergic diseases. This alone justifies ensuring that the existing threshold values for air pollutants are adhered to, in order to protect particularly allergy sufferers from health impairments. (Source: Allergo Journal International)
Source: Allergo Journal International - October 10, 2018 Category: Allergy & Immunology Source Type: research

What ’s new in the Global Initiative for Asthma 2018 report and beyond
AbstractBackgroundThe Global Initiative for Asthma (GINA) has regularly published and annually updated a  global strategy for asthma management and prevention that has formed the basis for many national guidelines. The 2018 update of the GINA report incorporates new evidence following the routine twice-yearly cumulative review of the literature by the GINA Scientific Committee.MethodsRecommendations in the 2018 edition were examined for new content and updates, and the scientific evidence behind these recommendations was examined and discussed. Focus was given to the management of asthma in adults in the general popul...
Source: Allergo Journal International - October 10, 2018 Category: Allergy & Immunology Source Type: research

Allergies and vaccination: a  myth demystified
ConclusionStandard vaccinations do not increase the risk for manifesting allergic disease or specific sensitization to environmental allergens. If individual protection is desired, and taking into account the particular risks and provisos, children with allergic disease and anaphylactic reactions to vaccines can also be vaccinated. (Source: Allergo Journal International)
Source: Allergo Journal International - September 18, 2018 Category: Allergy & Immunology Source Type: research

Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
AbstractThe prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a  treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be mo re efficacious than SLIT with an acceptable safety profile. However, SLIT is a...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research

Fragrances as allergens
AbstractContact allergies due to fragrances are common. If one adds up the reaction incidences of the indicators of fragrance allergy (fragrance mix [FM] I  + II, balsam of Peru and turpentine), these reach 17% in a hospital collective (Information Network of Departments of Dermatology [IVDK] data 2016) and are thus higher than those for nickel allergy (approximately 16%). In the case of positive reactions to FM I,>50% do not react to one of the components. This type of reaction should be interpreted as allergic with caution, unless other data (e.  g., positive history, application test) support thi...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research

Abstracts of the 13th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research

Positive and negative AIT trials: What makes the difference?
DiscussionA  clinical trial aims to evaluate the efficacy of an agent. However, studies with potential effective compounds may fail because of methodical issues. Sometimes, they are the cause of discrepancies between successful phase II and unsuccessful phase III trials. To understand more about failure of s tudies, investigators and editors should be encouraged to publish negative trials. (Source: Allergo Journal International)
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research

Placebo effects in allergen immunotherapy: an experts ’ opinion
AbstractPlacebo effects are common in medicine. Randomised clinical trials help us to understand their magnitude in different therapies. There are particular problems with placebo effects in allergen immunotherapy (AIT) as it is difficult to blind the active treatment and the endpoints are largely subjective. This may explain why large placebo effects are often found in AIT trials. Patients receiving open label AIT get the benefit of the active and placebo components but it can be difficult to say how much benefit is due to the active component. The use of active placebos has been proposed but brings its own problems (ethi...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research

Abstracts of the 13th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 30, 2018 Category: Allergy & Immunology Source Type: research

The biodiversity hypothesis and immunotolerance in allergy
ConclusionTherefore, tolerance induction emerges in allergology not only as a  potential concept for prevention, but also as a treatment approach in atopic diseases. (Source: Allergo Journal International)
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research

SCIT with a  high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups
ConclusionSCIT with the marketed dose of high-dose HDM allergoid was well tolerated in clinical development and in daily practice. There was no increased risk for the investigated patient subgroups. Tolerability was comparable to HDM sublingual immunotherapy (SLIT) tablets. (Source: Allergo Journal International)
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research

Non-celiac gluten/wheat sensitivity (NCGS) —a currently undefined disorder without validated diagnostic criteria and of unknown prevalence
AbstractWithin the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. The present position statement reflects the following aspects about NCGS from an allergist ’s and nutritionist’s point of view: (A) Validated diagnostic criteria and/or reliable ...
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research

SCIT with a  high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups
ConclusionSCIT with the marketed dose of high-dose HDM allergoid was well tolerated in clinical development and in daily practice. There was no increased risk for the investigated patient subgroups. Tolerability was comparable to HDM sublingual immunotherapy (SLIT) tablets. (Source: Allergo Journal International)
Source: Allergo Journal International - July 25, 2018 Category: Allergy & Immunology Source Type: research

Fragrances as allergens
AbstractContact allergies due to fragrances are common. If one adds up the reaction incidences of the indicators of fragrance allergy (fragrance mix [FM] I  + II, balsam of Peru and turpentine), these reach 17% in a hospital collective (Information Network of Departments of Dermatology [IVDK] data 2016) and are thus higher than those for nickel allergy (approximately 16%). In the case of positive reactions to FM I,>50% do not react to one of the components. This type of reaction should be interpreted as allergic with caution, unless other data (e.  g., positive history, application test) support thi...
Source: Allergo Journal International - July 25, 2018 Category: Allergy & Immunology Source Type: research

Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases
ConclusionsThese results indicate that VLPs modulate immune responses in ways which underline their exceptional promise as a  platform for the immunotherapy of allergic disorders. However, clinical evaluations remain limited, and further large-scale and longer-term studies will be necessary to substantiate the efficacy and safety of these novel therapies. (Source: Allergo Journal International)
Source: Allergo Journal International - July 9, 2018 Category: Allergy & Immunology Source Type: research

Evaluation of a  modified skin prick test for diagnosis of Hymenoptera venom allergy
ConclusionsSPT300 shows a  high but not substantially superior sensitivity utilizing both WV and BV extract for diagnosis of HV allergy compared to SPT100 and IDT1. However, since SPT300 with BV extract demonstrated a very low specificity, our results indicate that SPT300 has limited added value in the diagnosis of HV alle rgy. (Source: Allergo Journal International)
Source: Allergo Journal International - June 13, 2018 Category: Allergy & Immunology Source Type: research

The biodiversity hypothesis and immunotolerance in allergy
ConclusionTherefore, tolerance induction emerges in allergology not only as a  potential concept for prevention, but also as a treatment approach in atopic diseases. (Source: Allergo Journal International)
Source: Allergo Journal International - June 12, 2018 Category: Allergy & Immunology Source Type: research

Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
AbstractThe prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a  treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be mo re efficacious than SLIT with an acceptable safety profile. However, SLIT is a...
Source: Allergo Journal International - June 6, 2018 Category: Allergy & Immunology Source Type: research

Perioperative drug reactions – practical recommendations for allergy testing and patient management
ConclusionFinal outcomes of the diagnostic procedures should be providing thorough information of the patient about the findings, drugs that should be avoided in the future as well as alternative preparations, and, if necessary, preventive measures to be taken in the event of further surgical interventions. (Source: Allergo Journal International)
Source: Allergo Journal International - June 4, 2018 Category: Allergy & Immunology Source Type: research

Penicillin allergy – recommendations for diagnostic work up and patient management
ConclusionThe overall predictive value of combined in vitro and in vivo allergy testing with β‑lactam antibiotics is approximately 90%. However, subsequent controlled provocation testing is recommended in order to reliably exclude allergic hypersensitivity. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research

Perioperative drug reactions – practical recommendations for allergy testing and patient management
ConclusionFinal outcomes of the diagnostic procedures should be providing thorough information of the patient about the findings, drugs that should be avoided in the future as well as alternative preparations, and, if necessary, preventive measures to be taken in the event of further surgical interventions. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research

NSAID hypersensitivity – recommendations for diagnostic work up and patient management
ConclusionThe diagnostic work-up begins with a  detailed patient’s history. Skin tests are only useful in SNIDR and SNIUAA, while in vitro tests are helpful merely in exceptional cases. In general, the diagnosis can only be confirmed by provocation testing, when required. Although cross-reactivity is usually present, provocation testing is of ten able to find an alternative, tolerable analgesic. Individual patient management usually enables a solution to be found for most patients. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research

Allergic heparin hypersensitivity – recommendations for diagnostic work up and patient management
This article provides an overview of selected scientific articles and is based on a  literature search in PubMed and specialist databases.ResultsMost commonly, heparin allergic patients develop lymphocyte-mediated, eczematous local reactions directly at the injection sites (usually on the lower abdomen) hours to days after initiating regular subcutaneous heparin injections. The high sensitivity of skin-prick and intradermal testing procedures means that subcutaneous provocation tests are seldom necessary for diagnosis. The “compartment allergy” phenomenon is a particular feature of heparin-induced loc...
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research