Therapy of allergic rhinitis in routine care: evidence-based benefit assessment of freely combined use of various active ingredients
ConclusionThe free combination therapies of mast cell stabilizers, decongestants, AHs and nasal GCs, frequently used in the routine care of patients with AR, cannot be recommended because they are not evidence-based. Due to the fact that over-the-counter antiallergic drugs are not reimbursable in Germany, there is no medical supervision of the therapy. In addition, there are doubts about appropriate treatment, especially of patients with persistent rhinitis with severe symptoms, as these patients often use several preparations at the same time to alleviate their symptoms. (Source: Allergo Journal International)
Source: Allergo Journal International - July 20, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to non-steroidal anti-inflammatory drugs: results of an Austrian cohort study
ConclusionOPT with alternative NSAIDs are useful in patients with NSAID hypersensitivity as tolerability varies between the individual substances. (Source: Allergo Journal International)
Source: Allergo Journal International - July 14, 2020 Category: Allergy & Immunology Source Type: research

Identification of a  53 kDa protein, as a new high molecular weight allergen from Fraxinus excelsior (Ash) pollen
In this study, a high molecular weight allergen from ash pollen was identified.MethodsIn all, 20 individuals allergic to ash participated in the study. Characterization and immunoreactivity of ash pollen proteins was performed using sodium dodecyl sulfate polyacrylamide electrophoresis (SDS-PAGE), two-dimensional (2D) gel electrophoresis and immunoblotting.ResultsImmunoglobulin E (IgE)-binding proteins with apparent molecular mass ranging from 9  to 110 kDa were detected in ash pollen extract. Serum IgE of 7 (35%) patients reacted with a 53-kDa protein band. Analysis of 2D immunoblots showed several I...
Source: Allergo Journal International - June 30, 2020 Category: Allergy & Immunology Source Type: research

Anaphylaxis to lidocaine and cross-reactivity to articaine and prilocaine with tolerance to bupivacaine
(Source: Allergo Journal International)
Source: Allergo Journal International - June 24, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to biologics (part  II): classifications and current diagnostic and treatment approaches
ConclusionHSRs to BS are gradually increasing with the widening of their clinical use and indications. It is very important to prevent HSRs and to know the degree of severity as well as the emergency treatment algorithm. This review summarizes the diagnostic tests that should be applied: (a)  immediately during/after a reaction, and (b) subsequently, and in the case that a switch of BS is not possible, desensitization is an option. (Source: Allergo Journal International)
Source: Allergo Journal International - June 19, 2020 Category: Allergy & Immunology Source Type: research

A  prediction of dust mite populations in different categories of housing quality in Auckland, New Zealand
ConclusionsOccupant behaviour is suggested as an influencing factor with a  call for policy makers to consider real-time feedback loops to dwelling occupants, in conjunction with structural interventions, to improve the health of the interior environment. (Source: Allergo Journal International)
Source: Allergo Journal International - June 18, 2020 Category: Allergy & Immunology Source Type: research

Omalizumab in three children with severe vernal keratoconjunctivitis
ConclusionAlthough the clinical benefit of omalizumab in asthma and chronic spontaneous urticaria (CSU) has been established in several clinical trials, there are very little data about its effect on severe VKC. In addition to few previously reported cases we can report the rapid effectiveness of omalizumab in VKC clinically and in terms of quality of life. Randomized trials are needed to include omalizumab in third-line treatment of VKC for prevention of visual impairment and further sequelae such as corneal damage. (Source: Allergo Journal International)
Source: Allergo Journal International - May 26, 2020 Category: Allergy & Immunology Source Type: research

Hypersensitivity reactions to biologics (part  I): allergy as an important differential diagnosis in complex immune-derived adverse events
ConclusionThere is an urgent need for a  simpler symptom- or system-based classification and scoring system to create an awareness for HSRs to BSs. A better understanding of the pathophysiology of HSRs and increased clinical experience in the treatment of side effects will provide timely control of unexpected reactions. As a result, im munotherapy with BSs will become safer in the future. (Source: Allergo Journal International)
Source: Allergo Journal International - May 12, 2020 Category: Allergy & Immunology Source Type: research

Dietary implications in acetylsalicylic acid intolerance
ConclusionDietary therapy in ASA-intolerant patients is not recommended. (Source: Allergo Journal International)
Source: Allergo Journal International - May 11, 2020 Category: Allergy & Immunology Source Type: research

Development of a  practice guideline for dietary counselling of children with IgE-mediated food allergy
ConclusionThis guideline provides a  comprehensive guide to dietary counselling for food allergy by dietitians in Switzerland. It will inform best practice and improve patient-centred care and encourage a consistent approach, but it will need to be reviewed and updated as more robust evidence is produced. (Source: Allergo Journal International)
Source: Allergo Journal International - April 7, 2020 Category: Allergy & Immunology Source Type: research

Current challenges in molecular diagnostics of insect venom allergy
AbstractBackgroundAdvanced component-resolved diagnostics (CRD) in Hymenoptera venom allergy (HVA) has improved the precise description of individual sensitization profiles. However, diagnostic gaps, peptide-based cross-reactivity, early identification of severe reactors and diagnosis of patients with a  clear history of sting reactions but negative specific IgE and skin tests, remain challenging.MethodsSystematic literature search in PubMed and critical analysis of recently published studies on insect venom allergy diagnostics.Results and discussionCRD has increased the sensitivity of IgE testing and improved the dis...
Source: Allergo Journal International - March 9, 2020 Category: Allergy & Immunology Source Type: research

Natural history of systemic reactions and risk factors in children and adults with Hymenoptera venom allergy
ConclusionsThere is limited evidence with regard to the natural history of HVA both in adults and in children. Several risk factors may influence the natural history of HVA, namely patient-related, allergen-related and reaction-related. Other factors are inherent to the use of venom immunotherapy (VIT). (Source: Allergo Journal International)
Source: Allergo Journal International - March 2, 2020 Category: Allergy & Immunology Source Type: research

Venom immunotherapy in patients with mastocytosis
ConclusionsPatients with primary MCAS and IgE-mediated HVA are candidates to receive VIT. Their management does not differ much from general population with the exception of VIT duration. (Source: Allergo Journal International)
Source: Allergo Journal International - March 2, 2020 Category: Allergy & Immunology Source Type: research

Venom immunotherapy in Europe and the United States
AbstractBackgroundHymenoptera stings are accountable for significant morbidity and deterioration in health-related quality of life due to the allergic reactions they cause, the most severe of which can culminate in fatal anaphylaxis. The availability of high quality venom extracts for use in the diagnosis and treatment of insect venom allergy has improved the prognosis and the health-related quality of life of venom-allergic patients. All over the world subcutaneous venom immunotherapy is currently the most effective form of allergen-based immunotherapy with an early, sustained and long-term efficacy. Even though the type ...
Source: Allergo Journal International - March 2, 2020 Category: Allergy & Immunology Source Type: research

Mastocytosis as a  risk factor for insect venom allergy
ConclusionsMastocytosis represents a risk factor for severe reaction in patients with HVA. An early diagnosis of CMD in these patients is very important since they are at high risk of severe osteoporosis and early therapy can be immediately started. Moreover, proper advice and prescription of adrenaline can be assessed. Finally, in order to stop venom immunotherapy or whether to continue it lifelong, diagnosis of CMD has to be carried out. (Source: Allergo Journal International)
Source: Allergo Journal International - March 2, 2020 Category: Allergy & Immunology Source Type: research

Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
AbstractPhysicians think of mast cells and IgE primarily in the context of allergic disorders, including fatal anaphylaxis. This ‘bad side’ of mast cells and IgE is so well accepted that it can be difficult to think of them in other contexts, particularly those in which they may have beneficial functions. However, there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions par tially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites. Accordingl...
Source: Allergo Journal International - March 2, 2020 Category: Allergy & Immunology Source Type: research

Anaphylactic reaction at a  pizzeria in a 13-year-old female patient
(Source: Allergo Journal International)
Source: Allergo Journal International - February 20, 2020 Category: Allergy & Immunology Source Type: research

Allergy to tree-of-heaven pollen in Germany: detection by positive nasal provocation
(Source: Allergo Journal International)
Source: Allergo Journal International - February 20, 2020 Category: Allergy & Immunology Source Type: research

Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-00110-9Affiliation and disclaimer have been misrepresented and are hereby corrected:Vera  Mahler:Affiliation: Med. Faculty, Friedrich-Alexander-University (FAU) Erlangen-N ürnberg, Germany.Disclaimer: The views expressed in this … (Source: Allergo Journal International)
Source: Allergo Journal International - February 12, 2020 Category: Allergy & Immunology Source Type: research

Abstracts of the 32nd Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 15, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Consumer protection and risk assessment: sensitising substances in consumer products
Correction to:Allergo J Int 2019 28:167 –182https://doi.org/10.1007/s40629-019-0093-3The article “Consumer protection and risk assessment: sensitising substances in consumer products”, written by Hermann-Josef Thierse and Andreas Luch, was originally published Online First without Open Access. … (Source: Allergo Journal International)
Source: Allergo Journal International - November 15, 2019 Category: Allergy & Immunology Source Type: research

Severe skin reactions: clinical picture, epidemiology, etiology, pathogenesis, and treatment
ConclusionThe rarity and unpredictability of the reactions make a  randomized double-blind therapeutic trial extremely difficult. Using meta-analyses, it is possible to trace a trend in the use of systemic treatment options. Supportive care remains the most important treatment strategy for all clinical entities. (Source: Allergo Journal International)
Source: Allergo Journal International - November 11, 2019 Category: Allergy & Immunology Source Type: research

ARIA guideline 2019: treatment of allergic rhinitis in the German health system
DiscussionA  comprehensive ICP guideline can reflect real-life care better than traditional guideline models. (Source: Allergo Journal International)
Source: Allergo Journal International - October 22, 2019 Category: Allergy & Immunology Source Type: research

Drug-induced anaphylaxis —elicitors, mechanisms and diagnosis
AbstractDrugs are one of the major causes of anaphylaxis. For example 2346  cases of drug-induced anaphylaxis were reported to the anaphylaxis register as of March 2019. The most common triggers of drug-induced anaphylaxis were nonsteroidal anti-inflammatory drugs (NSAIDs;n = 902) and antibiotics (n = 721). Drug-induced anaphylaxis can be caused by IgE-dependent (e.g., penicillins) and IgE-independent mechanisms. Recently MRG-PX2 has been identified as a receptor for non-IgE-dependent mechanisms. Drug-induced anaphylaxis results more frequently in lethal reactions and is more commonly as so...
Source: Allergo Journal International - October 17, 2019 Category: Allergy & Immunology Source Type: research

Characterization of a  cohort of storage mite sensitized subjects
ConclusionsSM are a  common sensitization in the study population and should be included in standard skin prick test arrays. Cross sensitization to house dust mites is limited and nasal symptoms are most frequent. Nasal provocation testing is necessary to secure clinical diagnosis of allergy and further research is ne eded to evaluate the clinical relevance of the high sensitization rates found for intradermal testing. (Source: Allergo Journal International)
Source: Allergo Journal International - October 10, 2019 Category: Allergy & Immunology Source Type: research

Ash pollen allergy and aerobiology
ConclusionSymptoms in individuals sensitized to ash pollen vary according to the pollen count and may be masked by pollen from other trees that flower at the same time of year. Sensitization to ash/Ole  e 1 can be higher than to birch/Bet v 1. The determination of IgE to common ash (Fraxinus excelsior) is more sensitive than to American ash (Fraxinus americana). Ash dieback due to Chalara appears to increase pollen emission. Allergies to ash pollen can be significantly underestimated due to a  failure to (correctly) identify them; they can also be masked by other pollen families (birch). Harmful or...
Source: Allergo Journal International - September 30, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-0100-8In the “Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics” Figs. 5 and 6 (allergy passports) are in German. Here you will find the allergy passports in … (Source: Allergo Journal International)
Source: Allergo Journal International - September 19, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 14th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 29, 2019 Category: Allergy & Immunology Source Type: research

IgE-mediated hypersensitivity to chlorhexidine among first-year dental students
ConclusionsAlthough most participants reported no known exposure to CHX, 8.6% showed CHX sensitisation suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reactions in the future. (Source: Allergo Journal International)
Source: Allergo Journal International - August 12, 2019 Category: Allergy & Immunology Source Type: research

Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics
AbstractThis guideline on diagnostic procedures for suspected beta-lactam antibiotic (BLA) hypersensitivity was written by the German and Austrian professional associations for allergology, and the Paul-Ehrlich Society for Chemotherapy in a  consensus procedure according to the criteria of the German Association of Scientific Medical Societies. BLA such as penicillins and cephalosporins represent the drug group that most frequently triggers drug allergies. However, the frequency of reports of suspected allergy in patient histories cle arly exceeds the number of confirmed cases. The large number of suspected BLA allerg...
Source: Allergo Journal International - July 22, 2019 Category: Allergy & Immunology Source Type: research

What we learned from TAO – 10 years of German therapy allergen ordinance
ConclusionsIn Germany, TAO ensures that all previously untested named patient products for the treatment of frequent allergies are subjected to an assessment of their risk/benefit ratio according to the current state of science. (Source: Allergo Journal International)
Source: Allergo Journal International - July 15, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Air pollutants and primary allergy prevention
Correction to:Allergo J Int 2018https://doi.org/10.1007/s40629-018-0078-7An error was identified in the review on “Air pollutants and primary allergy prevention”. The given PM2.5 increment of 2  µg/m3 was wrong and should be replaced with an increment of 5  µg/m3.This was the case on:Page  9, legend … (Source: Allergo Journal International)
Source: Allergo Journal International - June 27, 2019 Category: Allergy & Immunology Source Type: research

Atopic eczema score of emotional consequences —a questionnaire to assess emotional consequences of atopic eczema
ConclusionAESEC is a  questionnaire for assessing the emotional consequences of living with AE. It may prove useful in evaluating the burden of disease, beyond skin symptoms and time-specific quality of life. (Source: Allergo Journal International)
Source: Allergo Journal International - June 3, 2019 Category: Allergy & Immunology Source Type: research

Update of reference values for IgG antibodies against typical antigens of hypersensitivity pneumonitis
AbstractBackgroundSpecific (s)IgG antibodies against environmental and occupational antigens, especially from bacteria, moulds, yeasts, birds and chemicals play an important role for hypersensitivity pneumonitis (HP). An increased serum level of sIgG is one criterion in the diagnostic procedure of HP and crucial for the detection of the triggering antigen for successful avoidance of further exposure. In contrast to specific IgE, sIgG concentrations in healthy individuals vary greatly depending on the antigen, which makes it difficult to differentiate from patients with HP. The aim of this study is to update or establish sI...
Source: Allergo Journal International - May 27, 2019 Category: Allergy & Immunology Source Type: research

Development of subcutaneous allergen immunotherapy (part  2): preventive aspects and innovations
ConclusionSCIT preparations are among the most innovative treatment options in the immunotherapy of allergic diseases. Due to the numerous immunological approaches, they will make treatment safer and more effective in the future with reduced effort. (Source: Allergo Journal International)
Source: Allergo Journal International - May 13, 2019 Category: Allergy & Immunology Source Type: research

German pollen calendar 4.0: update of the regional pollen calendars 4.0 with measurement data for the period 2011 –2016
(Source: Allergo Journal International)
Source: Allergo Journal International - May 2, 2019 Category: Allergy & Immunology Source Type: research

Effectiveness of a  portable air filtration device in reducing allergen exposure during household chores
DiscussionTypical household chores can result in high levels of exposure to indoor dust and allergens. The use of an AP however can reduce the inhalable dust concentrations, but the effect on allergen exposure was in most cases not large enough to achieve statistical significance. (Source: Allergo Journal International)
Source: Allergo Journal International - April 29, 2019 Category: Allergy & Immunology Source Type: research

Case series of anaphylactic reactions after rabies vaccinations with gelatin sensitization
AbstractSide effects due to allergic reactions to vaccine antigen or to additives such as chicken protein or gelatin have been known for some time. Recent findings regarding reactions mediated via the carbohydrate epitope galactose-alpha-1,3-galactose (alpha-gal), a  constituent of animal gelatin, broaden the spectrum of gelatin-related allergies. This case series presents four patients who developed anaphylactic reactions following rabies vaccination using the vaccine Rabipur®. After appropriate allergy testing by skin prick testing and the determination of specific IgE to allergens in the vaccine, triggering by ...
Source: Allergo Journal International - April 18, 2019 Category: Allergy & Immunology Source Type: research

Evolution of subcutaneous allergen immunotherapy (part  1): from first developments to mechanism-driven therapy concepts
ConclusionWhen adequately administered by physicians with allergological expertise, SCIT preparations are safe, well-tolerated, and clinically effective. (Source: Allergo Journal International)
Source: Allergo Journal International - April 15, 2019 Category: Allergy & Immunology Source Type: research

Consumer protection and risk assessment: sensitising substances in consumer products
ConclusionsToday, skin sensitising substances can be legally regulated and labelled and, depending on the exposure, their content in consumer products can be reduced or eliminated. Furthermore, the risk assessment of potentially sensitising substances makes consumer products safer. Further improvements in research approaches are required in the area of health and consumer protection with regard to allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - April 2, 2019 Category: Allergy & Immunology Source Type: research

Wheat-dependent exercise-induced anaphylaxis with Tri-a-14-sensitization as part of a  lipid transfer protein syndrome
(Source: Allergo Journal International)
Source: Allergo Journal International - February 14, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 31st Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 29, 2019 Category: Allergy & Immunology Source Type: research

Guideline: Hereditary angioedema due to C1 inhibitor deficiency
(Source: Allergo Journal International)
Source: Allergo Journal International - January 17, 2019 Category: Allergy & Immunology Source Type: research

Abstracts of the 31th Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 15, 2019 Category: Allergy & Immunology Source Type: research

Prevalence of Hymenoptera venom allergy and sensitization in the population-representative German KORA cohort
ConclusionsSelf-reported Hymenoptera sting reactions and venom sensitization are frequent in the general German population. In many cases, sensitization and clinically relevant allergy are not observed in the same individual, indicating that comprehensive diagnostic approaches are a  prerequisite for the identification of patients at risk for severe reactions. (Source: Allergo Journal International)
Source: Allergo Journal International - January 9, 2019 Category: Allergy & Immunology Source Type: research

Comparison of extended intervals and dose reduction of omalizumab for asthma control
This study evaluated asthma control after either dosage interval extension or dose reduction in patients with asthma controlled by omalizumab.MethodsThirty-seven patients were assigned to receive either extended treatment interval (n = 26) or a reduction in omalizumab dosage (n = 11). The primary outcome was time until loss of asthma control.ResultsNineteen patients (73%) of the extended interval group maintained good asthma control for at least 7 –39 months. Of the remaining 7 patients, the median time to loss of asthma control was 8 months (range 5–35 months). In con...
Source: Allergo Journal International - December 14, 2018 Category: Allergy & Immunology Source Type: research

Occupational asthma due to tampico fiber bystander exposure in a  brush production company—case report and literature review
ConclusionTampico fibers are robust fibers obtained from the leaves of the MexicanAgave lechugilla. The literature describes several cases of skin reactions in the form of irritant contact dermatitis due to occupational exposure to agave leaves or contact with agave sap. In the present case, the asthma symptoms of a  female worker in a brush factory were attributed to inhalant bystander exposure to tampico fibers in the workplace. The unequivocal evidence of sensitization to tampico fibers met the medical requirements for the recognition of an occupational disease (BK 4301). (Source: Allergo Journal International)
Source: Allergo Journal International - December 3, 2018 Category: Allergy & Immunology Source Type: research

Alpha-tocopherol acetate nasal spray in the treatment of pollen-induced allergic rhinitis
This study compared the effectiveness and tolerability of alpha-tocopherol acetate nasal spray (ATANS) to those of beclomethasone nasal spray (BNS) and loratadine (LT) for the treatment of pollen-induced allergic rhinitis.MethodsThis active-controlled, patient-preference, observational trial lasted 7  days. Tested variables were nasal symptoms, endoscopic examination, additional medications, general effectiveness, safety, and tolerability.ResultsOf 116 patients, 63  patients decided to use ATANS, 32 BNS and 21 LT. During the treatment, the mean daily rhinitis symptom score decreased significantly in all...
Source: Allergo Journal International - November 28, 2018 Category: Allergy & Immunology Source Type: research

Safety of a  high-dose house dust mite allergoid in pediatric patients
(Source: Allergo Journal International)
Source: Allergo Journal International - November 6, 2018 Category: Allergy & Immunology Source Type: research

Allergen immunotherapy for oral allergy syndrome: what is the evidence for efficacy?
ConclusionReliable recommendations on the use of AIT with pollen allergens in pollen-related food allergy are not possible as yet. AIT with birch pollen allergens appears to have a  positive effect on concomitant food allergy in some patients with birch pollen allergy. (Source: Allergo Journal International)
Source: Allergo Journal International - October 25, 2018 Category: Allergy & Immunology Source Type: research