Fragrances as allergens
AbstractContact allergies due to fragrances are common. If one adds up the reaction incidences of the indicators of fragrance allergy (fragrance mix [FM] I + II, balsam of Peru and turpentine), these reach 17% in a hospital collective (Information Network of Departments of Dermatology [IVDK] data 2016) and are thus higher than those for nickel allergy (approximately 16%). In the case of positive reactions to FM I,>50% do not react to one of the components. This type of reaction should be interpreted as allergic with caution, unless other data (e. g., positive history, application test) support this interpretat...
Source: Allergo Journal International - July 25, 2018 Category: Allergy & Immunology Source Type: research
Virus-like particles (VLP) in prophylaxis and immunotherapy of allergic diseases
ConclusionsThese results indicate that VLPs modulate immune responses in ways which underline their exceptional promise as a platform for the immunotherapy of allergic disorders. However, clinical evaluations remain limited, and further large-scale and longer-term studies will be necessary to substantiate the efficacy and safety of these novel therapies. (Source: Allergo Journal International)
Source: Allergo Journal International - July 9, 2018 Category: Allergy & Immunology Source Type: research
Evaluation of a modified skin prick test for diagnosis of Hymenoptera venom allergy
ConclusionsSPT300 shows a high but not substantially superior sensitivity utilizing both WV and BV extract for diagnosis of HV allergy compared to SPT100 and IDT1. However, since SPT300 with BV extract demonstrated a very low specificity, our results indicate that SPT300 has limited added value in the diagnosis of HV alle rgy. (Source: Allergo Journal International)
Source: Allergo Journal International - June 13, 2018 Category: Allergy & Immunology Source Type: research
The biodiversity hypothesis and immunotolerance in allergy
ConclusionTherefore, tolerance induction emerges in allergology not only as a potential concept for prevention, but also as a treatment approach in atopic diseases. (Source: Allergo Journal International)
Source: Allergo Journal International - June 12, 2018 Category: Allergy & Immunology Source Type: research
Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
AbstractThe prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be mo re efficacious than SLIT with an acceptable safety profile. However, SLIT is assoc...
Source: Allergo Journal International - June 6, 2018 Category: Allergy & Immunology Source Type: research
Perioperative drug reactions – practical recommendations for allergy testing and patient management
ConclusionFinal outcomes of the diagnostic procedures should be providing thorough information of the patient about the findings, drugs that should be avoided in the future as well as alternative preparations, and, if necessary, preventive measures to be taken in the event of further surgical interventions. (Source: Allergo Journal International)
Source: Allergo Journal International - June 4, 2018 Category: Allergy & Immunology Source Type: research
Penicillin allergy – recommendations for diagnostic work up and patient management
ConclusionThe overall predictive value of combined in vitro and in vivo allergy testing with β‑lactam antibiotics is approximately 90%. However, subsequent controlled provocation testing is recommended in order to reliably exclude allergic hypersensitivity. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research
Perioperative drug reactions – practical recommendations for allergy testing and patient management
ConclusionFinal outcomes of the diagnostic procedures should be providing thorough information of the patient about the findings, drugs that should be avoided in the future as well as alternative preparations, and, if necessary, preventive measures to be taken in the event of further surgical interventions. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research
NSAID hypersensitivity – recommendations for diagnostic work up and patient management
ConclusionThe diagnostic work-up begins with a detailed patient’s history. Skin tests are only useful in SNIDR and SNIUAA, while in vitro tests are helpful merely in exceptional cases. In general, the diagnosis can only be confirmed by provocation testing, when required. Although cross-reactivity is usually present, provocation testing is of ten able to find an alternative, tolerable analgesic. Individual patient management usually enables a solution to be found for most patients. (Source: Allergo Journal International)
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research
Allergic heparin hypersensitivity – recommendations for diagnostic work up and patient management
This article provides an overview of selected scientific articles and is based on a literature search in PubMed and specialist databases.ResultsMost commonly, heparin allergic patients develop lymphocyte-mediated, eczematous local reactions directly at the injection sites (usually on the lower abdomen) hours to days after initiating regular subcutaneous heparin injections. The high sensitivity of skin-prick and intradermal testing procedures means that subcutaneous provocation tests are seldom necessary for diagnosis. The “compartment allergy” phenomenon is a particular feature of heparin-induced local allergic reac...
Source: Allergo Journal International - June 1, 2018 Category: Allergy & Immunology Source Type: research
Non-celiac gluten/wheat sensitivity (NCGS) —a currently undefined disorder without validated diagnostic criteria and of unknown prevalence
AbstractWithin the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. The present position statement reflects the following aspects about NCGS from an allergist ’s and nutritionist’s point of view: (A) Validated diagnostic criteria and/or reliable biomarkers a...
Source: Allergo Journal International - May 28, 2018 Category: Allergy & Immunology Source Type: research
NSAID hypersensitivity – recommendations for diagnostic work up and patient management
ConclusionThe diagnostic work-up begins with a detailed patient’s history. Skin tests are only useful in SNIDR and SNIUAA, while in vitro tests are helpful merely in exceptional cases. In general, the diagnosis can only be confirmed by provocation testing, when required. Although cross-reactivity is usually present, provocation testing is of ten able to find an alternative, tolerable analgesic. Individual patient management usually enables a solution to be found for most patients. (Source: Allergo Journal International)
Source: Allergo Journal International - May 25, 2018 Category: Allergy & Immunology Source Type: research
Allergic heparin hypersensitivity – recommendations for diagnostic work up and patient management
This article provides an overview of selected scientific articles and is based on a literature search in PubMed and specialist databases.ResultsMost commonly, heparin allergic patients develop lymphocyte-mediated, eczematous local reactions directly at the injection sites (usually on the lower abdomen) hours to days after initiating regular subcutaneous heparin injections. The high sensitivity of skin-prick and intradermal testing procedures means that subcutaneous provocation tests are seldom necessary for diagnosis. The “compartment allergy” phenomenon is a particular feature of heparin-induced local allergic reac...
Source: Allergo Journal International - May 25, 2018 Category: Allergy & Immunology Source Type: research
