Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events
ConclusionThere is an urgent need for a simpler symptom- or system-based classification and scoring system to create an awareness for HSRs to BSs. A better understanding of the pathophysiology of HSRs and increased clinical experience in the treatment of side effects will provide timely control of unexpected reactions. As a result, im munotherapy with BSs will become safer in the future. (Source: Allergo Journal International)
Source: Allergo Journal International - May 11, 2020 Category: Allergy & Immunology Source Type: research
Dietary implications in acetylsalicylic acid intolerance
ConclusionDietary therapy in ASA-intolerant patients is not recommended. (Source: Allergo Journal International)
Source: Allergo Journal International - May 10, 2020 Category: Allergy & Immunology Source Type: research
Development of a practice guideline for dietary counselling of children with IgE-mediated food allergy
ConclusionThis guideline provides a comprehensive guide to dietary counselling for food allergy by dietitians in Switzerland. It will inform best practice and improve patient-centred care and encourage a consistent approach, but it will need to be reviewed and updated as more robust evidence is produced. (Source: Allergo Journal International)
Source: Allergo Journal International - April 6, 2020 Category: Allergy & Immunology Source Type: research
Current challenges in molecular diagnostics of insect venom allergy
AbstractBackgroundAdvanced component-resolved diagnostics (CRD) in Hymenoptera venom allergy (HVA) has improved the precise description of individual sensitization profiles. However, diagnostic gaps, peptide-based cross-reactivity, early identification of severe reactors and diagnosis of patients with a clear history of sting reactions but negative specific IgE and skin tests, remain challenging.MethodsSystematic literature search in PubMed and critical analysis of recently published studies on insect venom allergy diagnostics.Results and discussionCRD has increased the sensitivity of IgE testing and improved the discrim...
Source: Allergo Journal International - March 8, 2020 Category: Allergy & Immunology Source Type: research
Natural history of systemic reactions and risk factors in children and adults with Hymenoptera venom allergy
ConclusionsThere is limited evidence with regard to the natural history of HVA both in adults and in children. Several risk factors may influence the natural history of HVA, namely patient-related, allergen-related and reaction-related. Other factors are inherent to the use of venom immunotherapy (VIT). (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research
Venom immunotherapy in patients with mastocytosis
ConclusionsPatients with primary MCAS and IgE-mediated HVA are candidates to receive VIT. Their management does not differ much from general population with the exception of VIT duration. (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research
Venom immunotherapy in Europe and the United States
AbstractBackgroundHymenoptera stings are accountable for significant morbidity and deterioration in health-related quality of life due to the allergic reactions they cause, the most severe of which can culminate in fatal anaphylaxis. The availability of high quality venom extracts for use in the diagnosis and treatment of insect venom allergy has improved the prognosis and the health-related quality of life of venom-allergic patients. All over the world subcutaneous venom immunotherapy is currently the most effective form of allergen-based immunotherapy with an early, sustained and long-term efficacy. Even though the type ...
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research
Mastocytosis as a risk factor for insect venom allergy
ConclusionsMastocytosis represents a risk factor for severe reaction in patients with HVA. An early diagnosis of CMD in these patients is very important since they are at high risk of severe osteoporosis and early therapy can be immediately started. Moreover, proper advice and prescription of adrenaline can be assessed. Finally, in order to stop venom immunotherapy or whether to continue it lifelong, diagnosis of CMD has to be carried out. (Source: Allergo Journal International)
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
AbstractPhysicians think of mast cells and IgE primarily in the context of allergic disorders, including fatal anaphylaxis. This ‘bad side’ of mast cells and IgE is so well accepted that it can be difficult to think of them in other contexts, particularly those in which they may have beneficial functions. However, there is evidence that mast cells and IgE, as well as basophils (circulating granulocytes whose functions par tially overlap with those of mast cells), can contribute to host defense as components of adaptive type 2 immune responses to helminths, ticks and certain other parasites. Accordingly, allergies oft...
Source: Allergo Journal International - March 1, 2020 Category: Allergy & Immunology Source Type: research
Anaphylactic reaction at a pizzeria in a 13-year-old female patient
(Source: Allergo Journal International)
Source: Allergo Journal International - February 19, 2020 Category: Allergy & Immunology Source Type: research
Allergy to tree-of-heaven pollen in Germany: detection by positive nasal provocation
(Source: Allergo Journal International)
Source: Allergo Journal International - February 19, 2020 Category: Allergy & Immunology Source Type: research
Correction to “ARIA guideline 2019: treatment of allergic rhinitis in the German health system”
Correction to:Allergo J Int 2019https://doi.org/10.1007/s40629-019-00110-9Affiliation and disclaimer have been misrepresented and are hereby corrected:Vera Mahler:Affiliation: Med. Faculty, Friedrich-Alexander-University (FAU) Erlangen-N ürnberg, Germany.Disclaimer: The views expressed in this … (Source: Allergo Journal International)
Source: Allergo Journal International - February 11, 2020 Category: Allergy & Immunology Source Type: research
Abstracts of the 32nd Spring Symposium of the German Society of Allergy and Clinical Immunology
(Source: Allergo Journal International)
Source: Allergo Journal International - January 14, 2020 Category: Allergy & Immunology Source Type: research
Correction to: Consumer protection and risk assessment: sensitising substances in consumer products
Correction to:Allergo J Int 2019 28:167 –182https://doi.org/10.1007/s40629-019-0093-3The article “Consumer protection and risk assessment: sensitising substances in consumer products”, written by Hermann-Josef Thierse and Andreas Luch, was originally published Online First without Open Access. … (Source: Allergo Journal International)
Source: Allergo Journal International - November 14, 2019 Category: Allergy & Immunology Source Type: research
Severe skin reactions: clinical picture, epidemiology, etiology, pathogenesis, and treatment
ConclusionThe rarity and unpredictability of the reactions make a randomized double-blind therapeutic trial extremely difficult. Using meta-analyses, it is possible to trace a trend in the use of systemic treatment options. Supportive care remains the most important treatment strategy for all clinical entities. (Source: Allergo Journal International)
Source: Allergo Journal International - November 10, 2019 Category: Allergy & Immunology Source Type: research
