Expert consensus on prophylactic treatment of hereditary angioedema
SummaryHereditary angioedema (HAE) is a  chronic, genetic condition which severely impacts those afflicted with intermittent recurrent vascular edema in mucosal and submucosal tissue or in the dermis and subcutis. These swellings adversely impact the wellbeing of patients, both physically and emotionally. Depending on the location, patie nts present to doctors in a range of disciplines, and not infrequently misdiagnoses occur, such as appendicitis or an allergy, with subsequent incorrect treatment. An HAE attack can also be life-threatening if larynx is affected. However, medications for treating the more common mast cel...
Source: Allergo Journal International - September 2, 2022 Category: Allergy & Immunology Source Type: research

Treatment with IL5-/IL-5 receptor antagonists in drug reaction with eosinophilia and systemic symptoms (DRESS)
ConclusionBlockade of the IL-5/IL ‑5 receptor axis appears to be a promising treatment in DRESS with fast clinical improvement, which may allow more rapid reduction of CS, and a good safety profile. In addition, a summary of recommendations on when to use blockade of the IL-5/IL‑5 receptor axis in DRESS treatment is provided. (Source: Allergo Journal International)
Source: Allergo Journal International - August 23, 2022 Category: Allergy & Immunology Source Type: research

Abstracts of the 17th German Allergy Congress, Wiesbaden, 08. –10. September 2022
(Source: Allergo Journal International)
Source: Allergo Journal International - August 17, 2022 Category: Allergy & Immunology Source Type: research

Indicating biologics for chronic rhinosinusitis with nasal polyps (CRSwNP)
ConclusionDupilumab, omalizumab, and mepolizumab are approved for patients 18  years of age and older with CRSwNP as add-on therapy to intranasal corticosteroids when, for dupilumab and mepolizumab, therapy with systemic corticosteroids and/or surgery does not achieve sufficient disease control. Therapy with omalizumab is indicated when therapy with intranasal corticosteroid s does not result in sufficient disease control. Dedicated recommendations for the documentation of the use in the German health care system are given, which are based on the position papers of our author group already published on this topic. (Source...
Source: Allergo Journal International - July 28, 2022 Category: Allergy & Immunology Source Type: research

Idiopathic hypereosinophilic syndrome —diagnosis and treatment
AbstractSustained elevation of eosinophils above 5  × 109 /l in peripheral blood (PB) should prompt further investigation. Clonal eosinophilia accounts for the much smaller proportion of eosinophilias (<  10%), but exclusion of such a neoplasia is prognostically and therapeutically relevant. Molecular genetic analysis from PB, cytogenetics from bone marrow, and bone marrow histology are primarily used to exclude clonal eosinophilia. Far more common is reactive eosinophilia, the cause of which may be drugs, allergies, solid tumors, lymphomas, worm infections, autoimmune diseases, or idiopathic hypereosinophilic...
Source: Allergo Journal International - July 20, 2022 Category: Allergy & Immunology Source Type: research

In silico investigation for drug-like pharmacophores against food allergen profilins
ConclusionThis information regarding binding affinity and stability of the identified pharmacophores against food allergen profilins designates them as lead molecules for in vitro studies. (Source: Allergo Journal International)
Source: Allergo Journal International - July 18, 2022 Category: Allergy & Immunology Source Type: research

Sensitisation profile of Chinese allergic rhinitis patients and effectiveness of a  joint allergy-ENT clinic
ConclusionThe ARJ clinic significantly improved AR symptoms. SLIT was effective and safe for patients who failed conventional treatments. VAS positively correlated with nasoendoscopy findings. Testing for Dermatophagoides pterynosinus as a  single agent during skin testing was sufficient for the diagnosis of HDM AR and should be prioritized when resources are restricted. Further studies should be done to investigate the treatment outcome of AR patients and the effectiveness of SLIT in the Chinese population. (Source: Allergo Journal International)
Source: Allergo Journal International - July 7, 2022 Category: Allergy & Immunology Source Type: research

Olfactory and gustatory disorders in COVID-19
This article reviews th e current state of science on COVID-19-related olfactory disorders, focusing on epidemiology, pathophysiology, cure rates, currently available treatment options, and research on new treatments. (Source: Allergo Journal International)
Source: Allergo Journal International - June 20, 2022 Category: Allergy & Immunology Source Type: research

Anaphylaxis to additives in vaccines
SummaryAnaphylaxis in connection with the administration of vaccines occurs only very rarely. Triggers of immunoglobulin IgE-mediated and non-IgE-mediated anaphylaxis —in addition to the active ingredient itself—may be excipients contained in the vaccine due to their special properties. Some of the excipients in medicinal products are the same compounds used as additives in food. Furthermore, residues from the manufacturing process (e.g., chicken egg white, c asein, antibiotics, formaldehyde) or contaminants (e.g., from the primary packaging material) may be potential triggers of anaphylaxis in vaccines. This review ar...
Source: Allergo Journal International - June 14, 2022 Category: Allergy & Immunology Source Type: research

Climate change and allergies
AbstractThe climate crisis poses a  major challenge to human health as well as the healthcare system and threatens to jeopardize the medical progress made in recent decades. However, addressing climate change may also be the greatest opportunity for global health in the 21st century. The climate crisis and its consequences, such as rising temperatures, forest fires, floods, droughts, and changes in the quality and quantity of food and water, directly and indirectly affect human physical and mental health. More intense and frequent heat waves and declining air quality have been shown to increase all-cause mortality, especi...
Source: Allergo Journal International - June 8, 2022 Category: Allergy & Immunology Source Type: research

Anaphylaxis to drug excipients
SummaryIn addition to the therapeutic agent, drugs contain excipients such as stabilizers, preservatives, solubilizers, or dyes, some of which are identical to additives in foods. Anaphylaxis to these excipients is probably an underestimated problem. After the first descriptions of anaphylactic reactions to drug excipients appeared more than 30  years ago, the number of corresponding reports has increased significantly over the years. However, a diagnostic gap exists in the clarification of drug allergic reactions when the index product is not known and/or is not available for testing. In the present work, individual exc...
Source: Allergo Journal International - May 31, 2022 Category: Allergy & Immunology Source Type: research

Two severe perioperative hypersensitivity reactions in a  single patient—a case report of a medication error
(Source: Allergo Journal International)
Source: Allergo Journal International - May 19, 2022 Category: Allergy & Immunology Source Type: research

One Health: areas in the living environment of people and animals and their effects on allergy and asthma
ConclusionBiodiverse green spaces, especially forests and meadows, may offer some protection against asthma and allergies. Contact with soil and ground also seems important for the diverse skin microbiome, especially in childhood, and thus presumably beneficial for the immune system. Therefore, people and man ’s best friend, the dog, should spend sufficient time in green, biodiverse environments, despite—or perhaps because—of rapid urbanization. People should also actively create such biodiverse surroundings in their closer living environment. On a broader level, in the spirit of the One Health co ncept, those respo...
Source: Allergo Journal International - May 17, 2022 Category: Allergy & Immunology Source Type: research

Improved IgG antibody diagnostics of hypersensitivity pneumonitis and pulmonary mycoses by means of newly evaluated serum antibody ranges and frequencies using IgG ImmunoCAP ™
ConclusionThis study is the first to evaluate the ranges not only of avian andAspergillus fumigatus antigens, as has been done up to now, but also of antibodies against 24  other environmental antigens. Quantification of IgG antibodies regarding their specific ranges can help to improve the serodiagnostics of immune-mediated lung diseases. In the lower ranges IgG antibodies are mainly physiological, while higher ranges correlate with the mentioned diseases as HP and ABPA/allergic bronchopulmonary mycoses (ABPM). The determined frequencies of the eight HP antibodies can be helpful in establishing HP screening tests. (Sourc...
Source: Allergo Journal International - May 17, 2022 Category: Allergy & Immunology Source Type: research

“Adrenaline junkie”: a case report of repeated use of epinephrine
(Source: Allergo Journal International)
Source: Allergo Journal International - May 12, 2022 Category: Allergy & Immunology Source Type: research