Correction to: Fragrances as allergens
Correction to:Allergo J Int 2018https://doi.org/10.1007/s40629-018-0075-xThe conflicts of interest of the authors Axel Schnuch and Peter Griem had been omitted.The correct information is given … (Source: Allergo Journal International)
Source: Allergo Journal International - October 19, 2018 Category: Allergy & Immunology Source Type: research
Air pollutants and primary allergy prevention
ConclusionIf the evidence for the causal role of air pollutants in the onset of allergies is inconclusive, one must assume that it is probably not possible to achieve primary prevention of allergies by improving air quality. However, there is sufficient evidence to show that air pollutants can trigger exacerbations of allergic diseases. This alone justifies ensuring that the existing threshold values for air pollutants are adhered to, in order to protect particularly allergy sufferers from health impairments. (Source: Allergo Journal International)
Source: Allergo Journal International - October 10, 2018 Category: Allergy & Immunology Source Type: research
What ’s new in the Global Initiative for Asthma 2018 report and beyond
AbstractBackgroundThe Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. The 2018 update of the GINA report incorporates new evidence following the routine twice-yearly cumulative review of the literature by the GINA Scientific Committee.MethodsRecommendations in the 2018 edition were examined for new content and updates, and the scientific evidence behind these recommendations was examined and discussed. Focus was given to the management of asthma in adults in the general populatio...
Source: Allergo Journal International - October 10, 2018 Category: Allergy & Immunology Source Type: research
Allergies and vaccination: a myth demystified
ConclusionStandard vaccinations do not increase the risk for manifesting allergic disease or specific sensitization to environmental allergens. If individual protection is desired, and taking into account the particular risks and provisos, children with allergic disease and anaphylactic reactions to vaccines can also be vaccinated. (Source: Allergo Journal International)
Source: Allergo Journal International - September 18, 2018 Category: Allergy & Immunology Source Type: research
Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
AbstractThe prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2% of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be mo re efficacious than SLIT with an acceptable safety profile. However, SLIT is assoc...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research
Fragrances as allergens
AbstractContact allergies due to fragrances are common. If one adds up the reaction incidences of the indicators of fragrance allergy (fragrance mix [FM] I + II, balsam of Peru and turpentine), these reach 17% in a hospital collective (Information Network of Departments of Dermatology [IVDK] data 2016) and are thus higher than those for nickel allergy (approximately 16%). In the case of positive reactions to FM I,>50% do not react to one of the components. This type of reaction should be interpreted as allergic with caution, unless other data (e. g., positive history, application test) support this interpretat...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research
Abstracts of the 13th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research
Positive and negative AIT trials: What makes the difference?
DiscussionA clinical trial aims to evaluate the efficacy of an agent. However, studies with potential effective compounds may fail because of methodical issues. Sometimes, they are the cause of discrepancies between successful phase II and unsuccessful phase III trials. To understand more about failure of s tudies, investigators and editors should be encouraged to publish negative trials. (Source: Allergo Journal International)
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research
Placebo effects in allergen immunotherapy: an experts ’ opinion
AbstractPlacebo effects are common in medicine. Randomised clinical trials help us to understand their magnitude in different therapies. There are particular problems with placebo effects in allergen immunotherapy (AIT) as it is difficult to blind the active treatment and the endpoints are largely subjective. This may explain why large placebo effects are often found in AIT trials. Patients receiving open label AIT get the benefit of the active and placebo components but it can be difficult to say how much benefit is due to the active component. The use of active placebos has been proposed but brings its own problems (ethi...
Source: Allergo Journal International - September 1, 2018 Category: Allergy & Immunology Source Type: research
Abstracts of the 13th German Allergy Congress
(Source: Allergo Journal International)
Source: Allergo Journal International - August 30, 2018 Category: Allergy & Immunology Source Type: research
The biodiversity hypothesis and immunotolerance in allergy
ConclusionTherefore, tolerance induction emerges in allergology not only as a potential concept for prevention, but also as a treatment approach in atopic diseases. (Source: Allergo Journal International)
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research
SCIT with a high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups
ConclusionSCIT with the marketed dose of high-dose HDM allergoid was well tolerated in clinical development and in daily practice. There was no increased risk for the investigated patient subgroups. Tolerability was comparable to HDM sublingual immunotherapy (SLIT) tablets. (Source: Allergo Journal International)
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research
Non-celiac gluten/wheat sensitivity (NCGS) —a currently undefined disorder without validated diagnostic criteria and of unknown prevalence
AbstractWithin the last decade, non-celiac gluten/wheat sensitivity (NCGS) has been increasingly discussed not only in the media but also among medical specialties. The existence and the possible triggers of NCGS are controversial. Three international expert meetings which proposed recommendations for NCGS were not independently organized and only partially transparent regarding potential conflicts of interest of the participants. The present position statement reflects the following aspects about NCGS from an allergist ’s and nutritionist’s point of view: (A) Validated diagnostic criteria and/or reliable biomarkers a...
Source: Allergo Journal International - August 1, 2018 Category: Allergy & Immunology Source Type: research
SCIT with a high-dose house dust mite allergoid is well tolerated: safety data from pooled clinical trials and more than 10 years of daily practice analyzed in different subgroups
ConclusionSCIT with the marketed dose of high-dose HDM allergoid was well tolerated in clinical development and in daily practice. There was no increased risk for the investigated patient subgroups. Tolerability was comparable to HDM sublingual immunotherapy (SLIT) tablets. (Source: Allergo Journal International)
Source: Allergo Journal International - July 25, 2018 Category: Allergy & Immunology Source Type: research
