Mometasone Furoate Loaded Aspasomal Gel for Topical Treatment of Psoriasis: Formulation, Optimization, In-Vitro and In-Vivo Performance.

Mometasone Furoate Loaded Aspasomal Gel for Topical Treatment of Psoriasis: Formulation, Optimization, In-Vitro and In-Vivo Performance. J Dermatolog Treat. 2020 Jun 30;:1-41 Authors: Shinde G, Desai P, Shelke S, Patel R, Bangale G, Kulkarni D Abstract Present investigation was aimed to develop Aspasomal gel of Mometasone Furoate for the treatment Psoriasis and deliver drug at controlled rate and decrease dosing frequency. The vesicles were fabricated using film hydration method and optimized using 32 factorial Design and were evaluated for percent drug loading, vesicle size, Zeta potential, Polydispersity index and morphological studies. Gel was prepared using carbopol by loading optimized drug loaded asposomes and was evaluated for drug content, pH, viscosity and spreadability. The drug release study from the gel was done using dialysis and goat skin. Anti- oxidant potency of the prepared aspasomal gel was determined by Ferric Reducing Assay whereas, in-vivo performance for inflammation and skin irritation was carried out using Wistar rats. Optimized aspasomes demonstrated desired properties for entrapment efficiency (74.72 ± 1.8), vesicle size (282.9 ± 1.7), PDI (0.2), zeta potential (-20.2mV) with spherical shape. The results recorded for drug release from the aspasomal gel exhibited sustained release when compared with marketed cream. Aspasomal gel of Mometasone furoate form depot in epidermis that was confirmed by ex-...
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research