Defining lipids and T cell receptors involved in the intrinsic allergenicity of nut proteins
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 25, 2020 Category: Allergy & Immunology Source Type: research

Drug-related relapses in drug reaction with eosinophilia and systemic symptoms (DRESS)
ConclusionPatients with DRESS frequently suffered from drug related relapses. Half of the patients with drug-related relapses developed a MDH with proven sensitizations not only to the DRESS inducing drugs, but also to newly applied drugs. When not sensitized, drugs involved in drug related relapses could be reintroduced, if needed. Here, we propose a procedure for drug testing and future management of drug-related relapses in DRESS. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 23, 2020 Category: Allergy & Immunology Source Type: research

Increasing incidence of anaphylaxis in Hong Kong from 2009 to 2019 —discrepancies of anaphylaxis care between adult and paediatric patients
AbstractBackgroundAnaphylaxis has been increasing in developed countries but there is very little published data on the burden of anaphylaxis and the pattern of adrenaline autoinjector (AAI) prescription from Asia. We aim to determine the incidence rates of anaphylaxis and prescription rates of AAI over the past decade in Hong Kong.MethodsUsing a centralized electronic database of Hong Kong ’s sole public-funded healthcare provider, we obtained and analysed all patients between 2009 and 2019 with physician-reported diagnosis of anaphylaxis. Incidence rates were calculated using population statistics as the denominato...
Source: Clinical and Translational Allergy - November 19, 2020 Category: Allergy & Immunology Source Type: research

Variation in IgE binding potencies of seven Artemisia species depending on content of major allergens
Conclusion and clinical relevanceThere was high sequence similarity but different content of the three group allergens from differentArtemisia species. Choice ofArtemisia annua andA. argyi pollen source for diagnosis and immunotherapy is recommended in China. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 18, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 17, 2020 Category: Allergy & Immunology Source Type: research

Retraction Note to: Partially hydrolysed, prebiotic supplemented whey formula for the prevention of allergic manifestations in high risk infants: a multicentre double-blind randomised controlled trial
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 9, 2020 Category: Allergy & Immunology Source Type: research

The role of antifungals in the management of patients with severe asthma
AbstractIn patients with asthma, the inhalation of elevated amounts of fungal spores and hyphae may precipitate the onset of asthma or worsen control to the extent of being life-threatening. Sensitisation to fungi, especiallyAspergillus fumigatus, is found in 15% to 48% of asthmatics in secondary care and is linked to worse asthma control, hospitalisation, bronchiectasis and fixed airflow obstruction, irrespective of whether allergic bronchopulmonary aspergillosis (ABPA) is diagnosed. ABPA represents a florid response to the presence ofAspergillus spp. but up to 70% of patients with severe asthma exhibit sensitisation to d...
Source: Clinical and Translational Allergy - November 6, 2020 Category: Allergy & Immunology Source Type: research

Anomalous asthma and chronic obstructive pulmonary disease Google Trends patterns during the COVID-19 pandemic
ConclusionsDuring March 2020, there was a peak in searches on asthma and COPD, which was probably mostly driven by media coverage, as suggested by their simultaneity in several countries with different epidemiological situations. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 2, 2020 Category: Allergy & Immunology Source Type: research

Genomics of asthma, allergy and chronic rhinosinusitis: novel concepts and relevance in airway mucosa
AbstractGenome wide association studies (GWASs) have revealed several airway disease-associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic rhinosinusitis (CRS), however, is not yet fully understood. The aim of this review is to evaluate the airway relevance of loci and genes identified in GWAS studies. GWASs were searched from databases, and a list of loci associating significantly (p  
Source: Clinical and Translational Allergy - October 28, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Is diet partly responsible for differences in COVID-19 death rates between and within countries?
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 26, 2020 Category: Allergy & Immunology Source Type: research

Validation of the DECA criteria for allergic conjunctivitis severity and control
AbstractBackgroundAllergic conjunctivitis (AC) is usually associated to allergic rhinitis (AR), but the severity and control of ocular symptoms should be assessed independently to improve diagnosis and treatment. The criteria from the Spanish consensus document on allergic conjunctivitis (DECA) aimed to be used as a patient-reported instrument for AC management. Here we validate these criteria for classifying AC severity and defining its control following COSMIN guidelines recommendations.MethodsPatients with moderate or severe AR [reflective total nasal symptom score (rTNSS) score  ≥ 8] and concomitant AC...
Source: Clinical and Translational Allergy - October 23, 2020 Category: Allergy & Immunology Source Type: research

Fungal and bacterial microbiome dysbiosis and imbalance of trans-kingdom network in asthma
ConclusionWe showed mycobiome and bacteriome dysbiosis in asthma featured by alterations in biodiversity, community composition, inter-kingdom and intra-kingdom network. We also observed several functional genes associated with asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 22, 2020 Category: Allergy & Immunology Source Type: research

Unravelling the expression of interleukin-9 in chronic rhinosinusitis: A possible role for Staphylococcus aureus
AbstractChronic rhinosinusitis with nasal polyps (CRSwNP) is a Th2 biased inflammation, associated with nasal colonization ofStaphylococcus (S.)aureus. Interleukin (IL)-9 is a pro-inflammatory Th2 cytokine with a pivotal role in asthma, allergy and chronic obstructive pulmonary disease (COPD), but is less studied in CRSwNP. We aimed to characterize the expression and cellular source of IL-9 and examinedS. aureus as potential local trigger in CRSwNP. We showed increased numbers of interleukin-9 producing neutrophils and mononuclear cells in the tissue of CRSwNP patients. This interleukin-9 production was stimulated byS. aur...
Source: Clinical and Translational Allergy - October 19, 2020 Category: Allergy & Immunology Source Type: research

Current transition management of adolescents and young adults with allergy and asthma: a European survey
ConclusionAlthough there was agreement that transition is important for AYA with allergy and asthma, there are crucial limitations and variations in the current provision of transition services across Europe. Standardisation of AYA management and specific training are required. This should improve management and continuity of care during adolescence and into adulthood to achieve the best healthcare outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 6, 2020 Category: Allergy & Immunology Source Type: research

Primary non-adherence to inhaled medications measured with e-prescription data from Poland
ConclusionsOut of e-prescriptions for inhaled medications issued in 2018 in Poland, 15.3% were not redeemed. The degree of primary non-adherence was influenced by age, but not gender. Significant differences between MDIs and DPIs and between inhalers with/without a dosage counter were observed. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 6, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 27, 2020 Category: Allergy & Immunology Source Type: research

Correction to: Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)
An amendment to this paper has been published and can be accessed via the original article. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 14, 2020 Category: Allergy & Immunology Source Type: research

Initiating pollen sensitization – complex source, complex mechanisms
AbstractThe mechanisms involved in the induction of allergic sensitization by pollen are not fully understood. Within the last few decades, findings from epidemiological and experimental studies support the notion that allergic sensitization is not only dependent on the genetics of the host and environmental factors, but also on intrinsic features of the allergenic source itself. In this review, we summarize the current concepts and newest advances in research focusing on the initial mechanisms inducing pollen sensitization. Pollen allergens are embedded in a complex and heterogeneous matrix composed of a myriad of bioacti...
Source: Clinical and Translational Allergy - August 30, 2020 Category: Allergy & Immunology Source Type: research

The association between airborne pollen monitoring and sensitization in the hot desert climate
ConclusionsThis is the first study to monitor airborne pollen in the state of Qatar. The main pollen detected were Amaranthaceae and Poaceae. Pollen may represent a possible exacerbating factor in adult patients with allergic diseases such as asthma and allergic rhinitis. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 9, 2020 Category: Allergy & Immunology Source Type: research

IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis
AbstractThe pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic se...
Source: Clinical and Translational Allergy - August 2, 2020 Category: Allergy & Immunology Source Type: research

Allergen exposure chambers: implementation in clinical trials in allergen immunotherapy
AbstractAllergen exposure chambers (AECs) have been developed for controlled allergen challenges of allergic patients mimicking natural exposure. As such, these facilities have been utilized e.g., for proof of concept, dose finding or the demonstration of onset of action and treatment effect sizes of antiallergic medication. Moreover, clinical effects of and immunological mechanisms in allergen immunotherapy (AIT) have been investigated in AECs. In Europe AIT products have to fulfill regulatory requirements for obtaining market authorization through Phase I to III clinical trials. Multiple Phase II (dose-range-finding or p...
Source: Clinical and Translational Allergy - July 28, 2020 Category: Allergy & Immunology Source Type: research

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer —a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)
AbstractElevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utili...
Source: Clinical and Translational Allergy - July 16, 2020 Category: Allergy & Immunology Source Type: research

Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis
AbstractBackgroundOne of the important pathogeneses of eustachian tube dysfunction (ETD) is nasal inflammatory disease. The prevalence of allergic rhinitis (AR) in adults ranges from 10 to 30% worldwide. However, research on the status of eustachian tubes in AR patients is still very limited.MethodsThis prospective controlled cross-sectional study recruited 59 volunteers and 59 patients with AR from Sun Yat-sen Memorial Hospital. Visual analogue scale (VAS) scores for AR symptoms and seven-item Eustachian Tube Dysfunction Questionnaire (ETDQ-7) scores were collected for both groups. Nasal endoscopy, tympanography and eusta...
Source: Clinical and Translational Allergy - July 14, 2020 Category: Allergy & Immunology Source Type: research

Citrullinated histone H3, a marker of extracellular trap formation, is increased in blood of stable asthma patients
ConclusionsAsthma is characterized by increased circulating H3cit likely related to the enhanced lung ETs formation. Inhibition of ETs might be a therapeutic option in selected asthma phenotypes, such as neutrophilic asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 12, 2020 Category: Allergy & Immunology Source Type: research

Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper
AbstractFarmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respiratory effects such as work-related asthma and rhinitis. However, being born and raised or working on a farm reduces the risk of atopic asthma and rhinitis later in life. A risk of chronic bronchitis and bronchial obstruction/COPD has been reported in confinement buildings and livestock farmers. This position paper reviews the literature linking exposure information to intensive animal farming and the risk of work-...
Source: Clinical and Translational Allergy - July 5, 2020 Category: Allergy & Immunology Source Type: research

Distinct type 2-high inflammation associated molecular signatures of chronic rhinosinusitis with nasal polyps with comorbid asthma
ConclusionsPatients with CRSwNP  + AS have distinct type 2-high inflammation-associated molecular signatures in nasal tissues compared to patients with CRSwNP-alone. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 2, 2020 Category: Allergy & Immunology Source Type: research

The disease burden in patients with respiratory allergies induced by house dust mites: a year-long observational survey in three European countries
ConclusionsIn a 13-month, fortnightly survey of patients in France, Italy and Spain with a self-reported history of moderate-to-severe, poorly controlled, HDM-induced allergic rhinitis and asthma, we found that a relevant minority of participants regularly reported a severe or very severe impact of their allergy on tiredness, sleep and professional activities (including time off work). The disease burden peaked in autumn and late spring. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 30, 2020 Category: Allergy & Immunology Source Type: research

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation – summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019
AbstractConcerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use sets up a system of requirements, rewards and incentives to ensure that medicinal products are researched, developed and authorized to meet the therapeutic needs o f children. Allergen Immunotherapy (AIT) is believed to contain a strong potential for immunomodulatory effects inducing sustained clinical efficacy after cessation of treatment (disease modifying effect) and thereby may prevent the pro...
Source: Clinical and Translational Allergy - June 28, 2020 Category: Allergy & Immunology Source Type: research

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis
ConclusionsIn an observational real-world setting, add-on omalizumab for severe allergic asthma was effective in improving asthma control, lung function and in reducing exacerbations, including in those patients with CRSwNP. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 25, 2020 Category: Allergy & Immunology Source Type: research

Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases —POLLAR symposium under the auspices of Finland’s Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing
AbstractIn December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the Finnish Environment Institute and the European Commission, under the auspices of Finland’s Presidency of the EU. As a side event, a symposium organized as the final POLLAR (Impact of air POLLution on Asthma and Rhinitis) meeting explored the digital transformation of health and care to sustain planetary health in airway diseases. The Finnish Allergy Programme collaborates w...
Source: Clinical and Translational Allergy - June 18, 2020 Category: Allergy & Immunology Source Type: research

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model
ConclusionDuring COVID-19 pandemic, allergists have the responsibility of balancing individual patients ’ needs with public health issues, and innovative tools, such as telemedicine and digital medicine services, can be helpful to reduce the risk of viral spreading while delivering up-to-date personalized care. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 17, 2020 Category: Allergy & Immunology Source Type: research

Molecular approach to a patient ’s tailored diagnosis of the oral allergy syndrome
AbstractOral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are exposed to some fresh plant foods has been called pollen food allergy syndrome (PFAS). In the wake of PFAS, several different associations of allergenic sources have been progressively proposed and called syndromes. Molecular allergology has shown that these associations are based on IgE co-recognition t...
Source: Clinical and Translational Allergy - June 16, 2020 Category: Allergy & Immunology Source Type: research

Epinephrine delivery via EpiPen ® Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances
ConclusionsEpinephrine delivery via EpiPen resulted in greater early systemic exposure to epinephrine vs IM syringe as assessed by epinephrine plasma levels. Delivery via EpiPen was consistent across participants with a wide range of STMD, even when the needle may not have penetrated the muscle.Trial registrationsThis trial was registered with the German Clinical Trials Register (DRKS-ID: DRKS00011263; secondary ID, EudraCT 2016-000104-29) on 23 March 2017. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 9, 2020 Category: Allergy & Immunology Source Type: research

Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 7, 2020 Category: Allergy & Immunology Source Type: research

New approach to intermittent and mild asthma therapy: evolution or revolution in the GINA guidelines?
AbstractNew recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especially regarding the treatment of intermittent and mild asthma. Due to safety concerns, GINA experts no longer recommend treatment with a short-acting β2 agonist alone. Henceforth, all adults and adolescents (but not yet children) with mild asthma should receive either symptom-driven or daily low-dose ICS. The main goal of this new approach is to reduce the risk of serious asthma exacerbations and asthma-re...
Source: Clinical and Translational Allergy - June 2, 2020 Category: Allergy & Immunology Source Type: research

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients
ConclusionsSensitization to skin resident fungi includingMalassezia globosa is uncommon in European CholU patients, but is associated with atopy and pronounced wheal formation upon dermal contact with their own sweat.Trial registration German Clinical Trials Registry DRKS-ID: DRKS00004277 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 31, 2020 Category: Allergy & Immunology Source Type: research

Viral infections and wheezing –asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?
AbstractSevere and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the vast majority of respiratory tract infections (RTI) leading to wheezing and asthma are of a viral origin and severity and recurrence are the consequence of a greater exposure to infectious agents in a period when the immune system is still relatively immature. Therefore, boosting the efficiency of the host immune response against viral infections seems to be a rational preven...
Source: Clinical and Translational Allergy - May 29, 2020 Category: Allergy & Immunology Source Type: research

Is diet partly responsible for differences in COVID-19 death rates between and within countries?
AbstractReported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be sign...
Source: Clinical and Translational Allergy - May 26, 2020 Category: Allergy & Immunology Source Type: research

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24  years from the BAMSE birth cohort
ConclusionIgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 24, 2020 Category: Allergy & Immunology Source Type: research

EAACI anaphylaxis guidelines: systematic review protocol
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 19, 2020 Category: Allergy & Immunology Source Type: research

COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium
AbstractThe growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated a...
Source: Clinical and Translational Allergy - May 17, 2020 Category: Allergy & Immunology Source Type: research

EAACI Task force Clinical epidemiology of anaphylaxis: experts ’ perspective on the use of adrenaline autoinjectors in Europe
ConclusionOur data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 10, 2020 Category: Allergy & Immunology Source Type: research

Clinical trials in allergen immunotherapy in the age group of children and adolescents: current concepts and future needs
AbstractAllergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adolescents and adults. Though regulatory requirements for marketing authorization have been clearly outlined and an increasing number of high quality trials has been initiated, multiple concepts and details in study design may be further elaborated, harmonized and improved. An international group of experts in the field of AIT has thoroughly reviewed and discussed current concepts and provided an outlook on furthe...
Source: Clinical and Translational Allergy - April 23, 2020 Category: Allergy & Immunology Source Type: research

Impact on quality of life and safety of sublingual and subcutaneous immunotherapy in children with severe house dust mite and pollen-associated allergic rhinoconjunctivitis
AbstractBackgroundPollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previous direct comparative studies investigating quality of life (QoL) of all three immunotherapy regimes. The aim of this study was to compare QoL and safety in children receiving these immunotherapies for AR.MethodsDemographic characteristics, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Visual Analogue (VAS) scores were assessed in 249 children undergoing HDM and pollen immunotherapy at ...
Source: Clinical and Translational Allergy - April 19, 2020 Category: Allergy & Immunology Source Type: research

Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes
AbstractBackgroundNasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.MethodsAn open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. The active group also received an additional sea-water NI solution supplemented with algae extracts. The primary endpoint was symptom control, assessed by the control of allergic rhinitis and ...
Source: Clinical and Translational Allergy - March 12, 2020 Category: Allergy & Immunology Source Type: research

Development of a model care pathway for the management of Hymenoptera venom allergy: evidence-based key interventions and indicators
ConclusionA set of 123 key interventions and of six process indicators were found to be appropriate for the development and standardization of the clinical content of the Hymenoptera venom allergy care pathway. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 3, 2020 Category: Allergy & Immunology Source Type: research

Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis
ConclusionIgE polysensitization, to perennial and seasonal allergens, and levels of total IgE seem to be the main determinants of atopic multimorbidity in subjects with rhinitis. This indicates that disease-modifying treatment that targets IgE sensitization may be of value when decreasing the risk of developing atopic multimorbidity. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 20, 2020 Category: Allergy & Immunology Source Type: research

Eczema phenotypes and risk of allergic and respiratory conditions in school age children
ConclusionEczema phenotypes were differentially associated with risks of respiratory and allergic conditions in school-aged children. Children with early transient and persistent eczema might benefit from more intense follow-up for early identification and treatment of asthma and allergies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 18, 2020 Category: Allergy & Immunology Source Type: research

Modified protocol of omalizumab treatment to prevent carboplatin-induced drug hypersensitivity reactions: a case study
AbstractCarboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation are likely to be IgE-mediated; in that case, addition of omalizumab premedication should be strongly considered. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 28, 2020 Category: Allergy & Immunology Source Type: research

Healthy people in healthy premises: the Finnish Indoor Air and Health Programme 2018 –2028
AbstractClean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase the risk of certain diseases. Finns have taken major steps to improve the quality of indoor air for several decades. The primary focus of these activities has been the prevention and reduction of exposure to poor indoor air quality through guidance and regulation directing remediation of damaged buildings. Nevertheless, reported symptoms related to poor indoor air quality are common in Finland. In addition to ex...
Source: Clinical and Translational Allergy - January 16, 2020 Category: Allergy & Immunology Source Type: research