The disease burden in patients with respiratory allergies induced by house dust mites: a year-long observational survey in three European countries
ConclusionsIn a 13-month, fortnightly survey of patients in France, Italy and Spain with a self-reported history of moderate-to-severe, poorly controlled, HDM-induced allergic rhinitis and asthma, we found that a relevant minority of participants regularly reported a severe or very severe impact of their allergy on tiredness, sleep and professional activities (including time off work). The disease burden peaked in autumn and late spring. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 1, 2020 Category: Allergy & Immunology Source Type: research

Allergen Immunotherapy (AIT) in children: a vulnerable population with its own rights and legislation – summary of EMA-initiated multi-stakeholder meeting on Allergen Immunotherapy (AIT) for children, held at Paul-Ehrlich-Institut, Langen, Germany, 16.1.2019
AbstractConcerning development of medicinal products, children belong to a so-called “special population” for which additional legislation applies: Regulation (EC) No 1901/2006 on medicinal products for paediatric use sets up a system of requirements, rewards and incentives to ensure that medicinal products are researched, developed and authorized to meet the therapeutic needs o f children. Allergen Immunotherapy (AIT) is believed to contain a strong potential for immunomodulatory effects inducing sustained clinical efficacy after cessation of treatment (disease modifying effect) and thereby may prevent the pro...
Source: Clinical and Translational Allergy - June 29, 2020 Category: Allergy & Immunology Source Type: research

Effectiveness of omalizumab in patients with severe allergic asthma with and without chronic rhinosinusitis with nasal polyps: a PROXIMA study post hoc analysis
ConclusionsIn an observational real-world setting, add-on omalizumab for severe allergic asthma was effective in improving asthma control, lung function and in reducing exacerbations, including in those patients with CRSwNP. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 26, 2020 Category: Allergy & Immunology Source Type: research

Digital transformation of health and care to sustain Planetary Health: The MASK proof-of-concept for airway diseases —POLLAR symposium under the auspices of Finland’s Presidency of the EU, 2019 and MACVIA-France, Global Alliance against Chronic Respiratory Diseases (GARD, WH0) demonstration project, Reference Site Collaborative Network of the European Innovation Partnership on Active and Healthy Ageing
AbstractIn December 2019, a conference entitled “Europe That Protects: Safeguarding Our Planet, Safeguarding Our Health” was held in Helsinki. It was co-organized by the Finnish Institute for Health and Welfare, the Finnish Environment Institute and the European Commission, under the auspices of Finland’s Presidency of the EU. As a side event, a symposium organized as the final POLLAR (Impact of air POLLution on Asthma and Rhinitis) meeting explored the digital transformation of health and care to sustain planetary health in airway diseases. The Finnish Allergy Programme collaborates w...
Source: Clinical and Translational Allergy - June 19, 2020 Category: Allergy & Immunology Source Type: research

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model
ConclusionDuring COVID-19 pandemic, allergists have the responsibility of balancing individual patients ’ needs with public health issues, and innovative tools, such as telemedicine and digital medicine services, can be helpful to reduce the risk of viral spreading while delivering up-to-date personalized care. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 18, 2020 Category: Allergy & Immunology Source Type: research

Molecular approach to a patient ’s tailored diagnosis of the oral allergy syndrome
AbstractOral allergy syndrome (OAS) is one of the most common IgE-mediated allergic reactions. It is characterized by a number of symptoms induced by the exposure of the oral and pharyngeal mucosa to allergenic proteins belonging to class 1 or to class 2 food allergens. OAS occurring when patients sensitized to pollens are exposed to some fresh plant foods has been called pollen food allergy syndrome (PFAS). In the wake of PFAS, several different associations of allergenic sources have been progressively proposed and called syndromes. Molecular allergology has shown that these associations are based on IgE co-recognition t...
Source: Clinical and Translational Allergy - June 17, 2020 Category: Allergy & Immunology Source Type: research

Epinephrine delivery via EpiPen ® Auto-Injector or manual syringe across participants with a wide range of skin-to-muscle distances
ConclusionsEpinephrine delivery via EpiPen resulted in greater early systemic exposure to epinephrine vs IM syringe as assessed by epinephrine plasma levels. Delivery via EpiPen was consistent across participants with a wide range of STMD, even when the needle may not have penetrated the muscle.Trial registrationsThis trial was registered with the German Clinical Trials Register (DRKS-ID: DRKS00011263; secondary ID, EudraCT 2016-000104-29) on 23 March 2017. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 10, 2020 Category: Allergy & Immunology Source Type: research

Pru p 3 oral immunotherapy efficacy, induced immunological changes and quality of life improvement in patients with LTP syndrome
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 8, 2020 Category: Allergy & Immunology Source Type: research

New approach to intermittent and mild asthma therapy: evolution or revolution in the GINA guidelines?
AbstractNew recommendations from the Global Initiative for Asthma (GINA) were released in a pocket guide form on April 12, 2019. These recommendations provide very important changes to the management of asthma, especially regarding the treatment of intermittent and mild asthma. Due to safety concerns, GINA experts no longer recommend treatment with a short-acting β2 agonist alone. Henceforth, all adults and adolescents (but not yet children) with mild asthma should receive either symptom-driven or daily low-dose ICS. The main goal of this new approach is to reduce the risk of serious asthma exacerbations and asthma-re...
Source: Clinical and Translational Allergy - June 3, 2020 Category: Allergy & Immunology Source Type: research

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients
ConclusionsSensitization to skin resident fungi includingMalassezia globosa is uncommon in European CholU patients, but is associated with atopy and pronounced wheal formation upon dermal contact with their own sweat.Trial registration German Clinical Trials Registry DRKS-ID: DRKS00004277 (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 1, 2020 Category: Allergy & Immunology Source Type: research

Viral infections and wheezing –asthma inception in childhood: is there a role for immunomodulation by oral bacterial lysates?
AbstractSevere and recurrent infections of the respiratory tract in early childhood constitute major risk factors for the development of bronchial hyper-responsiveness and obstructive respiratory diseases in later life. In the first years of life, the vast majority of respiratory tract infections (RTI) leading to wheezing and asthma are of a viral origin and severity and recurrence are the consequence of a greater exposure to infectious agents in a period when the immune system is still relatively immature. Therefore, boosting the efficiency of the host immune response against viral infections seems to be a rational preven...
Source: Clinical and Translational Allergy - May 29, 2020 Category: Allergy & Immunology Source Type: research

Is diet partly responsible for differences in COVID-19 death rates between and within countries?
AbstractReported COVID-19 deaths in Germany are relatively low as compared to many European countries. Among the several explanations proposed, an early and large testing of the population was put forward. Most current debates on COVID-19 focus on the differences among countries, but little attention has been given to regional differences and diet. The low-death rate European countries (e.g. Austria, Baltic States, Czech Republic, Finland, Norway, Poland, Slovakia) have used different quarantine and/or confinement times and methods and none have performed as many early tests as Germany. Among other factors that may be sign...
Source: Clinical and Translational Allergy - May 27, 2020 Category: Allergy & Immunology Source Type: research

Male sex is strongly associated with IgE-sensitization to airborne but not food allergens: results up to age 24  years from the BAMSE birth cohort
ConclusionIgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 25, 2020 Category: Allergy & Immunology Source Type: research

EAACI anaphylaxis guidelines: systematic review protocol
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 20, 2020 Category: Allergy & Immunology Source Type: research

COST Action ‘ImpARAS’: what have we learnt to improve food allergy risk assessment. A summary of a 4 year networking consortium
AbstractThe growing world population and increased pressure on agricultural resources are driving a shortage of dietary protein sources. As a result, industry is developing more sustainable novel food protein sources such as insects, algae and duckweed and using new processing techniques. Consumer exposure to these novel or processed proteins, could cause new food allergies, exacerbating a public health issue which is already directly affecting an estimated 20 million Europeans. Introduction of novel foods should not add to the burden of food allergy and this calls for a reliable, harmonised, evidence-based and validated a...
Source: Clinical and Translational Allergy - May 18, 2020 Category: Allergy & Immunology Source Type: research

EAACI Task force Clinical epidemiology of anaphylaxis: experts ’ perspective on the use of adrenaline autoinjectors in Europe
ConclusionOur data confirm the lack of consensus regarding the number of AAIs to prescribe. Despite the European Medical Agency recommendation, the majority of allergy experts prescribed one autoinjector per patient. However, under distinct circumstances (e.g. mastocytosis, asthma, excess body weight, a history of severe anaphylaxis, or restricted access to immediate emergency), experts tended to prescribe more AAIs, which is in accordance with the European Academy of Allergy and Clinical Immunology guidelines. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 11, 2020 Category: Allergy & Immunology Source Type: research

Clinical trials in allergen immunotherapy in the age group of children and adolescents: current concepts and future needs
AbstractAllergen immunotherapy (AIT) is the only treatment option available for allergic patients with disease-modifying intention. Both efficacy and safety has been demonstrated for multiple trials in children, adolescents and adults. Though regulatory requirements for marketing authorization have been clearly outlined and an increasing number of high quality trials has been initiated, multiple concepts and details in study design may be further elaborated, harmonized and improved. An international group of experts in the field of AIT has thoroughly reviewed and discussed current concepts and provided an outlook on furthe...
Source: Clinical and Translational Allergy - April 24, 2020 Category: Allergy & Immunology Source Type: research

Impact on quality of life and safety of sublingual and subcutaneous immunotherapy in children with severe house dust mite and pollen-associated allergic rhinoconjunctivitis
AbstractBackgroundPollen and house dust mite (HDM) subcutaneous immunotherapy (SLIT) and pollen subcutaneous immunotherapy (SCIT) are effective therapies for children with allergic rhinoconjunctivitis (AR). There are no previous direct comparative studies investigating quality of life (QoL) of all three immunotherapy regimes. The aim of this study was to compare QoL and safety in children receiving these immunotherapies for AR.MethodsDemographic characteristics, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) and Visual Analogue (VAS) scores were assessed in 249 children undergoing HDM and pollen immunotherapy at ...
Source: Clinical and Translational Allergy - April 20, 2020 Category: Allergy & Immunology Source Type: research

Effect of nasal irrigation on allergic rhinitis control in children; complementarity between CARAT and MASK outcomes
AbstractBackgroundNasal irrigations (NI) are increasingly used as an over-the-counter adjunctive treatment for allergic rhinitis (AR), but clinical studies on their effectiveness are limited.MethodsAn open-label, controlled, non-randomized, real-life study was conducted to evaluate the effectiveness of NI with a new hypertonic solution as add-on treatment for AR. Children and adolescents with AR were prescribed symptomatic treatment. The active group also received an additional sea-water NI solution supplemented with algae extracts. The primary endpoint was symptom control, assessed by the control of allergic rhinitis and ...
Source: Clinical and Translational Allergy - March 13, 2020 Category: Allergy & Immunology Source Type: research

Development of a model care pathway for the management of Hymenoptera venom allergy: evidence-based key interventions and indicators
ConclusionA set of 123 key interventions and of six process indicators were found to be appropriate for the development and standardization of the clinical content of the Hymenoptera venom allergy care pathway. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 4, 2020 Category: Allergy & Immunology Source Type: research

Study of atopic multimorbidity in subjects with rhinitis using multiplex allergen component analysis
ConclusionIgE polysensitization, to perennial and seasonal allergens, and levels of total IgE seem to be the main determinants of atopic multimorbidity in subjects with rhinitis. This indicates that disease-modifying treatment that targets IgE sensitization may be of value when decreasing the risk of developing atopic multimorbidity. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 21, 2020 Category: Allergy & Immunology Source Type: research

Eczema phenotypes and risk of allergic and respiratory conditions in school age children
ConclusionEczema phenotypes were differentially associated with risks of respiratory and allergic conditions in school-aged children. Children with early transient and persistent eczema might benefit from more intense follow-up for early identification and treatment of asthma and allergies. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - February 19, 2020 Category: Allergy & Immunology Source Type: research

Modified protocol of omalizumab treatment to prevent carboplatin-induced drug hypersensitivity reactions: a case study
AbstractCarboplatin administration can usually be safely continued via a so-called desensitisation protocol when hypersensitivity reactions arise. Severe break-through reactions that occur early during desensitisation are likely to be IgE-mediated; in that case, addition of omalizumab premedication should be strongly considered. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 29, 2020 Category: Allergy & Immunology Source Type: research

Healthy people in healthy premises: the Finnish Indoor Air and Health Programme 2018 –2028
AbstractClean and fresh indoor air supports health and well-being. However, indoor air can contain pollutants that can cause a variety of symptoms and reduce well-being. Individual exposure agents can also increase the risk of certain diseases. Finns have taken major steps to improve the quality of indoor air for several decades. The primary focus of these activities has been the prevention and reduction of exposure to poor indoor air quality through guidance and regulation directing remediation of damaged buildings. Nevertheless, reported symptoms related to poor indoor air quality are common in Finland. In addition to ex...
Source: Clinical and Translational Allergy - January 17, 2020 Category: Allergy & Immunology Source Type: research

Indoor mold odor in the workplace increases the risk of Asthma-COPD Overlap Syndrome: a population-based incident case –control study
AbstractBackgroundPrevious studies have suggested an increased risk of asthma related to indoor dampness problems, but their role in the etiology of Asthma-COPD Overlap Syndrome has not been studied. We utilized a population-based incident case –control study to assess potential effect of indoor dampness and molds at home and at work on development of ACOS.MethodsWe recruited systematically all new cases of asthma diagnosed during a 2.5-year study period (1997 –2000) and randomly selected controls from the source population of adults 21–63 years old and representing 500,000 persons-years in the Pirka...
Source: Clinical and Translational Allergy - January 15, 2020 Category: Allergy & Immunology Source Type: research

A meta-analysis of baseline characteristics in trials on mite allergen avoidance in asthmatics: room for improvement
This study updates and extends the existing Cochrane review by G øtzsche and Johansen (Cochrane Database of Systematic Reviews, 2008, Art. No: CD001187), with a focus on baseline asthma outcomes and allergen exposures.MethodsWe used the existing trials in the original Cochrane review and included newly published studies. The baseline data for the mite allergen load from the mattress, the standardized asthma symptom score (ASS), the forced expiratory volume in 1  s percentage of predicted (FEV1 %pred.), and the histamine provocative concentration causing a 20% drop in FEV1 (PC20) were extracted. First, the mean ...
Source: Clinical and Translational Allergy - January 6, 2020 Category: Allergy & Immunology Source Type: research

Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper
AbstractBecause of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well documented that —potentially severe—side-effects can occur with the accumulation of systemic steroid courses over the years. A consensus document summarizing the benefits of systemic steroids for each upper airway disease type, as well as highlighting the potential harms of this treatment is currently lacking. Therefore, a panel of international experts in the field of Rhinology reviewed ...
Source: Clinical and Translational Allergy - January 3, 2020 Category: Allergy & Immunology Source Type: research

House dust mite sensitisation and association with atopic dermatitis in Brunei
AbstractIgE sensitisation in tropical areas is under-reported. A 2  year retrospective cohort study of allergy data specific to aero and food allergens in Brunei demonstrated that specific IgE levels to house dust mite (Dermatophagoides pteronyssinus, D.farinae, Blomia tropicalis) were highest in this population and correlated with atopic dermatitis (p 
Source: Clinical and Translational Allergy - December 23, 2019 Category: Allergy & Immunology Source Type: research

Association between component-resolved diagnosis of house dust mite and efficacy of allergen immunotherapy in allergic rhinitis patients
AbstractData regarding clinical relevance of house dust mite (HDM) components over allergen immunotherapy (AIT) for allergic rhinitis (AR) are lacking. 18 adult AR patients receiving HDM-AIT for 52  weeks were followed up to assess serum levels of sIgE and sIgG4 to HDM components. The study showed that Der p1, p2, p23, Der f1 and f2, are important sensitizing components of HDM, of which Der p1 appears to be the most clinically relevant allergenic component for effective AIT. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 19, 2019 Category: Allergy & Immunology Source Type: research

Rhinovirus species and tonsillar immune responses
ConclusionsRhinovirus species associated differently with clinical characteristics and tonsillar cytokine responses. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 2, 2019 Category: Allergy & Immunology Source Type: research

Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration
ConclusionOur results suggest that decreased level of miR-146a in HBECs from patients with asthma may contribute to the development of neutrophilic phenotype of asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 27, 2019 Category: Allergy & Immunology Source Type: research

Association of IKZF1 SNPs in cold medicine-related Stevens –Johnson syndrome in Thailand
ConclusionIn addition to the Japanese, Korean and Indian populations, Thai cases with CM-SJS/TEN and SOC were significantly associated withIKZF1 SNPs. With our previous report of the critical role ofIKZF1 in mucocutaneous inflammation, these results suggest thatIKZF1 is important in the pathogenesis of CM-SJS/TEN with SOC. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 22, 2019 Category: Allergy & Immunology Source Type: research

Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the  prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of t hese mechanisms into clinics. Many large epidemiologic studi...
Source: Clinical and Translational Allergy - November 20, 2019 Category: Allergy & Immunology Source Type: research

Adherence to adrenaline autoinjector prescriptions in patients with anaphylaxis
This study evaluates adherence to adrenaline autoinjector prescriptions in a cohort of well-characterized anaphylaxis patients. The overall retrieval rate was 76% with the highest rate in patients with severe anaphylaxis. Special attention is needed in patients with unknown elicitors and in young adults, comprising the largest proportion of non-adherent patients.Trial registration No intervention performed. Retrospective data used with permission from the Danish Data Protection Agency and Regional Committees on Health Research Ethics (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 8, 2019 Category: Allergy & Immunology Source Type: research

Eliciting dose is associated with tolerance development in peanut and cow ’s milk allergic children
ConclusionApproximately 1 out of 4 children with DBPCFC confirmed peanut allergy developed tolerance, compared to more than half of the children with milk or egg allergy, respectively. Tolerance development in peanut and milk allergy is significantly associated with ED at initial DBPCFC. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 6, 2019 Category: Allergy & Immunology Source Type: research

Helsinki by nature: The Nature Step to Respiratory Health
ConclusionsIn Finland and elsewhere in Europe, successful programmes have been implemented to reduce the burden of respiratory disorders and other NCDs. Unhealthy behaviour can be changed by well-coordinated actions involving all stakeholders. The growing public health concern caused by NCDs in urban surroundings cannot be solved by health care alone; a multidisciplinary approach is mandatory. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 30, 2019 Category: Allergy & Immunology Source Type: research

Short-acting β2-agonists (SABA) bronchodilator sales and outdoor mould in central France
ConclusionsDaily SABA sales are positively associated withAlternaria spores in the general population of children and young adults. The association between daily SABA sales and temporal changes toAlternaria andAspergillus–Penicillium in male children indicate that outdoor moulds contribute to asthma morbidity. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 25, 2019 Category: Allergy & Immunology Source Type: research

The safety and tolerability profile of bilastine for chronic urticaria in children
ConclusionsIn line with the recent guideline recommendation for the use of second generation H1 antihistamines in children we have reviewed the safety and tolerability profile of bilastine in children with chronic urticaria. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 23, 2019 Category: Allergy & Immunology Source Type: research

Risk factors for severe systemic sting reactions in wasp ( Vespula spp.) and honeybee ( Apis mellifera ) venom allergic patients
ConclusionThe clinical history is essential for the allergological workup and therapeutic decision on Hymenoptera venom allergies. A short latency time and the absence of skin symptoms are indicators for severe systemic sting reactions, followed by the patient ’s age and baseline serum tryptase levels. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 11, 2019 Category: Allergy & Immunology Source Type: research

Correction to: ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
Following publication of the original article [1], the authors reported that one of the authors ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the correct name of the affected author and the corresponding author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 10, 2019 Category: Allergy & Immunology Source Type: research

Correction to: MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
Following publication of the original article [1], the authors reported that one of the collaborators ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the corresponding author and institutional author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 9, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
Following publication of the original article [1], the authors reported that one of the collaborators ’ names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. In the author list of this Correction article, only the corresponding author and institutional author are presented. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 9, 2019 Category: Allergy & Immunology Source Type: research

Clinically relevant effect of rupatadine 20  mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis
ConclusionsThis responder analysis confirms the superior efficacy of rupatadine vs placebo to treat SAR. Rupatadine promoted higher proportions of responders according to stringent response criteria and in a dose-dependent manner, with faster and higher response rates in the 20  mg group. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 9, 2019 Category: Allergy & Immunology Source Type: research

Histamine H4 receptor regulates IL-6 and INF- γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis
AbstractHistamine H1 receptor (H1R) and histamine H4 receptor (H4R) are essential in allergic inflammation. The roles of H4R have been characterized in T cell subsets, whereas the functional properties of H4R in monocytes remain unclear. In the current study, the responses of H4R in peripheral monocytes from patients with allergic rhinitis (AR) were investigated. The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN- γ and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. We demonstrated that when monocytes from A...
Source: Clinical and Translational Allergy - September 30, 2019 Category: Allergy & Immunology Source Type: research

Is chronic urticaria more than skin deep?
AbstractChronic urticaria is a disease characterized by the appearance of weals, angioedema or both longer than 6  weeks. Degranulation of cutaneous or submucosal mast cells leads to release of mediators including histamine resulting in redness, swelling and itch. Because mast cells are widely distributed throughout the body, the question is why they are not activated systemically or does systemic activation o ccur without overt end organ dysfunction? We have conducted an exploratory literature search for reports that have evidence of organ-specific dysfunction in chronic urticaria that might justify prospective obser...
Source: Clinical and Translational Allergy - September 25, 2019 Category: Allergy & Immunology Source Type: research

High oral corticosteroid exposure and overuse of short-acting beta-2-agonists were associated with insufficient prescribing of controller medication: a nationwide electronic prescribing and dispensing database analysis
ConclusionsExposure to high-dose of OCS (101 per 100,000 patients) and SABA over-use (24 per 100,000) were frequent, and were associated with a low maintenance-to-total prescription ratio but not with primary non-adherence. These results suggest there is a need for initiatives to reduce OCS and SABA inappropriate prescribing. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 23, 2019 Category: Allergy & Immunology Source Type: research

Milk- and wheat protein drinks for double blind placebo controlled food challenge in adults: a simple tool for diagnosis
(Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 18, 2019 Category: Allergy & Immunology Source Type: research

Contraindications to immunotherapy: a global approach
ConclusionAs new data arise, revisions might soon be needed allowing AIT in the cases of patients treated with ACE inhibitors and beta-blockers, in elderly patients and in patients with concomitant autoimmune diseases and neoplasias in remission. The decision to prescribe AIT is always tailor-made, balancing risk vs benefit. Creating globally accepted guidelines would help Allergologists in their decision making. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 11, 2019 Category: Allergy & Immunology Source Type: research

Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
ConclusionIn 20  years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - September 9, 2019 Category: Allergy & Immunology Source Type: research

The prevalence of asthma in adult population of southwestern Iran and its association with chronic rhinosinusitis: a GA 2 LEN study
AbstractBackgroundAsthma is recognized as a major public health concern in the world. The aim of this investigation was to evaluate the prevalence of asthma by using the Global Allergy and Asthma Network of Excellence (GA2LEN) questionnaire and examine its association with chronic rhinosinusitis, in the province of Bushehr, Southwestern of Iran.MethodsIn a cross-sectional, population-based study, a total of 5420 invited individuals, aged 15 –65, were selected through a multi-stage, stratified, cluster random sampling and from which 5201 completed the GA2LEN questionnaire (response rate  = 95.9%). The pr...
Source: Clinical and Translational Allergy - August 30, 2019 Category: Allergy & Immunology Source Type: research