Association of elevated fractional exhaled nitric oxide concentration and blood eosinophil count with severe asthma exacerbations
AbstractBackgroundBlood eosinophil count (BEC) and fractional exhaled nitric oxide (FeNO) concentration are established biomarkers in asthma, associated particularly with the risk of exacerbations. We evaluated the relationship of BEC and FeNO as complementary and independent biomarkers of severe asthma exacerbations.MethodsThis observational study included data from the Optimum Patient Care Research Database. Asthma patients (18 –80 years) with valid continuous data for 1 year before FeNO reading, ≥ 1 inhaled corticosteroid prescription, and BEC recorded ≤ 5 years bef...
Source: Clinical and Translational Allergy - August 21, 2019 Category: Allergy & Immunology Source Type: research

An update to the Milk Allergy in Primary Care guideline
AbstractThe Milk Allergy in Primary (MAP) Care guideline was first published in 2013 in this journal. MAP aimed to provide simple and accessible algorithms for UK clinicians in primary care, detailing all the steps between initial presentation, through diagnosis, management and tolerance development. Despite its UK focus, it soon became clear that MAP was being accessed internationally and thus an updated International Milk Allergy in Primary Care (iMAP) guideline was published in 2017. Both guidelines used existing international consensus guidelines to develop accessible algorithms accompanied by patient information leafl...
Source: Clinical and Translational Allergy - August 12, 2019 Category: Allergy & Immunology Source Type: research

Gene expression of TMEM178 , which encodes a negative regulator of NFATc1, decreases with the progression of asthma severity
AbstractIn two independent microarray studies involving primary airway epithelial cells, the relative gene expression ofTMEM178 decreases with the progression of asthma severity. Our manuscript creates a paradigm for future studies dissecting the role of Tmem178 in the pathogenesis of severe asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - August 8, 2019 Category: Allergy & Immunology Source Type: research

Characteristics, quality of life and control of respiratory allergic diseases caused by house dust mites (HDMs) in Spain: a cross-sectional study
AbstractThis multicentre, cross-sectional study conducted in Spain assessed the clinical characteristics and quality of life of patients who were aged 14 –55 years and had allergic rhinitis and/or asthma, which was due to house dust mite sensitisation, for at least 2 years. Overall, 296 patients were included; 60% had allergic rhinitis (mostly persistent moderate-to-severe) and 40% had rhinitis and asthma (mostly intermittent or mild-to-persisten t). Patients with rhinitis had moderately reduced quality of life, which was significantly worse in adults than adolescents. The impact of asthma on quality of lif...
Source: Clinical and Translational Allergy - August 6, 2019 Category: Allergy & Immunology Source Type: research

Eosinophilic disorders: evaluation of current classification and diagnostic criteria, proposal of a practical diagnostic algorithm
AbstractEosinophilic disorders represent a group of pathologic conditions with highly heterogeneous pathophysiology and clinical presentation and variable prognosis, ranging from asymptomatic or mild, to severe and complex cases, with fatal outcome. Interest in this group of disorders has increased during the last two decades, with consistent progress made regarding understanding of molecular mechanisms, refining of diagnostic criteria, classification and evaluation of therapeutic options. There are still many gaps and difficulties in evaluating eosinophilic syndromes and diseases in medical practice. The disease prognosis...
Source: Clinical and Translational Allergy - July 25, 2019 Category: Allergy & Immunology Source Type: research

Elderly versus younger patients with hereditary angioedema type I/II: patient characteristics and safety analysis from the Icatibant Outcome Survey
AbstractBackgroundHereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is characterized by recurrent swelling in subcutaneous or submucosal tissues. Symptoms often begin by age 5 –11 years and worsen during puberty, but attacks can occur at any age and recur throughout life. Disease course in elderly patients is rarely reported.MethodsThe Icatibant Outcome Survey (IOS) is an observational study evaluating the safety, tolerability, and efficacy of icatibant. We conducted descriptive analyses in younger (age  
Source: Clinical and Translational Allergy - July 19, 2019 Category: Allergy & Immunology Source Type: research

Increased platelet activating factor levels in chronic spontaneous urticaria predicts refractoriness to antihistamine treatment: an observational study
AbstractBackgroundPlatelet activating factor (PAF) is an endogenous, active phospholipid released from inflammatory cells, platelets, and endothelial cells, and is involved in the regulation of immune responses. Degradation of PAF by PAF acetylhydrolase (PAF-AH) has been shown to be associated with anaphylaxis, asthma, and peanut allergy. The purpose of this study was to investigate relationships among clinical parameters, including urticaria severity and treatment responsiveness, and PAF and PAF-AH levels in sera from patients with chronic spontaneous urticaria (CSU).MethodsSerum PAF and PAF-AH levels were measured by enz...
Source: Clinical and Translational Allergy - July 17, 2019 Category: Allergy & Immunology Source Type: research

High occurrence of antihistamine resistance in patients with recurrent idiopathic angioedema
AbstractAntihistamines are the most prescribed therapy in recurrent idiopathic angioedema, yet little is known about their efficacy. Herein, we report on clinical improvement with antihistamine therapy in 120 patients evaluating angioedema attack frequency. A high incidence (36%) of antihistamine refractory cases was observed. Forty percent of patients on antihistamine prophylaxis suffered from 1 or more angioedema attacks per month. Our findings stress the need for additional treatment options for recurrent idiopathic angioedema. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 12, 2019 Category: Allergy & Immunology Source Type: research

Molecular clustering of genes related to the atopic syndrome: Towards a more tailored approach and personalized medicine?
ConclusionsThis study shows a model to define clusters within the atopic syndrome based on gene expression profiles of immune cell lineages. Our results support the hypothesis that both genetic mechanisms and immune dysregulation play a role in the pathogenesis. It also opens up the possibility for novel therapeutic targets and a more tailored approach towards personalized medicine. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - July 10, 2019 Category: Allergy & Immunology Source Type: research

Comparison of two multiplex arrays in the diagnostics of allergy
The objective of this analysis was to compare the multiplex ImmunoCAP ISAC (Thermo Fisher Scientific, Sweden) and the multiplex Alex Allergy Explorer (Macro Array Diagnostics GmbH, Austria) platform on specific IgE to grass pollen (Phl p 1, Phl p 5), tree pollen (Bet v 1), house dust mites (Der p 1, Der p 2) and cat (Fel d 1) allergens in allergic patients. Our findings demonstrate a good correlation of presently used methods to detect serum sIgE. Multiplex testing of  allergen-specific IgE can be the method of choice for a prospective component-resolved diagnosis of type I allergy, and the basis for th...
Source: Clinical and Translational Allergy - July 8, 2019 Category: Allergy & Immunology Source Type: research

Sesame oleosins are minor allergens
ConclusionSesame oleosins are minor allergens and appear to have no additonal value in diagnosing sesame allergy in adults based on sIgE and sIgG detection. There is a high need for additional diagnostic tools in those patients to minimize the number of required food challenges. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 28, 2019 Category: Allergy & Immunology Source Type: research

Twelve-year follow-up study after endoscopic sinus surgery in patients with chronic rhinosinusitis with nasal polyposis
AbstractBackgroundChronic rhinosinusitis with nasal polyposis (CRSwNP) is a therapeutic challenge because of the high recurrence rate. Surgical intervention should be considered in patients who fail to improve after medical treatment. We monitored recurrence and revision surgery over 12  years after endoscopic sinus surgery in CRSwNP patients.MethodsIn this prospective cohort study, 47 patients with CRSwNP, who underwent primary or revision extended endoscopic sinus surgery, were followed. Clinical symptoms and total nasal endoscopic polyp score were evaluated before, 6  years and 12 years after surgery.Resu...
Source: Clinical and Translational Allergy - June 14, 2019 Category: Allergy & Immunology Source Type: research

Subcutaneous immunotherapy with depigmented-polymerized allergen extracts: a systematic review and meta-analysis
ConclusionsCompared to placebo, AIT with DPAEs is effective in patients with pollen- or HDM-induced rhinoconjunctivitis with or without allergic asthma and improves health-related quality of life. It does not differ significantly in safety and tolerability. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - June 5, 2019 Category: Allergy & Immunology Source Type: research

A specific synbiotic-containing amino acid-based formula restores gut microbiota in non-IgE mediated cow ’s milk allergic infants: a randomized controlled trial
ConclusionsThe AAF including specific synbiotics effectively modulates the gut microbiota and its metabolic activity in non-IgE mediated CMA infants bringing it close to a healthy breastfed profile.Trial registration Registered on 1 May 2013 with Netherlands Trial Register Number NTR3979. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 31, 2019 Category: Allergy & Immunology Source Type: research

Identification of immunodominant IgE binding epitopes of Der p 24, a major allergen of Dermatophagoides pteronyssinus
ConclusionsWe identified Der p 24 as a major HDM allergen with strong IgE binding activity via an immunodominant IgE epitope in the N-terminal 32-residue region, which triggers IgE production in vivo. The identified Der p 24 epitope may support HDM allergy diagnosis and treatment. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 23, 2019 Category: Allergy & Immunology Source Type: research

Clinical and serological follow-up of patients with WDEIA
AbstractThe clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recommendation of wheat consumption, if considered safe to the patient based on case-history and challenge results, could be advised. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 16, 2019 Category: Allergy & Immunology Source Type: research

Psychosocial working conditions, asthma self-management at work and asthma morbidity: a cross-sectional study
ConclusionsAdverse psychosocial working conditions are associated with poorer asthma self-management behaviour at work and with increased asthma morbidity. The latter association may be mediated by asthma self-management behaviour.Trial registration German Clinical Trials Register, registration number: DRK S00011309, date of registration: 22.12.2016. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - May 9, 2019 Category: Allergy & Immunology Source Type: research

Skin microdialysis: methods, applications and future opportunities —an EAACI position paper
AbstractSkin microdialysis (SMD) is a versatile sampling technique that can be used to recover soluble endogenous and exogenous molecules from the extracellular compartment of human skin. Due to its minimally invasive character, SMD can be applied in both clinical and preclinical settings. Despite being available since the 1990s, the technique has still not reached its full potential use as a tool to explore pathophysiological mechanisms of allergic and inflammatory reactions in the skin. Therefore, an EAACI Task Force on SMD was formed to disseminate knowledge about the technique and its many applications. This position p...
Source: Clinical and Translational Allergy - April 10, 2019 Category: Allergy & Immunology Source Type: research

Correction to: Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
Following publication of the original article [1], the authors reported that one of the authors ’ name was spelled incorrectly. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 4, 2019 Category: Allergy & Immunology Source Type: research

Prevalence of food hypersensitivity in relation to IgE sensitisation to common food allergens among the general adult population in West Sweden
ConclusionsThe prevalence of self-reported food hypersensitivity in West Sweden indicates a rising trend. The correspondence between self-reported symptoms and IgE-sensitisation to foods is generally poor, except for hazelnut and almond which exhibit moderate or fair correlation. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - April 1, 2019 Category: Allergy & Immunology Source Type: research

Quality standards in respiratory real-life effectiveness research: the REal Life EVidence AssessmeNt Tool (RELEVANT): report from the Respiratory Effectiveness Group —European Academy of Allergy and Clinical Immunology Task Force
ConclusionsUsing such quality appraisal tools is mandatory to assess whether specific observational real-life effectiveness studies can be used to inform guideline development and/or decision-making in clinical practice. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 27, 2019 Category: Allergy & Immunology Source Type: research

The REal Life EVidence AssessmeNt Tool (RELEVANT): development of a novel quality assurance asset to rate observational comparative effectiveness research studies
ConclusionsRELEVANT is the first quality checklist to assist in the appraisal of published observational CER developed through iterative feedback derived from pilot implementation and inter-rater agreement evaluation. Developed for a REG-EAACI Task Force quality appraisal of recent asthma CER, RELEVANT also has wider utility to support appraisal of CER literature in general (including pre-publication). It may also assist in manuscript development and in educating relevant stakeholders about key quality markers in observational CER. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - March 27, 2019 Category: Allergy & Immunology Source Type: research

Cofactors of wheat-dependent exercise-induced anaphylaxis do not increase highly individual gliadin absorption in healthy volunteers
AbstractBackgroundIn wheat-dependent exercise-induced anaphylaxis (WDEIA), cofactors such as exercise, acetylsalicylic acid (ASA), alcohol or unfavorable climatic conditions are required to elicit a reaction to wheat products. The mechanism of action of these cofactors is unknown, but an increase of gliadin absorption has been speculated. Our objectives were to study gliadin absorption with and without cofactors and to correlate plasma gliadin levels with factors influencing protein absorption in healthy volunteers.MethodsTwelve healthy probands (six males, six females; aged 20 –56 years) ingested 32 g of g...
Source: Clinical and Translational Allergy - March 25, 2019 Category: Allergy & Immunology Source Type: research

Adverse drug reaction classification by health professionals: appropriate discrimination between allergy and intolerance?
AbstractBackgroundThe correct classification of an adverse drug reaction (ADR) as allergy (immunological) or intolerance (non-immunological) has important clinical implications. The aim of this study was to examine the ability of health professionals to discriminate between allergy and intolerance, classify the severity of the ADR and degree of contraindication.MethodsHealth professionals were presented ten ‘real-life’ ADR scenarios using an online questionnaire and asked to: categorise the reaction as allergy or intolerance, rate the severity of the reaction and judge the level of contraindication of the causa...
Source: Clinical and Translational Allergy - March 19, 2019 Category: Allergy & Immunology Source Type: research

Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007 –2012: the importance of comprehensive data availability
AbstractBackgroundHalf of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approach applied to the same subjects may allow a more useful classification compared to the hypothesis-driven one.AimTo compare previously defined hypothesis-driven with newly derived data-driven asthma phenotypes, identified by latent class analysis (LCA), in adults with current asthma from NHANES 2007 –2012.MethodsAdults ( ≥ 18 years) with current asthma from the NHANES were include...
Source: Clinical and Translational Allergy - March 13, 2019 Category: Allergy & Immunology Source Type: research

Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma
AbstractAimsMobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurred by the disease and to improve the digital transformation of health and care. The ultimate goal is to change the management strategy in chronic diseases.MethodsMASK implements ICT technologies for individualized and predictive medicine to develop novel care pathways by a ...
Source: Clinical and Translational Allergy - March 11, 2019 Category: Allergy & Immunology Source Type: research

Cosmetics for neonates and infants: haptens in products ’ composition
AbstractCosmetics and skin care products for neonates and infants are considered as ‘‘hypoallergenic’’, “tested” or ‘‘safe’’. Nevertheless, the prevalence of haptens in these products is a matter of concern, since allergic contact dermatitis in children is gaining an importance. We aimed to assess the prevalence of haptens in cosmetics designed for children youn ger than 1 year. To identify haptens, the components of the cosmetics listed on packaging were compared with substances from European baseline series, Cosmetics series and Fragrance series. Survey com...
Source: Clinical and Translational Allergy - March 8, 2019 Category: Allergy & Immunology Source Type: research

Two grass pollen tablets commercially available for allergy immunotherapy display different IgE epitope repertoires
AbstractBackgroundThe distribution of Pooideae species varies across Europe. Especially, Timothy is less represented in Southern than in Northern Europe. Since allergenic cross-reactivity between pollens from different grasses is only partial, grass pollen-allergic patients are expected to display different sensitization profiles, with specific IgE directed against different combinations of allergenic epitopes, depending on their living places in Europe and the grasses they are exposed to. In this context, this study aimed at comparing two tablets commercially available for allergy immunotherapy, namely a 5-grass (Cocksfoo...
Source: Clinical and Translational Allergy - February 27, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of major mite allergens from European standardized commercial extracts for in vivo diagnosis: addressing the need for precision medicine
AbstractBackgroundSkin prick testing is the first-line interventional method to diagnose IgE mediated allergic diseases. Methodological differences in manufacturing processes and extract standardization may lead to variations in the reagent quality and potency. The current study evaluates sixteen commercially availableDermatophagoides pteronyssinus andBlomia tropicalis extracts for allergy diagnosis from different European manufacturers regarding allergen composition and content and whether these differences could influence their biological activity.MethodsMite-allergic subjects (n  = 21) were skin-tested wit...
Source: Clinical and Translational Allergy - February 25, 2019 Category: Allergy & Immunology Source Type: research

Characterization of a subgroup of non-type 2 asthma with cow ’s milk hypersensitivity in young subjects
AbstractBackgroundAsthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control.ObjectiveOur aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins.MethodsSex- and age-matched subjects (10 –35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow’s milk hyp...
Source: Clinical and Translational Allergy - February 22, 2019 Category: Allergy & Immunology Source Type: research

Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens
AbstractBackgroundJapanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens may cause IgE-mediated allergic reactions. The transgenic rice seeds that contain genetically modified Cry j 1 and Cry j 2, the two major allergens of JC pollen, have been developed as candidates for oral immunotherapy. Although the antigens in the transgenic rice seeds (Tg-rice seeds) were engineered such that they decrease binding ability with IgE and they are of insufficient length to cross-link I...
Source: Clinical and Translational Allergy - February 20, 2019 Category: Allergy & Immunology Source Type: research

Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies
AbstractBackgroundSkin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen.MethodsIn this open multicentre study 431 patients, aged 18 –64 years were enrolled. Patients had a history of IgE-mediated allergy and a sensitisation (previous positive SPT of any manufacturer) against at least one of the investigated allergens: 6-grass pollen, house dust mite, birch and mugwort pollen. In our study, these allergens were tested in five concentrations each. To establish the optimal trade-off between sensitivity ...
Source: Clinical and Translational Allergy - February 18, 2019 Category: Allergy & Immunology Source Type: research

Identification of the recently described plasminogen gene mutation p.Lys330Glu in a family from Northern Germany with hereditary angioedema
We report a family from Northern Germany with six individuals suffering from recurrent swellings, indicating HAE. Laboratory tests and genetic diagnostics of the genesSERPING1, encoding C1 esterase inhibitor (C1-INH), andF12, encoding coagulation factor XII, were unremarkable. In three affected and one yet unaffected member of the family, we were then able to identify the c.988A  >  G (also termed c.1100A >  G) mutation in theplasminogen (PLG) gene, which has recently been described in several families with HAE. This mutation leads to a missense mutation with an amino acid exchange p.Lys33...
Source: Clinical and Translational Allergy - February 14, 2019 Category: Allergy & Immunology Source Type: research

Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort
This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.Material and methodA cross-sectional multicentre study enrolled children aged 6 –7 and 13–14 years and adults aged 20–44 years from a Polish national cohort. The diagnosis of allergic diseases was made by a physician. Skin prick tests to 13 allergens and serum IgE levels to 4 allergens were tested.ResultsAmong the 3856 participants, single disease (asthma, allergic rhinitis or atopic dermatitis) was diagnosed in 27.7% subjects and ...
Source: Clinical and Translational Allergy - February 11, 2019 Category: Allergy & Immunology Source Type: research

Health-related quality of life worsens by school age amongst children with food allergy
AbstractBackgroundFood allergy is negatively associated with health-related quality of life (HRQL). Although differences exist between parents and children, less is known about age-specific differences amongst children. As such, we aimed to identify if age, as well as other factors, are associated with food allergy-specific HRQL in an objectively defined population of children.MethodsOverall, 63 children (boys: n  = 36; 57.1%) with specialist-diagnosed food allergy to 1 + foods were included. Parents/guardians completed the Swedish version of a disease-specific questionnaire designed to assess o...
Source: Clinical and Translational Allergy - February 7, 2019 Category: Allergy & Immunology Source Type: research

Stepwise approach towards adoption of allergen immunotherapy for allergic rhinitis and asthma patients in daily practice in Belgium: a BelSACI-Abeforcal-EUFOREA statement
AbstractAllergic rhinitis (AR) affects 23 –30% of the European population with equal prevalence reported in Belgium. Despite guidelines on the correct use of effective treatment, up to 40% of AR patients remain uncontrolled. Allergen immunotherapy (AIT) has been shown to improve the level of control up to 84% of patients being controlled by AIT. Recently, new guidelines for AIT have been published, supporting the clinical evidence for effectiveness of various subcutaneous and sublingual products for AIT in patients who are allergic to airborne allergens. AIT in AR patients not only reduces nasal and/or ocular symptom...
Source: Clinical and Translational Allergy - February 4, 2019 Category: Allergy & Immunology Source Type: research

The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients
ConclusionsAutoantibody profiling of IgG-reactivity using microarray technology revealed an autoantibody-based subgroup in patients with AD. The four identified autoantigens and especially S100A12 could, if characterized further, increase the understanding of different pathogenic mechanisms behind AD and thereby enable better treatment. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 31, 2019 Category: Allergy & Immunology Source Type: research

Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases
ConclusionThe Vilnius Declaration represents an important step for the fight against air pollution in chronic respiratory diseases globally and has a clear strategic relevance with regard to the EU Health Strategy as it will bring added value to the existing public health knowledge. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - January 28, 2019 Category: Allergy & Immunology Source Type: research

The roadmap for the Allergology specialty and allergy care in Europe and adjacent countries. An EAACI position paper
AbstractThe high prevalence of allergic diseases warrants for sufficient health care provisions available to patients with allergic diseases. Allergy care should be delivered by well-trained specialists. However, the current status of allergy care is not well documented. For this reason a survey among European and a few non-European countries was launched by the National Allergy Society Committee from the European Academy of Allergy and Clinical Immunology and the Union Europ éenne des Médecins Spécialistes section and board of Allergology. The survey shows that in the vast majority of countries allerg...
Source: Clinical and Translational Allergy - January 24, 2019 Category: Allergy & Immunology Source Type: research

A specific synbiotic-containing amino acid-based formula in dietary management of cow ’s milk allergy: a randomized controlled trial
AbstractBackgroundHere we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow ’s milk allergy (CMA).MethodsSubjects were randomized to receive test product (AAF including fructo-oligosaccharides andBifidobacterium breve M-16V) or control product (AAF) for 8  weeks, after which infants could continue study product until 26 weeks. Fecal percentages of bifidobacteria andEubacterium rectale/Clostridium coccoides group ...
Source: Clinical and Translational Allergy - January 15, 2019 Category: Allergy & Immunology Source Type: research

Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review
AbstractThere is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While some of this heterogeneity of response is due to adherence and environmental causes, genetic variation also influences response to treatment and genetic markers may help guide treatment. Over the past years, researchers have investigated the relationship between a large number of genetic variations and response to ICS by performing pharmacogenomic studies. In this systematic review we will provide a summary of recent pharmacogenomic studies on ICS and discuss the latest insight into the potential functional role of identifie...
Source: Clinical and Translational Allergy - January 9, 2019 Category: Allergy & Immunology Source Type: research

Dual exposure to smoking and household air pollution is associated with an increased risk of severe asthma in adults in Brazil
ConclusionsExposure to household pollution is associated with poorer control, greater severity, and poorer pulmonary function; double-exposed individuals have a greater risk of severe asthma and decreased lung function than those exposed only to household pollution. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 10, 2018 Category: Allergy & Immunology Source Type: research

Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
ConclusionCSU patients had significantly lower serum vitamin D levels than the controls in most studies. However, the results did not prove causation, and the mechanisms were not clearly explained. Despite the scarcity of available studies, this systematic review showed that a high dosage of vitamin D supplementation for 4 –12 weeks might help to decrease the disease activity in some CSU patients. Well-designed randomized placebo-controlled studies are needed to determine the cut-off levels of vitamin D for supplementation and treatment outcomes. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - December 4, 2018 Category: Allergy & Immunology Source Type: research

Elevated expression of IL-17RB and ST2 on myeloid dendritic cells is associated with a Th2-skewed eosinophilic inflammation in nasal polyps
ConclusionsIncreased expressions of IL-17RB and ST2 on mDCs are associated with enhanced local Th2 inflammation in NP, suggesting that mDCs might play a role in IL-25- and IL-33-induced type 2 responses and eosinophilic inflammation in NP. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 29, 2018 Category: Allergy & Immunology Source Type: research

Highlights and recent developments in airway diseases in EAACI journals (2017)
AbstractThe European Academy of Allergy and Clinical Immunology (EAACI) owns three journals: Allergy, Pediatric Allergy and Immunology and Clinical and Translational Allergy. One of the major goals of EAACI is to support health promotion in which prevention of allergy and asthma plays a critical role and to disseminate the knowledge of allergy to all stakeholders including the EAACI junior members. There was substantial progress in 2017 in the identification of basic mechanisms of allergic and respiratory disease and the translation of these mechanisms into clinics. Better understanding of molecular and cellular mechanisms...
Source: Clinical and Translational Allergy - November 27, 2018 Category: Allergy & Immunology Source Type: research

Early aggressive intervention for infantile atopic dermatitis to prevent development of food allergy: a multicenter, investigator-blinded, randomized, parallel group controlled trial (PACI Study) —protocol for a randomized controlled trial
This study is a multi-center, pragmatic, two-parallel group, assessor-blind, superiority, individually randomized controlled trial. Atopic dermatitis infants (N  = 650) 7–13 weeks old who develop an itchy rash within the previous 28 days are randomly assigned to the aggressive treatment or the conventional treatment in a 1:1 ratio. The primary outcome is oral food challenge-proven IgE-mediated hen’s egg allergy at the age of 28 weeks.DiscussionThis is a novel pragmatic RCT study to examine the efficacy of early aggressive treatment for atopic dermatitis to prevent later food allergy...
Source: Clinical and Translational Allergy - November 23, 2018 Category: Allergy & Immunology Source Type: research

Identification of Pen m 4 as a potential cause of occupational asthma to Gammarus shrimp
We present the case of a 34-year-old male patient employed for 8  years in a company manufacturing and packaging animal feed. The patient developed occupational asthma to dry Gammarus powder. The diagnosis was confirmed by specific bronchial provocation test. The determination of specific IgE antibodies was positive for Pen m 4, a sarcoplasmic calcium binding pr otein, with a level of 6.7 ISU-E. The sensitization to Pen m 4 described here may identify a new allergen causing occupational asthma in these workers. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 9, 2018 Category: Allergy & Immunology Source Type: research

Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
ConclusionIn conclusion, the distribution of AAT genotypes in HDM allergic asthmatic patients did not differ from those found in Spanish population. Neither severe ATTD or deficient AAT genotypes appear to confer different clinical expression of asthma. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - November 2, 2018 Category: Allergy & Immunology Source Type: research

MASK 2017: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma multimorbidity using real-world-evidence
AbstractmHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best evidence-based approach to care pathways suited to real-life using mobile technology in allergic rhinitis (AR) and asthma multimorbidity. Patients largely use over-the-counter medications dispensed in pharmacies. Shared decision making centered around the patient and based on s...
Source: Clinical and Translational Allergy - October 25, 2018 Category: Allergy & Immunology Source Type: research

A qualitative study exploring parents ’ experiences with epinephrine use for their child’s anaphylactic reaction
ConclusionsHandling reactions correctly provided parents with confidence to treat subsequent reactions. Witnessing the effects of an EAI and receiving positive feedback from health care providers further strengthened their confidence to quickly and competently intervene in future reactions. (Source: Clinical and Translational Allergy)
Source: Clinical and Translational Allergy - October 18, 2018 Category: Allergy & Immunology Source Type: research