Significant improvement in lung function and asthma control after benralizumab treatment for severe refractory eosinophilic asthma
Publication date: Available online 8 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Francesco Menzella, Patrizia Ruggiero, Carla Galeone, Chiara Scelfo, Diego Bagnasco, Nicola Facciolongo (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 10, 2020 Category: Respiratory Medicine Source Type: research

Methacholine-induced cough as an indicator of bronchodilator-responsive cough
Publication date: Available online 8 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Noriyuki Ohkura, Masaki Fujimura, Johsuke Hara, Yusuke Nakade, Miki Abo, Takashi Sone, Hideharu Kimura, Kazuo Kasahara (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 10, 2020 Category: Respiratory Medicine Source Type: research

Rapid effect of benralizumab for severe asthma with chronic rhinosinusitis with nasal polyps
Publication date: Available online 9 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Osamu Matsuno, Seijiro Minamoto (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 10, 2020 Category: Respiratory Medicine Source Type: research

ORMDL3 modulates airway epithelial cell repair in children with asthma under glucocorticoid treatment via regulating IL-33
Publication date: Available online 6 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Yaqin Li, Xiaoyan Li, Wenjing Zhou, Qing Yu, Yanming Lu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 8, 2020 Category: Respiratory Medicine Source Type: research

Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate following once-daily inhalation as a combination in healthy subjects
Publication date: Available online 6 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Soniya Vaidya, Juergen Jauernig, Brian Ethell, Nasri Abdallah, Surendra Machineni, Anton Drollmann, Olivier Heudi, Stefanie Last, Michael Hahn, Rajkumar Radhakrishnan, Stanislav Ignatenko, Hanns-Christian Tillmann (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 8, 2020 Category: Respiratory Medicine Source Type: research

QA project: Hemodynamic Safety of Endobronchial Administration of Phenylephrine for Control of Airway Bleeding by Bronchoscopy
Publication date: Available online 7 October 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Nathaniel Ivanick, Chan Yeu Pu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - October 8, 2020 Category: Respiratory Medicine Source Type: research

Dihydroquercetin attenuates lipopolysaccharide-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132–3p
Publication date: October 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 64Author(s): Jian-Hua Liu, Liang Cao, Chang-Hong Zhang, Chen Li, Zhi-Hua Zhang, Qi Wu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 29, 2020 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: August 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 63Author(s): (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 26, 2020 Category: Respiratory Medicine Source Type: research

Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship
Publication date: August 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 63Author(s): Gali Epstein-Shochet, Stephen Pham, Steven Beck, Safaa Naiel, Olivia Mekhael, Spencer Revill, Aaron Hayat, Megan Vierhout, Becky Bardestein-Wald, David Shitrit, Kjetil Ask, A. Bruce Montgomery, Martin R. Kolb, Mark W. Surber (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 23, 2020 Category: Respiratory Medicine Source Type: research

Real-life safety and efficacy of omalizumab in Japanese patients with severe allergic asthma who were subjected to dosing table revision or expansion: A post-marketing surveillance
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Koichiro Asano, Kazuya Sumi, Hajime Yoshisue, Noriko Nakamura, Makoto Nagasaki, Takayoshi Sasajima, Hisako Matsumoto (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 18, 2020 Category: Respiratory Medicine Source Type: research

Effectiveness of Mepolizumab Therapy in Patients with Severe Eosinophilic Asthma: Austrian real-life data
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Andreas Renner, Katharina Marth, Karin Patocka, Marco Idzko, Wolfgang Pohl (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 17, 2020 Category: Respiratory Medicine Source Type: research

Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Heng Wen, Hu Zhang, Weina Wang, Yuebing Li (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 17, 2020 Category: Respiratory Medicine Source Type: research

Role of 20-Hydroxyeicosatetraenoic acid in pulmonary hypertension and proliferation of pulmonary arterial smooth muscle cells
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Jinhua Wang, Guili Lian, Li Luo, Tingjun Wang, Changsheng Xu, Huajun Wang, Liangdi Xie (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 17, 2020 Category: Respiratory Medicine Source Type: research

LncRNA STARD13-AS blocks lung squamous carcinoma cells growth and movement by targeting miR-1248/C3A
Publication date: Available online 17 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Guosen Li, Xiangyun Guo (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 17, 2020 Category: Respiratory Medicine Source Type: research

Pharmacokinetics and safety of tiotropium+olodaterol 5 μg/5 μg fixed-dose combination in Chinese patients with COPD
Publication date: August 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 63Author(s): Zhenlei Wang, Yusuke Tadayasu, Na Hu, Shiqing Shu, Chao Hu, Zhu Luo (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 12, 2020 Category: Respiratory Medicine Source Type: research

Genetic variants in MIR2113 and MIR129-LEP are associated with the susceptibility of COPD in the Chinese Han population
Publication date: Available online 12 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Jing Jing, Dan Xu, Zheng Li, Min Jiang, Jing Wang, Jian Zhang (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 12, 2020 Category: Respiratory Medicine Source Type: research

Pharmacokinetics and safety of tiotropium+olodaterol 5 μg/5 μg fixed-dose combination in Chinese patients with COPD
Publication date: Available online 9 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Zhenlei Wang, Yusuke Tadayasu, Na Hu, Shiqing Shu, Chao Hu, Zhu Luo (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 9, 2020 Category: Respiratory Medicine Source Type: research

Common molecular pathways targeted by Nintedanib in cancer and IPF: a bioinformatic study
Publication date: Available online 5 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): C. Landi, A. Carleo, L. Vantaggiato, L. Bergantini, M. d’Alessandro, P. Cameli, G. Sebastiani, F. Dotta, E. Bargagli (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 6, 2020 Category: Respiratory Medicine Source Type: research

Evaluation of waterpipe smoke toxicity in C57BL/6 mice model
Publication date: Available online 2 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Aniella Abi-Gerges, Carole Dagher-Hamalian, Pamela Abou-Khalil, Joe Braham Chahine, Pia Hachem, Christian Khalil (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 2, 2020 Category: Respiratory Medicine Source Type: research

An in vitro bioassay for evaluating the effect of inhaled bronchodilators on airway smooth muscle
Publication date: Available online 2 September 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Joanna Muddle, Varsha Kanabar, Marc Brown, Clive Page, Ben Forbes (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - September 2, 2020 Category: Respiratory Medicine Source Type: research

Dual-Histamine Receptor Blockade with Cetirizine - Famotidine Reduces Pulmonary Symptoms in COVID-19 Patients
Publication date: Available online 29 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Reed B. Hogan, Reed B. Hogan, Tim Cannon, Maria Rappai, John Studdard, Doug Paul, Thomas P. Dooley (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 30, 2020 Category: Respiratory Medicine Source Type: research

Comparative Anti-inflammatory Effect of Curcumin at Air-Liquid Interface and Submerged Conditions using Lipopolysaccharide Stimulated Human Lung Epithelial A549 Cells
Publication date: Available online 27 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Yue Hu, Yunhua Sheng, Xiaoli Ji, Ping Liu, Liming Tang, Gang Chen, Guiliang Chen (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 27, 2020 Category: Respiratory Medicine Source Type: research

Inhaled Nintedanib is Well-Tolerated and Delivers Key Pharmacokinetic Parameters Required to Treat Bleomycin-Induced Pulmonary Fibrosis
Publication date: Available online 22 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Mark W. Surber, Steve Beck, Stephen Pham, Angela T. Marsden, Senthil K. Gandi, James Baily, Mary C. McElroy (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 23, 2020 Category: Respiratory Medicine Source Type: research

The proliferative and anti-apoptosis functions of KGF/KGFR contributes to bronchial epithelial repair in asthma
Publication date: Available online 17 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Jiongbo Wang, Hongju Sun, Yunshun Liu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 18, 2020 Category: Respiratory Medicine Source Type: research

Current and Emerging treatment options for lung cancer in patients with pre-existing connective tissue disease
Publication date: Available online 15 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Weihua Shao, Qian Zhou, Xiaokui Tang (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 17, 2020 Category: Respiratory Medicine Source Type: research

DHQ attenuates LPS-induced acute lung injury through modulating FOXO3-mediated NF-κB signaling via miR-132-3p
Publication date: Available online 15 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Jian-Hua Liu, Liang Cao, Chang-Hong Zhang, Chen Li, Zhi-Hua Zhang, Qi Wu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 15, 2020 Category: Respiratory Medicine Source Type: research

Fixed-dose combination of three drugs, i.e. LABA/LAMA/ICS for COPD: results of a real-world study from India
Publication date: Available online 7 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Sundeep Salvi, Ashish Kumar Deb, Mayank Agarwal, Venkateswara Reddy Tummuru, Rahul Kodgule, V.S. Hemalatha, Anil Kumar Awasthi, K.P. Suraj, Vinod Kumar Pavitran, Shashi Prakash Mourya, Paul Thomas, Abhijit Vaidya, Sushmeeta Chhowala, Jaideep Gogtay (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 13, 2020 Category: Respiratory Medicine Source Type: research

Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma
Publication date: Available online 9 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Muhammed Fatih Dogan, Ali Parlar, Saliha Aysenur Cam, Elif Merve Tosun, Fatma Uysal, Seyfullah Oktay Arslan (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 13, 2020 Category: Respiratory Medicine Source Type: research

Magnesium lithospermate B improves pulmonary artery banding induced right ventricular dysfunction by alleviating inflammation via p38MAPK pathway
Publication date: Available online 9 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Chen Qu, Ying Xu, Xilan Yang, Xiang Lu (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 13, 2020 Category: Respiratory Medicine Source Type: research

Inhalation: A means to explore and optimize nintedanib’s pharmacokinetic/pharmacodynamic relationship
Publication date: Available online 1 August 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Gali Epstein-Shochet, Stephen Pham, Steven Beck, Safaa Naiel, Olivia Mekhael, Spencer Revill, Aaron Hayat, Megan Vierhout, Becky Bardestein-Wald, David Shitrit, Kjetil Ask, A. Bruce Montgomery, Martin R. Kolb, Mark W. Surber (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 2, 2020 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: June 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 62Author(s): (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - July 15, 2020 Category: Respiratory Medicine Source Type: research

Bergenin-activated SIRT1 inhibits TNF-α-induced proinflammatory response by blocking the NF-κB signaling pathway
Publication date: Available online 29 June 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Min Chen, Cuifen Chen, Yun Gao, Dongming Li, Dan Huang, Ziyu Chen, Xuanna Zhao, Qiu Huang, Dong Wu, Tianwen Lai, Guomei Su, Bin Wu, Beixian Zhou (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 29, 2020 Category: Respiratory Medicine Source Type: research

The Effects of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase Inhibitor treatments on Lipopolysaccharide-induced Airway Inflammation in Mice
Publication date: Available online 13 May 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Reshed Abohalaka, Turgut Emrah Bozkurt, Emirhan Nemutlu, Sevgen Celik Onder, Inci Sahin-Erdemli (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 15, 2020 Category: Respiratory Medicine Source Type: research

A randomized, double-blind study to compare the efficacy and safety of two doses of mometasone furoate delivered via Breezhaler® or Twisthaler® in patients with asthma
Publication date: Available online 7 May 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Roland Buhl, Ana-Maria Tanase, Motoi Hosoe, Weihua Cao, Ivan Demin, Christian Bartels, Jürgen Jauernig, Dominik Ziegler, Francesco Patalano, Bettina Hederer, Frank Kanniess, Hanns-Christian Tillmann (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 7, 2020 Category: Respiratory Medicine Source Type: research

Mdivi-1 attenuates lipopolysaccharide-induced acute lung injury by inhibiting MAPKs, oxidative stress and apoptosis
Publication date: Available online 3 April 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Songyun Deng, Lina Zhang, Yunan Mo, Yan Huang, Wenchao Li, Qianyi Peng, Li Huang, Yuhang Ai (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 4, 2020 Category: Respiratory Medicine Source Type: research

JMV5656, a short synthetic derivative of TLQP-21, alleviates acid-induced lung injury and fibrosis in mice
Publication date: Available online 20 March 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Vanessa Zambelli, Laura Rizzi, Paolo Delvecchio, Elena Bresciani, Laura Molteni, Ramona Meanti, Verdiè Pascal, Jean-Alain Fehrentz, Robert J. Omeljaniuk, Giacomo Bellani, Antonio Torsello (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 21, 2020 Category: Respiratory Medicine Source Type: research

Tolerability of nintedanib-related diarrhea in patients with idiopathic pulmonary fibrosis
Publication date: Available online 20 March 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Yasutaka Hirasawa, Mitsuhiro Abe, Jiro Terada, Masashi Sakayori, Kenichi Suzuki, Keiichiro Yoshioka, Takeshi Kawasaki, Kenji Tsushima, Koichiro Tatsumi (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 21, 2020 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: April 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 61Author(s): (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 18, 2020 Category: Respiratory Medicine Source Type: research

Determinants of response to bronchodilator in patients with cough variant asthma- A randomized, single-blinded, placebo-controlled study
Publication date: Available online 21 February 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Fang Yi, Lina Han, Baojuan Liu, Xu Zhang, Yongxin Xue, Wei Luo, Qiaoli Chen, Kefang LaiAbstractBackgroundNot all patients with cough variant asthma (CVA) show responsiveness to bronchodilators (RB) in clinic. Whether there are specific clinical and pathophysiological features can indicate RB in patients with CVA needs further investigation. Thus, we aimed to investigate the RB in patients with CVA and associated factors.MethodsForty-two CVA patients were randomized in a 2:1 ratio to receive oral bambuterol hydroch...
Source: Pulmonary Pharmacology and Therapeutics - February 22, 2020 Category: Respiratory Medicine Source Type: research

Open triple therapy for chronic obstructive pulmonary disease: Patterns of prescription, exacerbations and healthcare costs from a large Italian claims database
ConclusionsThis large observational study based on claims data reliably identified subjects with COPD treated with open TT and their burden on the NHS. Moreover, it could describe the real clinical management of the open TT, before the marketing of the fixed one. These findings are useful for health policymakers in order to promote the appropriate utilization of both currently marketed and future therapies. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 22, 2020 Category: Respiratory Medicine Source Type: research

Hypertonic saline reduces cell infiltration into the lungs after brain death in rats
ConclusionsHSS is capable of reducing inflammatory cell infiltration into the lung after BD induction, which is associated with the reduction of ICAM-1 expression in organ vessels. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 8, 2020 Category: Respiratory Medicine Source Type: research

Bioequivalence studies of inhaled indacaterol maleate in healthy Chinese volunteers under gastrointestinal non-blocking or blocking with concomitant charcoal administration
ConclusionsThe results showed that 150 μg indacaterol (+/− 9 g charcoal) was well tolerated in all subjects. The two formulations are bioequivalent in terms of the rate and absorption both in charcoal-block and non-block conditions. The improved charcoal-based regimen demonstrated to be effective and fully blockade of GI absorption of indacaterol. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - February 8, 2020 Category: Respiratory Medicine Source Type: research

Effect of piperlongumine during exposure to cigarette smoke reduces inflammation and lung injury
Publication date: Available online 24 January 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Monielle Sant’Ana Leal, Helena R. Souza, Lucas Possebon, Marinônio L. Cornélio, Yanira Riffo-Vasquez, Ana Paula Girol, Sonia M. OlianiAbstractChronic obstructive pulmonary disease (COPD) is related to smoking and anti-inflammatory therapy is indicated. Among the mediators with anti-inflammatory properties, we highlight piperlongumine (PL), an alkaloid/amide of Piper longum. Here we evaluated the PL administration on an experimental model of respiratory inflammation resulting from exposure to ciga...
Source: Pulmonary Pharmacology and Therapeutics - January 25, 2020 Category: Respiratory Medicine Source Type: research

Asthmatic children and MDI verbal inhalation technique counseling
In this study many children younger than 18 years old with asthma were collected from University hospital outpatient clinics throughout two years period Their MDI inhalation technique was checked and the number of MDI inhalation technique mistakes were detected and corrected at the first visit and every month for two more visits (three visits). Their peak expiratory flow (PEF) and forced expiratory volume in 1 s (FEV1) as a percentage of the forced vital capacity (FVC) were checked at every visit.Results81 asthmatic subjects (54 female) younger than 18 years old were collected with a mean (SD) age 14.4 (1.8) years old. M...
Source: Pulmonary Pharmacology and Therapeutics - January 25, 2020 Category: Respiratory Medicine Source Type: research

Dual use of bronchodilators versus monotherapy, and its impact on pulmonary rehabilitation in COPD patients
Publication date: Available online 21 January 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Vicente Benavides-Cordoba, Sebastian Aviles, Camila Asc.ar, Lina Orozco, Ricardo Mosquera, Julian RiveraAbstractIntroductionLong-acting bronchodilators are the therapy with the best evidence for treating stable chronic obstructive pulmonary disease (COPD). Long-acting combinations of β2 agonists and anticholinergics (LABA-LAMA) are recommended in advanced stages when monotherapy has not generated the desired effects. Pulmonary Rehabilitation (PR) is an effective non-pharmacological strategy. The aim of this st...
Source: Pulmonary Pharmacology and Therapeutics - January 22, 2020 Category: Respiratory Medicine Source Type: research

Mepolizumab effectiveness on small airway obstruction, corticosteroid sparing and maintenance therapy step-down in real life
Publication date: Available online 21 January 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Sposato Bruno, Camiciottoli Gianna, Bacci Elena, Scalese Marco, Carpagnano Giovanna Elisiana, Pelaia Corrado, Santus Pierachille, Maniscalco Mauro, Masieri Simonetta, Angelo Corsico, Nicola Scichilone, Baglioni Stefano, Murgia Nicola, Folletti Ilenia, Bardi Giulio, Grosso Amelia, Cameli Paolo, Latorre Manuela, Antonino Musarra, Bargagli ElenaAbstractBackgroundMepolizumab (MEP) has been recently introduced to treat severe eosinophilic asthma. Trials have demonstrated a significant effectiveness in this phenotype. We...
Source: Pulmonary Pharmacology and Therapeutics - January 21, 2020 Category: Respiratory Medicine Source Type: research

Presence and function of β-adrenergic receptors in primary equine bronchial epithelia cells
Publication date: Available online 18 January 2020Source: Pulmonary Pharmacology & TherapeuticsAuthor(s): Linda Marie Schellenberg, Jana Bonicelli, Ina Hochheim, Ralf Regenthal, Getu AbrahamAbstractThe β-adrenergic receptor (β-AR) plays an important role in regulating a variety of cell and organ functions in different animal species and is an important target in asthma pathogenesis and therapy. The β-AR expression and function in equine bronchial epithelial cells (EBEC) were not known but innervation and significant decrease in receptor level were reported in the equine bronchial tissues from asthmatic h...
Source: Pulmonary Pharmacology and Therapeutics - January 18, 2020 Category: Respiratory Medicine Source Type: research

Editorial Board
Publication date: February 2020Source: Pulmonary Pharmacology & Therapeutics, Volume 60Author(s): (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - January 17, 2020 Category: Respiratory Medicine Source Type: research

Multiple single nucleotide polymorphisms of the transient receptor potential vanilloid 1 (TRPV1) genes associate with cough sensitivity to capsaicin in healthy subjects
ConclusionCapsaicin cough challenge sensitivity in healthy subjects is dependent on multiple TRPV1 polymorphisms. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - January 12, 2020 Category: Respiratory Medicine Source Type: research

Contribution of angiotensin II in hepatic ischemia /reperfusion induced lung injury: Acute versus chronic usage of captopril
ConclusionAngiotensin II plays a key role in tissue inflammation and airway hyperresponsiveness (AHR) via enhancing production of TNF-α. With more protection observed in lung, acute captopril could attenuate liver-induced lung injury via lowering TNF-α; a suggested possible mediator of airway hyperreactivity.Graphical abstract (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - January 9, 2020 Category: Respiratory Medicine Source Type: research