Long-Term Follow-up of a Patient with Type 2 Timothy Syndrome and the Partial Efficacy of Mexiletine.
We report a detailed case of type 2 TS due to a p.(Gly402Ser) mutation in exon 8 of the CACNA1C gene. The patient shows a marked prolongation of repolarization with a mean QTc of 540 ms. He shows no structural heart disease, syndactyly, or cranio-facial abnormalities. However, he shows developmental delays, without autism, and dental abnormalities. The cardiac phenotype is very severe, with a resuscitated cardiac arrest at 2.5 years of age, followed by 26 appropriate shocks during nine years of follow-up. Adding mexiletine to nadolol resulted in a reduction of the QTc and a slight decrease in the number of appropriate shoc...
Source: Gene - January 29, 2021 Category: Genetics & Stem Cells Authors: Hermida A, Jedraszak G, Kubala M, Mathiron A, Berna P, Bennis Y, Hermida JS Tags: Gene Source Type: research
Urinary Excretion of Nadolol as a Possible In Vivo Probe for Drug Interactions Involving P-glycoprotein.
This article is protected by copyright. All rights reserved.
PMID: 33387374 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Pharmacology)
Source: The Journal of Clinical Pharmacology - January 2, 2021 Category: Drugs & Pharmacology Authors: Shimazaki S, Kuroda J, Shimomura K, Misaka S Tags: J Clin Pharmacol Source Type: research
The Efficacy of Beta-Blockers in Patients With Long QT Syndrome 1 –3 According to Individuals’ Gender, Age, and QTc Intervals: A Network Meta-analysis
In conclusion, nadolol was recommended as a relatively effective strategy for LQT2 in order to improve the prognosis of patients during a long follow-up period. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - December 14, 2020 Category: Drugs & Pharmacology Source Type: research
Severe hypoglycemia in children treated with nadolol: A case report and FDA adverse event reporting system (FAERS) database analysis.
CONCLUSION: Hypoglycemia is a reported life-threatening ADR associated with nadolol, especially in infants, in whom this drug should be used with caution.
PMID: 33300862 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Pharmacology and Therapeutics)
Source: International Journal of Clinical Pharmacology and Therapeutics - December 12, 2020 Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Bio analytical validation for nadolol and bendroflumethiazide material
Publication date: Available online 24 November 2020Source: Materials Today: ProceedingsAuthor(s): V.M.K. Naveen, B. Veeraswami, G. Srinivasa Rao (Source: Materials Today: Proceedings)
Source: Materials Today: Proceedings - November 25, 2020 Category: Materials Science Source Type: research
Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer
In this study, we explored the correlations of NNMT to tumor-infiltrating immune cells (TIICs) and immune marker sets in The Cancer Genome Atlas Stomach Adenocarcinoma STAD (TCGA-STAD). Subsequently, we screened the NNMT correlated genes and performed the enrichment analysis of these genes. We eventually predicted the 19 most potential small-molecule drugs using the connectivity map (CMap) and Comparative Toxicogenomics Database (CTD). Also, nadolol, tranexamic acid, felbinac and dapsone were considered the four most promising drugs for GC. In summary, NNMT can be used as a prognostic biomarker that reflect immune infiltra...
Source: Frontiers in Genetics - October 28, 2020 Category: Genetics & Stem Cells Source Type: research
Protective effects of morphine in a rat model of post-traumatic stress disorder: Role of hypothalamic-pituitary-adrenal axis and beta- adrenergic system.
Abstract
Post-traumatic stress disorder (PTSD) arises after tremendous traumatic experiences. Recently, we have reported that morphine has time-dependent protective effects against behavioral and morphological deficits in the single prolonged stress (SPS) as an experimental model of PTSD in adult male rats. To find the mechanisms underlying the protective effects of morphine against SPS-induced PTSD-like symptoms, the present study investigated the interaction between morphine and hypothalamic-pituitary-adrenal (HPA) axis and beta - adrenergic system, which crucially involved in the stress response, on PTS...
Source: Behavioural Brain Research - August 18, 2020 Category: Neurology Authors: Abdullahi PR, Abdullahi ER, Sameni H, Vafaei AA, Ghanbari A, Rashidy-Pour A Tags: Behav Brain Res Source Type: research
The effects of β1 and β1+2 adrenergic receptor blockade on the exercise-induced mobilization and ex vivo expansion of virus-specific T cells: implications for cellular therapy and the anti-viral immune effects of exercise.
This study determined if β2 adrenergic receptor (AR) signaling precipitated the VST response to acute exercise. Healthy participants (n = 12) completed 30 min of steady-state cycling exercise after ingesting a placebo, a β1 + 2 AR antagonist (nadolol) or a β1 AR antagonist (bisoprolol). Circulating VSTs to cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus (AdV) antigens were enumerated before and after exercise, and peripheral blood mononuclear cells were cultured with viral peptides for 8 days to expand multi-VSTs. Compared with placebo, nadolol blunted the exercise-induced mobilization of CMV-V...
Source: Cell Stress and Chaperones - August 9, 2020 Category: Cytology Authors: Kunz HE, Agha NH, Hussain M, LaVoy EC, Smith KA, Mylabathula P, Diak D, Baker FL, O'Connor DP, Bond RA, Katsanis E, Bollard CM, Simpson RJ Tags: Cell Stress Chaperones Source Type: research
Successful trans-maternal nadolol pharmacotherapy in a fetus presenting with long QT syndrome type 2 complicated by torsade de pointes
Publication date: Available online 25 July 2020Source: Journal of Cardiology CasesAuthor(s): Yuriko Shima, Hitoshi Horigome, Yoshihiro Nozaki, Lisheng Lin, Takumi Ishiodori, Yusuke Yano, Miho Takahashi, Takashi Murakami, Hiro Yamasaki, Hidetoshi Takada (Source: Journal of Cardiology Cases)
Source: Journal of Cardiology Cases - July 26, 2020 Category: Cardiology Source Type: research
β-blocker therapy for infantile haemangioma.
Authors: Koh SP, Leadbitter P, Smithers F, Tan ST
Abstract
INTRODUCTION: 15% of proliferating infantile haemangioma (IH) require intervention because of the threat to function or life, ulceration or tissue distortion. Propranolol is the mainstay treatment for problematic proliferating IH. Other β-blockers and angiotensin-converting enzyme (ACE) inhibitors have been explored as alternative treatments.
AREAS COVERED: The demonstration of a haemogenic endothelium origin of IH with a neural crest phenotype and multi-lineage differentiation capacity, regulated by the renin-angiotensin system, underscor...
Source: Expert Review of Clinical Pharmacology - July 15, 2020 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Comparison of the effectiveness of 11 mainstay treatments for secondary prophylaxis of variceal bleeding in patients with cirrhosis: A network meta-analysis.
In conclusion, the present network meta-analysis suggested that for a decreased mortality due to variceal rebleeding in patients with cirrhosis, nadolol plus ISMN may be a preferable choice, while ES is associated with a higher risk of unfavourable treatment outcomes. Further well-controlled studies are required to further elucidate the appropriate treatment options.
PMID: 32346409 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 30, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research
A case of catecholaminergic polymorphic ventricular tachycardia masquerading as an intractable seizure
Reza Shabanian, Manizheh Ahani, Shima Zandiyeh, Aliyeh Nikdoost, Minoo Dadkhah, Parvin Akbari Asbagh, Reza Shervin BadvAnnals of Pediatric Cardiology 2020 13(2):141-143
A 5-year-old boy with the history of intractable seizure for the past 2 years was transferred to the emergency room for cardiopulmonary resuscitation because of the prolonged seizure and profound cyanosis. He was intubated and resuscitated by cardioversion for a bizarre shape ventricular tachycardia (VT). After noxious stimulation, he showed multiple polymorphic ventricular premature beats that were followed by a bidirectional VT in favor of catecholaminer...
Source: Annals of Pediatric Cardiology - April 24, 2020 Category: Cardiology Authors: Reza Shabanian Manizheh Ahani Shima Zandiyeh Aliyeh Nikdoost Minoo Dadkhah Parvin Akbari Asbagh Reza Shervin Badv Source Type: research
Ventricular arrhythmia suppression with ivabradine in a patient with catecholaminergic polymorphic ventricular tachycardia refractory to nadolol, flecainide, and sympathectomy
This article is protected by copyright. All rights reserved (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - April 6, 2020 Category: Cardiology Authors: Utkarsh Kohli,
Zaid Aziz,
Andrew D. Beaser,
Hemal M. Nayak Tags: CASE REPORT Source Type: research
Protective Effect of Propranolol and Nadolol on Social Defeat-Induced Behavioral Impairments in Rats
Publication date: Available online 9 March 2020Source: Neuroscience LettersAuthor(s): Safiyya Zaidi, Fatin Atrooz, Daniel Valdez, Hesong Liu, Camila Kochi, Richard A. Bond, Samina Salim (Source: Neuroscience Letters)
Source: Neuroscience Letters - March 9, 2020 Category: Neuroscience Source Type: research
Systemic β-Adrenergic Receptor Activation Augments the ex vivo Expansion and Anti-Tumor Activity of Vγ9Vδ2 T-Cells
TCR-gamma delta (γδ) T-cells are considered important players in the graft-vs.-tumor effect following allogeneic hematopoietic cell transplantation (alloHCT) and have emerged as candidates for adoptive transfer immunotherapy in the treatment of both solid and hematological tumors. Systemic β-adrenergic receptor (β-AR) activation has been shown to mobilize TCR-γδ T-cells to the blood, potentially serving as an adjuvant for alloHCT and TCR-γδ T-cell therapy. We investigated if systemic β-AR activation, using acute dynamic exercise as an experimental model, can increase the mobilization, ex vivo expansion, and anti-t...
Source: Frontiers in Immunology - January 23, 2020 Category: Allergy & Immunology Source Type: research
