Pseudohypoparathyroidism: a diagnosis to consider once a PTH elevation is detected
Conclusions: this case underlines the diagnostic path complexity in patients with PTH elevation and the importance of considering all the possible differential diagnoses in order to undertake a timely and correct course of treatment.PMID:35666115 | DOI:10.23750/abm.v93iS3.13072 (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - June 6, 2022 Category: General Medicine Authors: Ilaria Brambilla Federico Rossi Carmelo Pistone Amelia Licari Maria De Filippo Martina Votto Enrico Tondina Carmen Guarracino Source Type: research
Contemporary maternal and fetal outcomes in the treatment of LQTS during pregnancy: Is nadolol bad for the fetus?
β-Blocker therapy, specifically nadolol, is the recommended treatment for long QT syndrome (LQTS). Previous studies assessing maternal and fetal outcomes were published before the nadolol era. (Source: Heart Rhythm)
Source: Heart Rhythm - May 4, 2022 Category: Cardiology Authors: Benjamin H. Hammond, Iqbal El Assaad, Joshua M. Herber, Elizabeth V. Saarel, Daniel Cantillon, Peter F. Aziz Source Type: research
Contemporary Maternal and Fetal Outcomes in Treatment of LQTS during Pregnancy: Is Nadolol Bad for the Fetus?
Beta blocker therapy, specifically nadolol, is the recommended treatment for long QT syndrome (LQTS). Previous studies assessing maternal and fetal outcomes were published prior to nadolol era. (Source: Heart Rhythm)
Source: Heart Rhythm - May 4, 2022 Category: Cardiology Authors: Benjamin H. Hammond, Iqbal El Assaad, Joshua M. Herber, Elizabeth V. Saarel, Daniel Cantillon, Peter F. Aziz Source Type: research
P26 Could the formulation and/or method of administration of oral nadolol have a clinically significant impact on the dose delivered to the patient
Conclusion
In this case, the patient was complex and unstable, and her clinical condition may well have contributed to the increase in ectopy experienced. However, the work done by regional QC identified the risk of inaccuracy and/or variation in the dose of nadolol delivered using different formulations and/or methods of administration.
The solubility limit of nadolol in water is estimated to be ~8mg/ml. Dispersed oral solutions must be thoroughly mixed prior to patient use especially if a proportional dose is required. Inconsistency of the dose of nadolol delivered should be considered when using this method.
Further, th...
Source: Archives of Disease in Childhood - April 20, 2022 Category: Pediatrics Authors: Aindow, A., Edrich, C., Corris, M., Milligan, K., Dwyer, P. Tags: Oral presentations Source Type: research
Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease
Inform Med Unlocked. 2022;30:100932. doi: 10.1016/j.imu.2022.100932. Epub 2022 Mar 26.ABSTRACTDengue fever is a virus spread by mosquitoes that has no effective treatment or vaccination. Several dengue cases combined with the current COVID-19 pandemic, exacerbates this problem. Two proteins, NS5 methyltransferase and NS2B/NS3 primary protease complexes, are crucial for dengue viral replication and are the target sites for antiviral development. Thus, this study screened published literature and identified 162 marine fungus-derived compounds with active bioavailability. Following Lipinski's rules and antiviral property pred...
Source: Molecular Medicine - April 4, 2022 Category: Molecular Biology Authors: Mahamudul Hasan Md Mukthar Mia Shahab Uddin Munna Md Mowdudul Hasan Talha Kanon Das Source Type: research
Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease
Inform Med Unlocked. 2022;30:100932. doi: 10.1016/j.imu.2022.100932. Epub 2022 Mar 26.ABSTRACTDengue fever is a virus spread by mosquitoes that has no effective treatment or vaccination. Several dengue cases combined with the current COVID-19 pandemic, exacerbates this problem. Two proteins, NS5 methyltransferase and NS2B/NS3 primary protease complexes, are crucial for dengue viral replication and are the target sites for antiviral development. Thus, this study screened published literature and identified 162 marine fungus-derived compounds with active bioavailability. Following Lipinski's rules and antiviral property pred...
Source: Molecular Medicine - April 4, 2022 Category: Molecular Biology Authors: Mahamudul Hasan Md Mukthar Mia Shahab Uddin Munna Md Mowdudul Hasan Talha Kanon Das Source Type: research
Nadolol Treatment of Infantile Hemangiomas
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - April 1, 2022 Category: Pediatrics Source Type: research
An International Multi-Center Cohort Study on β-blockers for the Treatment of Symptomatic Children with Catecholaminergic Polymorphic Ventricular Tachycardia
Conclusions: B1-selective BBs were associated with a significantly higher risk for arrhythmic events in symptomatic children with CPVT compared with non-selective BBs, specifically nadolol. Nadolol, or propranolol if nadolol is unavailable, should be the preferred BB for treating symptomatic children with CPVT.PMID:34874747 | DOI:10.1161/CIRCULATIONAHA.121.056018 (Source: Circulation)
Source: Circulation - December 7, 2021 Category: Cardiology Authors: Puck J Peltenburg Dania Kallas Johan M Bos Krystien V V Lieve Sonia Franciosi Thomas M Roston Isabelle Denjoy Katrina B Sorensen Seiko Ohno Ferran Roses-Noguer Takeshi Aiba Alice Maltret Martin J LaPage Joseph Atallah John R Giudicessi Sally-Ann B Clur Ni Source Type: research
An International Multi-Center Cohort Study on β-blockers for the Treatment of Symptomatic Children with Catecholaminergic Polymorphic Ventricular Tachycardia
Conclusions: B1-selective BBs were associated with a significantly higher risk for arrhythmic events in symptomatic children with CPVT compared with non-selective BBs, specifically nadolol. Nadolol, or propranolol if nadolol is unavailable, should be the preferred BB for treating symptomatic children with CPVT.PMID:34874747 | DOI:10.1161/CIRCULATIONAHA.121.056018 (Source: Circulation)
Source: Circulation - December 7, 2021 Category: Cardiology Authors: Puck J Peltenburg Dania Kallas Johan M Bos Krystien V V Lieve Sonia Franciosi Thomas M Roston Isabelle Denjoy Katrina B Sorensen Seiko Ohno Ferran Roses-Noguer Takeshi Aiba Alice Maltret Martin J LaPage Joseph Atallah John R Giudicessi Sally-Ann B Clur Ni Source Type: research
Noninferiority and Safety of Nadolol vs Propranolol in Infants With Infantile Hemangioma
This randomized clinical trial evaluates the noninferiority and safety of oral nadolol compared with oral propranolol in infants with infantile hemangiomas. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - November 8, 2021 Category: Pediatrics Source Type: research
Intrauterine Growth Retardation in Pregnant Women with Long QT Syndrome Treated with Beta-Receptor Blockers
Neonatology. 2021 Jun 29:1-10. doi: 10.1159/000516845. Online ahead of print.ABSTRACTPregnant women with inherited long QT syndrome (iLQTS) are at an increased risk for preterm delivery and intrauterine growth retardation (IUGR) due to their underlying disease. Additionally, they are at a risk of arrhythmogenic events, particularly during the postpartum period because of physiological changes and increased emotional/physical stress. β-receptor blockers can effectively prevent life-threatening Torsades de Pointes ventricular tachycardia and they are the treatment of choice in iLQTS. Use of β-receptor blockers in pregnancy...
Source: Neonatology - June 29, 2021 Category: Perinatology & Neonatology Authors: Tatjana Welzel Birgit Donner Johannes N van den Anker Source Type: research
Intrauterine Growth Retardation in Pregnant Women with Long QT Syndrome Treated with Beta-Receptor Blockers
Neonatology. 2021 Jun 29:1-10. doi: 10.1159/000516845. Online ahead of print.ABSTRACTPregnant women with inherited long QT syndrome (iLQTS) are at an increased risk for preterm delivery and intrauterine growth retardation (IUGR) due to their underlying disease. Additionally, they are at a risk of arrhythmogenic events, particularly during the postpartum period because of physiological changes and increased emotional/physical stress. β-receptor blockers can effectively prevent life-threatening Torsades de Pointes ventricular tachycardia and they are the treatment of choice in iLQTS. Use of β-receptor blockers in pregnancy...
Source: Neonatology - June 29, 2021 Category: Perinatology & Neonatology Authors: Tatjana Welzel Birgit Donner Johannes N van den Anker Source Type: research
Intrauterine Growth Retardation in Pregnant Women with Long QT Syndrome Treated with Beta-Receptor Blockers
Pregnant women with inherited long QT syndrome (iLQTS) are at an increased risk for preterm delivery and intrauterine growth retardation (IUGR) due to their underlying disease. Additionally, they are at a risk of arrhythmogenic events, particularly during the postpartum period because of physiological changes and increased emotional/physical stress. β-receptor blockers can effectively prevent life-threatening Torsades de Pointes ventricular tachycardia and they are the treatment of choice in iLQTS. Use of β-receptor blockers in pregnancy is recommended, although IUGR is commonly reported for prenatally exposed infants. I...
Source: Neonatology - June 29, 2021 Category: Perinatology & Neonatology Source Type: research
The cytotoxic and apoptotic effects of beta-blockers with different selectivity on cancerous and healthy lung cell lines
Mol Biol Rep. 2021 Jun 16. doi: 10.1007/s11033-021-06409-7. Online ahead of print.ABSTRACTβ-blockers having specific affinities to β-adrenergic receptors are routinely used to treat cardiovascular problems. Additionally, it has been demonstrated that these drugs can be effective in treating apoptosis-related diseases. The current study was conducted to investigate the cytotoxic and apoptotic effects of β-1 selective esmolol, β-2 selective ICI-118,551, and non-selective nadolol blockers on the cancerous and healthy lung cells. MTT test was used to evaluate cytotoxicity. Apoptotic actions were examined by using Annexin V...
Source: Molecular Biology Reports - June 17, 2021 Category: Molecular Biology Authors: Berna Kavakc ıoğlu Yardımcı Fatime Geyikoglu Ferhunde Aysin Kubra Koc Nihal Simsek Ozek Vural K üçükatay Source Type: research
The cytotoxic and apoptotic effects of beta-blockers with different selectivity on cancerous and healthy lung cell lines
Mol Biol Rep. 2021 Jun 16. doi: 10.1007/s11033-021-06409-7. Online ahead of print.ABSTRACTβ-blockers having specific affinities to β-adrenergic receptors are routinely used to treat cardiovascular problems. Additionally, it has been demonstrated that these drugs can be effective in treating apoptosis-related diseases. The current study was conducted to investigate the cytotoxic and apoptotic effects of β-1 selective esmolol, β-2 selective ICI-118,551, and non-selective nadolol blockers on the cancerous and healthy lung cells. MTT test was used to evaluate cytotoxicity. Apoptotic actions were examined by using Annexin V...
Source: Mol Biol Cell - June 17, 2021 Category: Molecular Biology Authors: Berna Kavakc ıoğlu Yardımcı Fatime Geyikoglu Ferhunde Aysin Kubra Koc Nihal Simsek Ozek Vural K üçükatay Source Type: research
