Carvedilol for portal hypertension in cirrhosis: systematic review with meta-analysis
Conclusions
Carvedilol may be more effective in decreasing HVPG than propranolol or nebivolol and it may be as effective as EVL or nadolol plus ISMN in preventing variceal bleeding. However, the overall quality of evidence is low. Further large-scale randomised studies are required before we can make firm conclusions.
Trial registration number
CRD42015020542. (Source: BMJ Open)
Source: BMJ Open - May 3, 2016 Category: Journals (General) Authors: Li, T., Ke, W., Sun, P., Chen, X., Belgaumkar, A., Huang, Y., Xian, W., Li, J., Zheng, Q. Tags: Open access, Gastroenterology and hepatology, Medical management Research Source Type: research
Mesoporous silica based MCM-41 as solid-phase extraction sorbent combined with micro-liquid chromatography-quadrupole-mass spectrometry for the analysis of pharmaceuticals in waters.
Abstract
This paper reports the first application of the silica based mesoporous material MCM-41 as a sorbent in solid phase extraction, to pre-concentrate pharmaceuticals of very different polarity (atenolol, nadolol, pindolol, timolol, bisoprolol, metoprolol, betaxolol, ketoprofen, naproxen, ibuprofen, diclofenac, tolfenamic acid, flufenamic acid and meclofenamic acid) in surface waters. The analytes were extracted from 100mL water samples at pH 2.0 (containing 10(-3)mol/L of sodium chloride) by passing the solution through a cartridge filled with 100mg of MCM-41. Following elution, the pharmaceuticals w...
Source: Talanta - March 20, 2016 Category: Chemistry Authors: Dahane S, Martínez Galera M, Marchionni ME, Socías Viciana MM, Derdour A, Gil García MD Tags: Talanta Source Type: research
Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period
Publication date: Available online 2 March 2016 Source:Brain, Behavior, and Immunity Author(s): B. Levi, P. Matzner, Y. Goldfarb, L. Sorski, L. Shaashua, R. Melamed, E. Rosenne, G.G. Page, S. Ben-Eliyahu We recently reported that immune stimulation can be compromised if animals are simultaneously subjected to stressful conditions. To test the generalizability of these findings, and to elucidate neuroendocrine mediating mechanisms, we herein employed CpG-C, a novel TLR-9 immune-stimulating agent. Animals were subjected to ongoing stress (20-hrs of wet cage exposure) during CpG-C treatment, and antagoni...
Source: Brain, Behavior, and Immunity - March 3, 2016 Category: Neurology Source Type: research
Separation of Nadolol Stereoisomers Using Chiralpak IA Chiral Stationary Phase.
Abstract
Chiralpak IA adsorbent is used for both analytical and preparative chromatographic separation of nadolol stereoisomers. The results include a complete screening of the mobile phase composition for both the baseline resolution of all four nadolol stereoisomers (analytical separation) and the simulated moving bed (SMB) pseudo-binary separation of the most retained stereoisomer. The experimental results show that analytical baseline resolution of nadolol stereoisomers can be achieved using alcohol/hydrocarbon and alcohol/acetonitrile solvent mixtures. The 10%ethanol/90%acetonitrile mixture is present...
Source: Chirality - March 1, 2016 Category: Molecular Biology Authors: Arafah RS, Ribeiro AE, Rodrigues AE, Pais LS Tags: Chirality Source Type: research
Stress impairs the efficacy of immune stimulation by CpG-C: Potential neuroendocrine mediating mechanisms and significance to tumor metastasis and the perioperative period.
Abstract
We recently reported that immune stimulation can be compromised if animals are simultaneously subjected to stressful conditions. To test the generalizability of these findings, and to elucidate neuroendocrine mediating mechanisms, we herein employed CpG-C, a novel TLR-9 immune-stimulating agent. Animals were subjected to ongoing stress (20-hrs of wet cage exposure) during CpG-C treatment, and antagonists to glucocorticoids, β-adrenoceptor, COX2, or opioids were employed (RU486, nadolol, etodolac, naltrexone). In F344 rats, marginating-pulmonary NK cell numbers and cytotoxicity were studied, and t...
Source: Brain, Behavior, and Immunity - March 1, 2016 Category: Neurology Authors: Levi B, Matzner P, Goldfarb Y, Sorski L, Shaashua L, Melamed R, Rosenne E, Page GG, Ben-Eliyahu S Tags: Brain Behav Immun Source Type: research
Cardiovascular drugs in the treatment of infantile hemangioma.
Abstract
Since the introduction of propranolol in the treatment of complicated infantile hemangiomas (IH) in 2008, other different beta-blockers, including timolol, acetabutolol, nadolol and atenolol, have been successfully used for the same purpose. Various hypotheses including vasoconstriction, inhibition of angiogenesis and the induction of apoptosis in proliferating endothelial cells have been advanced as the potential beta-blocker-induced effect on the accelerated IH involution, although the exact mechanism of action of beta-blockers remains unknown. This has generated an extraordinary interest in IH ...
Source: World Journal of Cardiology - January 26, 2016 Category: Cardiology Authors: Fernandez-Pineda I, Williams R, Ortega-Laureano L, Jones R Tags: World J Cardiol Source Type: research
The Nonmetabolized β-Blocker Nadolol
Is a Substrate of OCT1, OCT2, MATE1, MATE2-K, and P-Glycoprotein,
but Not of OATP1B1 and OATP1B3
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.5b00733 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - January 19, 2016 Category: Drugs & Pharmacology Authors: Shingen Misaka, Jana Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Müller, Hartmut Glaeser, Jörg König and Martin F. Fromm Source Type: research
β‐Blockers have differential effects on the murine asthma phenotype
Conclusion and Implicationsβ‐Blockers have different effects on the murine asthma phenotype that correlate with reported differences in activation or inhibition of downstream β2‐adrenoceptor signalling pathways. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - October 13, 2015 Category: Drugs & Pharmacology Authors: V J Thanawala, D J Valdez, R Joshi, G S Forkuo, S Parra, B J Knoll, M Bouvier, P Leff, R A Bond Tags: RESEARCH PAPER Source Type: research
Beta blocker treatment for infantile hemangiomas.
Abstract
Infantile hemangiomas (IH) are common childhood vascular tumors. Treatment of IH has undergone rapid change in recent years. Since 2008, oral propranolol has been used to treat complicated IH and has proven superior to previously used therapies. More recently, the efficacy of other systemic beta blockers, specifically atenolol and nadolol, has been reported. In addition, topical timolol solution has been effective for treatment of smaller, more superficial IH. The purpose of this article is to review the current literature of beta-blocker therapy for IH.
PMID: 26436966 [PubMed -...
Source: Dermatol Online J - October 9, 2015 Category: Dermatology Authors: Rouhana HF, Fruge JH, Massengale WT Tags: Dermatol Online J Source Type: research
Oral Nadolol for Children with Infantile Hemangiomas and Sleep Disturbances with Oral Propranolol
ConclusionsThe use of oral nadolol in the treatment of IH in our series of 7 patients, resolved the propranolol‐related sleep disturbances in 5 (71%), while in one patient the symptoms recurred after 4 months of oral nadolol at a dose of 2 mg/kg/day. In most cases, switching beta‐blockers did not compromise efficacy, and is recommended when sleep disturbance necessitates discontinuation of beta‐blocker therapy of IH. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - October 8, 2015 Category: Dermatology Authors: José Bernabeu‐Wittel, Basilio Narváez‐Moreno, José Manuel Torre‐García, Israel Fernández‐Pineda, Javier Jesús Domínguez‐Cruz, Félix Coserría‐Sánchez, Concha Álvarez‐del‐Vayo, Julián Conejo‐Mir Tags: Original Article Source Type: research
Aqueous chlorination of acebutolol: kinetics, transformation by-products, and mechanism.
This study investigated the reaction kinetics and the transformation by-products of acebutolol during aqueous chlorination. Acebutolol is one of the commonly used β-blockers for the treatment of cardiovascular diseases. It has been frequently detected in the aquatic environment. In the kinetics study, the second-order rate constant for the reaction between acebutolol and chlorine (k app) was determined at 25 ± 0.1 °C. The degradation of acebutolol by free available chlorine was highly pH dependence. When the pH increased from 6 to 8, it was found that the k app for the reaction between acebutolol and free available...
Source: Environmental Science and Pollution Research International - October 1, 2015 Category: Environmental Health Authors: Khalit WN, Tay KS Tags: Environ Sci Pollut Res Int Source Type: research
Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise testing compared with β-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable cardiac disease predisposing to malignant ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - September 29, 2015 Category: Cardiology Authors: Ida S. Leren, Jørg Saberniak, Eman Majid, Trine F. Haland, Thor Edvardsen, Kristina H. Haugaa Source Type: research
Nadolol decreases the incidence and severity of ventricular arrhythmias during exercise stress testing compared with β-selective β-blockers in patients with catecholaminergic polymorphic ventricular tachycardia
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable cardiac disease predisposing to malignant ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - September 29, 2015 Category: Cardiology Authors: Ida S. Leren, Jørg Saberniak, Eman Majid, Trine F. Haland, Thor Edvardsen, Kristina H. Haugaa Source Type: research
Nadolol Decreases Incidence and Severity of Ventricular Arrhythmias During Exercise Testing Compared to Beta-1 Selective Beta Blockers in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inheritable cardiac disease predisposing to malignant ventricular arrhythmias. (Source: Heart Rhythm)
Source: Heart Rhythm - September 29, 2015 Category: Cardiology Authors: Ida S. Leren, Jørg Saberniak, Eman Majid, Trine F. Haland, Thor Edvardsen, Kristina H. Haugaa Source Type: research
Anti-thrombotic effects of nebivolol and carvedilol: Involvement of β2 receptors and COX-2/PGI2 pathways.
CONCLUSIONS: We demonstrated for the first time that nebivolol and carvedilol, independently of their adrenergic receptor blocking activities, induced anti-thrombotic effects in vivo that involved β2 adrenoceptors and the activation of the COX-2/PGI2 pathway.
PMID: 26398401 [PubMed - in process] (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 26, 2015 Category: Drugs & Pharmacology Authors: Kozlovski VI, Lomnicka M, Bartus M, Sternak M, Chlopicki S Tags: Pharmacol Rep Source Type: research
