Anti-thrombotic effects of nebivolol and carvedilol: Involvement of β2 receptors and COX-2/PGI2 pathways.

CONCLUSIONS: We demonstrated for the first time that nebivolol and carvedilol, independently of their adrenergic receptor blocking activities, induced anti-thrombotic effects in vivo that involved β2 adrenoceptors and the activation of the COX-2/PGI2 pathway. PMID: 26398401 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/26398401?dopt=Abstract

Source: Pharmacological Reports - September 26, 2015 Category: Drugs & Pharmacology Authors: Kozlovski VI, Lomnicka M, Bartus M, Sternak M, Chlopicki S Tags: Pharmacol Rep Source Type: research