Propranolol therapy for infantile hemangioma.
CONCLUSIONS: Although large-scale randomized controlled trials must be conducted in order to further evaluate the safety and the possible role of propranolol in the treatment of IH, the reviewed literature suggests that propranolol carries promise as a potential replacement for corticosteroids as first-line therapy or as a part of a multimodal approach.
PMID: 23680605 [PubMed - in process] (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 8, 2013 Category: Pediatrics Authors: Gunturi N, Ramgopal S, Balagopal S, Scott JX Tags: Indian Pediatr Source Type: research
Carvedilol for Preventing Recurrent Variceal Bleeding: Waiting for convincing evidence
Conclusions:Carvedilol was as effective as nadolol plus isorsorbide‐5 ‐mononitrate mononitrate in the prevention of gastroesophageal variceal rebleeding with fewer severe adverse events and similar survival. (Source: Hepatology)
Source: Hepatology - January 28, 2013 Category: Internal Medicine Authors: Jaime Bosch Tags: Hepatology Elsewhere Source Type: research
Pharmacoelectrophysiology of Viral-Free Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes
Development of pharmaceutical agents for cardiac indication demands elaborate safety screening in which assessing repolarization of cardiac cells remains a critical path in risk evaluations. An efficient platform for evaluating cardiac repolarization in vitro significantly facilitates drug developmental programs. In a proof of principle study, we examined the effect of antiarrhythmogenic drugs (Vaughan Williams class I–IV) and noncardiac active drugs (terfenadine and cisapride) on the repolarization profile of viral-free human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Extracellular field poten...
Source: Toxicological Sciences - January 22, 2013 Category: Toxicology Authors: Mehta, A., Chung, Y., Sequiera, G. L., Wong, P., Liew, R., Shim, W. Tags: Research Article Source Type: research
Separation of Nadolol Stereoisomers by Chiral Liquid Chromatography at Analytical and Preparative Scales.
Abstract
The separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile-phase compositions was performed using different alcohol-hydrocarbon mixtures. The results obtained confirm the use of 20:80:0.3 ethanol-hexane-diethylamine reported by McCarthy (1994) but introduce other possibilities for the complete resolution of the four nadolol stereoisomers at analytical scale, namely, the mixtures 30-40:70-60:0.3 ethanol-heptane-diethylamine. Additionally, this work describes how retentio...
Source: Chirality - January 21, 2013 Category: Molecular Biology Authors: Ribeiro AE, Rodrigues AE, Pais LS Tags: Chirality Source Type: research
