Syncope in a Child with Pulmonary Hypertension and Positive Gene Tests for Hereditary Hemorrhagic Telangiectasia and Long QT Syndrome.
We present a 10 year old boy with syncope who was found to have long-QT syndrome and severe pulmonary hypertension (PH) both in the absence of a secondary cause, to our knowledge this is the first report with this unusual coexistence. His genetic tests were positive for hereditary hemorrhagic telangiectasia and long QT syndrome (LQTS) without any family history of PH or LQTS. We demonstrated that digital subtraction pulmonary angiography was more useful compared to CT angiogram to demonstrate pulmonary vascular changes which correlated with a no-response to acute vasoreactivity testing during right heart catheterization. H...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - October 30, 2019 Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
Cardiac influence of the {beta}3-adrenoceptor in the goldfish (Carassius auratus): a protective role under hypoxia? [RESEARCH ARTICLE]
Serena Leo, Alfonsina Gattuso, Rosa Mazza, Mariacristina Filice, Maria Carmela Cerra, and Sandra Imbrogno
The goldfish (Carassius auratus) exhibits a remarkable capacity to survive and remain active under prolonged and severe hypoxia, making it a good model for studying cardiac function when oxygen availability is a limiting factor. Under hypoxia, the goldfish heart increases its performance, representing a putative component of hypoxia tolerance; however, the underlying mechanisms have not yet been elucidated. Here, we aimed to investigate the role of β3-adrenoreceptors (ARs) in the mechanisms that modulate goldfish...
Source: Journal of Experimental Biology - October 9, 2019 Category: Biology Authors: Leo, S., Gattuso, A., Mazza, R., Filice, M., Cerra, M. C., Imbrogno, S. Tags: RESEARCH ARTICLE Source Type: research
Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing non-cardiac surgery.
CONCLUSIONS: The evidence for early all-cause mortality with perioperative beta-blockers was uncertain. We found no evidence of a difference in cerebrovascular events or ventricular arrhythmias, and the certainty of the evidence for these outcomes was low and very low. We found low-certainty evidence that beta-blockers may reduce atrial fibrillation and myocardial infarctions. However, beta-blockers may increase bradycardia (low-certainty evidence) and probably increase hypotension (moderate-certainty evidence). Further evidence from large placebo-controlled trials is likely to increase the certainty of these findings, and...
Source: Cochrane Database of Systematic Reviews - September 25, 2019 Category: General Medicine Authors: Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, Wildner B, Kammler J, Steinwender C Tags: Cochrane Database Syst Rev Source Type: research
Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing cardiac surgery.
CONCLUSIONS: We found no evidence of a difference in early all-cause mortality, myocardial infarction, cerebrovascular events, hypotension and bradycardia. However, there may be a reduction in atrial fibrillation and ventricular arrhythmias when beta-blockers are used. A larger sample size is likely to increase the certainty of this evidence. Four studies awaiting classification may alter the conclusions of this review.
PMID: 31544227 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 22, 2019 Category: General Medicine Authors: Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, Wildner B, Kammler J, Steinwender C Tags: Cochrane Database Syst Rev Source Type: research
Cardiac influence of the {beta}3-adrenoceptor in the goldfish (Carassius auratus): a protective role under hypoxia? [RESEARCH ARTICLE]
Serena Leo, Alfonsina Gattuso, Rosa Mazza, Mariacristina Filice, Maria Carmela Cerra, and Sandra Imbrogno The goldfish (Carassius auratus) exhibits a remarkable capacity to survive and remain active under prolonged and severe hypoxia, representing a well-suited model to study cardiac function when oxygen availability represents a limiting factor. Under hypoxia, the goldfish heart increases its performance, this representing a putative component of hypoxia tolerance; however, underlying mechanisms have not been yet elucidated. We aimed to investigate the role of β3-ARs in the mechanisms which modulate the goldfish hear...
Source: Journal of Experimental Biology - September 15, 2019 Category: Biology Authors: Leo, S., Gattuso, A., Mazza, R., Filice, M., Cerra, M. C., Imbrogno, S. Tags: RESEARCH ARTICLE Source Type: research
The behaviour of some antihypertension drugs on human serum paraoxonase ‐1: an important protector enzyme against atherosclerosis
ConclusionUsage of these drugs would be hazardous in some cases. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - July 25, 2019 Category: Drugs & Pharmacology Authors: Yeliz Demir Tags: Research Paper Source Type: research
Pharmacokinetic variability of beta ‐adrenergic blocking agents used in cardiology
AbstractThe aim of this study was to evaluate the pharmacokinetic variability of beta ‐adrenergic blocking agents used in cardiology by reviewing single‐dose and steady‐state pharmacokinetic studies from the literature. PubMed was searched for pharmacokinetic studies of beta‐adrenergic blocking agents, both single‐dose and steady‐state studies. The studies included report ed maximum plasma concentration (Cmax) and/or area under the concentration curve (AUC). The coefficient of variation (CV%) was calculated for all studies, and a CV%<40% was considered low or moderate variability, and a CV%>40% was consid...
Source: Pharmacology Research and Perspectives - July 11, 2019 Category: Drugs & Pharmacology Authors: Frederik N. Ågesen,
Peter E. Weeke,
Peer Tfelt‐Hansen,
Jacob Tfelt‐Hansen,
for ESCAPE‐NET Tags: ORIGINAL ARTICLE Source Type: research
Investigation mechanisms between normal, developing and regenerating livers for regenerative liver drug design.
Abstract
Aim: A systematic multimolecule drug design procedure is proposed for promoting hepatogenesis and liver regeneration. Materials & methods: Genome-wide microarray data including three hepatic conditions are obtained from the GEO database (GSE15238). System modeling and big data mining methods are used to construct real genome-wide genetic-and-epigenetic networks (GWGENs). Then, we extracted the core GWGENs by applying principal network projection on real GWGENs of normal, developing and regenerating livers, respectively. After that, we investigated the significant signal pathways and epigenetic...
Source: Regenerative Medicine - June 16, 2019 Category: Genetics & Stem Cells Authors: Wong SW, Yeh SJ, Li CW, Wang LH, Chen BS Tags: Regen Med Source Type: research
LncRNA OIP5-AS1 Promotes the Proliferation of Hemangioma Vascular Endothelial Cells via Regulating miR-195-5p/NOB1 Axis
Conclusion: Taken together, lncRNA OIP5-AS1 acted as a ceRNA to drive proliferation, migration and invasion of HemECs through regulating miR-195-5p/NOB1 axis.
Introduction
Infant hemangioma (IH) is a benign neoplasm commonly seen in childhood, which is more common in premature infants and infants with low birth weight (Smith et al., 2017). There are three distinct clinical histological stages in IH: the early proliferative stage, when undeveloped blood vessels are rapidly growing; plateau stage and final regressive stage, with scattered capillaries and large drainage vessels (Csoma et al., 2017). IH is characterize...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research
A large deletion in RYR2 exon 3 is associated with nadolol and flecainide refractory catecholaminergic polymorphic ventricular tachycardia
This article is protected by copyright. All rights reserved (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - March 24, 2019 Category: Cardiology Authors: Utkarsh Kohli,
Zaid Aziz,
Andrew D. Beaser,
Hemal M. Nayak Tags: CASE REPORT Source Type: research
Syncope in a new mother: a case of long-QT syndrome presenting after childbirth.
Authors: Wereski R, Dobson R, Newman EJ, Connelly D
Abstract
Diagnosis of inherited arrhythmia syndromes, including long-QT syndrome (LQTS), is challenging; however, early detection and initiation of therapies can reduce otherwise high rates of mortality. Two months following the birth of her first child a previously well 21-year-old female experienced four episodes of transient loss of consciousness (TLOC). The history was atypical for seizures but a video electroencephalogram (EEG) captured an episode with abnormal bifrontal epileptic discharge. She was commenced on levetiracetam. Within weeks of the bir...
Source: Journal of the Royal College of Physicians of Edinburgh - March 8, 2019 Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Interaction of Herbal Products with Prescribed Medications: A Systematic Review and Meta-analysis
Publication date: Available online 17 January 2019Source: Pharmacological ResearchAuthor(s): Charles Awortwe, Henrike Bruckmueller, Ingolf CascorbiAbstractAlthough several studies on pharmacokinetic and/or pharmacodynamic herb–drug interactions (HDI) have been conducted in healthy volunteers, there is large uncertainty on the validity of these studies. A qualitative review and a meta-analysis were performed to establish the clinical evidence of these interaction studies. Out of 4026 screened abstracts, 32 studies were included into the qualitative analysis. The meta-analysis was performed on eleven additional studies. St...
Source: Pharmacological Research - January 18, 2019 Category: Drugs & Pharmacology Source Type: research
Dispersive solid-phase extraction using multi-walled carbon nanotubes combined with liquid chromatography–mass spectrometry for the analysis of β-blockers: Experimental and theoretical studies
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Aleksandra Jakubus, Maciej Gromelski, Karolina Jagiello, Tomasz Puzyn, Piotr Stepnowski, Monika PaszkiewiczAbstractThis manuscript presents a dispersive solid phase extraction (dSPE) method combined with liquid chromatography mass spectrometry (LC-MS/MS) to simultaneous determination and quantification of six β-blockers in environmental water samples. The proposed method is based on a multi-walled carbon nanotubes (MWCNTs) as a sorbent, because of their remarkable sorption capacity. Crucial parameters which may affect extraction efficiency such ...
Source: Microchemical Journal - January 15, 2019 Category: Chemistry Source Type: research
Migraine Headache Prophylaxis.
Abstract
Migraines impose significant health and financial burdens. Approximately 38% of patients with episodic migraines would benefit from preventive therapy, but less than 13% take prophylactic medications. Preventive medication therapy reduces migraine frequency, severity, and headache-related distress. Preventive therapy may also improve quality of life and prevent the progression to chronic migraines. Some indications for preventive therapy include four or more headaches a month, eight or more headache days a month, debilitating headaches, and medication-overuse headaches. Identifying and managing en...
Source: American Family Physician - January 1, 2019 Category: Primary Care Authors: Ha H, Gonzalez A Tags: Am Fam Physician Source Type: research
